SCREENING OF ANTI-ANXIETY ACTIVITY OF UNRIPE FRUITS OF MUSA PARADISIACA LINN.

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (09) ◽  
pp. 33-35
Author(s):  
C. S Hallikeri ◽  
◽  
S. D Joshi ◽  
P Patil ◽  
V. H Kulkarni ◽  
...  
Keyword(s):  
Amino Acids ◽  
Operant Behavior ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Standard Drug ◽  
Musa Paradisiaca ◽  
Cns Depressant ◽  
Phytochemical Investigation ◽  
Cns Depressant Activity ◽  
Unripe Fruits

The alcoholic extract of unripe fruits of Musa paradisiaca Linn. (Musaceae) was evaluated for antianxiety activity by using operant behavior (behavioral disinhibition) model of anxiety in albino rats. Phytochemical investigation of alcoholic extract revealed the presence of flavonoids, amino acids,vitamins and carbohydrates. Alcoholic extract showed significant anti-punishment and anti-frustration activities at dose level of 500 mg/kg/day for 5 days which is comparable to standard drug, diazepam 5mg/kg. The presence of amino acid and flavonoids in alcoholic extract could be attributed for the antianxiety and other CNS depressant activity.

scholarly journals Pharmacological evaluation for Anti-Anxiety and CNS depressant activity of hydro-alcoholic leaves extract of Pongamia pinnata

2021 ◽  
Vol 11 (4-S) ◽  
pp. 22-25
Author(s):  
Jagannath Panda ◽  
Biswajit Samantaray ◽  
Gurudutta Pattnaik
Keyword(s):  
Amino Acids ◽  
Body Weight ◽  
Leaf Extract ◽  
Pongamia Pinnata ◽  
Control Group ◽  
Alcoholic Extract ◽  
Standard Methods ◽  
Cns Depressant ◽  
Depressant Action ◽  
Cns Depressant Activity

The aim of this study was to assess the anti-anxiety and CNS depressant properties of hydro-alcoholic extract of Pongamia pinnata leaves (HALEPP). Standard methods were used to screen the HALEPP's phytochemicals, which showed that the extract contains Flavones, alkaloids, glycosides, proteins and amino acids, gum and mucilage as well as flavonoids, saponins, and steroid hormones. Even at the dose level of 1000 mg/kg body weight, the HALEPP showed no signs of toxicity or mortality in the acute toxicity report. The anti-anxiety behaviour of was studied using light and dark model methods in rats. The CNS depressant action was studied using the extract and actophotometer (Rolex) in rats. The research group (HALEPP 200 gm/kg treated) animals displayed strong anti-anxiety and CNS depressant behaviour similar to the control group (diazepam treated) animals in the current study. The study's findings suggest that the hydro-alcoholic Pongamia pinnata leaf extract has strong anti-anxiety and CNS depressant properties. Keywords: Pongamia pinnata, Anti-Anxiety & CNS depressant

ISOLATION, CHARACTERIZATION AND ANTIFERTILITY ACTIVITY OF THE ACTIVE MOIETY FROM THE STEM OF MUSA PARADISIACA L.

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (09) ◽  
pp. 49-54
Author(s):  
P Soni ◽  
◽  
A. A. Siddiqui ◽  
J Dwivedi ◽  
V Soni
Keyword(s):  
Estrogenic Activity ◽  
Solvent System ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Traditional Use ◽  
Mass Spectral ◽  
Musa Paradisiaca ◽  
Antiestrogenic Activity ◽  
Isolated Compound ◽  
Oral Acute Toxicity

Bioactive principles from the hyroalcoholic (50%) extract of Musa paradisiaca L. stem were isolated and characterized to evaluate antifertility activity in female albino rats. Oral acute toxicity study was done with crude extract for 24h. The hydro alcoholic extract of M. paradisiaca stem was subjected to silica gel column chromatography using gradient solvent system DCM: Eth, Mth: Eth and Mth., ten different fraction were collected. The yield of fraction Mu-HA- Mps was 580 mg, further fractionated for purification by using solvent DCM-MeOH (3:2) to yield compound Mu-HA-Mps (20.22 %w/w). Isolated compound Mu-HA-Mps was subjected to evaluation of its antifertility potential by antiovulatory and estrogenic activity. The isolated compound Mu-HA-Mps was found to exhibit significant antiovulatory and antiestrogenic activity at doses of 100 and 200 mg/kg body weight. Isolated compound Mu-HAMps was subjected to structure elucidation by UV, IR, NMR and MASS spectral analytical methods. The results of the present study provide evidence of anti-fertility activity of isolated compound Mu-HA-Mps as claimed in the traditional use. The hydroalcoholic extract of Musa paradisiaca L. furnished a compound whose structure was established as 4’-methoxy-7-hydroxyisoflavone on the basis of physical and spectral basis and could be a good source of drug for birth control.

scholarly journals CNS Activity of the Methanol Extracts of Sapindus emarginatus Vahl in Experimental Animal Models

2009 ◽  
Vol 1 (3) ◽  
pp. 583-593 ◽  
Author(s):  
J. Srikanth ◽  
P. Muralidharan
Keyword(s):  
Animal Models ◽  
Muscle Relaxant ◽  
Methanol Extract ◽  
Behavioral Pattern ◽  
Albino Rats ◽  
Sleeping Time ◽  
Cns Depressant ◽  
Cns Activity ◽  
Cns Depressant Activity ◽  
Muscle Relaxant Activity

The aim of the present study is to investigate central nervous system (CNS) activity of the methanol extract of Pericarp of Sapindus emarginatus (Sapindaceae) in Swiss albino mice and Wistar albino rats. A daily dose of 100 and 200 mg/kg of the extract was administered to the animals for 15 days, after which various CNS experiments were recorded and compared with the control animals. General behavior, exploratory behavior, muscle relaxant activity cocaine induced hyperactivity and phenobarbitone sodium-induced sleeping time were studied. The results revealed that the methanol  extract  of  Pericarp of Sapindus emarginatus at 100 and 200  mg/kg  caused  a  significant  reduction  in  the  spontaneous activity (general behavioral profile), remarkable decrease in exploratory behavioral  pattern (Y-maze  and  head  dip  test), a reduction in muscle relaxant activity (rotarod and traction tests), inhibition of cocaine induced hyperactivity and also significantly potentiated phenobarbitone sodium–induced sleeping time. The results suggest that methanol extract of Sapindus emarginatus exhibit CNS depressant activity in tested animal models. Keywords: Sapindus emarginatus; Cocaine; CNS activity; Experimental animals. © 2009 JSR Publications. ISSN: 2070-0237(Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v1i3.1772      J. Sci. Res. 1 (3), 583-593 (2009) 

Evaluation of Neuropharmacological Effects of Dichrostachys cinerea Root

1970 ◽  
Vol 1 (4) ◽  
pp. 367-374
Author(s):  
Ramya Kuber B ◽  
Thaakur SanthRani
Keyword(s):  
Motor Activity ◽  
Ethanolic Extract ◽  
Tail Suspension Test ◽  
Spontaneous Motor Activity ◽  
Phytochemical Analysis ◽  
Alcoholic Extract ◽  
Dichrostachys Cinerea ◽  
Cns Depressant ◽  
Immobility Time ◽  
Cns Depressant Activity

Dichrostachys cinerea (DC) root juice is widely used by tribals of Chittoor District against paralysis. The ethanolic extract was given at a dose of 100, 200 and 400 mg/kg/p.o. Spontaneous motor activity, analgesia, grip strength, alertness and immobility in tail suspension test (TST) and forced swimming test (FST) were assessed.  The extract at given doses significantly dose dependently decreased exploratory activity, spontaneous motor activity, increased immobility time in both FST and TST, decreased climbing and swimming behaviour in FST and did not alter other parameters. Preliminary phytochemical analysis of ethonolic extract showed the presence of saponins, steroids, glycosides, carbohydrates and tannins. Results of the present study indicated that the alcoholic extract may have active constituents with CNS depressant activity and at the given doses they are devoid of memory impairment and neurotoxicity

scholarly journals A study of hypoglycemic effect of Caesalpinia bonduc extract on alloxan induced diabetic albino rats

2017 ◽  
Vol 6 (9) ◽  
pp. 2153
Author(s):  
Reshma Nadaf
Keyword(s):  
Blood Glucose ◽  
Diabetic Control ◽  
Hypoglycemic Effect ◽  
Control Group ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Test Drug ◽  
Standard Drug ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: The objective of the study was to scientifically investigate the oral hypoglycemic activity of Caesalpinia bonduc on Alloxan induced diabetic albino rats. To compare the hypoglycemic effect of Caesalpinia bonduc with that of the standard drug Glibenclamide used in the treatment of diabetes mellitus.Methods: Adult healthy albino rats of wister strain of either sex weighing 150-200gms were included in the study. The animals were divided into 4 groups namely control, diabetic control, standard and test groups with 6 animals in each group. Diabetes was chemically induced using alloxan to produce hyperglycemia in rats. Standard drug Glibenclamide suspended in gum acacia was administered for standard group. Test drug Caesalpinia bonduc was administered for test group. Morning around 9 a.m. blood glucose levels were recorded on 1st, 3rd, 7th, 14th, 21st, and 28th days.Results: The control group of rats showed no variation. The diabetic control rats showed consistent hyperglycemia. Comparing the test drug Caesalpinia bonduc to the standard drug Glibenclamide, the test drug was 1.38 times more efficacious than the standard.Conclusions: The alcoholic extract of Caesalpinia bonduc (seeds) has shown more anti diabetic activity by lowering the blood glucose levels in diabetic rats significantly. These findings suggest that hypoglycemic potential of the test compound Caesalpinia bonduc is promising and found to be more significant than the standard compound.

scholarly journals A study on anxiolytic activity and locomotor behavior of Curcuma amada rhizomes using Wistar albino rats

2018 ◽  
Vol 7 (8) ◽  
pp. 1557
Author(s):  
Prajna V. Raj ◽  
Megha Rani N. ◽  
Roopa P. Nayak ◽  
S. N. Rao
Keyword(s):  
Ethanolic Extract ◽  
Developed Countries ◽  
Locomotor Behavior ◽  
Anxiolytic Activity ◽  
Albino Rats ◽  
Curcuma Amada ◽  
Cns Depressant ◽  
Causes Of Disease ◽  
Wistar Albino Rats ◽  
Cns Depressant Activity

Background: Global burden of disease statistics indicate that 4 of 10 most important causes of disease worldwide are psychiatric in origin. Anxiety affects 1/8th of total population of the world and is a very important area of research interest in psychopharmacology. Medicinal plants and plant products are the oldest tried health-care products. Their importance is growing not only in developing countries but in many developed countries. Curcuma amada Roxb. (CA) commonly known as Mango Ginger is a rhizomatous aromatic herb which is used in this country for culinary purposes and also to treat various diseases. The rhizomes of Curcuma amada was screened for anxiolytic activity and locomotor behavior in Wistar albino rats.Methods: Wistar albino rats were divided into three groups as control (Distilled water with 0.1% CMC), standard (Diazepam - 1mg/kg) and test - Ethanolic Extract of Curcuma amada Rhizome (EECAR-250 mg/kg). They were administered drugs orally for a period of 10 days, and screened for anxiolytic activity using Light dark arena model and Actophotometer for assessing the locomotor behavior on the 10th day. The number of crossings and time spent in light arena for anxiolytic activity, and the number of movements in Actophotometer was noted. Data was analyzed by one way ANOVA followed by Tukey Kramer multiple comparison test using GraphPad InStat software.Results: Curcuma amada (250mg/kg) showed increased time spent in light arena and decreased locomotor behavior which was statistically significant.Conclusions: Curcuma amada possesses significant anxiolytic with CNS depressant activity.

scholarly journals Anti - inflammatory activity of ten indigenous plants in carrageenan induced paw oedema in albino rats

Biomedicine ◽  
2021 ◽  
Vol 41 (3) ◽  
pp. 649-653
Author(s):  
Manjula Shimoga Durgoji Rao ◽  
Sucheta Prasanna Kumar ◽  
Vasanthalaxmi Krishnanada Rao
Keyword(s):  
Tectona Grandis ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Lawsonia Inermis ◽  
Indigenous Plants ◽  
Standard Drug ◽  
Crude Extracts ◽  
Phytochemical Compounds ◽  
Anti Inflammatory

Introduction and Aim: Inflammation is a symptom associated with many diseases, can be treated with steroidal and non-steroidal anti-inflammatory drugs, which can cause severe side effects when used as long-term treatments. Plants have the ability to synthesize a wide verity of phytochemical compounds as secondary metabolites which shows anti-inflammatory activity. The anti-inflammatory activity of crude extracts of leaves of Jasminum grandiflorum (Jg), Vinca rosea (Vr), Azadirachta indica (Ai), Lawsonia inermis (Li), Nerium indicum (Ni), Calotropis gigantea (Cg), Tectona grandis (Tg), Andrographis paniculata (Ap), Tabernaemontana corymbosa (Tc) and Marsedinia volubilis (Mv) as well as alcoholic extracts of leaves of Cg, Tg and Ap were evaluated in Wistar rats.   Methods: Acute anti-inflammatory activity of crude extracts of ten indigenous plants were studied by calculating the volume changes in the hind paw after injecting carrageenan in rats comparing with Ibuprofen which was used as a standard drug in this study. Anti-inflammatory effect of alcoholic extract of leaves of Ap, Tg and Cg (200mg/kg body weight) also studied.   Results: The groups treated with crude extract & alcoholic extract of Cg, Tg and Ap showed significant reduction in the oedema compared to control and other plant extracts. The result was very significant in Ap treated rats.   Conclusion:  Plants are one of the most important sources of medicines. In our study, the anti-inflammatory activity of ten indigenous plants could be due to presence of naturally occurring antioxidant flavonoids. The leaves of Ap are very rich in flavonoids, could be the reason for significant anti-inflammatory activity found in Ap treated rats.

scholarly journals Analgesic and Neuropharmacological Activities of Methanol Extract from the Leaf of Nicotiana plumbaginifolia Viv.

2015 ◽  
Vol 18 (2) ◽  
pp. 85-89 ◽  
Author(s):  
Mehedi Shahriar ◽  
Sadia Afreen Chowdhury ◽  
Mohammad Zafar Imam ◽  
Bidyut Kanti Datta
Keyword(s):  
Body Weight ◽  
Analgesic Activity ◽  
Pharmaceutical Journal ◽  
Nicotiana Plumbaginifolia ◽  
Mice Model ◽  
Standard Drug ◽  
Cns Depressant ◽  
Plus Maze ◽  
Tail Immersion ◽  
Cns Depressant Activity

The aim of study was to evaluate the analgesic and neuropharmacological activities of the leaf of Nicotiana plumbaginifolia. The central analgesic activity of the methanolic extract was evaluated in Swiss Albino mice by using tail immersion, hot plate and acetic acid-induced writhing tests at 100, 200 and 400 mg/kg body weight. These tests showed significant analgesic activity of the extract compared to the standard drug, diclofenac-Na (1 mg/kg b.w.). The neuropharmacological activities were evaluated using hole cross, open field, light/dark box and elevated plus maze stage tests in mice model at 100, 200 and 400 mg/kg body weight. The results of neuropharmacological assays demonstrated potential CNS depressant activity of the extract when compared to the standard drug, diazepam (1 mg/kg b.w.)Bangladesh Pharmaceutical Journal 18(2): 85-89, 2015

Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats

1970 ◽  
Vol 1 (3) ◽  
pp. 281-286
Author(s):  
Pradeep Deshmukh ◽  
Tanaji Nandgude ◽  
Mahendra Singh Rathode ◽  
Anil Midha ◽  
Nitin Jaiswal
Keyword(s):  
Methyl Cellulose ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Root Bark ◽  
Significant Activity ◽  
Alcoholic Extract ◽  
Calotropis Gigantea ◽  
Wistar Albino Rats ◽  
Experimental Liver ◽  
Hepatoprotective Drug

The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P<0.001, P<0.01 and P<0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P<0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001).

A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles via a Key Intermediate of ortho-Ethoxyvinyl Nitroaryls by Domino Rearrangement and Their Anti- Inflammatory Activity

2020 ◽  
Vol 16 (8) ◽  
pp. 1161-1165
Author(s):  
Bashetti Nagaraju ◽  
Jagarlapudi V. Shanmukhakumar ◽  
Nareshvarma Seelam ◽  
Tondepu Subbaiah ◽  
Bethanamudi Prasanna
Keyword(s):  
Stannous Chloride ◽  
Biologically Active ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
One Pot ◽  
Simple Method ◽  
Standard Drug ◽  
Entire Study ◽  
One Pot Synthesis ◽  
Anti Inflammatory

Background: Recently, there has been a lot of scientific interest in exploring the syntheses of oxygen and nitrogen-containing heterocyclic compounds due to their pharmacological activities. In addition, benzisoxazoles play a very important role in organic synthesis as key intermediates. Objective: In this paper, we focused on developing a novel synthetic route for biologically active arylisoxazoles under normal conditions, and simplified it to get high purities and yields, and also reported their anti-inflammatory activities. Method: An efficient and simple method has been explored for the synthesis of novel 3-methyl arylisoxazoles from o-nitroaryl halides via o-ethoxyvinylnitroaryls, using dihydrated stannous chloride (SnCl2.2H2O) in MeOH / EtOAc (1:1) via Domino rearrangement in one pot synthesis. Result: We synthesized novel 3-methylarylisoxazoles from o-nitroarylhalides via o-ethoxyvinylnitroaryls, using dihydrated stannous chloride (SnCl2.2H2O) in MeOH / EtOAc (1:1) via domino rearrangement. In this reduction, nitro group and ethoxy vinyl group change to the functional acyl ketones, followed by hetero cyclization. Here, the reaction proceeds without the isolation of intermediates like 2-acylnitroarenes and 2- acylanilines. All the synthesized compounds were completely characterized by the NMR and mass spectra. The compounds were also explored for their anti-inflammatory activity by carrageenan-induced inflammation in the albino rats (150-200 g) of either sex used in this entire study with the use of Diclofenac sodium as the standard drug. The initial evaluations identified leading targets with good to moderate anti-inflammatory activity. Conclusion: A simple, one-pot and convenient method has been explored for the synthesis of novel 3- methylarylisoxazoles with high purity and reaction yields. All the compounds 3a, 3c, 3d, 3f, 3g and 3h exhibited 51-64% anti-inflammatory activities.

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