scholarly journals INTEGRAL ASSESSMENT OF THE SEVERITY OF THYROTOXICOSIS

2020 ◽  
Vol 23 (2) ◽  
pp. 119-123
Author(s):  
I. V. Makarov ◽  
R. A. Galkin ◽  
R. M. Romanov ◽  
V. M. Golubova
Keyword(s):  
Clinical Laboratory ◽  
Integral Index ◽  
Moderate Severity ◽  
Severity Estimation ◽  
Integral Estimation ◽  
Personalized Approach ◽  
Integral Assessment ◽  
Toxic Goiter ◽  
Instrumental Methods ◽  
Integrated Estimation

Introduction. Estimate thyrotoxicosis severity considering proposed integral index based on a medical history, the main clinical, laboratory and instrumental methods of research Purpose. A study of 37 patients with toxic goiter using the proposed thyrotoxicosis severity integrated estimation was conducted. 23 (62.1%) were diagnosed with diffuse toxic goiter (DTZ), and 14 (37.8%) had multinodular toxic goiter (MTZ). There were 31 women (83.7%) and 6 men (16.2%). Results. Using our integrated thyrotoxicosis severity estimation 11 people (29.7%) were diagnosed with mild thyrotoxicosis, 25 people (67.5%) - moderate severity, 1 man (2.7%) - severe thyrotoxicosis. Compared with the classification specified in the Federal Clinical Recommendations (2014), 1.6 times more cases of mild thyrotoxicosis and 6 times less cases of severe thyrotoxicosis were detected. Conclusion. The proposed thyrotoxicosis severity integral estimation index is simple and affordable for clinical practice usage, it allows to more accurately estimate patient’s condition severity, suggests a personalized approach not only to thyrotoxicosis severity estimation, but also to determine further treatment tactics.

scholarly journals ANALYSIS OF DIAGNOSTIC PARAMETERS OF RESPIRATORY FAILURE IN PATIENTS WITH BRONCHIAL ASTHMA

2015 ◽  
Vol 4 (2) ◽  
pp. 10-12
Author(s):  
Dmitry Alexandrovich Anisimov ◽  
Lyudmila Nikitichna Goncharov ◽  
Anna Albertovna Dyachkova
Keyword(s):  
Respiratory Failure ◽  
Bronchial Asthma ◽  
Clinical Laboratory ◽  
Pathological Condition ◽  
External Respiration ◽  
Clinical Parameters ◽  
Arterial Blood ◽  
Criteria For Diagnosis ◽  
Invasive Techniques ◽  
Instrumental Methods

Respiratory failure (NAM)-a pathological condition in which there is provided the maintenance of normal blood gas or it is achieved through more intensive operation of external respiration and heart, resulting in decreased functional capacity of the organism [1,2]. The main method of diagnosis of DN is the study of the gas composition of the arterial blood, but because of the complexity of the analysis, which involves complex invasive techniques for obtaining arterial blood by puncture of a major artery in the therapeutic Department is not carried out [1,3]. A plurality of classifications days, the lack of clear criteria for diagnosis was to analyze assessment days by a combination of clinical, laboratory and instrumental methods patient days. As a model of acute respiratory failure were selected from patients with mild intermittent and persistent severity of asthma, which bore a slight aggravation, burdened days 1 severity, number of 30 people. SatO2 blood was the criterion for assessing the severity of DN. In the evaluation of clinical parameters, such as shortness of breath and respiratory rate, it was revealed that the values of these parameters increase is inversely proportional to the drop SatO2 blood. In assessing such clinical parameters as the rate of breathing and instrumental measure FEV1 did not find such dependence. Thus, to assess the severity of DN in patients with bronchial asthma it is necessary to conduct a comprehensive analysis of the clinical and instrumental methods.

scholarly journals PREGNANCY AND OUTCOMES OF DELIVERY IN WOMEN WITH GENITAL ENDOMETRIOSIS

2020 ◽  
Vol 18 (5) ◽  
pp. 569-574
Author(s):  
M. A. Pavlovskaya ◽  
◽  
L. V. Gutikova ◽  
Y. V. Kukharchyk ◽  
◽  
...  
Keyword(s):  
Chronic Hypoxia ◽  
Clinical Laboratory ◽  
Normal Pregnancy ◽  
Main Group ◽  
Control Group ◽  
Fetal Growth Retardation ◽  
Perinatal Complications ◽  
Complicated Course ◽  
Previously Treated ◽  
Instrumental Methods

Background. The problem of genital endometriosis is relevant both in medical and in social aspects.Aim of the research. To analyze the course of pregnancy, childbirth and their outcomes in genital endometriosis to justify the critical terms of the complicated course of pregnancy and determine approaches for the development of therapeutic and preventive measures.Material and methods. The main group – 160 pregnant women, previously treated for genital endometriosis. The control group was 50 healthy women with a normal pregnancy. The generally accepted clinical laboratory and instrumental methods of the research were used. Statistical analysis of the data was carried out using the software package Statistica 10.0. Results. Gestational periods of 6-12 weeks, 18-22 weeks, 30-34 weeks of pregnancy are critical for women of the main group. The course of pregnancy is complicated by the threat of an early miscarriage (50%), placental disorders (65%), chronic hypoxia (35%) and fetal growth retardation (20%), anomalies of labor (60%).Conclusions. The complicated course of pregnancy in patients with genital endometriosis justifies the need to develop a comprehensive program for the prevention of gestational and perinatal complications.

scholarly journals Risk factors of gestational hypertension development

2017 ◽  
Vol 30 (2) ◽  
pp. 65-68
Author(s):  
Olga Bulavenko ◽  
Oksana Vaskiv
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Clinical Laboratory ◽  
Gestational Hypertension ◽  
Varicose Veins ◽  
Pregnancy Termination ◽  
Control Group ◽  
Post Secondary ◽  
Hypertension Development ◽  
Instrumental Methods

Abstract The problem of gestational hypertension (GH) remains to be of current concern in obstetric practice. The purpose of this study, therefore, was to determine the risk factors for GH development. We examined 53 pregnant women and allocated them to 2 groups: the main group - pregnant women with gestational hypertension (n = 30) and the control group - pregnant women without the pathology (n = 23). The selection of persons for the study was carried out on the basis of detailed history taking, examination and complaints, using standard clinical, laboratory and instrumental methods of investigation. The data was processed on a PC (standard statistical package Statistica 6.0). Our results show that the gestational hypertension development is closely linked with such risk factors as: age ≤ 18 years old and over 35 years old, unmarried status, living in a city/town, post-secondary education, unemployment, obesity, first labor in consecutively pregnant women, the threat of pregnancy termination, cardiovascular system diseases, urinary tract pathology, varicose veins, as well as ABO-sensibilization.

scholarly journals Fahr’s disease

2019 ◽  
pp. 35-42
Author(s):  
N. M. Nevmerzhytska ◽  
V. V. Orzheshkovskyi
Keyword(s):  
Basal Ganglia ◽  
Clinical Laboratory ◽  
Resonance Spectroscopy ◽  
Pathophysiological Mechanism ◽  
Scientific Review ◽  
Functional Studies ◽  
Positron Emission ◽  
Physiological Calcification ◽  
Instrumental Methods ◽  
The Brain

The scientific review based on an analysis of the literature examines key points in the etiology, pathomorphology and clinical picture of basal ganglia calcification. It also involves the so-called physiological calcification of the central nervous system. Juvenile and senile forms of a disease and frequency of occurrence of this nosological form are described. The historical information and modes of inheritance are briefly provided. The article considers the numerous synonyms of this disease and the causes of secondary calcification of the brain (Fahr’s syndrome). Four genes are described associated with primary calcification of the basal ganglia: SLC20A2 and XPR1 coding transmembrane conveyors of inorganic phosphate; PDGFB and PDGFRB which are involved in integrity of a blood-brain barrier and survival of pericytes. Pathogenetic mechanisms of clinical displays of a disease are presented. The article displays the features of macro- and microscopic changes in the brain with this nosology. The characteristic signs of the initial and advanced forms of the disease are described in detail, taking into account the age of the debut of calcification of the basal ganglia. The main and auxiliary instrumental methods for diagnosing this disease are also considered, the results of positron emission tomography and magnetic resonance spectroscopy are described, which confirm the pathophysiological mechanism of neurological manifestations of the disease associated with the disorganization of the front-striatal pathways in the area of ​​calcified basal ganglia. A number of additional general clinical laboratory and functional studies are listed to confirm or exclude the diagnosis of primary family idiopathic ferrocalcinosis (Fahr’s diseases). The main directions in the treatment of the described pathology are given.

scholarly journals Change in the state of an exploited fish population: From individual indicators to integral assessment

2020 ◽  
Vol 28 (4) ◽  
pp. 405-410
Author(s):  
E. I. Boznak ◽  
V. G. Tereshchenko ◽  
A. B. Zakharov
Keyword(s):  
Fish Habitat ◽  
Fish Population ◽  
The State ◽  
Age Group ◽  
Integral Index ◽  
Theoretical Concepts ◽  
The Status ◽  
European Part Of Russia ◽  
Integral Assessment ◽  
The Impact

We adapted the approach used for the integral assessment of the status of ecosystems in order to assess population status. Classic theoretical concepts of fish population dynamics are the basis of this approach. The convolution of information about changes in several structural and functional characteristics into one integral index was performed using the analytical function of desirability. The index varied 0 to 1 and quantitatively characterizes the state of the population. This approach was tested on the example of the European grayling Thymallus thymallus (Linnaeus, 1758), inhabiting the Vym River (basin of the Northern Dvina River, North of the European part of Russia). The materials were collected during the environmental monitoring carried out by the Institute of Biology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences (IB FRC Komi SC UB RAS) in 2002, 2005–2019. The population parameters used in the calculations (relative abundance; average and maximum age of fish; the proportion of matured individuals in the 4+ age group; average specific growth rate of fish at the age of 6+; body weight of fish in the age group 6+) were characterized on the basis of the control net catches. Compared with the period 2005–2006, the value of the integral index in 2015–2018 decreased by almost two times. This indicates deterioration in the condition of the grayling group in the study area. There were no serious disturbances in the fish habitat in this area. The main hydrochemical and hydrobiological indicators have not changed significantly. The main reason for the observed changes is likely the significant increase in the impact of recreational anglers. The proposed integral index may be useful both for assessing the state of fish populations and for developing measures for the rational management of fish stocks.

scholarly journals POSSIBILITIES OF MATHEMATICAL PREDICTION OF ACUTE EROSIVE-ULCERATIVE LESIONS OF UPPER PARTS OF GASTROINTESTINAL TRACT IN PATIENTS WITH SEVERE BURNS

2017 ◽  
Vol 176 (2) ◽  
pp. 51-56
Author(s):  
O. N. Ergashev ◽  
E. N. Zinov’Ev ◽  
Yu. M. Vinogradov
Keyword(s):  
Data Analysis ◽  
Gastrointestinal Tract ◽  
Preventive Measures ◽  
Clinical Laboratory ◽  
Severe Burns ◽  
Effective System ◽  
Ulcerative Lesions ◽  
Instrumental Methods ◽  
High Possibility ◽  
Extensive Burns

OBJECTIVE. The authors created an effective system of prediction of acute erosive-ulcerative lesions of the stomach and duodenum in victims with extensive burns. MATERIALS AND METHODS. The patients (85) were divided into two groups. The first group included 45 patients (53 %) with erosive ulcerative lesions of the stomach and duodenum which developed during 14 days after injury. The second group numbered 40 patients (47 %) without complications. The clinical, laboratory and instrumental methods of investigations were applied. RESULTS. According to data analysis of patient’s examination, the scale of assessment of sign rates was developed. The amount of rates corresponded to the index of prediction (IP). The values of IP were calculated at the interval from -15 to +15 units. The high possibility (85 %) of development of acute erosive and ulcerative lesions of the stomach and duodenum could be expected in cases when IP was about +15 units. CONCLUSIONS. The developed predictive scale of erosive-ulcerative complications of gastrointestinal tract appeared to be highly reliable and allowed doctors to use preventive measures on time.

scholarly journals Risk-oriented integral assessment of the Ukrainian banks effectiveness

2019 ◽  
Vol 14 (3) ◽  
pp. 121-139
Author(s):  
Mariya Rubakha ◽  
Lesia Tkachyk ◽  
Olha Zamaslo ◽  
Olesya Irshak
Keyword(s):  
High Efficiency ◽  
Banking System ◽  
Ratio Analysis ◽  
Mathematical Methods ◽  
Bank Profitability ◽  
Priority Task ◽  
Integral Estimation ◽  
Banking Business ◽  
Integral Assessment ◽  
Graphic Methods

Ensuring efficiency improvement of banks is a priority task for Ukrainian banking system at the stage of creating the developed financial sector of economy. The study of a bank performance, which takes into account a risk factor of banking business, is particularly relevant due to the need to ensure competitiveness and stability of both individual banks and the banking system as a whole.The aim of this article is to develop a methodology for integral evaluation of the Ukrainian banks according to the efficiency and risk criteria. Ratio analysis, mathematical methods, comparison and grouping, synthesis, table, matrix and graphic methods make the methodological basis of the research. The object of the analysis is the activities of Ukrainian banks.The study was conducted to elaborate a method for risk-oriented integral estimation of efficiency of the banks functioning. One can state that high efficiency and low risk of a bank’s work do not depend on the volume of assets, equity and profit for Ukrainian banks.The analysis made it possible to evaluate the strategies for the development of Ukrainian banks. The vast majority of Ukrainian banks have chosen a moderate strategy in the context of balancing the efficiency and riskiness of their activities. According to the results of factor analysis using Raiffeisen Bank Aval as an example, the main factors of gross profit growth were determined as increase in bank profitability and expansion of its active operations volume relative to its own capital.

scholarly journals Clinical, laboratory and instrumental methods of pre-surgical diagnosis of the parathyroid glands cancer

2017 ◽  
Vol 11 (3) ◽  
pp. 136-145 ◽  
Author(s):  
Natalia G. Mokrysheva ◽  
Julia A. Krupinova ◽  
Svetlana S. Mirnaya
Keyword(s):  
Clinical Laboratory ◽  
Parathyroid Glands ◽  
Instrumental Methods ◽  
Roche Cobas

Обоснование. При выявлении у пациента манифестной формы первичного гиперпаратиреоза (ПГПТ) дифференциальная диагностика между доброкачественным и злокачественным новообразованиями околощитовидных желез (ОЩЖ), которые могут быть причиной заболевания, затруднительна. Дифференциальная диагностика злокачественной и доброкачественной опухоли до операции определяет объем хирургического вмешательства и дальнейшую тактику наблюдения. Цель. Определить клинические и лабораторно-инструментальные предикторы рака ОЩЖ. Методы. Проведено одноцентровое одномоментное ретроспективное исследование, в которое включено 385 пациентов с ПГПТ (273 с аденомами ОЩЖ, 66 с гиперплазиями и 19 пациентов с раком ОЩЖ), обследованных и прооперированных в ФГБУ “НМИЦ эндокринологии” с 2000 по 2014 г. Первичной конечной точкой исследования стало определение уровня ионизированного кальция (Са++), паратгормона (ПТГ) и объема опухоли ОЩЖ, характерных для злокачественных новообразований ОЩЖ. Уровень Са++ определялся ионоселективным методом, ПТГ – электрохемилюминесцентным методом на анализаторе фирмы Roche Cobas 6000. Объем ОЩЖ рассчитывался по формуле эллипса: V(см3) = (A × B × C) × 0,49 с помощью ультразвукового исследования аппаратом Valuson E8 фирмы GeneralElectric. Результаты. В группе пациентов с раком ОЩЖ выявлено повышение уровня Са++ более 1,60 ммоль/л (р = 0,004) и ПТГ более 600 пг/мл (p = 0,03). Объем опухоли более 6 см3 встречался чаще в группе раков, чем в группе доброкачественных новообразований ОЩЖ (р = 0,01). Заключение. В группу высокого риска наличия карциномы ОЩЖ среди пациентов с ПГПТ входят лица с сочетанием гиперкальциемии более 1,6 ммоль/л (Са++), повышением ПТГ более 600 пг/мл и размером опухоли более 6 см3.

scholarly journals Integral assessment of innovation and investment potential of automotive industry of Ukraine

2020 ◽  
pp. 44-48
Author(s):  
Inna SHEVCHENKO ◽  
Anastasiia PLAKHTII
Keyword(s):  
Automotive Industry ◽  
Integral Index ◽  
Automobile Plant ◽  
Investment Projects ◽  
Process Innovations ◽  
Material Efficiency ◽  
Capital Efficiency ◽  
Product And Process ◽  
Integral Assessment ◽  
High Level

Introduction. The automotive industry traditionally belongs to the innovation-active subsectors, where a large number of product and process innovations are produced annually, many newest engineering solutions are put into practice. In scientific literature there are numerous studies of innovation and investment potential at the macro, meso and micro levels of its manifestation, but scientists have not yet paid attention to the innovation and investment potential of the automotive industry. The purpose of the paper is development and testing the methodological tools for integral assessment of innovation and investment potential of the automotive industry. Results. In the article the authors propose an integral index of innovation and investment potential of automotive enterprises and a scale of interpretation of the values of this indicator. The integral assessment of innovation and investment potential of the automotive industry of Ukraine in the period 2014-2018 is done, in particular such automakers as: PJSC “Zaporizhzhya automobile plant”, сorporation “Bogdan”, PrJSC “Eurocar”, PrJSC “AvtoKrAZ”, PrJSC “BAZ”, PrJSC “Chasivoyarsky buses”, PrJSC “Chernihiv automobile plant”, PJSC “Cherkasy bus”. It was revealed that currently the leader of innovation and investment development of the automotive industry of Ukraine is PrJSC “Eurocar”, which is characterized by a high level of innovation and investment potential. This situation is due to the traditionally effective partnership on the basis of franchising and car assembly activities of PrJSC “Eurocar” with leading foreign automakers such as Škoda Auto, Volkswagen AG, Hyundai Motor Company. Other domestic automakers are characterized by an average level of innovation and investment potential, except for PrJSC “BAZ”, which is currently characterized by a low level of innovation and investment potential. Conclusion. In the period 2014-2018, the stimulators of the innovation and investment potential of the automotive industry of Ukraine were indicators of the cost of implemented investment projects, capital efficiency, material efficiency and productivity. Instead, mainly the destructive influence on the integral index of innovation and investment potential of the automotive industry of Ukraine in 2014-2018 was carried out by indicators of management efficiency, introduction of innovations, profitability of activity.

scholarly journals APPLICATION OF NEURAL NETWORKS IN MEDICAL DIAGNOSTICS

2021 ◽  
pp. 40-51
Author(s):  
V. A. Sapozhkov ◽  
O. N. Budadin ◽  
A. S. Churilova ◽  
B. F. Falkov ◽  
Zh. Yu. Sapozhkova
Keyword(s):  
Artificial Intelligence ◽  
Neural Networks ◽  
Artificial Neural Networks ◽  
Clinical Laboratory ◽  
Medical Diagnostics ◽  
Automation System ◽  
Laboratory Examination ◽  
Artificial Neural ◽  
Personalized Approach ◽  
Diagnostic Outcomes

This article discusses the possibilities of application of artificial neural networks to solve problems of increasing the diagnostic outcomes in clinical laboratory examination. High diagnostic sensitivity (96 %) and diagnostic accuracy (89.5 %) of the results were shown on a large amount of cellular material digitized by artificial intelligence microscopy automation system like the Vision Cyto Pap. The high resolution and sharpness of digital slides, the mode of viewing objects (cells) in the gallery, quick access to the results of preclassification, all of these factors together allow to reduce turnearound time in more than 2.5 times reducing disadvantages of the microscopy.<br>Application of artificial neural networks does not substitute a doctor’s skills. The role in validation of reports eligible only for cytopathologist. This concept indicates a carefully approach for staff working with a microscope, respectful attitude to them professional skills, and highlights a personalized approach to patients.

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