scholarly journals Distribution Pattern of Serum Uric Acid Level Before and After National Festival Dashain among Patients Visiting Tertiary Hospital, Kathmandu, Nepal

2020 ◽  
Vol 10 (2) ◽  
pp. 36-39
Author(s):  
Dipesh Tamrakar ◽  
Sabina Shakya ◽  
Sadikshya Shrestha ◽  
Salina Pradhananga ◽  
Vijay Kumar Sharma ◽  
...  
Keyword(s):  
Uric Acid ◽  
Distribution Pattern ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Tertiary Hospital ◽  
University Teaching ◽  
P Value ◽  
Continuous Variables ◽  
Before And After ◽  
The Mean

Introduction: Dashain, one of the national festivals in Nepal, celebrated with excessive consumption of high purine content foods, alcoholic and soft beverages. These foods have been associated with higher Serum Uric Acid (SUA) levels leading to hyperuricemia. This study was intended to evaluate the distribution pattern of SUA level a month before and after this festival for two consecutive years.   Methods and Materials: The data of 5818 patients visiting Clinical Biochemistry Laboratory, Tribhuvan University Teaching Hospital for SUA test (a month before and after Dashain festival for two consecutive years; 2017 - 2018 A.D.) were collected and analyzed. The statistical analysis was done using SPSS version 21. Continuous variables were expressed as mean ± SD taking 95% confidence interval and p values of <0.05 was considered to be statistically significant. Mann-Whitney U test was used to compare the variables.   Results: The mean SUA levels before and after Dashain in two consecutive years were 333.5 ± 112.1 μmol/L and 334.2±114.7 μmol/L in 2017 A.D. and 322.6 ± 103.9μmol/L and 343.2± 111.4 μmol/L in 2018 A.D. There was a significantly elevated level of the mean SUA level after Dashain festival in 2018 among both sexes (p-value <0.05). The age-wise distribution of mean SUA after the Dashain festival was consistent with increasing age among the study population.   Conclusion: The study concluded that the Dashain festival has an impact on increasing the SUA level.  

scholarly journals Estimation of Serum Uric Acid in Cases of Hyperuriceamia and Gout

2011 ◽  
Vol 51 (181) ◽  
Author(s):  
R K Pokharel ◽  
BK Yadav ◽  
B Jha ◽  
K Parajuli
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Relevant Information ◽  
University Teaching ◽  
Acute Gout ◽  
College Hospital ◽  
The Mean

Introduction: Gout is crystal deposit arthritis and is an ancient disease. The biologic precursor to gout is hyperuricaemia. The prevalence of hyperuricaemia and gout has an increasing trend all over the world including the developing countries. The purpose of this study is to estimate serum uric acid level in hyperuricaemic and gout patients attending a medical college hospital. Methods: A consecutive 150 hyperuricaemics and 150 gout patients attending Tribhuwan University Teaching Hospital from June to September 2005 were included in this study. The serum uric acid level was measured by the enzymatic (PAP- Uricase) method. The patients with acute gout were interviewed and relevant information was obtained. Results: Males comprised 84 % of gout cases. Hyperuricaemia was common in both sexes. The mean age for gout was 47.49 and 56.65 years in males and females respectively. The mean age for the first gout attack was 42.1 ± 14.0 years. Family history was positive in 22 % of cases. The overall mean serum uric acid level in hyperuricaemics was 7.2 ± 0.7 mg/dL and 8.4 ± 1.1 mg/dL in acute gout (p 0.0001). The mean serum uric acid level was signifi cantly (p 0.0001) high among males both at the asymptomatic phase and at acute gout. Gout was more common in non-vegetarians (95 %) and alcoholics (65.3 %). Serum uric acid level was inversely related with the amount of daily water intake (p 0.0001). Conclusions: Serum uric acid level is signifi cantly high among the male gouty arthritic patients. However, it is also high among asymptomatic hyperuricaemic cases of both sexes.  Keywords: asymptomatic hyperuricaemia, gout, serum uric acid level.

A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sushma Goad ◽  
Anita Verma ◽  
Subhash Chandra
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Level Elevation ◽  
The Mean

Background: To Study Serum Uric Acid level elevation in Hypertensive Disorders of Pregnancy. Methods: 50 Patients diagnosed as having Pre-eclampsia with age between 18-37 years and 50 controls with similar age group. Results: The mean serum uric acid level in control group was 3.41 ± 0.62 and in patient 7.01 ± 0.58 which was statistically significant (p =0.001). Conclusion: Serum uric acid levels were significantly higher in preeclampsia could be a useful indicator of fetal complication in preeclampsia patients. Keywords: serum uric acid, preeclampsia, laboratory.

scholarly journals Serum uric acid level in type 2 diabetes mellitus

2019 ◽  
Vol 6 (4) ◽  
pp. 1265
Author(s):  
D. Vasantha Kalyani ◽  
M. Ilamaran ◽  
P. Suresh Kumar ◽  
Saranya Nagalingam
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
The Mean ◽  
Artery Disease

Background: Diabetes mellitus is the most important risk factor associated with two to four fold increased incidence of coronary artery disease. The major risk factors for CAD are hypercholesterolemia, hypertension, diabetes mellitus, and cigarette smoking Objectives: To study the level of serum uric acid in type 2 diabetes mellitus and the correlation between elevated serum uric acid level and the component of metabolic syndrome like obesity, hypertension, dyslipidemia.Methods: The study was done as descriptive analytical study among the diabetic patients in a tertiary care setting during the period January 2018 to February 2019. The inclusion and exclusion criteria were clearly defined and the study participants were recruited for the study after getting the informed consent. The socio demographic profile, clinical and laboratory data were collected from the blood sample obtained from the patients with the standardized procedures. Data was entered in Microsoft excel spread sheet and analyzed statistically using SPSS statistical software. Student ‘t’ test and Chi-square test values were applied for significance.Results: Serum uric acid in the study population and control varied from 3.0 to 8.1 and 2.7 to 5.5 mg/dl respectively. The mean and standard deviation of uric acid among cases was 5.08±1.42 while in control it was 3.55±0.62 respectively. The serum uric acid level of diabetics was very much elevated compare with controls and it was highly significant. Significant correlation was noticed between serum uric acid and BMI as well as WHR. Elevated uric acid levels were significantly noticed among those with hypertension, dyslipidemia, coronary artery disease and chronicity of the diabetes.Conclusions: Uric acid was significantly elevated in diabetic population and the mean value of serum uric acid level was higher in longer duration of diabetes, hypertension, dyslipidemia, central obesity which are the components of metabolic syndrome.

scholarly journals A study of angiographic severity in patients with coronary artery disease and hyperuricemia

2015 ◽  
Vol 7 (2) ◽  
pp. 1-4 ◽  
Author(s):  
Subhraprakash Pramanik ◽  
Koushik Mondal ◽  
Arpan Kumar Dey ◽  
Pijush Kanti Mandal ◽  
Shovan Kumar Das ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
P Value ◽  
Gensini Score ◽  
Artery Disease

Backgrounds: Hyperuricemia has not yet been established as cardiovascular risk factor. We aimed to study the angiographic severity in patients with coronary artery disease (CAD) and hyperuricemia.Materials and Methods: In this observational cross-sectional study we measured serum uric acid level in 82 patients of CAD who underwent coronary angiography in catheterisation laboratory of our Institution. Severity of CAD was determined on the basis of Gensini score, number of diseased vessels, critical lesions and total occlusions.Results: The prevalence of hyperuricemia in patients with CAD was 42.68% in our study. Hyperuricemia was associated with higher Gensini score (33.33±10.64 vs. 22.90±6.75, p value <0.001), number of critical lesions (1.03±0.84 vs. 0.63±0.72, p value 0.031), total occlusions (0.67±0.47 vs. 0.37±0.48, p value 0.007) and dyslipidemia (63.6% vs. 30.6%, p value 0.003) more frequently compared to normouricemic patients. And also the higher serum uric acid level was correlated with higher Gensini score (beta 0.418, t 4.430, p value <0.001, 95% CI 0.036 and 0.094) and frequent number of total occlusion (beta 0.338, t 3.589, p value 0.001, 95% CI 0.462 and 1.613).Conclusion: Hyperuricemia was associated with higher Gensini score, frequent total occlusions and critical lesions in patients with Coronary Artery Disease compared to patients with normal uric acid level and also it was significantly correlated with higher Gensini score and frequent total occlusions.Asian Journal of Medical Sciences Vol.7(2) 2015 1-4

scholarly journals PREGNANCY INDUCED HYPERTENSION;

2018 ◽  
Vol 25 (08) ◽  
pp. 1168-1172
Author(s):  
Uzma Jamil ◽  
Anam Mukhtar ◽  
Shaista Hussain ◽  
Farida Munawar
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Late Pregnancy ◽  
Fetal Distress ◽  
Cross Sectional Study ◽  
Categorical Variables ◽  
P Value ◽  
Age Difference ◽  
Continuous Variables ◽  
Cross Sectional

Objectives: To investigate serum uric as an indicator of fetomaternal complicationsin women with late pregnancy. Study Design: Cross sectional study. Setting: Shalamar Medicaland Dental College Lahore ethical committee. Period: One year from October 2016 to October2017. Methodology: Continuous variables were presented as mean and standard deviationlike age and Serum malonaladehyde concentration; categorical variables were presented asnumbers and percentages like intra uterine growth restriction, Mild to moderate and sever preeclampsia and fetal distress. One way ANOVA, independent sample t test and chi square testwere applied to check significance of results, p value less than or equal to 0.05 was consideredas significant. Results: Overall, 100% (n=400) patients were included in this study. The meanage of the patients was 25.81±4.33 years. The age difference was not statistically significant,in groups (p=0.383). The mean serum uric acid levels of the patients for maturity (weeks)36, 37, 38, 39 and 40 was 247.96±2.52 (nmol/l), 253.95±2.04 (nmol/l), 261.19±3.15 (nmol/l),263.95±2.75 (nmol/l) and 296.19±2.55 (nmol/l) respectively. The differences were statisticallysignificant (p=0.000). Fetal distress, number with rising levels were (n=23) 71.8%, number withno change in levels were (n=3) 9.4% and number with falling levels were (n=6) 18.8%. Thedifferences were statistically significant. (p=0.000). Conclusion: The observations of our studyconcluded that serial increase of serum uric acid from 36th week to 40th week was observedin pregnancy induced hypertion patients, and raised serum level of uric acid had significantrelation with fetomaternal complications. like Fetal distress, preeclampsia, and intrauterinegrowth retardation. So serum uric acid can be used an indicator for fetometernal complicationsin late pregnancy.

scholarly journals Pengaruh Ramuan Jamu Antihiperkolesterolemia Terhadap Kadar Asam Urat Pasien Dengan Hiperkolesterol Ringan

2018 ◽  
Vol 1 (3) ◽  
pp. 172-176
Author(s):  
Zuraida Zulkarnain ◽  
Ulfa Fitriani ◽  
Enggar Wijayanti ◽  
Ulfatun Nisa
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Green Tea ◽  
Uric Acid Level ◽  
Acid Level ◽  
Normal Values ◽  
T Test ◽  
P Value ◽  
Before And After ◽  
Paired T Test

Ramuan jamu antihiperkolesterolemia terdiri dari daun jati cina, daun jati belanda, daun teh hijau, tempuyung, rimpang temulawak, rimpang kunyit dan herba meniran. Daun jati belanda dan daun teh hijau memiliki kandungan purin dalam bentuk kafein dan teobromin yang berpotensi menyebabkan peningkatan asam urat. Penelitian ini bertujuan untuk mengetahui kadar asam urat serum darah pasien yang meminum ramuan jamu antihiperkolesterolemia . Penelitian ini merupakan observasi klinik dengan jumlah subyek 50 orang di Rumah Riset Jamu (RRJ) Hortus Medicus pada tahun 2014. Subjek merupakan pasien dengan diagnosis hiperkolesterolemia ringan (kadar kolesterol serum 200-240 mg/dl) yang diterapi dengan ramuan jamu antihiperkolesterolemia selama 28 hari. Parameter yang dinilai adalah kadar asam urat serum pada awal (H-0) dan akhir obeservasi (H-28). Data diolah dengan uji t berpasangan menggunakan bantuan program SPSS. Hasil terjadi peningkatan rata-rata kadar asam urat dari 5,31+1,17 mg/dl menjadi 5,47+1,29 mg/dl. Peningkatan masih dalam rentang nilai normal. Pada uji t berpasangan diperoleh nilai p=0,384 yang berarti tidak ada perbedaan rerata kadar asam urat sebelum dan sesudah minum jamu. Kesimpulan terdapat peningkatan ringan rerata kadar asam urat serum pasien yang secara statistik tidak bermakna dan masih berada dalam rentang nilai normal setelah pemberian ramuan jamu antihiperkolesterolemia selama 28 hari.   The antihypercholesterolemic jamu formulaconsists of daun jati cina, jati belanda leaf, green tea leaf, tempuyung, curcuma rhizome, turmeric rhizome and meniran. Jati belanda and green tea leaves contain purines in the form of caffeine and theobromine which might increase the uric acid level. This study aimed to determine the uric acid levels in blood serum of patients who consumed antihypercholesterolemic jamu formula. This study was a clinical observation with a total subject of 50 patients at the Hortus Medicinal Jamu  Research Center (RRJ) in 2014. Subjects were patients with a diagnosis of mild hypercholesterolemia (serum cholesterol level of 200-240 mg / dl) treated with antihypercholesterolemicjamu formula for 28 days. The parameters assessed were serum uric acid levels at baseline (D-0) and end of observation (D-28).Data were analysed by paired t-test using SPSS. The results showed an increase in mean uric acid level from 5.31 + 1.17 mg / dl to 5.47 + 1.29 mg / dl. The increase was  still in the range of normal values. Based on paired t test p value = 0.384, there was no difference in mean uric acid levels before and after administration withjamu. It can be concluded that there was a mild increase in the serum uric acid levels of patients which were not statistically significant and were still in the range of normal values ​​after the administration of an antihypercholesterolemic jamu formula for 28 days

scholarly journals Serum uric acid level in acute ischemic stroke in eastern India

2017 ◽  
Vol 5 (6) ◽  
pp. 2353 ◽  
Author(s):  
Bijaya Kumar Behera ◽  
Pankaj Kumar Hui ◽  
Roniya Simethy
Keyword(s):  
Uric Acid ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid ◽  
Scale Score ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Diabetic Patients ◽  
The Mean

Background: Present study was done to estimate the level of serum uric acid in acute ischemic stroke and to find out whether it is protective against or increases the risk for ischemic stroke and its effect on stroke outcome.Methods: A total of 100 patients and 100 controls were taken randomly. Risk factors of stroke were considered such as hypertension, diabetes, adverse lipid profile, smoking and obesity. Serum uric acid level was measured in both cases and controls. Modified National Institute of Health (NIH) stroke scale score was calculated at the time of admission and discharge. Statistical analysis was done using SPSS 21.0 software.Results: Out of 100 patients studied 65 were males and 35 were females. The mean serum uric acid level in stroke cases was 6.11±1.47 where as it was 4.85±1.12 in controls. SUA levels was higher among males than females. The mean SUA in hypertensive subjects (6.58±1.33) was significantly higher than in normotensive subjects (5.23±1.42). There was statistically significant difference between SUA levels in diabetic (6.66±1.26) and non-diabetic patients (5.63±1.49). Mean SUA among overweight patients was (7.0±1.16) where as it was (5.22±1.23) in patients with normal weight. The mean SUA in smokers (6.33±1.38) was higher than that in non-smokers (6.02±1.51). There was significant positive correlation between SUA an NIH stroke scale score(P<0.05). SUA levels were significantly higher in patients who succumbed as compared to those who were discharged from hospital.Conclusions: SUA can be used as a marker for increased of stroke. Higher SUA is associated with a bad prognosis.

scholarly journals Level of Serum Uric Acid in Pre-eclamptic and Normal Pregnant Women

2020 ◽  
Vol 4 (1) ◽  
pp. 20-22
Author(s):  
Hudda Abbas ◽  
Samina Badar ◽  
Zunera Javed ◽  
Mohammad Ahmed Abdelmoneam Ramdan
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Outpatient Department ◽  
Obstetrics And Gynecology ◽  
P Value ◽  
Third Trimester

Objective: The objective of study was to find out serum uric acid level in normal andpreeclamptic pregnant women of third trimester visiting outpatient department of obstetrics and gynecology of Bahawal Victoria Hospital, Bahawalpur. Methodology: It was a cross sectional descriptive study conducted form July 2018 to June 2019. All primigravida women of age 18-35 years in third trimester of singleton pregnancy attending in Obstetrics and Gynecology Outpatient Department of Bahawal Victoria Hospital in study duration were included in the study. Statistical analysis was performed by using SPSS version 14. Chi-square test was performed to find the statistical difference regarding uric acid distribution between groups and ‘p’ value <0.05 was considered as a lowest level of significance. Results: Out of total 1212 women 84.6% were normal and 15.4% had preeclampsia. In our study out of 187 preeclamptic women, 63.6% had raised serum uric acid level and out of 268 normal pregnant women uric acid level was raised in only 39.5%. Results were found statistically significant. Conclusion: Results of our study suggest that serum uric acid level in pregnant women can be used as a useful and inexpensive marker in prediction of preeclampsia and preventive measures can be taken accordingly.

Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis

Rheumatology ◽  
2021 ◽  
Author(s):  
Jine Lu ◽  
Zhiyao Bai ◽  
Yunqing Chen ◽  
Yingxu Li ◽  
Min Tang ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Body Weight ◽  
Uric Acid ◽  
Retrospective Analysis ◽  
Serum Uric Acid ◽  
Weight Reduction ◽  
The Body ◽  
Before And After ◽  
Hospital Patients ◽  
The Mean

Abstract Objectives Weight reduction may reduce serum uric acid (SUA). This study aimed to examine the changes of SUA before and after bariatric surgery in patients with obesity with or without hyperuricaemia and gout. Methods This is a retrospective analysis of 147 routinely collected data on hospital patients with obesity who underwent bariatric surgery. The body weight and SUA were measured at baseline and after surgery at 1–7 days, 1, 3, 6 and 12 months. Results The mean (95% CI) weight reduction of 147 patients was 30.7 (28.7, 32.7) kg 1 year after surgery (P &lt; 0.001). SUA decreased rapidly from 419.0 (400.1, 437.8) µmol/l at baseline to 308.4 (289.6, 327.2) µmol/l at 1–7 days, flared up to 444.8 (423.9, 465.6) µmol/l at 1 month, then decreased again to 383.8 (361.5, 406.1) µmol/l at 3 months, 348.9 (326.3, 371.5) µmol/l at 6 months and 327.9 (305.3, 350.5) µmol/l at 12 months (P &lt; 0.001). Similar trends but more rapid reductions were observed in 55 hyperuricaemia patients and 25 gout patients. All 25 gout patients had an elevated SUA above the therapeutic target (≥360µmmol/l) at baseline, but in 10 patients it was reduced below this target at 12 months. The mean reduction (95% CI) of SUA in all patients and gout patients was 84.3 (63.1–105.4) and 163.6 (103.9, 223.3) µmmol/l, respectively. Conclusion Bariatric surgery significantly reduces body weight and SUA for obese patients with hyperuricaemia and gout. Gout may be considered as an indicator for this surgical treatment in people with severe obesity.

scholarly journals A STUDY OF SERUM URIC ACID IN DIABETES MELLITUS AND PREDIABETES IN A SOUTH INDIAN TERTIARY CARE HOSPITAL

2012 ◽  
Vol 02 (02) ◽  
pp. 18-23
Author(s):  
Sudhindra Rao M. ◽  
Bino John Sahayo
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
P Value ◽  
South Indian Population ◽  
Care Hospital ◽  
South Indian

Abstract Background: Several epidemiologic studies have reported that high serum levels of uric acid are strongly associated with prevalent health conditions such as obesity, insulin resistance, metabolic syndrome, essential hypertension and renal disease. This study aimed to investigate the level of serum uric acid in Type 2 diabetes mellitus, pre-diabetics and non diabetics (controls) in south Indian population. Methods: Uric acid level was measured by Uricase-PAP methodology in patients with Diabetes (n=71)/Pre diabetes (n=12)/ Control groups (n=34). Using ANOVA test, uric acid levels in the above three groups were compared based on age, sex and other factors which can affect uric acid level. Results: The mean serum uric acid level was lower in control group (3.84mg/dl), rose in pre-diabetics (4.88mg/dl) and again decreased in diabetics (3.78mg/dl). P value comparing control and pre-diabetes was 0.009, p-value comparing pre-diabetes and diabetes was 0.003 and p-value comparing control and diabetes was 0.982 (p value <0.05 being significant). Conclusion: The serum uric acid level being higher in pre-diabetes than controls and lower in diabetes mellitus than pre-diabetes may serve as a potential inexpensive biomarker of deterioration of glucose metabolism.

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