Evaluation of Neuropharmacological Effects of Dichrostachys cinerea Root

1970 ◽  
Vol 1 (4) ◽  
pp. 367-374
Author(s):  
Ramya Kuber B ◽  
Thaakur SanthRani
Keyword(s):  
Motor Activity ◽  
Ethanolic Extract ◽  
Tail Suspension Test ◽  
Spontaneous Motor Activity ◽  
Phytochemical Analysis ◽  
Alcoholic Extract ◽  
Dichrostachys Cinerea ◽  
Cns Depressant ◽  
Immobility Time ◽  
Cns Depressant Activity

Dichrostachys cinerea (DC) root juice is widely used by tribals of Chittoor District against paralysis. The ethanolic extract was given at a dose of 100, 200 and 400 mg/kg/p.o. Spontaneous motor activity, analgesia, grip strength, alertness and immobility in tail suspension test (TST) and forced swimming test (FST) were assessed.  The extract at given doses significantly dose dependently decreased exploratory activity, spontaneous motor activity, increased immobility time in both FST and TST, decreased climbing and swimming behaviour in FST and did not alter other parameters. Preliminary phytochemical analysis of ethonolic extract showed the presence of saponins, steroids, glycosides, carbohydrates and tannins. Results of the present study indicated that the alcoholic extract may have active constituents with CNS depressant activity and at the given doses they are devoid of memory impairment and neurotoxicity

SCREENING OF ANTI-ANXIETY ACTIVITY OF UNRIPE FRUITS OF MUSA PARADISIACA LINN.

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (09) ◽  
pp. 33-35
Author(s):  
C. S Hallikeri ◽  
◽  
S. D Joshi ◽  
P Patil ◽  
V. H Kulkarni ◽  
...  
Keyword(s):  
Amino Acids ◽  
Operant Behavior ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Standard Drug ◽  
Musa Paradisiaca ◽  
Cns Depressant ◽  
Phytochemical Investigation ◽  
Cns Depressant Activity ◽  
Unripe Fruits

The alcoholic extract of unripe fruits of Musa paradisiaca Linn. (Musaceae) was evaluated for antianxiety activity by using operant behavior (behavioral disinhibition) model of anxiety in albino rats. Phytochemical investigation of alcoholic extract revealed the presence of flavonoids, amino acids,vitamins and carbohydrates. Alcoholic extract showed significant anti-punishment and anti-frustration activities at dose level of 500 mg/kg/day for 5 days which is comparable to standard drug, diazepam 5mg/kg. The presence of amino acid and flavonoids in alcoholic extract could be attributed for the antianxiety and other CNS depressant activity.

scholarly journals Evaluation of Antidepressant Activity of Ethanolic Extract of Abies webbiana and Berberis aristata in Laboratory Animals

2019 ◽  
Vol 9 (1) ◽  
pp. 244-247 ◽  
Author(s):  
Sucheta Gautam ◽  
Neetu Sachan ◽  
Alankar Shrivastav ◽  
Dilipkumar Pal
Keyword(s):  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Laboratory Animals ◽  
Control Group ◽  
Standard Group ◽  
Therapeutic Effects ◽  
Conventional Drug ◽  
Immobility Time ◽  
Swimming Test

Abstract Objective: Abies webbiana and Berberis aristata is an herbal plant that has several therapeutic effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated anti-depressant effect of ethanolic extract from Abies webbiana and Berberis aristata by using Forced Swimming Test (FST) and Tail Suspension Test (TST). Methods: Two doses of ethanolic extract of Abies webbiana and berberis aristata (200 mg/kg and 400 mg/kg) was given orally. Immobility time were measured after 30 min after the dosing and compared with control group and Flouxetine (25mg/kg) as a standard group. Results: The ethanolic extract of BA and AW (400 mg/kg) was found to be effective and it exhibited activity similar to that of the conventional drug Flouxetine (25mg/kg) (p<0.001) whereas 200 mg/kg dose showed higher activity with significantly increased swimming time and suspension time and decreased immobility time than 400 mg/kg of ethanolic extracts and Flouxetine (25mg/kg). Conclusion: These results proposed 400 mg/kg of ethanolic extract was showed higher anti-depressant activity as compared to control which is similar to the standard.

scholarly journals Pharmacological evaluation for Anti-Anxiety and CNS depressant activity of hydro-alcoholic leaves extract of Pongamia pinnata

2021 ◽  
Vol 11 (4-S) ◽  
pp. 22-25
Author(s):  
Jagannath Panda ◽  
Biswajit Samantaray ◽  
Gurudutta Pattnaik
Keyword(s):  
Amino Acids ◽  
Body Weight ◽  
Leaf Extract ◽  
Pongamia Pinnata ◽  
Control Group ◽  
Alcoholic Extract ◽  
Standard Methods ◽  
Cns Depressant ◽  
Depressant Action ◽  
Cns Depressant Activity

The aim of this study was to assess the anti-anxiety and CNS depressant properties of hydro-alcoholic extract of Pongamia pinnata leaves (HALEPP). Standard methods were used to screen the HALEPP's phytochemicals, which showed that the extract contains Flavones, alkaloids, glycosides, proteins and amino acids, gum and mucilage as well as flavonoids, saponins, and steroid hormones. Even at the dose level of 1000 mg/kg body weight, the HALEPP showed no signs of toxicity or mortality in the acute toxicity report. The anti-anxiety behaviour of was studied using light and dark model methods in rats. The CNS depressant action was studied using the extract and actophotometer (Rolex) in rats. The research group (HALEPP 200 gm/kg treated) animals displayed strong anti-anxiety and CNS depressant behaviour similar to the control group (diazepam treated) animals in the current study. The study's findings suggest that the hydro-alcoholic Pongamia pinnata leaf extract has strong anti-anxiety and CNS depressant properties. Keywords: Pongamia pinnata, Anti-Anxiety & CNS depressant

scholarly journals EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA ROOT L. ON ACUTE RESTRAINT STRESS-INDUCED ANXIETY AND DEPRESSION IN SWISS ALBINO MICE

2018 ◽  
Vol 11 (10) ◽  
pp. 182 ◽  
Author(s):  
Shashikumara Shashikumara ◽  
Prathima C ◽  
Amrutheswari B
Keyword(s):  
Restraint Stress ◽  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Phytochemical Analysis ◽  
Mimosa Pudica ◽  
Swiss Albino Mice ◽  
Acute Restraint Stress ◽  
Immobility Time ◽  
Albino Mice

Objective: The present study is undertaken to study the ameliorative effects of ethanolic extract of Mimosa pudica root (EMPR) on stress-induced anxiety and depressive-like behavior in Swiss albino mice.Methods: The animals were subjected to acute restraint stress (ARS) for 7 days, and on the 8th day after drugs administration, the antianxiety effect was evaluated using elevated plus maze (EPM) test. Antidepressant activity was evaluated by animal despair models-forced swim test and tail suspension test. Phytochemical analysis of the extract was also conducted.Results: EMPR (1000 and 2000 mg/kg) and the combined test groups have shown significant antianxiety effects similar to the standard diazepam as indicated by an improved open arm exploratory behavior in EPM model. EMPR also significantly reduced the immobility time in the animal despair models tested.Conclusion: Results suggest that EMPR possesses significant anxiolytic and antidepressant activity in male Swiss albino mice.

scholarly journals EVALUATION OF ANTI-STRESS ACTIVITY OF ETHANOLIC EXTRACTS OF TERMINALIA CATAPPA L. IN SWISS ALBINO MICE

2018 ◽  
Vol 11 (6) ◽  
pp. 253
Author(s):  
Imtiyaz Ansari ◽  
Rajeshwari Shashikant Sorte
Keyword(s):  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Soxhlet Extraction ◽  
Tail Suspension Test ◽  
Active Role ◽  
Swiss Albino Mice ◽  
Terminalia Catappa ◽  
Immobility Time ◽  
Ethanolic Extracts ◽  
Albino Mice

Objective: The aim of the study was to evaluate the anti-stress activity of ethanolic extract of Terminalia catappa L. in Swiss albino mice. Methods: The extract used in this study was prepared by Soxhlet extraction of fresh dried leaves of T. catappa L. using ethanol as an extraction solvent. Stress is involved in the pathogenesis of a variety of diseases including hypertension, peptic ulcer, immunodepression, reproductive dysfunction, and behavior disorder. Overload of stress increases free radicals, produces damage to neuronal receptors and a variety of tissues. In this experimental research study two models, namely, forced swim test (FST) and tail suspension test (TST) were used for the screening of anti-stress activity. 50, 100, and 200 mg/kg ethanolic extracts of T. catappa L. were given orally, while 2mg/kg of Diazepam which acts as a standard was given intraperitoneally. The data obtained were analyzed by one-way ANOVA, followed by Dunnett’s test. p<0.05 was considered to be significant. Result: The entire three test groups of the ethanolic extract of leaves of T. catappa L. showed decrease in immobility time in both FST (immobility for 42.5±3.5 s and mobility at 197.5±3.5 s) against diazepam (immobility 82.6±4.17 s and mobility at 157.3±4.17 s) and TST (92±2.28 s and mobility at 148±2.28) when compared against control as well as against diazepam (116.3±2.73 s and mobility at 123.6±2.73) which was used as a standard. Conclusion: There is substantial evidence that flavonoids play an active role in providing anti-stress activity. This study is an attempt to find out the alternative medication for treating chronic stress with single medication which was shown a beneficial effect in animal models, may be useful for curing symptoms of stress.

scholarly journals Antidepressant activity of Trigonella foenum leaves in Wistar albino rats

2019 ◽  
Vol 8 (5) ◽  
pp. 963
Author(s):  
Roopa P. Nayak ◽  
Prabhakar Adake ◽  
Hafis T. K.
Keyword(s):  
Drug Administration ◽  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Experimental Models ◽  
Albino Rats ◽  
Study Results ◽  
Immobility Time ◽  
Wistar Albino Rats

Background: To evaluate antidepressant activity of ethanolic extract of Trigonella foenum in animal models.Methods: A total of 60 healthy male Wistar albino rats weighing 220-250 grams were used and they were divided into 10 groups of 6 rats in each. First five groups (1st -5th) were evaluated by Forced Swim Test (FST) and remaining by Tail Suspension Test (TST). 1st group (control) received normal saline 10 mg/kg, 2nd group (standard) Imipramine 10 mg/kg and 3rd, 4th and 5th groups (test) respectively received Trigonella foenum leaf ethanolic extract [TFEE] in different doses 100 mg, 200 mg, and 400 mg/kg per orally for 14 days. They were evaluated for antidepressant activity using FST after 60 minutes of drug administration on 14th day. Similarly, remaining five groups (6th to 10th) received the same drugs and evaluated using TST after 60 minutes of drug administration. Duration of immobility was noted for six minutes for each rat.Results: One way ANOVA and Tukey Krammer test were used for statistical analysis. The immobility periods were expressed in mean±SD. The immobility period in FST were 207.16±28.7, 50.08±2.9, 46.14±1.2, 40.5±3.4 and 40.0±3.6 seconds respectively for control, standard and three test groups of TFEE (100/200/400 mg/kg). Similarly, immobility periods of 163.11±31.9, 125.03±11.2, 138.81±16.44, 138.16±12.65, 127.58±4.3 seconds were noted for TST for remaining six groups. It was found that TFEE possess statistically significant (p<0.05) antidepressant activity, as evidenced by decrease in the immobility time in both the tests when compared to control group.Conclusions: Present study results demonstrated that TFEE possess antidepressant property in experimental models of depression.

Mechanistic Evaluation of Antinociceptive Effects of Bioactive Guided Fractions of Barleria prionitis

2017 ◽  
Vol 10 (3) ◽  
pp. 3715-3727
Author(s):  
Venkatesh Sama ◽  
Azmathunnisa Begum ◽  
Rajesh Bolleddu ◽  
Ravi Alvala ◽  
Jaya Prakash D
Keyword(s):  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Plate Test ◽  
Cns Depressant ◽  
Whole Plant ◽  
Antinociceptive Effects ◽  
Cns Depressant Activity ◽  
Pain Stimuli

Barleria prionitis Linn.(Acanthaceae) is a prickly shrub and traditionally whole plant is used as anti-inflammatory, expectorant, analgesic, diuretic, antirheumaticand antidiabetic. This study was conducted to investigate the antinociceptive and CNS depressant activity of ethanolic extract and the fractions of B. prionitis in mice. Ethanol extract and its fractions were tested at a dose of 200 and 400 mg/kg. Ethanol, petroleum ether and chloroform fractions demonstrated significant antinociceptive activity at 400 mg/kg and significantly increased the latency in hot plate test and the action was antagonised by naloxone, indicating a potential opioid-like mechanism. In conclusion, the ethanol, pet ether and chloroform fractions of B. prionitis markedly demonstrated the antinociceptive action. The CNS depressant and good protective effect on pain stimuli suggest that the possible mechanisms appear to be due to involvement of opioid and/or peripheral receptors. 

scholarly journals A study on anxiolytic activity and locomotor behavior of Curcuma amada rhizomes using Wistar albino rats

2018 ◽  
Vol 7 (8) ◽  
pp. 1557
Author(s):  
Prajna V. Raj ◽  
Megha Rani N. ◽  
Roopa P. Nayak ◽  
S. N. Rao
Keyword(s):  
Ethanolic Extract ◽  
Developed Countries ◽  
Locomotor Behavior ◽  
Anxiolytic Activity ◽  
Albino Rats ◽  
Curcuma Amada ◽  
Cns Depressant ◽  
Causes Of Disease ◽  
Wistar Albino Rats ◽  
Cns Depressant Activity

Background: Global burden of disease statistics indicate that 4 of 10 most important causes of disease worldwide are psychiatric in origin. Anxiety affects 1/8th of total population of the world and is a very important area of research interest in psychopharmacology. Medicinal plants and plant products are the oldest tried health-care products. Their importance is growing not only in developing countries but in many developed countries. Curcuma amada Roxb. (CA) commonly known as Mango Ginger is a rhizomatous aromatic herb which is used in this country for culinary purposes and also to treat various diseases. The rhizomes of Curcuma amada was screened for anxiolytic activity and locomotor behavior in Wistar albino rats.Methods: Wistar albino rats were divided into three groups as control (Distilled water with 0.1% CMC), standard (Diazepam - 1mg/kg) and test - Ethanolic Extract of Curcuma amada Rhizome (EECAR-250 mg/kg). They were administered drugs orally for a period of 10 days, and screened for anxiolytic activity using Light dark arena model and Actophotometer for assessing the locomotor behavior on the 10th day. The number of crossings and time spent in light arena for anxiolytic activity, and the number of movements in Actophotometer was noted. Data was analyzed by one way ANOVA followed by Tukey Kramer multiple comparison test using GraphPad InStat software.Results: Curcuma amada (250mg/kg) showed increased time spent in light arena and decreased locomotor behavior which was statistically significant.Conclusions: Curcuma amada possesses significant anxiolytic with CNS depressant activity.

scholarly journals PHYTOCHEMICAL SCREENING AND ANTIDEPRESSANT ACTIVITY OF LEAVES EXTRACT OF DESMODIUM GANGETICUM

2021 ◽  
Vol 10 (2) ◽  
pp. 01-08
Author(s):  
Mr. Bablu Malviya ◽  
Mr. Narendra Patel ◽  
Dr.C.K. Tyagi ◽  
Dr. Prabhakar Budholiya
Keyword(s):  
Medicinal Plant ◽  
Antidepressant Drugs ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Raw Material ◽  
Phytochemical Analysis ◽  
Medicinal And Aromatic Plants ◽  
Immobility Time ◽  
Chemical Studies ◽  
Powder Analysis

According to Biological Conservation Letter, more than 7,000 species of plants found in various ecosystems are said to be medicinal in the country. So, India is one of the world’s richest sources of medicinal and aromatic plants. Desmodium gangeticum is an important medicinal plant. It is commonly used in ayurvedic formulations for the treatment of various disorders. Phytochemical evaluations, pharmacogonostic evaluation, organoleptic characters, TLC profile was carried out to set them as diagnostic indices for the identification/validation of the raw material and standardization of the formulations. Preliminary phytochemical analysis showed the presence of active constituents which is necessary for the pharmacological activity. Organoleptic properties, phyto-chemical studies, powder analysis, showed the presence of adulteration in the powder. Majority of the antidepressant drugs improve depressive symptoms, but they exert multiple undesirable side effects. The search for more productive and well tolerated drugs is in progress. Phytochemical analysis of Desmodium gangeticum revealed the presence of alkaloids, phenols, flavonoids, Saponins, Steroids. Desmodium gangeticum is a well known medicinal plant as anti-inflammatory, antimicrobial and nephroprotective etc. It is a very good drug for urinogenital problems, hepatic problems, oxidative stress etc. The present study was depict to evaluate the antidepressant activity of hydroalcoholic extract of Desmodium gangeticum in mice. It was evaluated using the Tail Suspension Test (TST) and Forced Swimming Test (FST) in mice. Desmodium gangeticum (200 and 400 mg/kg) was administered orally in separate groups of Swiss albino mice weighing 20-25 for 14 days in TST and FST tests.. The Leaves extract of Desmodium gangeticum showed a dose dependant reduction in duration of immobility in mice. The dose of 400 mg/kg of Leaves extract of Desmodium gangeticum significantly reduced the immobility time of mice in both FST and TST. The effectual of extract was found to be similar to fluoxetine (20 mg mg/kg, po). It was found to be toxicologically safe with no deaths of mice when administered orally at the dose of 2000 mg/kg. From the current study, it can be concluded that the Leaves extract of Desmodium gangeticum possess dominant antidepressant activity as reveal by the TST and FST tests and is toxicologically safe.

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