S53P4 Bioactive Glass - an Alternative Treatment of Bone Defects

2017 ◽  
Vol 68 (2) ◽  
pp. 387-389
Author(s):  
Cristian Trambitas ◽  
Tudor Sorin Pop ◽  
Alina Dia Trambitas Miron ◽  
Dorin Constantin Dorobantu ◽  
Klara Brinzaniuc
Keyword(s):  
Bioactive Glass ◽  
Soft Tissues ◽  
Bone Cells ◽  
Antibacterial Properties ◽  
Bone Defects ◽  
Surrounding Tissue ◽  
Congenital Disease ◽  
Bioactive Glasses ◽  
Rapid Healing ◽  
Specific Reactions

A challenging problem in orthopedic practice is represented by bone defects may they occur from trauma, malignancy, infection or congenital disease. Bioactive Glasses have a widely recognized ability to foster the growth of bone cells, and to bond strongly with both hard and soft tissues. Upon implantation, Bioactive Glasses undergoes specific reactions, leading to the formation of an amorphous calcium phosphate or crystalline hydroxyapatite phase on the surface of the glass, which is responsible for its strong bonding with the surrounding tissue. This phenomenon sustains a more rapid healing of bone defects and presents great antibacterial properties. In this paper we report on a clinical study that uses S53P4 Bioactive Glass to successfully treat bone defects and testify of the good compatibility of this material with human tissues.

Evaluation of Bioactive Glass (13-93) Scaffolds with an Oriented Microstructure for Regenerating Load-bearing Bones

2012 ◽  
Vol 1465 ◽  
Author(s):  
Xin Liu ◽  
Mohammed N. Rahaman
Keyword(s):  
Bioactive Glass ◽  
Bone Repair ◽  
Bone Cells ◽  
Three Dimensional ◽  
Bone Defects ◽  
Control Group ◽  
Bioactive Glasses ◽  
Low Load ◽  
Ability To Regenerate ◽  
Rat Calvarial Defect

ABSTRACTBioactive glass is an attractive scaffold material for use in filling bone defects because of its widely recognized ability to support the growth of bone cells and to bond firmly with hard and soft tissue. Use of bioactive glasses in the form of porous three-dimensional scaffolds for bone repair applications has been receiving considerable interest in recent years. However, bioactive glass scaffolds have been limited to the repair of low-load bone defects because of their low strength. In the present work, porous and strong bioactive glass scaffolds with an oriented microstructure were prepared by unidirectional freezing of camphene-based suspensions, and evaluated for their ability to regenerate bone in a non-healing rat calvarial defect model. Scaffolds of 13-93 glass (53SiO2, 6Na2O, 12K2O, 5MgO, 20CaO, 4P2O5; wt%) with a porosity of 50% and columnar pores of diameter 50–150 μm showed a compressive strength of 47 ± 5 MPa and an elastic modulus of 11 ± 3 GPa. Total bone regeneration in the oriented scaffolds, 18% after implantation for 12 weeks to 24% after 24 weeks, was not significantly different from that in 13-93 scaffolds with a microstructure similar to that of dry human trabecular bone (control group). The results indicated that these oriented bioactive glass (13-93) scaffolds could potentially be used in the regeneration of loaded bone.

scholarly journals Evaluation of Vertical Guided Bone Regeneration Using a Particulate Form of Experimental Bioactive Glass in a Rabbit: A Case Report with Literature Review

2021 ◽  
Vol 11 (3) ◽  
pp. 308-314
Author(s):  
Timur V. Melkumyan ◽  
Nuritdin Kh. Kamilov ◽  
Fatima Yu. Daurova ◽  
Angela D. Dadamova
Keyword(s):  
Bioactive Glass ◽  
Soft Tissues ◽  
Surgical Techniques ◽  
Bone Defects ◽  
Bone Tissue Regeneration ◽  
Tibia Bone ◽  
Barrier Membrane ◽  
Dental Implantation ◽  
Rabbit Tibia ◽  
Osteoplastic Material

Background: There are a large number of different types of bone-grafting materials that are used for the regeneration of atrophied alveolar ridges in order to make dental implantation possible. However, available surgical techniques and materials for bone augmentation do not contribute to the achievement of the desired reliable results and require a search for new solutions to an existing problem. A group of synthetic osteoplastic materials based on bioactive glass (BAG) may become a matter of choice in bone tissue regeneration because of special osteogenic properties. The aim of this study was to visually and histologically evaluate the behavior of an experimental BAG in rabbit tibia bone samples, which were collected from the animal 6 weeks after filling the bone defects. Methods and Results: The observation was carried out on one outbred rabbit whose tibia bone defects were filled with an experimental osteoplastic material based on the BAG. The chemical composition of the experimental osteoplastic material included SiO2 (41%), Na2O (21%), CaO (28.5%), P2O5 (6%), CaF2 (1.5%), MgO (1%), Al2O3 (1%). For histological analysis, H&E staining of paraffin-embedded tissues was performed according to the standard technique. Light microscopy of tissue samples was performed using a Leitz HM-LUX microscope (Germany). Six weeks after filling the bone defects, a strong bond between the augmented hard tissue and rabbit tibia was recognized. Also, a dense fusion of adjacent soft tissues with a newly formed bone without signs of chronic inflammation or graft particles in granular tissue was noted. Microscopic examination of the stained sections showed the presence of mature viable BT with a uniform distribution of osteocytes. Also, residual fragments of the degraded biomaterial surrounded by the fibers of a woven bone were revealed in several slices. Conclusion: In accordance with the results of this experiment, it can be concluded that the usage of BAG related to the system SiO2(41%)-Na2O(21%)-CaO(28.5%)-P2O5(6%)-CaF2(1.5%)-MgO(1%)-Al2O3(1%) may increase the volume of bone without application of barrier membrane. However, further research involving more animals needs to be done to estimate the scientific significance of the obtained data and to evaluate the mechanical properties of augmented bone.

Fabrication of Zn-Sr–doped laser-spinning glass nanofibers with antibacterial properties

2016 ◽  
Vol 31 (6) ◽  
pp. 819-831 ◽  
Author(s):  
María Magdalena Echezarreta-López ◽  
Trinidad de Miguel ◽  
Félix Quintero ◽  
Juan Pou ◽  
Mariana Landín
Keyword(s):  
Antibacterial Activity ◽  
Bioactive Glass ◽  
Antibacterial Properties ◽  
Growth Index ◽  
Bactericidal Effect ◽  
Bioactive Glasses ◽  
Bioactive Materials ◽  
Nanofibrous Structure ◽  
The Media ◽  
45S5 Bioglass

The morphology and dimensions of bioactive materials are essential attributes to promote tissue culture. Bioactive materials with nanofibrous structure have excellent potential to be used as bone-defect fillers, since they mimic the collagen in the extracellular matrix. On the other hand, bioactive glasses with applications in regenerative medicine may present antibacterial properties, which depend on glass composition, concentration and the microorganisms tested. Likewise, their morphology may influence their antibacterial activity too. In the present work, the laser-spinning technique was used to produce bioactive glass nanofibers of two different compositions: 45S5 Bioglass® and ICIE16M, bioactive glass doped with zinc and strontium. Their antibacterial activity against Staphylococcus aureus was tested by culturing them in dynamic conditions. Bacterial growth index profiles during the first days of experiment can be explained by the variations in the pH values of the media. The bactericidal effect of the doped nanofibers at longer times is justified by the release of zinc and strontium ions. Cytotoxicity was analyzed by means of cell viability tests performed with BALB/3T3 cell line.

Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study

2019 ◽  
Vol 70 (6) ◽  
pp. 1983-1987
Author(s):  
Cristian Trambitas ◽  
Anca Maria Pop ◽  
Alina Dia Trambitas Miron ◽  
Dorin Constantin Dorobantu ◽  
Flaviu Tabaran ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bioactive Glass ◽  
Bone Repair ◽  
Bone Defects ◽  
Calvarial Bone ◽  
Specific Protocol ◽  
Repair Mechanisms ◽  
Male Wistar Rats

Large bone defects are a medical concern as these are often unable to heal spontaneously, based on the host bone repair mechanisms. In their treatment, bone tissue engineering techniques represent a promising approach by providing a guide for osseous regeneration. As bioactive glasses proved to have osteoconductive and osteoinductive properties, the aim of our study was to evaluate by histologic examination, the differences in the healing of critical-sized calvarial bone defects filled with bioactive glass combined with adipose-derived mesenchymal stem cells, compared to negative controls. We used 16 male Wistar rats subjected to a specific protocol based on which 2 calvarial bone defects were created in each animal, one was filled with Bon Alive S53P4 bioactive glass and adipose-derived stem cells and the other one was considered control. At intervals of one week during the following month, the animals were euthanized and the specimens from bone defects were histologically examined and compared. The results showed that this biomaterial was biocompatible and the first signs of osseous healing appeared in the third week. Bone Alive S53P4 bioactive glass could be an excellent bone substitute, reducing the need of bone grafts.

scholarly journals Role of Autologous Platelet Gel (APG) in Bone Healing: A Rabbit Study

2021 ◽  
Vol 11 (1) ◽  
pp. 395
Author(s):  
Antonio Scarano ◽  
Francesco Inchingolo ◽  
Biagio Rapone ◽  
Alberta Greco Lucchina ◽  
Erda Qorri ◽  
...  
Keyword(s):  
Critical Size ◽  
Bone Defects ◽  
New Bone Formation ◽  
Platelet Gel ◽  
Woven Bone ◽  
Rapid Healing ◽  
Rabbit Bone ◽  
Autologous Platelet ◽  
New Zealand Rabbits

Purpose: The aim of the present study is to evaluate the influence and efficacy of autologous platelets on bone regeneration in a rabbit defects model. Materials and Methods: A total of 12 critical size tibial defects were produced in six New Zealand rabbits: A total of six defects were filled with autologous platelet gel (APG) and six defects were maintained as untreated controls. No membranes were used to cover the bone osteotomies. The histology and histomorphometry were performed at four weeks on retrieved samples of both groups. Results: No complications were reported in any of the animals nor for the defects produced. A significantly higher lamellar and woven bone percentage was reported for the APG group with a lower level of marrow spaces (p < 0.05). Evidence of newly formed bone was found in the superficial portion of the bone defect of APG samples where no aspects of bone resorption were observed. Conclusions: The evidence of the present research revealed that APG increases new bone formation restricted to the cortical portion and induces more rapid healing in rabbit bone defects than in untreated defects.

scholarly journals Synthesis and Characterization of Silver–Strontium (Ag-Sr)-Doped Mesoporous Bioactive Glass Nanoparticles

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 34
Author(s):  
Shaher Bano ◽  
Memoona Akhtar ◽  
Muhammad Yasir ◽  
Muhammad Salman Maqbool ◽  
Akbar Niaz ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Composite Coatings ◽  
Antibacterial Properties ◽  
Bone Diseases ◽  
Osteogenic Potential ◽  
Diffusion Method ◽  
Charge Composition ◽  
In Vitro Bioactivity ◽  
Mesoporous Bioactive Glass

Biomedical implants are the need of this era due to the increase in number of accidents and follow-up surgeries. Different types of bone diseases such as osteoarthritis, osteomalacia, bone cancer, etc., are increasing globally. Mesoporous bioactive glass nanoparticles (MBGNs) are used in biomedical devices due to their osteointegration and bioactive properties. In this study, silver (Ag)- and strontium (Sr)-doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were prepared by a modified Stöber process. In this method, Ag+ and Sr2+ were co-substituted in pure MBGNs to harvest the antibacterial properties of Ag ions, as well as pro-osteogenic potential of Sr2 ions. The effect of the two-ion concentration on morphology, surface charge, composition, antibacterial ability, and in-vitro bioactivity was studied. Scanning electron microscopy (SEM), X-Ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) confirmed the doping of Sr and Ag in MBGNs. SEM and EDX analysis confirmed the spherical morphology and typical composition of MBGNs, respectively. The Ag-Sr MBGNs showed a strong antibacterial effect against Staphylococcus carnosus and Escherichia coli bacteria determined via turbidity and disc diffusion method. Moreover, the synthesized Ag-Sr MBGNs develop apatite-like crystals upon immersion in simulated body fluid (SBF), which suggested that the addition of Sr improved in vitro bioactivity. The Ag-Sr MBGNs synthesized in this study can be used for the preparation of scaffolds or as a filler material in the composite coatings for bone tissue engineering.

Atomistic insights into the structure and elasticity of densified 45S5 bioactive glasses

2021 ◽  
Author(s):  
Youssef Ouldhnini ◽  
Achraf Atila ◽  
Said Ouaskit ◽  
abdellatif hasnaoui
Keyword(s):  
Regenerative Medicine ◽  
Soft Tissues ◽  
Soda Lime ◽  
Model System ◽  
Bioactive Glasses

Glasses have applications in regenerative medicine due to their bioactivity, enabling interactions with hard and soft tissues. Soda-lime phosphosilicate glasses, such as 45S5, represent a model system of bioactive glasses....

Study of the Bioactive Behavior of Thermally Treated Modified 58S Bioactive Glass

2008 ◽  
Vol 396-398 ◽  
pp. 131-134 ◽  
Author(s):  
Ourania Menti Goudouri ◽  
Xanthippi Chatzistavrou ◽  
Eleana Kontonasaki ◽  
Nikolaos Kantiranis ◽  
Lambrini Papadopoulou ◽  
...  
Keyword(s):  
Thermal Treatment ◽  
Bioactive Glass ◽  
Sol Gel ◽  
Bioactive Glasses ◽  
X Ray ◽  
Characteristic Temperatures ◽  
Calcium Silicates ◽  
Crystal Phases ◽  
Thermally Treated

Thermal treatment of bioactive glasses can affect their microstructure and thus their bioactivity. The aim of this study was the characterization of the thermally treated sol-gel-derived bioactive glass 58S at characteristic temperatures and the dependence of its bioactive behavior on the specific thermal treatment. The thermal behavior of the bioactive glass was studied by thermal analysis (TG/DTA). Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Diffractometry (XRD) were used for the characterization of the bioactive glass. The bioactive behavior in Simulated Body Fluid (SBF) was examined by Scanning Electron Microscopy (SEM-EDS) and FTIR. The major crystal phases after thermal treatment were Calcium Silicates, Wollastonite and Pseudowollastonite, while all thermally treated samples developed apatite after 48 hours in SBF. A slight enhancement of bioactivity was observed for the samples heated at the temperature range 910-970oC.

scholarly journals Bioactive glass can potentially reinforce large bone defects

2016 ◽  
Vol 4 ◽  
Author(s):  
Van Gestel Nicole ◽  
Hulsen Dennis ◽  
Arts Jacobus ◽  
Geurts Jan ◽  
Ito Keita ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Defects ◽  
Large Bone ◽  
Large Bone Defects

scholarly journals Effects of Mullite, Maghemite, and Silver Nanoparticles Incorporated in β-Wollastonite on Tensile Strength, Magnetism, Bioactivity, and Antimicrobial Activity

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4643
Author(s):  
Hamisah Ismail ◽  
Farah ‘Atiqah Abdul Azam ◽  
Zalita Zainuddin ◽  
Hamidun Bunawan ◽  
Muhamad Afiq Akbar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Tensile Strength ◽  
Body Fluid ◽  
Rice Husk Ash ◽  
Antibacterial Properties ◽  
Bone Defects ◽  
Antibacterial Efficacy ◽  
In Vitro Bioactivity ◽  
Defect Recovery

β-wollastonite (βW) has sparked much interest in bone defect recovery and regeneration. Biomaterial-associated infections and reactions between implants with human cells have become a standard clinical concern. In this study, a green synthesized βW, synthesized from rice husk ash and a calcined limestone precursor, was incorporated with mullite, maghemite, and silver to produce β wollastonite composite (βWMAF) to enhance the tensile strength and antibacterial properties. The addition of mullite to the βWMAF increased the tensile strength compared to βW. In vitro bioactivity, antibacterial efficacy, and physicochemical properties of the β-wollastonite and βWMAF were characterized. βW and βWMAF samples formed apatite spherules when immersed in simulated body fluid (SBF) for 1 day. In conclusion, βWMAF, according to the tensile strength, bioactivity, and antibacterial activity, was observed in this research and appropriate for the reconstruction of cancellous bone defects.

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