scholarly journals Drug Abuse Patterns of Combined Amphetamine-Type Stimulants and Opioid Dependence in Malay Male Subjects in Kota Bharu, Kelantan, Malaysia

2021 ◽  
Vol 5 (2) ◽  
pp. 1-5
Author(s):  
Deeza-Syafiqah Mohd Sidek ◽  
Imran Ahmad ◽  
Ruzilawati Abu Bakar ◽  
Nik Norizah Nik Ibrahim
Keyword(s):  
Drug Abuse ◽  
Opioid Dependence ◽  
Control Group ◽  
Drug Usage ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
History Of ◽  
The Mean ◽  
Drug Dependent ◽  
Male Subjects

The objective of this study was to examine the socio-demographic characteristics and drug abused patterns of combined amphetamine-type stimulants (ATS) and opioid dependence in Malay Male subjects in Kota Bharu, Kelantan, Malaysia. Seventy drug dependent subjects who were diagnosed using Diagnostic and Statistical Manual-IV (DSM-IV), and 87 control subjects who fulfilled the inclusion and exclusion criteria were interviewed using a questionnaire.The median age (IQR) for drug dependent group was 28.0 (7.68) years old while median age for control group was 24.0 (10.55). The mean (SD) initiation age for ATS was 27.39 (9.79) while the mean (SD) initiation age for opioid was 22.20 (7.19). 57.1% of the drug dependent subjects used injections as their method of opioid ingestion, while 65.7% preferred chase to ingest ATS. Most of the subjects were HIV negative (61.4%). Majority have not sought any treatment regarding their drug usage (71.4%). Most of the drug dependent subjects have been arrested and convicted for drug use (88.6%). However, majority demonstrated no history of arrest or conviction for non-drug related crime (77.1%). This study provides an update on the socio-demographic and drug abuse patterns of combined amphetamine-type stimulants and opioid dependence subjects that may help in combating the alarming increase of the drug abuse.

Psychiatric Morbidity in Sentenced Segregated HIV-Positive Prisoners

1993 ◽  
Vol 163 (6) ◽  
pp. 802-805 ◽  
Author(s):  
Arthur Dorman ◽  
Art O'Connor ◽  
Eamonn Hardiman ◽  
Aideen Freyne ◽  
Helen O'Neill
Keyword(s):  
Drug Abuse ◽  
Matched Control ◽  
Psychiatric Morbidity ◽  
Hiv Positive ◽  
Control Group ◽  
Matched Control Group ◽  
History Of ◽  
The Mean ◽  
Group 2 ◽  
Group 1

In this comparative study with a control group of prisoners, psychiatric morbidity was measured in two groups of sentenced prisoners, each group completing the GHQ-30 and 21-item Beck Depression Inventory (BDI). Group 1 consisted of 40 segregated HIV-positive prisoners and group 2 a matched control group in the main prison who had no history of HIV seropositivity. All members of group 1 had a history of intravenous drug abuse. The mean GHQ-30 and BDI scores were significantly higher in group 1, and 90% of group 1 were psychiatric ‘cases’ compared with just over 42% of group 2. Levels of psychiatric morbidity present in a third group, consisting of HIV-positive prisoners who had not been segregated (prison authorities were unaware of their seropositivity) are an interesting pointer for further research.

Venlafaxine Treatment of Fibromyalgia

2003 ◽  
Vol 37 (11) ◽  
pp. 1561-1565 ◽  
Author(s):  
Kemal Sayar ◽  
Gokhan Aksu ◽  
Ismail Ak ◽  
Mehmet Tosun
Keyword(s):  
Serotonin Reuptake ◽  
Fibromyalgia Impact Questionnaire ◽  
Fixed Dose ◽  
Depression And Anxiety ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Pain Scores ◽  
Axis I ◽  
The Mean ◽  
Depression Scales

BACKGROUND: Although the pathophysiology of fibromyalgia is unknown, central monoaminergic transmission may play a role. Antidepressants have proved to be successful in alleviating symptoms of fibromyalgia. Medications that act on multiple neurotransmitters may be more effective in symptom management. OBJECTIVE: To assess the efficacy of venlafaxine, a potent inhibitor of both norepinephrine and serotonin reuptake, in the treatment of patients with fibromyalgia. METHODS: Fifteen patients with fibromyalgia were assessed prior to and after treatment with fixed-dose venlafaxine 75 mg/d. Before initiation of pharmacotherapy, patients were interviewed with the Structured Clinical Interview for Axis I disorders in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. The study lasted for 12 weeks, and patients were evaluated in weeks 6 and 12. The primary outcome measures were the Fibromyalgia Impact Questionnaire (FIQ) total score and pain score. The anxiety and depression levels of the patients were measured with the Beck Depression, the Beck Anxiety, the Hamilton Anxiety, and the Hamilton Depression scales. RESULTS: There was a significant improvement in the mean intensity of pain (F = 14.3; p = 0.0001) and in the disability caused by fibromyalgia (F = 42.7; p = 0.0001) from baseline to week 12 of treatment. The depression and anxiety scores also decreased significantly from baseline to week 12. The improvement in the FIQ scores did not correlate with the decrease of scores in both patient- and physician-rated depression and anxiety inventories. Change in pain scores also was not correlated with the change in depression and anxiety scores. CONCLUSIONS: Venlafaxine was quite promising in alleviating the pain and disability associated with fibromyalgia. This effect seems to be independent of its anxiolytic and antidepressant properties. Blockade of both norepinephrine and serotonin reuptake might be more effective than blockade of either neurotransmitter alone in the treatment of fibromyalgia.

scholarly journals An Investigation of the Relationship between Involvement Sites in Vitiligo Patients and Autoimmune Diseases and Hematological Parameters

2019 ◽  
Vol 4 (10) ◽  
Author(s):  
Ebru KARAGUN
Keyword(s):  
Hematological Parameters ◽  
Fasting Blood Glucose ◽  
Unknown Etiology ◽  
Control Group ◽  
Endocrine Disorders ◽  
Positive Correlation ◽  
Lymphocyte Ratio ◽  
History Of ◽  
The Mean ◽  
The Relationship

Aim-Objectives: Vitiligo is an acquired idiopathic disease which progresses with melanocyte destruction and is clinically characterized by depigmented lesions of unknown etiology. Vitiligo may be coexistence with a autoimmune and endocrine disorders. This study examined the sT3, fT4, TSH, Anti-TPO, Anti-Tg, Vitamin B12 and fasting blood glucose (FBG) values, and thrombocyte-to-lymphocyte ratio(TLR), neutrophil-to-lymphocyte ratio(NLR), the mean platelet volume(MPV) the correlation of depigmented lesions with the extent of body involvement sites(IS). Materials and Method: The study enrolled 67 patients aged 0‒65 who were diagnosed with non-segmental generalized vitiligo and in whom an increase in lesions had been observed in the last six months. The IS of the lesions in the patients were evaluated as IS ˂10%(1st group), 10%‒20% (2nd group), 20% - 30%(3rd group), 30% - 40%(4th group), 40% ‒50 %(5th group), and ˃50%(6th group). The control group consisted of patients who had presented to the outpatient clinic having had no history of vitiligo detected in themselves nor in their families. Results: No significant correlation was found between IS and sT3, fT4, TSH, Anti-TPO, Anti-Tg, Vit. B12, PBG or MPV. A moderately positive correlation was found between IS and duration (p <0.05) and a mildly positive correlation between IS and NLR and TLR (p <0.05). Conclusion: This study show that every patient diagnosed with vitiligo, independent of the IS, should undergo examination for autoimmune disease. A mild positive correlation between VTA and NLO-TLO was found to be an indicator of increased inflammation in vitiligo patients as the extent of lesions increased.

The Relationship of Drug Abuse to Unexplained Sudden Death

2008 ◽  
Vol 132 (12) ◽  
pp. 1903-1906
Author(s):  
Amy C. Gruszecki ◽  
Gerald McGwin, Jr ◽  
C. Andrew Robinson, Jr ◽  
Gregory G. Davis
Keyword(s):  
Drug Abuse ◽  
Cause Of Death ◽  
Control Group ◽  
Manner Of Death ◽  
Increased Risk ◽  
History Of ◽  
Matched Case ◽  
Relationship Of ◽  
The Relationship ◽  
Control Study

Abstract Context.—Forensic pathologists regularly investigate the deaths of individuals with a history of drug abuse. Autopsy, including toxicology testing, reveals no cause for death in a subset of this cohort. Objective.—To determine whether deaths with an undetermined cause and manner of death are associated with a history of drug abuse. Design.—Retrospective matched case-control study of 52 decedents whose cause of death remained undetermined following autopsy, matched 1:2 to a control group of living patients admitted for cholecystectomy according to age and date of death or procedure. Results.—Individuals whose cause of death was undetermined were 5.3 times (95% confidence interval, 1.9– 14.5) more likely to have a history of drug abuse than were patients with cholecystitis. Conclusions.—Decedents with a history of chronic drug abuse appear to be at an increased risk of dying by their chronic drug abuse, even in the absence of any anatomical or toxicologic finding at autopsy to account for death.

Prevalence of Premenstrial Disphoric Disorder Associated Factors among Students of Tabor Secondary and Preparatory School in Hawassa City, Ethiopia Cross Sectional

2020 ◽  
Author(s):  
Mulugeta Gobena Tadesse ◽  
Dereje Dirago Dire ◽  
Yacob Yacob Abraham
Keyword(s):  
Associated Factors ◽  
Depressive Disorders ◽  
Premenstrual Dysphoric Disorder ◽  
Emotional Symptoms ◽  
Cross Sectional ◽  
Preparatory School ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
History Of ◽  
Menstruating Women

Abstract Background: Premenstrual dysphoric disorder (PMDD)-is a severe and disabling form of premenstrual Syndrome affecting 3-8% of menstruating women. The disorder consists of a cluster of affective, behavioral and somatic symptoms that recur monthly during the luteal phase the menstrual cycle. Premenstrual dysphoric disorder (PMDD) was added to the list of depressive disorders in the diagnostic and statistical manual of mental disorders in 2013. The exact pathogenesis of the disorder is still unclear.Objective: To assess the prevalence of PMDD and its associated factors among students of Hawassa tabor secondary and preparatory school.Method: A cross sectional institutional based was conducted among 351 randomly selected female students of Hawassa tabor school. Data was collected by three students were facilitate the works with closed ended structured questionnaire and they was trained on how to collect the data. The collected data was entered, analyzed and cleaned by SPS.Results: prevalence of premenstrual dysphoric disorder in this study was 76.9%. Of each symptom is more than ninety present or 324 (92.3%) respondents can’t have experience unpleasant physical or emotional symptoms peculiar to the five days before the onset of menses & 27(7.7%) participants have show the symptoms. Among those 26 (7.4%) have present for the past ≥3 consecutive cycles. 46 (13.1%) have family history of such symptoms.Conclusions: These findings have implications for both women and medical providers, who should be aware that PMS symptoms are prevalent and often distressing, yet also understand that the severity of symptoms may remit over time.

Substance Use Disorders

2018 ◽  
Author(s):  
F Gerard Moeller
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Channel Blockers ◽  
Medical Problems ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Life Threatening ◽  
History Of ◽  
Abused Drugs ◽  
Nmda Receptor Channel

There is a consistent body of evidence showing that substance abuse and dependence can worsen preexisting medical conditions, can temporarily mimic medical and psychiatric disorders, and can themselves cause medical problems, including life-threatening overdose. Substance use disorders are common in young and middle-aged persons: the lifetime prevalence of these syndromes, including alcoholism, is over 20% for men and about 15% for women. This chapter discusses dependence, abuse, substance use disorder, and substance-induced disorders involving depressants, stimulants, opioids, cannabinoids, hallucinogens, N-methyl-D-aspartate (NMDA) receptor channel blockers, and inhalants. Epidemiology, etiology, pathophysiology, diagnosis (including clinical assessment and laboratory tests), and treatment are reviewed. Treatment of intoxication, overdose, withdrawal, and rehabilitation is discussed. A figure illustrates the neurocircuitry of addiction. Tables describe the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) diagnostic criteria for abuse and dependence; frequently misused drugs; neural effects of commonly abused drugs; the natural history of drug dependence; conditions affecting the outcome of urinary drug tests; and pharmacologic options for treatment of drug overdose. This chapter contains 1 figure , 6 tables and 112 references

scholarly journals Low Iron Level is related to Telogen Effluvium in Women

2013 ◽  
Vol 21 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Md Manjurul Karim ◽  
Md Abdul Wahab ◽  
Lubna Khondoker ◽  
Md Shirajul Islam Khan
Keyword(s):  
Hair Loss ◽  
Control Group ◽  
Case Group ◽  
Iron Level ◽  
History Of ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Medical University ◽  
Control Study

A case-control study conducted in the Department of Dermatology and Venereology of Bangabandhu Sheikh Mujib Medical University, Dhaka from July 2008- December 2010. A total 60 female patients of telogen effluvium attending in outpatient department (OPD) were enrolled in the study with 30 having hair loss considered as case (Group-A) and another 30 females had no history of hair loss were considered as control (Group-B). The study included 60 patients and the mean age were 25.4±7 years ranging from 18 to 42 years in group A and 24.8±5.6 years ranging from 17 to 36 years in group B. Maximum number was found in the age group of 21- 30 years in both groups and nearly three fourth (73.4%) patients were unmarried in group A and 18(60.0%) in group B. Most of the patients were student in both groups, which were 21(70.0%) and 17(56.7%) in group A and group B respectively and majority of the the patients were HSC level in both groups, 15(50.0%) and 14(46.7%) in Group A and Group B respectively. Most of the patients came from middle class, which were 20(66.7%) and 16(53.3%) in group A and group B respectively. The mean serum ferritin were 18.8±8.1 g/L ranging from 4.5 to 36.54 g/L and 36.6±9.9 mg/L ranging from 18.46 to 56.3 mg/ L in group A and group B respectively. The mean Hb level was 11.5±1.4 gm/dl ranging from 8.5 to 14.0 gm/dl in group A and 12.8±1.1 gm/dl ranging from 10.5 to 14.5 gm/dl in group B. The mean difference of Hb level was statistically significant (p<0.05) between two groups in unpaired t-test. It can be concluded that low iron level is associated with telogen effluvium in women. DOI: http://dx.doi.org/10.3329/bjmed.v21i2.13617 Bangladesh J Medicine 2010; 21: 84-89

Diagnosis of Attention Deficit Disorders in DSM-IV: Scientific Basis and Implications for Education

1993 ◽  
Vol 60 (2) ◽  
pp. 108-117 ◽  
Author(s):  
Keith McBurnett ◽  
Benjamin B. Lahey ◽  
Linda J. Pfiffner
Keyword(s):  
Attention Deficit ◽  
Field Trials ◽  
Scientific Basis ◽  
Statistical Manual ◽  
Hyperactivity Disorder ◽  
Diagnostic And Statistical Manual ◽  
History Of ◽  
Dsm Iv ◽  
Symptom List

The category of attention deficit hyperactivity disorder (ADHD) and its diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM) have undergone numerous revisions. The history of these revisions is briefly presented, followed by a summary of results of the Field Trials for the forthcoming fourth edition, the DSM-IV, regarding ADHD. The revised symptom list and empirical determination of symptom cutpoints resulted in increased reliability and predictive validity for educational impairment, as operationalized by measures of academic productivity and accuracy, for the new criteria. Three subtypes emerged, including a new subtype of predominantly hyperactive. The relevance, functions, and limitations of DSM-IV diagnosis for educational assessment of ADHD are discussed.

History of the Personality Disorders Narcissism and Psychopathic Personality

2020 ◽  
Author(s):  
Elizabeth Lunbeck
Keyword(s):  
Personality Disorder ◽  
Mental Disease ◽  
Early Years ◽  
Psychopathic Personality ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Past Half Century ◽  
History Of ◽  
Run Up ◽  
National Decline

Psychopathic personality (a term that has been largely supplanted in psychologists’ and psychiatrists’ nosologies by anti-social personality disorder) and narcissism are venerable, widely used, and fiercely contested categories of personality disorder. Psychopathic personality was originally delineated in the early years of the 20th century to encompass behavior that was, in experts’ estimation, decidedly not normal but that fit none of the other categories of mental disease. Critics of the diagnosis claimed it was but another label for individuals’ non-conformity with social norms, used to punish the poor and marginal. Narcissism has had an even more tumultuous history than psychopathy. Referring simultaneously to traits considered pathological (grandiosity, exploitativeness, manipulativeness) and to traits thought desirable (high self-esteem, capacity for leadership and authority), narcissism has been at the center of debates over national decline and the character of the modal American for the past half-century. Both categories have also sparked controversy along the trait/ state, dimensional/ categorical divide that flared in the run-up to the publication of the 5th edition of psychiatry’s Diagnostic and Statistical Manual of Mental Disorders in 2013. Thousands of papers have attempted to resolve the ambiguities surrounding both diagnoses, but these ambiguities have proven productive (of research and new knowledge) and are unlikely to be resolved soon.

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