NEUROTOXICOLOGICAL PROPERTIES OF THE COMPOUND AV-19 FOR PROPHYLAXIS AND TREATMENT OF COMPLICATIONS OF DIABETES MELLITUS

2020 ◽  
pp. 39-43
Author(s):  
D. V. Maltsev ◽  
A. A. Spasov ◽  
V. A. Kosolapov ◽  
K. T. Sultanova ◽  
M. V. Miroshnikov ◽  
...  
Keyword(s):  
Muscle Tone ◽  
Test Method ◽  
Test Results ◽  
Toxic Dose ◽  
Glycation End Products ◽  
Dependent Activity ◽  
Treatment Of Diabetes ◽  
Collagen Glycation ◽  
Dose Dependent ◽  
Average Effective Dose

The article presents the results of a study of the neurotoxicological profile of the new compound AB-19, acting on collagen glycation end products (AGE) and their receptors (RAGE), for the prevention and treatment of diabetes complications. The multi-test method «S. Irwin» was used. The test results were evaluated in parallel groups receiving the substance in doses starting with the average effective dose (ED50) and with a multiple increase by 5, 10, 20 and 50 times. It was found that the compound AB-19 in doses of 20, 100 and 200 mg / kg does not affect the functional and behavioral status of animals. However, with an increase to 400 mg / kg, typical manifestations of intoxication were observed: a decrease in muscle tone, hypothermia, sedation, tachypnea. As a result of the study, it was revealed that the neurotoxicological properties of the compound AB-19 are characterized by dose-dependent activity. A minimum toxic dose of 400 mg / kg ≤ Tdmin ≤ 1000 mg / kg was also indicated.

NEUROTOXICOLOGICAL PROFILE OF 5-НТ2А-ANTAGONIST OF IMIDAZOBENZIMIDAZOLE DERIVATIVE

2019 ◽  
pp. 23-28
Author(s):  
A. A. Spasov ◽  
D. S. Yakovlev ◽  
D. V. Maltsev ◽  
M. V. Miroshnikov ◽  
K. T. Sultanova ◽  
...  
Keyword(s):  
Oral Administration ◽  
Effective Dose ◽  
Control Group ◽  
Compound I ◽  
Toxic Dose ◽  
Test Parameters ◽  
Dependent Activity ◽  
High Doses ◽  
Dose Dependent ◽  
Average Effective Dose

Thearticlepresentstheresultsofastudyoftheneurotoxicologicalprofileofanew5-HT2A-antagonist(compoundI) using the method of multi-test observation by «S. Irwin». The test parameters were evaluated in parallel groups, receiving the compound in doses beginning with the average effective dose (ED50) and with a multiple increase of 2, 5, 7.5 and 10 times.The study revealed that the neurotoxicological properties of compound I are characterized by dose-dependent activity. It has been shown that neurotoxicological changes in the behavior of the animals did not occur with the administration of compound I at average effective dose of 10 mg / kg and doses, exceeding the effective by 2 and 5 times; the animals welfare corresponds to that of the control group. The most significant effects by the administration of the studied compound developed in high doses, exceeding the effective by 7.5 and 10 times. The limits of the minimum toxic dose (TDmin) for compound I by oral administration has been found to be 50 mg / kg <TDmin≤75 mg / kg.

Flavonoids as Potential Therapeutic Agents for the Management of Diabetic Neuropathy

2020 ◽  
Vol 26 (42) ◽  
pp. 5468-5487 ◽  
Author(s):  
Ankita Sood ◽  
Bimlesh Kumar ◽  
Sachin Kumar Singh ◽  
Pankaj Prashar ◽  
Anamika Gautam ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Diabetic Neuropathy ◽  
Glucose Utilization ◽  
Antioxidant Properties ◽  
Therapeutic Agents ◽  
Secondary Complications ◽  
Naturally Occurring ◽  
Glycation End Products ◽  
Treatment Of Diabetes ◽  
Pharmaceutical Industries

Flavonoids are secondary metabolites that are widely distributed in plants. These phenolic compounds are classified into various subgroups based on their structures: flavones, flavonols, isoflavones, flavanones, and anthocyanins. They are known to perform various pharmacological actions like antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic and antiallergic, etc. Diabetes is a chronic progressive metabolic disorder that affects several biochemical pathways and leads to secondary complications such as neuropathy, retinopathy, nephropathy, and cardiomyopathy. Among them, the management of diabetic neuropathy is one of the major challenges for physicians as well as the pharmaceutical industries. Naturally occurring flavonoids are extensively used for the treatment of diabetes and its related complications due to their antioxidant properties. Moreover, flavonoids inhibit various pathways that are involved in the progression of diabetic neuropathy like the reduction of oxidative stress, decrease in glycogenolysis, increase glucose utilization, decrease in the formation of advanced glycation end products, and inhibition of the α-glucosidase enzyme. This review entails current updates on the therapeutic perspectives of flavonoids in the treatment of neuropathic pain. This manuscript explains the pathological aspects of neuropathic pain, the chemistry of flavonoids, and their application in amelioration of neuropathic pain through preclinical studies either alone or in combination with other therapeutic agents.

Modulation of cerebral arterial tone by endothelium-derived relaxing factor

1993 ◽  
Vol 264 (4) ◽  
pp. H1245-H1250 ◽  
Author(s):  
J. E. Brian ◽  
R. H. Kennedy
Keyword(s):  
Nitric Oxide ◽  
Muscle Tone ◽  
Cerebral Arteries ◽  
Maximum Tension ◽  
Relaxing Factor ◽  
Middle Cerebral Arteries ◽  
Endothelium Derived Relaxing Factor ◽  
Vascular Smooth Muscle Tone ◽  
Dose Dependent ◽  
Arterial Tone

This study was designed to further elucidate the role of the endothelium in regulation of cerebral vascular smooth muscle tone. Dose-dependent vasoconstrictive effects of serotonin (5-HT) were examined in endothelium-intact and endothelium-denuded ring segments prepared from canine basilar and middle cerebral arteries. Some preparations were pretreated with 10(-5) M N omega-nitro-L-arginine (L-NNA), an agent that inhibits the production of L-arginine-derived nitric oxide, one of the compounds proposed to be endothelium-derived relaxing factor. L-NNA alone elicited marked dose-dependent increases in tension in endothelium-intact preparations; a significantly smaller response was seen in endothelium-denuded preparations. The effects of L-NNA on endothelium-intact preparations were partially reversed by washing and treatment with L-arginine. The maximum tension induced by 5-HT was approximately doubled by removal of the endothelium as well as by L-NNA treatment of endothelium-intact preparations; a slight increase in maximum tension occurred in endothelium-denuded preparations treated with L-NNA. The concentration of 5-HT producing half-maximal contraction (ED50) was not affected by L-NNA. These data suggest that L-arginine-derived nitric oxide modulates canine cerebral arterial tone in both the resting state and during contraction with 5-HT.

scholarly journals Biological Effect of Different Spinach Extracts in Comparison with the Individual Components of the Phytocomplex

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 382
Author(s):  
Laura Arru ◽  
Francesca Mussi ◽  
Luca Forti ◽  
Annamaria Buschini
Keyword(s):  
Antioxidant Defense ◽  
Extraction Methods ◽  
Oxidizing Agent ◽  
Endogenous Reactive Oxygen Species ◽  
Dependent Activity ◽  
Main Components ◽  
The Individual ◽  
Dose Dependent ◽  
Higher Doses ◽  
Oxidative Insult

The Mediterranean-style diet is rich in fruit and vegetables and has a great impact on the prevention of major chronic diseases, such as cardiovascular diseases and cancer. In this work we investigated the ability of spinach extracts obtained by different extraction methods and of the single main components of the phytocomplex, alone or mixed, to modulate proliferation, antioxidant defense, and genotoxicity of HT29 human colorectal cells. Spinach extracts show dose-dependent activity, increasing the level of intracellular endogenous reactive oxygen species (ROS) when tested at higher doses. In the presence of oxidative stress, the activity is related to the oxidizing agent involved (H2O2 or menadione) and by the extraction method. The single components of the phytocomplex, alone or mixed, do not alter the intracellular endogenous level of ROS but again, in the presence of an oxidative insult, the modulation of antioxidant defense depends on the oxidizing agent used. The application of the phytocomplex extracts seem to be more effective than the application of the single phytocomplex components.

The Research of IC Test Based on LTX-77 Test System

2014 ◽  
Vol 496-500 ◽  
pp. 1176-1179
Author(s):  
Li Tan ◽  
Yu Fang
Keyword(s):  
Test Object ◽  
Test System ◽  
Test Method ◽  
Test Results ◽  
Analog Ic ◽  
Test Platform ◽  
Logic Functions ◽  
Actual Test ◽  
Ic Test

LTX-77 test system is a large IC test system that is used for various kinds of analog IC, digital IC and analog digital mixed IC. It can be used to test DC parameters, AC parameters and logic functions. In the paper, the IC test platform is LTX-77 test system. IC ADC0804 was tested as the test object. The test method of IC is described in the view of actual test. The test results show that the test system is convenient and accurate, which has important practical value for IC manufacturers and users.

The Improved Friction Properties of Bonded MoS2 Films by MAO Treating of Al Substrate

2013 ◽  
Vol 275-277 ◽  
pp. 1911-1914 ◽  
Author(s):  
Han Jun Hu ◽  
Hui Zhou ◽  
Yu Gang Zheng ◽  
Kai Feng Zhang ◽  
Zhi Hua Wan
Keyword(s):  
Tribological Properties ◽  
Solid Lubricants ◽  
Ceramic Coatings ◽  
Test System ◽  
Test Method ◽  
Test Results ◽  
Specimen Test ◽  
Micro Arc Oxidation ◽  
A New Technique ◽  
Porous Microstructures

The bonded MoS2 films are widely used as solid lubricants in aerospace mechanisms due to their excellent tribological properties. Traditionally, the MoS2 was directly bonded on the Al substrate that was only treated by the technique named of sandblast. For improving the tribological properties of MoS2 films, micro arc oxidation (MAO) instead of sandblast was introduced as a new technique for treating of Al substrate. In this article, the tribological properties of MoS2 films which were bonded on different surface of Al substrate as mentioned above were discussed, respectively. It was concluded from the test results that the MoS2 films bonded on substrate treated by MAO have better tribological properties than those samples treated by sandblast. The endurance life against abrasion of the former is as high as twenty times of the latter by the stand test method of ball on disk using the UMT Multi-Specimen Test System. This test results could be illustrated by the following reasons. The first is the porous microstructures of MAO ceramic coatings on the Al substrate. The coatings have numerous pits to be good at increasing the binding force with the MoS2 films, and the pits can also provide a MoS2 lubricants reservoir during processes of friction. Both of them improved the MoS2 film’s ability of wear-protective. The second is that hardness of the coating is higher than the Al, and this ensures well wearing resistance, especially in practical application to big load-supporting moving parts, such as bearing, gear, etc…

Study on Conventional Domed Bursting Disc Material and Burst Pressure Test

2013 ◽  
Vol 690-693 ◽  
pp. 2371-2378
Author(s):  
Wei Pu Xu ◽  
Yi Ting Liu
Keyword(s):  
Stainless Steel ◽  
Tensile Test ◽  
316L Stainless Steel ◽  
Performance Test ◽  
Test Method ◽  
Burst Pressure ◽  
Test Results ◽  
Manufacturing Method ◽  
Pressure Test ◽  
Disc Material

A brief overview is given in the conventional domed bursting disc structure and manufacturing method. 316L stainless steel as a template is selected. With the investigation on bursting disc material tensile test method, the test results are summarized,also the burst results of disc burst pressure in different sizes. With the help of bursting disc material performance test and bursting disc burst pressure test of 316L , the test results provide a reference for other types of bursting disc.

scholarly journals Hedonic Test Method for Measuring Instant Pindang Seasoning Powder Preferences

2019 ◽  
Vol 3 (1) ◽  
pp. 34
Author(s):  
Dea Tio Mareta
Keyword(s):  
Test Method ◽  
Test Results ◽  
Drying Method ◽  
Typical Food ◽  
Hedonic Scale

Instant seasoning for cooking are commonly known by people who want something practical. Pindang is a typical food of Lampung and South Sumatra Province, consisting of various spices and herbs. Instant pindang seasoning powder made with foam mat drying method using 3 varations of foam additives. The purpose of this study was to determine the level of taste, aroma, and color of instant pindang seasoning powder made with three variations of foam additives, namely 5% (w/w), 10% (w/w), and 15% (w/w). The hedonic test for instant pindang seasoning powder were carried out on 35 panelists. Panelists were faced with 3 samples with 3 different sample numbers. Panelists were asked to assess how much preference for seasoning products using hedonic scale. The hedonic test results showed that, with the addition of 15% (w/w) foam is preferred in terms of color. As for aroma and taste, there were no significant differences between the three products. Keywords: foam mat drying , hedonic test, instant pindang seasoning powder, pindang

scholarly journals Pengaruh Latihan Dribbling With A Curving Line Trajectory Untuk Meningkatkan Keterampilan Dribbling Pemain Sepak Bola Ps. Undikam Mataram Tahun 2019

2019 ◽  
Vol 4 (4) ◽  
Author(s):  
Ismail Marzuki ◽  
Soemardiawan Soemardiawan
Keyword(s):  
Sampling Technique ◽  
Test Method ◽  
Soccer Players ◽  
Football Players ◽  
Test Results ◽  
Significance Level ◽  
Speed Test ◽  
Table Analysis ◽  
Observation Method ◽  
Line Trajectory

The focus of the problem in this research When competing frequently there are mistakes in dribbling, so from this it is necessary to have this exercise, to improve the dribbling skills of PS players. UNDIKMA Mataram. The purpose of this study is to determine whether there is an effect of Dribbling With A Curving Line Trajectory Exercise on the Dribbling Skills of PS Soccer Players. Mataram UNDIKMA 2019 ". The research methods used by researchers are the observation method, the documentation method and the deed test method. The study design uses a pretest-posttest design (initial test and final test). The population used in this study are all PS players. UNDIKMA Mataram in 2019. The number of samples in the study conducted was 22 which became a sample of 11 players PS soccer players. UNDIKMA Mataram. The sampling technique in this study using the saturation sampling technique is a sampling technique if all members of the population can be sampled. Analysis of statistical data with a significance level of 5% for the speed test results obtained by the t-value so from the results of research X1 (Dribbling With A Curving Line Trajectory, with Y1 obtained tcount is much greater than ttable, this shows that the hypothesis "Ha" (accepted ) then this research is significant, drawing conclusions from the table analysis at a significant level of 5% with a number of samples (n - 1) that is 11-1 = 10 at 1,812. Then it can be concluded that, 1) The Effect of Dribbling With A Curving Line Trajectory on Dribbling Skills PS Football Players. Mataram UNDIKMA 2019, Tcount> ttable (7.362> 1,812). 2). this shows that the hypothesis "Ha" (accepted) then this research is significant.

scholarly journals PENDIDIKAN KARAKTER MELALUI PEMBELAJARAN MATEMATIKA

2014 ◽  
Vol 10 (1) ◽  
Author(s):  
Salafudin *
Keyword(s):  
Statistical Analysis ◽  
Character Education ◽  
Sampling Technique ◽  
Problem Formulation ◽  
Test Method ◽  
Cluster Sampling ◽  
Test Results ◽  
Learning Mathematics ◽  
Character Building ◽  
Better Than

This study aimed to determine: (1) how was the design of character building by learning mathematics, and (2) whether the character building by learning mathematics could produce better learning outcome of mathematics than conventional mathematics learning.To answer these two questions, I used Research and Development ( R & D ) which consists of a preliminary study to obtain preliminary data on student learning outcomes before being given treatments of character building by learning mathematics. The next phase is the design of the character building by learning mathematics. Further testing and revision in class and repeated until it found the best learning model. From the first problem formulation, qualitative data analysis, such as the design of character building in learning mathematics was produced. The results of the qualitative analysis shows, character building by learning mathematics was quite effectively applied to implant positive character in students. To answer the second question, statistical analysis was used. The population in this study was all students of class VII of MTsN in Buaran of Pekalongan which totaled 220. By random cluster sampling technique two classes (a class VII A and VII B) was chosen. Class VII A was as an experiment class, and class VII B was as a control class. Data were taken by the test method, experimental classroom observation, and documentation. The data was then processed with an average difference test. Results of statistical analysis obtained t = 3.33 > t table = 1.67. This meant that learning achievement of the students in the experimental class, which was implemented character education in mathematics was better than the students who were taught by conventional methods. Based on these results, it could be conclude that the character building in mathematics was better than the conventional method of learning mathematics.

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