scholarly journals FRAKSI ETANOL RIMPANG TEMU PUTIH (Curcuma zedoaria (Christm.) Rosc.) SEBAGAI ANTIFUNGI TERHADAP Candida albicans dan Trichophyton rubrum

2019 ◽  
Author(s):  
Yuli Wahyu Trimulyani ◽  
Nurma Suri ◽  
Niken Dwi Astarina
Keyword(s):  
Candida Albicans ◽  
Minimum Inhibitory Concentration ◽  
Traditional Medicine ◽  
Inhibitory Concentration ◽  
Trichophyton Rubrum ◽  
Ethanol Extract ◽  
Positive Control ◽  
Curcuma Zedoaria ◽  
Synthetic Drugs ◽  
Layer Chromatography

Traditional medicine is used as natural because it has small effects and more economical than the synthetic drugs. One example of the plants used as a Traditional medicine are Curcuma zedoaria. The study to examine the activity fraction of Curcuma zedoaria rhizome ethanol extract agains Candida albicans and Trichophyton rubrum. The simplisia of Curcuma zedoaria rhizome was extracted with ethanol 70% using a maceration method. Thick extracts were then fractionated using saveral solven such as n-heksane, chloroform and ethanol. The testing method used disc antifungi activity with the concentration of 6.25%, 12.5%, 25%, 50%, 75%, ketokonazol as the positive control and aquades as the resolvent. The test compounds Thin Layer Chromatography (TLC) method with eluen chloroform: methanol: water (2:3:5(v/v/v)) and phase uses G60F254 had been done. The result showed that Curcuma zedoaria rhizome significantly inhibit of C. albicans and T. rubrum the best inhibit zone diameter that are concentration of 75% for both of them with a diameter 8.98 mm in C. albicans and 11.66 mm in T. rubrum. Minimum Inhibitory Concentration (MIC) C. albicans is obtained on concentration of 6.25% and T. rubrum is concentration on of 12.5%. The TLC results showed a compound of flavonoids (Rf 0.88), saponins (Rf 0.74), tannins (Rf 0.86). Minimum Inhibitory Concentration (MIC) in C. albicans and T. rubrum are fungistatik and Minimum Bactericidal Concentration (MBC) are not fungisid for both of them. The ethanol fraction of Curcuma zedoaria rhizome has an activity as an antifungal against C. albicans and T. Rubrum with flavonoids, tannins and saponins. Keywords: Antifungi, Candida albicans, Curcuma zedoaria, Fungistatic, Trichophyton rubrum.

scholarly journals Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic Fungus Scopulariopsis candelabrum and Their Antifungal Activity

2022 ◽  
Vol 9 ◽  
Author(s):  
Jun Tang ◽  
Xueshuang Huang ◽  
Ming-Hang Cao ◽  
Zhiyan Wang ◽  
Zhiyin Yu ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
High Resolution Mass Spectrometry ◽  
2D Nmr ◽  
Positive Control ◽  
Diffusion Method ◽  
Exserohilum Turcicum ◽  
Chemical Structures ◽  
Alkenoic Acid

During a screening for antifungal secondary metabolites, six new mono-/bis-alkenoic acid derivatives (2–7) and one known alkenoic acid derivative (1) were isolated from an endophytic fungi Scopulariopsis candelabrum. Their chemical structures were identified by 1H-NMR, 13C-NMR, 2D NMR, and high-resolution mass spectrometry, as well as comparisons with previously reported literatures. Among them, fusariumesters C‒F (2–5) are bis-alkenoic acid derivatives dimerized by an ester bond, while acetylfusaridioic acid A (6) and fusaridioic acid D (7) are alkenoic acid monomers. All the isolates were submitted to an antifungal assay against Candida albicans and the corn pathogen Exserohilum turcicum using the filter paper agar diffusion method. As a result, only compound 1 decorating with β-lactone ring turned out to be active against these two tested fungi. The broth microdilution assay against Candida albicans showed the minimum inhibitory concentration (MIC) value of 1 to be 20 μg/ml, while the minimum inhibitory concentration value of the positive control (naystatin) was 10 μg/ml. And the half maximal inhibitory concentration (IC50) value (21.23 μg/ml) of 1 against Exserohilum turcicum was determined by analyzing its inhibition effect on the mycelial growth, using cycloheximide (IC50 = 46.70 μg/ml) as the positive control.

scholarly journals Physicochemical and antimicrobial assessment of Iranian Propolis gathered in Qazvin province

2020 ◽  
Vol 10 (2) ◽  
pp. 82
Author(s):  
Fatemeh Samieerad ◽  
Nematollah Gheibi
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Minimum Inhibitory Concentration ◽  
Thin Layer ◽  
Inhibitory Concentration ◽  
Minimum Bactericidal Concentration ◽  
Antibacterial Effect ◽  
Ethanol Extract ◽  
Standard Strain ◽  
Layer Chromatography

Background: Propolis is one of the useful bee colony products that have been used in traditional medicine for centuries. In this study, the physicochemical characters and their antibacterial effect of Iranian Propolis collected from Qazvin province was assessed.Methods: In this study, Thin Layer Chromatography and Vacuum Liquid Chromatography to detect different compounds of the extract have been used. In the initial evaluation of Propolis extract, it was found that the extract includes variable compounds with different polarity; so, the initial classification of extract with different polarity solvents was essential. Finally, 0.1 gr hydro alcoholic Propolis was injected to the HPLC by ultrasound. The antibacterial effect of Iranian ethanol extract Propolis was measured using a microdilution method against Pseudomonas aeruginosa: P. aeruginosa and Staphylococcus aureus: S.aureus standard strains and the minimum bactericidal and inhibitory concentration were defined.Results: Primary analysis of the ethanol extract by analytical Thin Layer Chromatography, demonstrated the presence of flavonoid and phenol in it. Minimum inhibitory concentration and Minimum Bactericidal Concentration for Staphylococcus aureus: S.aureus standard strain was 2.5mg/ml. The same procedure was done for Pseudomonas aeruginosa: P. aeruginosa standard strain and the Minimum inhibitory concentration and Minimum Bactericidal Concentration were 50mg/ml of Propolis extracts.  Conclusion: According to the results, the alcoholic extract of propolis from Qazvin province of Iran provides significant antimicrobial activity. Its powerful activity may be due to high total phenolic and flavonoid contents.Keywords: Iranian propolis, Antibacterial activity, Phenolic compounds, Flavonoid compound

Phytochemical Screening and Antifungal Activity of Kulantrillo De Allambre (Adiantum capillus-veneris) Extract as a Formulated Vaginal Cream Against Candida albicans

10.17158/234 ◽  
2012 ◽  
Vol 18 (1) ◽  
Author(s):  
Kathleen G. Bersabal ◽  
Kyrie Marie D. Deluao ◽  
Meg C. Ibarra ◽  
Nessa Karla C. Jerusalem
Keyword(s):  
Candida Albicans ◽  
Minimum Inhibitory Concentration ◽  
Antifungal Activity ◽  
Physical Properties ◽  
Inhibitory Concentration ◽  
Positive Control ◽  
Phytochemical Screening ◽  
Antifungal Property ◽  
Vaginal Cream ◽  
Adiantum Capillus Veneris

Candida albicans is a fungus that is normally present on the skin and in mucous membranes such as vagina, mouth, or rectum. This fungus also can travel through the blood stream and affect the throat, intestines, and heart valves. It becomes an infectious agent when there is some change in the body environment that allows it to grow out of control; thus, causing a modern day disease brought on by antibiotics, drugs, processed foods, sugar and poor diet. Folkloric practice suggests that Kulantrillo de Allambre (Adiantum capillus-veneris) is effective as antifungal medication against Candida albicans; therefore, this study was undertaken to verify such claim. This effort included the phytochemical screening of active constituents, susceptibility and minimum inhibitory concentration tests involving the plant. To prove that Kulantrillo de Allambre possesses antifungal activity, a formulation of vaginal cream out of the plant extracts was tested. Alkaloids, saponins, steroids, flavonoids, tannins and anthraquinones were performed following the method described by Guevara et al. (2005). Kirby-Bauer Method was employed for the susceptibility test and two-fold agar dilution was employed for the MIC. Vaginal cream was formulated following the method of Ansel (2004). Tests revealed the presence of flavonoids only, which exhibit the antifungal property. Kirby-Bauer Method revealed that both test extract and positive control showed strong inhibition equivalent to 17.71 ± 6.3183 mm and 23.54 ± 4.9629 mm, respectively. Minimum Inhibitory Concentration of the plant extract was 50,000 ug/mL. Statistical analysis showed that there is no significant difference between the antifungal property of plant extract and positive control. Both test drugs have similar antifungal property, suggesting that the plant material is a good antifungal agent. The physical properties of vaginal cream conformed to the standard of physical properties of commercialized product available in the market.

scholarly journals In vitro study of antifungal effect of carica papaya peel var. California extract against Candida albicans

2021 ◽  
Vol 8 (1) ◽  
pp. 61-68
Author(s):  
Trisnawaty K ◽  
Anin Esta Rauna ◽  
Siti Rusdiana Puspa Dewi ◽  
Pudji Handayani
Keyword(s):  
Candida Albicans ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Ethanol Extract ◽  
Clinical Isolates ◽  
Diffusion Method ◽  
Control Group ◽  
Antifungal Effect ◽  
Peel Extract

Candida albicans is a normal microflora in the oral cavity which can be an opportunistic pathogen that could cause oral candidiasis when there are underlying predisposing conditions. Papaya as one of the most widely grown herbal plants in Indonesia has been known to cure diseases. Unused papaya peel only became a waste; however, the papaya peel is known to contain active compounds that have antifungal effect, especially raw ones. This study aimed to determine the antifungal effect of raw papaya peel extract of Californian variety and determine the minimum inhibitory concentration (MIC) of this extract on clinical isolates of C. albicans. This study was an experimental laboratory study with post-test only control group design. Ethanol-based extract of papaya peel was obtained from maceration process using 96% ethanol. Antifungal effect testing was carried out in vitro using disc diffusion method (Kirby-Bauer) on clinical isolates of C. albicans. The concentration of Ethanol extract of papaya peel used consisted of 2.5%, 5%, 10%, and 20% with positive control (nystatin) and negative control (distilled water). The results showed that 2.5%, 5%, 10%, and 20% papaya peel extracts were able to inhibit the growth of C. albicans with 2.5% concentration of raw papaya peel extract as minimum inhibitory concentration. Ethanol extract of raw papaya peel of Californian variety with 2.5%, 5%, 10%, and 20% concentrations has small antifungal effect against clinical isolates of C. albicans.

scholarly journals PENGARUH EKSTRAK BIJI Ganitri (Elaeocarpus sphaericus Schum.) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli

2020 ◽  
Vol 2 (01) ◽  
pp. 28-37
Author(s):  
Ega Bramaseta ◽  
Tristi Indah Dwi Kurnia ◽  
Hasyim As'ari
Keyword(s):  
Escherichia Coli ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Ethanol Extract ◽  
Average Diameter ◽  
Inhibition Zone ◽  
Positive Control ◽  
Negative Control ◽  
Seed Extract ◽  
Growth Of Bacteria

This research was conducted in the laboratory of Biology University PGRI Banyuwangi to determine the effect of ganitri seeds extract (Elaeocarpus sphaericus Schum.) in inhibiting the growth of bacteria Escherichia coli and to determine the Minimum Inhibitory Concentration (MIC) of ganitri seeds extract (Elaeocarpus sphaericus Schum.). The method is using wells with 1% tetracycline positive control and negative control of sterile distilled water. Serial concentrations ganitri seed extract (Elaeocarpus sphaericus Schum.) is used by 10%, 20%, 30%, 40%, and 50%, and in the MIC test using serial concentrations of 1%, 2.5%, 5%, 7.5% and 10%. Based on the test results, the largest inhibition zone is shown by a concentration of 50% with an average diameter of 0,954 cm zone of inhibition and inhibition zone indicated smallest concentration of 10% with an average diameter of 0,215 cm inhibition zone. ANOVA test result value (F.Hit> F.Table) with F.Hit amounted to 33,512 and F.Tabel significance value of 2.85 and 0.000 (P <0.05), as the value of P <0.05 then it can be concluded that there is a concentration of ganitri seeds extract (Elaeocarpus sphaericus Schum.) on the growth of test bacteria. The results of Duncan test showed the ganitri seeds extract (Elaeocarpus sphaericus Schum.) at a concentration of 50% have significantly different inhibatory zone by treatment with 10%, 20%, 30%, 40%, positive control, and negative control. While MIC ganitri seed ethanol extract (Elaeocarpus sphaericus Schum.) Were still able to inhibit the growth of test bacteria at a concentration of 1% with an average diameter of 0.037 cm inhibition zone. The Minimum Inhibitory concentration (MIC) ganitri seed extract (Elaeocarpus sphaericus Schum.) shown by a concentration of 1%, where this concentration is still able to inhibit the growth of bacteria Escherichia coli.  Keyword: Ganitri seed extract, Bacteria Escherichia coli, Serial concentration, Minimum Inhibitory concentration (MIC), Inhibition zone.

In Vitro Antibacterial activity of ethanolic extract of Myrsine africana against laboratory Strains of Pathogenic Organisms

2016 ◽  
Vol 5 (04) ◽  
pp. 4512
Author(s):  
Jackie K. Obey ◽  
Anthoney Swamy T* ◽  
Lasiti Timothy ◽  
Makani Rachel
Keyword(s):  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
E Coli ◽  
Zones Of Inhibition ◽  
In Vitro Antibacterial Activity ◽  
Myrsine Africana

The determination of the antibacterial activity (zone of inhibition) and minimum inhibitory concentration of medicinal plants a crucial step in drug development. In this study, the antibacterial activity and minimum inhibitory concentration of the ethanol extract of Myrsine africana were determined for Escherichia coli, Bacillus cereus, Staphylococcus epidermidis and Streptococcus pneumoniae. The zones of inhibition (mm±S.E) of 500mg/ml of M. africana ethanol extract were 22.00± 0.00 for E. coli,20.33 ±0.33 for B. cereus,25.00± 0.00 for S. epidermidis and 18. 17±0.17 for S. pneumoniae. The minimum inhibitory concentration(MIC) is the minimum dose required to inhibit growth a microorganism. Upon further double dilution of the 500mg/ml of M. africana extract, MIC was obtained for each organism. The MIC for E. coli, B. cereus, S. epidermidis and S. pneumoniae were 7.81mg/ml, 7.81mg/ml, 15.63mg/ml and 15.63mg/ml respectively. Crude extracts are considered active when they inhibit microorganisms with zones of inhibition of 8mm and above. Therefore, this study has shown that the ethanol extract of M. africana can control the growth of the four organisms tested.

scholarly journals Comparative Effects of Two Medicinal Plants and Common Disinfectants against Air-Borne Fungi in Poultry House

2019 ◽  
pp. 1-10
Author(s):  
Ifeoma Sandra Anagor ◽  
Chinelo Ursula Umedum ◽  
Stephen Nnaemeka Ezekwueche ◽  
Chibuzo Christain Uba
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Aqueous Extract ◽  
Fusarium Solani ◽  
Inhibitory Concentration ◽  
Candida Rugosa ◽  
Ethanol Extract ◽  
Vernonia Amygdalina ◽  
Minimum Fungicidal Concentration ◽  
Anambra State ◽  
Poultry Farms

Aim: This research was undertaken to compare the antifungal effects of Eupatorium odoratum leaf extract and Vernonia amygdalina extracts with common disinfectants on air-borne fungi in poultry houses. Place and Duration of Study: Air in four poultry farms within Ihiala Local Government Area, Anambra State was sampled between March 2017 and October 2017. Methodology: Poultry air of four different sites at Uli town in Ihiala local government area of Anambra state in Nigeria, were sampled using Sedimentation and Volumetric methods. Fresh leaves of Eupatorium odoratum and Vernonia amygdalina were collected from Uli town, Anambra State, air-dried, processed and extracted using Ethanol and water. Four-hundred (400) mg of the crude extracts were evaluated for Antifungal activity using agar diffusion method. The MIC and MFC were determined using Broth dilution methods. Results: Five isolates namely, Aspergillus flavus, Aspergillus tubingensis, Candida akabanensis, Candida rugosa, and Fusarium solani were identified. Antimicrobial evaluation of the crude extracts showed that ethanol extract of Eupatorium odoratum had activity against all the test isolates except Candida akabenensis and Fusarium solani. The aqueous extracts of Eupatorium odoratum and Vernonia amygladina had activity against all the isolate except Candida akabenensis and Fusarium solani and Candida rugosa. Common disinfectants used in this study namely Izal and Polidine showed inhibitory activity against all the isolates. Ethanol extract of Eupatorium odoratum recorded a minimum inhibitory concentration (MIC) of 100 mg/ml against A. flaus, F. solani, and A. tubingensis, while the minimum inhibitory concentration for Candida rugosa is 200 mg/ml. The minimum fungicidal concentration (MFC) of Ethanol extract of Eupatorium odoratum against A. flaus, F. solani, Candida rugosa and A. tubingensis were 200 mg/ml, 100 mg/ml, 400 mg/ml and 200 mg/ml respectively. Aqueous extract of Eupatorium odoratum recorded a minimum inhibitory concentration of 200 mg/ml against A. flaus and A. tubingensis, while the minimum inhibitory concentration against Candida rugosa is 400 mg/ml. The minimum fungicidal concentration of Aqueous extract of Eupatorium odoratum, were 200 mg/ml, 400 mg/ml and 200 mg/ml for A. flaus, Candida rugosa and A. tubingensis respectively. Ethanol extracts of Vernonia amygdalina leaf had lower minimum inhibitory concentrations of 100 mg/ml against A. flavus, A. tubingensis respectively, and 200 mg/ml against F. solani, while the minimum fungicidal concentrations recorded for A. flavus, A. tubingensis and F. solani were 200 mg/ml, 400 mg/ml and 100 mg/ml respectively. Aqueous extract of Vernonia amygdalina leaf had a minimum inhibitory concentration of 200 mg/ml and 400 mg/ml against A. flavus and A. tubingensis with a minimum fungicidal concentration of 400 mg/ml for both isolates only. The Minimum inhibitory concentration and minimum fungicidal concentration of both Izal and Polidine was between 12.5% V/V and 50% V/V against all the isolates except Polidine that had minimum fungicidal concentration of 100% V/V against Candida rugosa. Conclusion: The extracts of Eupatorium odoratum and Vernonia amygdalina has antifungal activity against all the isolates except Candida akabenensis. If considered and used as a disinfectant during misting, it may decrease the cost of disinfecting poultry farms using available disinfectants in the market. These suggestion, however, need further work to validate reliability.

scholarly journals In vitro activities of Traganum nudatum and Mentha pulegium extracts combined with amphotericin B against Candida albicans in production of hydrolytic enzymes

2020 ◽  
Author(s):  
Ikram Tefiani ◽  
Sidi Mohammed Lahbib Seddiki ◽  
Moustafa Yassine Mahdad
Keyword(s):  
Candida Albicans ◽  
Minimum Inhibitory Concentration ◽  
Amphotericin B ◽  
Inhibitory Concentration ◽  
Culture Media ◽  
Hydrolytic Enzymes ◽  
Normal Flora ◽  
Mentha Pulegium ◽  
Hydrolytic Activities

Background and Purpose: Candida albicans is an important microorganism in the normal flora of a healthy subject; however, it has an expedient pathogenic character that induces hydrolytic virulence. Regarding this, the present study aimed to find an in vitro alternative that could reduce the virulence of this yeast. Materials and Methods: For the purpose of the study, the effect of amphotericin B (AmB) combined with the extract of Traganum nudatum (E1) or Mentha pulegium (E2) was evaluated against the hydrolytic activities of esterase, protease, and phospholipase. This effect was determined by calculating the minimum inhibitory concentration (MIC), used to adjust the extract/AmB mixtures in culture media. Results: The evaluated Pz values, which corresponded to the different enzymatic activities, showed a decrease in the hydrolytic activities of C. albicans strains after the addition of E1/AmB and E2/AmB combinations at descending concentrations (lower than the obtained MICs). Conclusion: Based on the findings, it would be possible to reduce the pathogenesis of this species without destabilizing the balance of the flora.

scholarly journals Assessment of antimicrobial activity of Cola milleni seed and pulp extracts against Staphylococcus aureus, Escherichia coli and Penicillium notatum

2020 ◽  
Vol 12 (1) ◽  
pp. 71-75
Author(s):  
A.M. Aliyu ◽  
S.J. Oluwafemi ◽  
S. Kasim
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Ethanol Extract ◽  
Bioactive Components ◽  
Zone Of Inhibition ◽  
Penicillium Notatum ◽  
Standard Techniques

All over the world, hundreds of plants have been identified based on researchers and experimental evidence as good sources of medicinal agents. The bioactive components (phytochemicals) of both the seeds and pulp of Cola milleni were extracted using ethanol as solvent. The bioactive components detected were alkaloids, tanins, saponins, cardiac glycosides, carbohydrates, sterols, resins and terpenes while Flavonoids, anthraquinones, anthracyanides and phenol were not detected for both the seed and pulps. Antimicrobial activity of the ethanol extract (Seed and pulp) against Staphylococcus aureus, Escherichia coli and Penicillium notatum was carried out using standard techniques. Staphylococcus aureus had the highest zone of inhibition for pulp having a range of 9.7mm±0.58mm - 19.7mm±2.52mm while Penicllium notatum had the least with 0.00mm. S.aureus also had the highest zone of inhibition range of 14.3mm±2.08mm - 21.3mm±1.53mm for the seed extract while penicillium had the least inhibition range of 5.0mm±1.00mm - 5.7mm±0.58. E.coli showed the highest minimum inhibitory concentration with ethanol extract of the pulp (160mg/ml) while penicillium notatum was not reactive. The minimum inhibitory concentration of seed against penillium notatum was the highest (160mg/ml) while staphylococcus aureus showed the lowest of 40mg/ml. The antimicrobial activity is as a result of the presence of phytochemicals detected, which suggest the use of the plant for the treatment of diseases caused by these organisms. Key words: Cola millenii, Phytochemical, Antimicrobial activity, Bacteria, Fungi

scholarly journals The The Effects of Cinnamaldehyde (Cinnamon Derivatives) and Nystatin on Candida Albicans and Candida Glabrata

2019 ◽  
Vol 7 (7) ◽  
pp. 1067-1070 ◽  
Author(s):  
Sedigheh Bakhtiari ◽  
Soudeh Jafari ◽  
Jamileh Bigom Taheri ◽  
Tahereh Sadat Jafarzadeh Kashi ◽  
Zahra Namazi ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Minimum Inhibitory Concentration ◽  
Candida Species ◽  
Candida Glabrata ◽  
Inhibitory Concentration ◽  
Fungal Infections ◽  
Fungal Growth ◽  
Minimum Fungicidal Concentration ◽  
Microdilution Method

BACKGROUND: Candida species are the most common opportunistic fungal infections. Today, cinnamon plants have been considered for anti-Candida properties. AIM: This study aimed to investigate the effectiveness of cinnamaldehyde extract (from cinnamon derivatives) on Candida albicans and Candida glabrata species and comparison with nystatin. MATERIAL AND METHODS: In this study, cinnamaldehyde and nystatin were used. The specimens included Candida albicans and Candida glabrata. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were measured for each one by the microdilution method. This experiment was repeated three times. RESULTS: Cinnamaldehyde extract at a concentration of 62.5 μl/ml was able to prevent the growth of Candida albicans, at a concentration of 93.7 μl/ml, causing Candida albicans to disappear, at 48.8 μl/ml, to prevent the growth of Candida glabrata, and in the concentration of 62.5 μl/ml, causes the loss of Candida glabrata. In comparison, nystatin at 0.5 μg/ml concentration prevented the growth of Candida albicans, at concentrations of 1 μg/ml causing Candida albicans to be destroyed, at 4 μg/ml concentration to prevent the growth of Candida glabrata, and at a concentration of 8 μg/ml causes the loss of Candida glabrata. The results were the same every three times. CONCLUSIONS: Although cinnamaldehyde extract had an effect on fungal growth in both Candida albicans and Candida glabrata with a fatal effect; the effect on these two species was lower than nystatin.

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