A Comparison in Work-Up Between the First and Second Covid 19 Infection in the Same Patients in the ED Tawam Hospital, UAE

2021 ◽  
Author(s):  
Hussein Kzar Basi Al-Shamri
Keyword(s):  
Laboratory Tests ◽  
The Other ◽  
Routine Laboratory ◽  
Infection Group ◽  
X Ray ◽  
Severity Of Disease ◽  
Chest X Ray ◽  
Laboratory Investigations ◽  
Work Up ◽  
First Time

Aim of study: To identify the significance of routine laboratory investigations conducted in patients infected with COVID-19 for the second time as compared to being infected with COVID-19 for the first time in the UAE. Methods: 345 patients between the ages of 16 and 65 years who were infected with COVID-19 were included in the study. Patient’s charts were reviewed and all laboratory tests and imaging conducted were reviewed. Furthermore, patients were divided into two groups: one as a first time COVID-19 infection group and the other as a second time COVID-19 infection group. Results: Fifteen laboratory tests have been conducted. Of these tests, 44.4% (4 tests) (procalcitonin, phosphate, magnesium, amylase, and lipase) that were abnormally elevated in patients in the first infection group were found to be significantly reduced in patients with a second COVID-19 infection. Also, two imaging modalities done which included Chest–X ray and CT thorax without contrast were abnormal in all the patients in the second infection group. Conclusion and recommendations: We recommend not using the following labs in patients with COVID-19 infection for the second time: procalcitonin, magnesium, lipase, amylase, phosphate. However, we do recommend performing Chest X-ray and CT thorax without contrast in assessing severity of disease in patients with COVID-19 infection for the second time.

scholarly journals Complications of Neck Dissection in Thyroid Malignancy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H A Alaaeldin ◽  
M S Farahat ◽  
A N K Elhoofy ◽  
A M M Yonis
Keyword(s):  
Neck Dissection ◽  
Indirect Laryngoscopy ◽  
Thyroid Malignancy ◽  
Thyroid Lesion ◽  
Normal Thyroid ◽  
X Ray ◽  
Chest X Ray ◽  
Laboratory Investigations ◽  
Work Up ◽  
Normal Adults

Abstract Background The normal thyroid gland is caudal to the larynx and encircles the anterolateral portion of the trachea. It is about 10 to 20 grams in weight in normal adults. Aim of the Work The aim of this study is to characterize the morbidity and complications of neck dissection in thyroid malignancy. Patients and Methods The present study will include 20 patients with thyroid cancer. All patients will undergo total thyroidectomy plus neck dissection. Neck dissection procedure was performed unilaterally in 16 patients (80%), and bilaterally in 4 (20%), making a total of 24 ND procedures. Results There were fifteen females (75%) and five males (52%), their age ranged between 26 and 70 years with a mean of 50 years. All patients were subjected to thorough history taking, complete clinical examination and vocal cord assessment by indirect laryngoscopy. Laboratory investigations (T3, T4, TSH, serum Ca, and routine laboratory work up), followed by neck ultrasonography (US), and computed tomography (CT) were performed for all patients, as well as chest X-ray, and CT chest when needed. Biopsy from suspicious thyroid lesion and suspicious cervical LNs (whether blind or US guided) was performed. Conclusion Morbidity and complications of neck dissection are numerous and variable so meticulous dissection is needed.

scholarly journals Pneumomediastinum and pneumopericardium in an adolescent with asthma attacks. Case report

Case reports ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. 63-69
Author(s):  
María Fernanda Ochoa-Ariza ◽  
Jorge Luis Trejos-Caballero ◽  
Cristian Mauricio Parra-Gelves ◽  
Marly Esperanza Camargo-Lozada ◽  
Marlon Adrián Laguado-Nieto
Keyword(s):  
Case Report ◽  
Chest Pain ◽  
Subcutaneous Emphysema ◽  
Respiratory Symptoms ◽  
Laboratory Tests ◽  
Young Patients ◽  
Clinical Suspicion ◽  
X Ray ◽  
Chest X Ray ◽  
The Right

Introduction: Pneumomediastinum is defined as the presence of air in the mediastinal cavity. This is a rare disease caused by surgical procedures, trauma or spontaneous scape of air from the lungs; asthma is a frequently associated factor. It has extensive differential diagnoses due to its symptoms and clinical signs.Case presentation: A 17-year-old female patient presented with respiratory symptoms for 2 days, dyspnea, chest pain radiated to the neck and shoulders, right supraclavicular subcutaneous emphysema, wheezing in both lung fields, tachycardia and tachypnea. On admission, laboratory tests revealed leukocytosis and neutrophilia, and chest X-ray showed subcutaneous emphysema in the right supraclavicular region. Diagnosis of pneumomediastinum was confirmed through a CT scan of the chest. The patient was admitted for treatment with satisfactory evolution.Discussion: Pneumomediastinum occurs mainly in young patients with asthma, and is associated with its exacerbation. This condition can cause other complications such as pneumopericardium, as in this case. The course of the disease is usually benign and has a good prognosis.Conclusion: Because of its presentation, pneumomediastinum requires clinical suspicion to guide the diagnosis and treatment. In this context, imaging is fundamental.

scholarly journals Localisation of intracellular calcium in the neutrophil through the selective precipitation with the antimonate ion

2001 ◽  
Vol 20 (1) ◽  
pp. 4-8
Author(s):  
A. M. Koorts ◽  
A. N. Hall ◽  
M. Viljoen Viljoen
Keyword(s):  
Intracellular Calcium ◽  
The Other ◽  
Precipitation Reaction ◽  
Sodium Ions ◽  
Selective Precipitation ◽  
X Ray ◽  
Transmission Electron ◽  
Microscopy Method ◽  
Electron Microscopy Method ◽  
First Time

The antimonate ion was used for the first time in 1962 by Komnick for the precipitation of intracellular sodium ions. The antimonate ion can, however, also precipitate other cations and can be employed in subcellular calcium localisation studies. The greatest difficulty encountered with such subcellular calcium localisation studies is the selectivity of the antimonate ion for calcium in the presence of the other intracellular cations. Various x-ray analyses and chelation studies have shown that the antimonate precipitation reaction can be specific for calcium under appropriate conditions. A transmission electron microscopy method for the selective localisation of intracellular calcium in the neutrophil with the antimonate ion is discussed. It is indicated that the antimonate ion can specifically precipitate calcium in the presence of the other intracellular cations.

scholarly journals Multiple cyclotron line-forming regions in GX 301−2

2018 ◽  
Vol 620 ◽  
pp. A153 ◽  
Author(s):  
F. Fürst ◽  
S. Falkner ◽  
D. Marcu-Cheatham ◽  
B. Grefenstette ◽  
J. Tomsick ◽  
...  
Keyword(s):  
Relativistic Effects ◽  
Resonant Scattering ◽  
The Other ◽  
High Mass ◽  
Good Resolution ◽  
Gaussian Shape ◽  
X Ray ◽  
Cyclotron Line ◽  
First Time ◽  
The Continuum

We present two observations of the high-mass X-ray binary GX 301−2 with NuSTAR, taken at different orbital phases and different luminosities. We find that the continuum is well described by typical phenomenological models, like a very strongly absorbed NPEX model. However, for a statistically acceptable description of the hard X-ray spectrum we require two cyclotron resonant scattering features (CRSF), one at ∼35 keV and the other at ∼50 keV. Even though both features strongly overlap, the good resolution and sensitivity of NuSTAR allows us to disentangle them at ≥99.9% significance. This is the first time that two CRSFs have been seen in GX 301−2. We find that the CRSFs are very likely independently formed, as their energies are not harmonically related and, if the observed feature were due to a single line, the deviation from a Gaussian shape would be very large. We compare our results to archival Suzaku data and find that our model also provides a good fit to those data. We study the behavior of the continuum as well as the CRSF parameters as function of pulse phase in seven phase bins. We find that the energy of the 35 keV CRSF varies smoothly as a function of phase, between 30 and 38 keV. To explain this variation, we apply a simple model of the accretion column, taking into account the altitude of the line-forming region, the velocity of the in-falling material, and the resulting relativistic effects. We find that in this model the observed energy variation can be explained as being simply due to a variation of the projected velocity and beaming factor of the line-forming region towards us.

scholarly journals AB0624 PREDICTIVE PARAMETERS FOR DEVELOPMENT OF INTERSTITIAL LUNG DISEASE IN IDIOPATHIC INFLAMMATORY MYOSITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1607.2-1607
Author(s):  
T. Vojinovic ◽  
M. Fredi ◽  
P. Ceruti ◽  
D. Modina ◽  
F. Franceschini ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Interstitial Pneumonia ◽  
Chest Ct ◽  
The Other ◽  
Inflammatory Myositis ◽  
Idiopathic Inflammatory Myositis ◽  
X Ray ◽  
Other Hand ◽  
Chest X Ray

Background:Idiopathic Inflammatory Myositis (IIM) is a group of heterogeneous connective tissue diseases, primarily characterized by chronic muscle inflammation as well as myositis-specific or myositis-associated autoantibodies and a spectrum of different extra-muscular features.The most frequent organ involment in IIM is Interstitial Lung Disease (ILD), occurring in 5-80% of different IIMs cases and considered the hallmark of morbidity and mortality in patients with IIMs.Objectives:To retrospectively assess the predictive factors for development of ILD in IIM patientsMethods:We retrospectively analyzed the prevalence of ILD in a single-center cohort of 165 IIM patients. Patient data was collected from clinical charts. ILD was diagnosed by chest X-ray scan and chest CT scan. All chest CT and chest X-ray scans available and performed at our hospital were consequently re-evaluated by our expert pneumologist for uniform evaluation.Results:Myositis-related ILD (M-ILD) was found in 52 IIM patients (31.5%): 46.15% was affected by anti-synthetase syndrome (ARS), 21.15% by polymyositis (PM), 19.23% by dermatomyositis (DM) and 13.46% by overlap myositis. The pulmonary involvement was characterized by Non-specific interstitial pneumonia (NSIP) (30.6%), Unusual Interstitial Pneumonia (UIP) (38.77%), Bronchiolitis Obliterans with Organizing Pneumonia (BOOP) (20.4%), overlap NSIP/BOOP (4.1%) and Undetermined/Unspecific pattern (6.12%). Eighty four percent of M-ILD consisted of non-smokers and 69.23% presented with dyspnea at onset.ILD was diagnosed in 90.38% of patients within the first year of IIM diagnosis (early onset ILD) and was associated with dyspnea and/or cough in 70.2% and 17% respectively. On the other hand, late onset ILD presented mostly with dyspnea and/or cough in 60% of cases and was significantly associated with anti-Ku antobodies.At onset ILD was significantly associated with: ARS (p<0.0001; OR:12.98), anti-Jo-1 (p<0.0001; OR:6.1), anti-Ro (p=0.038; OR:2.2), mechanic’s hands (p<0.0001; OR:10.41), arthritis (p=0.01; OR:2.58), polyarthritis (p=0.001; OR:4.578), dyspnea (p<0.0001; OR:9.66), and high levels of CPK (p=0.0001) and GOT (p=0.0146). By contrast, the following features: DM (p=0.012; OR:0.36), facial rash (p=0.003; OR:0.31), anti-NXP-2 (p=0.019; OR<0.0001), anti-PL-12 (p=0,03; OR<0.0001) and myositis (p<0.0001; OR:0.173) present at onset were less frequently associated with M-ILD.At multivariate analysis M-ILD was predicted by anti-Ro (p=0.0448), polyarthritis (p=0.0093) and dyspnea (p=0.0001) at onset. On the other hand, patients presenting myositis (p=0.0383) and facial rash (p=0.0398) at onset were less likely to developed M-ILD.Conclusion:ILD occurs in about one third of patients with IIM, mostly affected by ARS. The presence of anti-Ro antibodies as well as polyarthritis and dyspnea at onset predict the development of ILD.Disclosure of Interests:None declared

scholarly journals Simple, fast and affordable triaging pathway for COVID-19

2020 ◽  
pp. postgradmedj-2020-138029
Author(s):  
Elizabeth Jane Eggleton
Keyword(s):  
Health Services ◽  
Viral Infection ◽  
Clinical Assessment ◽  
Blood Analysis ◽  
X Ray ◽  
Mild Disease ◽  
Global Pandemic ◽  
Chest X Ray ◽  
Severe Respiratory Infection ◽  
Laboratory Investigations

Coronavirus disease 2019 has caused a global pandemic. The majority of patients will experience mild disease, but others will develop a severe respiratory infection that requires hospitalisation. This is causing a significant strain on health services. Patients are presenting at emergency departments with symptoms of dyspnoea, dry cough and fever with varying severity. The appropriate triaging of patients will assist in preventing health services becoming overwhelmed during the pandemic. This is assisted through clinical assessment and various imaging and laboratory investigations, including chest X-ray, blood analysis and identification of viral infection with SARS-CoV-2. Here, a succinct triaging pathway that aims to be fast, reliable and affordable is presented. The hope is that such a pathway will assist health services in appropriately combating the pandemic.

Synthesis, lead lability and ring deformation of three 1,4,8,11,15,18,22,25-octasubstituted phthalocyaninato lead derivatives

2006 ◽  
Vol 10 (10) ◽  
pp. 1202-1211 ◽  
Author(s):  
Paul M. Burnham ◽  
Isabelle Chambrier ◽  
David L. Hughes ◽  
Benjamin Isare ◽  
Richard J. Poynter ◽  
...  
Keyword(s):  
The Other ◽  
Lead Ion ◽  
X Ray Diffraction ◽  
Steric Interactions ◽  
X Ray ◽  
The Core ◽  
Benzene Rings ◽  
Methylene Groups ◽  
The Mean ◽  
Work Up

The syntheses and attempted syntheses of some non-peripherally (1,4,8,11,15,18,22,25) octasubstituted lead phthalocyanines from their corresponding metal-free derivatives are described. Some compounds exhibited lability of the lead ion during work-up to regenerate the starting material. The results of single crystal X-ray diffraction analyses of 1,4,8,11,15,18,22,25-octahexyl-, 1,4,8,11,15,18,22,25-octa-iso-pentyl- and 1,4,8,11,15,18,22,25-octahexylsulfanyl lead phthalocyanines are reported and cast some light on the greater stability of 1,4,8,11,15,18,22,25-octahexylsulfanyl lead phthalocyanine, in terms of ease of loss of the lead ion, over the other two substituted lead phthalocyanines studied. The phthalocyanine cores of all three derivatives adopt a saddle-shaped geometry rather than the saucer-shaped conformation exhibited by unsubstituted lead phthalocyanine. The saddle-shaped conformation would appear to offer a means of relieving steric interactions between the substituents on adjacent benzene rings. That steric interactions are a feature of these molecules is perhaps reflected in the different distortions of the saddle conformations. This is greatest for compound 1,4,8,11,15,18,22,25-octa-iso-pentyl lead phthalocyanine bearing the isopentyl groups, expected to introduce the most interactions, and least for compound 1,4,8,11,15,18,22,25-octahexylsulfanyl lead phthalocyanine where S atoms rather than methylene groups are adjacent to the benzene ring. The molecules of 1,4,8,11,15,18,22,25-octahexyl- and 1,4,8,11,15,18,22,25-octahexylsulfanyl lead phthalocyanine pack together in pairs with their nearest neighbouring molecule; their lead atoms, displaced from the core and directed towards each other. The presence of the S atoms in 1,4,8,11,15,18,22,25-octahexylsulfanyl lead phthalocyanine leads to close Pb … S contacts between the molecules. Attractive Pb … S interactions in this compound may also account for the larger displacement of the Pb from the mean-plane of the four coordinated nitrogen atoms at the centre of the phthalocyanine core than is found for 1,4,8,11,15,18,22,25-octahexyl- and 1,4,8,11,15,18,22,25-octa-iso-pentyl lead phthalocyanines. The molecular packing of 1,4,8,11,15,18,22,25-octa-iso-pentyl lead phthalocyanine is more complex because of the presence of tetrahydrofuran molecules (the solvent of recrystallisation) within the crystal, offering additional interactions with the Pb atoms.

scholarly journals Lung Ultrasound Diagnostic Accuracy in Neonatal Pneumothorax

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Luigi Cattarossi ◽  
Roberto Copetti ◽  
Giacomo Brusa ◽  
Stefano Pintaldi
Keyword(s):  
Birth Weight ◽  
Respiratory Distress ◽  
Gestational Age ◽  
Lung Ultrasound ◽  
Chest Drainage ◽  
X Ray ◽  
Lower Accuracy ◽  
Chest X Ray ◽  
Diagnostic Work ◽  
Work Up

Background. Pneumothorax (PTX) still remains a common cause of morbidity in critically ill and ventilated neonates. At the present time, lung ultrasound (LUS) is not included in the diagnostic work-up of PTX in newborns despite of excellent evidence of reliability in adults. The aim of this study was to compare LUS, chest X-ray (CXR), and chest transillumination (CTR) for PTX diagnosis in a group of neonates in which the presence of air in the pleural space was confirmed.Methods. In a 36-month period, 49 neonates with respiratory distress were enrolled in the study. Twenty-three had PTX requiring aspiration or chest drainage (birth weight 2120 ± 1640 grams; gestational age = 36 ± 5 weeks), and 26 were suffering from respiratory distress without PTX (birth weight 2120 ± 1640 grams; gestational age = 34 ± 5 weeks). Both groups had done LUS, CTR, and CXR.Results. LUS was consistent with PTX in all 23 patients requiring chest aspiration. In this group, CXR did not detect PTX in one patient while CTR did not detect it in 3 patients. Sensitivity and specificity in diagnosing PTX were therefore 1 for LUS, 0.96 and 1 for CXR, and 0.87 and 0.96 for CTR.Conclusions. Our results confirm that also in newborns LUS is at least as accurate as CXR in the diagnosis of PTX while CTR has a lower accuracy.

scholarly journals Clinical utility of cerebrospinal fluid vitamin D-binding protein as a novel biomarker for the diagnosis of viral and bacterial CNS infections

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Young Jin Kim ◽  
Hương Giang Lê ◽  
Byoung-Kuk Na ◽  
Bo Gyu Kim ◽  
Youn-Kwan Jung ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cerebrospinal Fluid ◽  
Laboratory Tests ◽  
Binding Protein ◽  
The Other ◽  
Cns Infection ◽  
Vitamin D Binding Protein ◽  
Opening Pressure ◽  
Infection Group ◽  
Cns Infections

Abstract Background Rapid and accurate diagnosis of central nervous system (CNS) infections is important, and laboratory tests help diagnose CNS infections. Even when the patient has symptoms, laboratory tests often do not reveal any specific findings. The potential of vitamin D-binding protein (VDBP) to be used as a biomarker for viral and bacterial CNS infections was studied. Methods A total of 302 subjects with suspected CNS infection who underwent lumbar puncture were included. Clinical and laboratory data were collected retrospectively. VDBP levels were measured in the cerebrospinal fluid (CSF) samples. Genotyping for the GC gene encoding VDBP was also performed. VDBP levels were analyzed and compared by CNS infection, pathogen, CSF opening pressure, and GC genotype. Results A CNS infection group (n = 90) and a non-CNS infection group (n = 212) were studied. In terms of its receiver operating characteristic, CSF VDBP showed an area under the curve of 0.726 for the diagnosis of CNS infection. CSF VDBP levels were significantly different between the CNS infection and non-infection groups. The CNS infection group with enterovirus showed a statistically lower distribution of CSF VDBP levels than the other virus groups. The group with CSF opening pressure > 25 cmH2O showed higher CSF VDBP levels than the other groups. There was no significant difference in GC gene allele distribution between the CNS infection and non-infection groups. Conclusions CSF VDBP levels were increased in patients with CNS infection. The CSF VDBP showed potential as a new biomarker for viral and bacterial CNS infections.

scholarly journals A CNN Classification Model For Diagnosis Covid19

2020 ◽  
Author(s):  
Ahmed Abdullah Farid ◽  
hatem khater ◽  
gamal selim
Keyword(s):  
Neural Network ◽  
Virus Disease ◽  
Real Data ◽  
Classification Model ◽  
X Ray ◽  
Corona Virus ◽  
Chest X Ray ◽  
Neural Network Structure ◽  
Extraction Model ◽  
First Time

The paper demonstrates the analysis of Corona Virus Disease based on a CNN probabilistic model. It involves a technique for classification and prediction by recognizing typical and diagnostically most important CT images features relating to Corona Virus. The main contributions of the research include predicting the probability of recurrences in no recurrence (first time detection) cases at applying our proposed Convolution neural network structure. The Study is validated on 2002 chest X-ray images with 60 confirmed positive covid19 cases and (650 bacterial &ndash; 412 viral -880 normal) x-ray images. The proposed CNN compared with traditional classifiers with proposed CHFS feature extraction model. The experimental study has done with real data demonstrates the feasibility and potential of the proposed approach for the said cause. The result of proposed CNN structure has been successfully done to achieve 98.20% accuracy of covid19 potential cases with comparable of traditional classifiers.

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