scholarly journals From the Complex Process of Gold Ions Recovery in New Antimicrobial Product

2019 ◽  
Vol 70 (3) ◽  
pp. 1080-1084
Author(s):  
Maria Mihailescu ◽  
Petru Negrea ◽  
Narcis Duteanu ◽  
Adina Negrea ◽  
Mihaela Ciopec ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
High Resistance ◽  
Antibacterial Agents ◽  
Adsorption Process ◽  
Toxicity Tests ◽  
Antibacterial Materials ◽  
Good Antibacterial Activity ◽  
Complex Process ◽  
Domestic Use ◽  
Antibacterial Material

Production of new antibacterial materials is really important due to high resistance bacteria at classical antibiotics. In present study,using the adsorption process of gold ions loaded onto Amberlite XAD7-L-glutamic acid, antibacterial material wasproduced.The antibacterial activity of produced material was studied. In order to test this activity, frstly it was necessary to know the microbiological behaviour of Au(III), by running several toxicity tests. Synthesized material show good antibacterial activity against a broad spectrum of bacteria collected form BegaRiver. These studies were performed in order to find a new application of such materials as paints used as antibacterial agents in hospitals and for domestic use.

scholarly journals Curcumin-loaded polyvinyl butyral film with antibacterial activity

e-Polymers ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 673-681
Author(s):  
Yanchao Qiao ◽  
Lijie Duan
Keyword(s):  
Mechanical Property ◽  
Thermal Stability ◽  
Antibacterial Activity ◽  
Polyvinyl Butyral ◽  
Counting Method ◽  
E Coli ◽  
Antibacterial Materials ◽  
Good Antibacterial Activity ◽  
Colony Counting ◽  
Widespread Interest

AbstractAntibacterial materials have found widespread interest in different fields nowadays. In this study, curcumin (Cur) was incorporated into the polyvinyl butyral (PVB) matrix by dissolving in ethanol for improving the functional properties of a pure PVB film. We found that Cur was uniformly dispersed in the PVB matrix, which showed good compatibility. Moreover, the incorporation of Cur could also improve thermal stability, hydrophilicity, and mechanical property. The UV-vis spectra of the PVB–Cur film demonstrated that the film could block ultraviolet radiation. Subsequently, the antibacterial activity of the PVB–Cur film was measured by the colony-counting method against S. aureus and E. coli. The results showed that the PVB–Cur film exhibited good antibacterial activity. Therefore, the PVB–Cur film was considered as a promising material for food and medical packaging applications.

Progress in the Preparation of Silver Nanometer Antibacterial Material

2020 ◽  
Vol 996 ◽  
pp. 76-81
Author(s):  
Ben Jiao Li ◽  
Song Li ◽  
Bin Rong Ma ◽  
Yong Jing ◽  
Zhe Ming Zhang ◽  
...  
Keyword(s):  
Chemical Method ◽  
Antibacterial Agents ◽  
Antibacterial Properties ◽  
Physical Method ◽  
Biological Method ◽  
Preparation Methods ◽  
Antibacterial Materials ◽  
Development And Utilization ◽  
Antibacterial Material ◽  
Further Development

Silver inorganic antibacterial agents have been widely used inbiotechnology, bioengineering science, electronics, optics and water treatment because of their strong bactericidal ability, high safety and durable antibacterial properties. In this paper, the preparation methods of silver nanoparticles are reviewed, including physical method, chemical method and biological method, in order to provide a reference for the further development and utilization of silver nano-antibacterial materials.

Synthesis of New Piperazine Substituted Chalcone Sulphonamides as Antibacterial Agents

2020 ◽  
Vol 17 (2) ◽  
pp. 136-143
Author(s):  
Yan-Ling Tang ◽  
Yong-Kun Li ◽  
Min-Xin Li ◽  
Hui Gao ◽  
Xiao-Bi Yang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Bacillus Subtilis ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Good Antibacterial Activity ◽  
In Vitro Antibacterial Activity ◽  
Global Threat

Background: Infection is a global threat to human health, and there is an urgent need to develop new effective antibacterial drugs to treat bacterial infections. Objective: To study the antibacterial activity of piperazine substituted chalcone sulphonamides. Materials and Methods: A series of novel piperazine substituted chalcone sulphonamides have been prepared, and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains were evaluated. Results: The results showed that derivatives 6a, 6c and 6h displayed good antibacterial activity against Bacillus subtilis with MIC values of 4.0-8.0 mg/mL. Conclusion: Piperazine substituted chalcone sulphonamides may be used as potential antibacterial agents.

scholarly journals Evaluation of the Antibacterial Material Production in the Fermentation of Bacillus amyloliquefaciens-9 from Whitespotted Bamboo Shark (Chiloscyllium plagiosum)

Marine Drugs ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 119
Author(s):  
Wenjie Zhang ◽  
Ling Wei ◽  
Rong Xu ◽  
Guodong Lin ◽  
Huijie Xin ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Bacillus Amyloliquefaciens ◽  
Fermentation Conditions ◽  
Antibacterial Materials ◽  
Material Production ◽  
Chiloscyllium Plagiosum ◽  
Antibacterial Material ◽  
Burman Design ◽  
Bamboo Shark ◽  
Plackett Burman Design

Bacillus amyloliquefaciens-9 (GBacillus-9), which is isolated from the intestinal tract of the white-spotted bamboo shark (Chiloscyllium plagiosum), can secrete potential antibacterial materials, such as β-1,3-1,4-glucanase and some antimicrobial peptides. However, the low fermentation production has hindered the development of GBacillus-9 as biological additives. In this study, the Plackett–Burman design and response surface methodology were used to optimize the fermentation conditions in a shake flask to obtain a higher yield and antibacterial activity of GBacillus-9. On the basis of the data from medium screening, M9 medium was selected as the basic medium for fermentation. The data from the single-factor experiment showed that sucrose had the highest antibacterial activity among the 10 carbon sources. The Plackett–Burman design identified sucrose, NH4Cl, and MgSO4 as the major variables altering antibacterial activity. The optimal concentrations of these compounds to enhance antibacterial activity were assessed using the central composite design. Data showed that sucrose, NH4Cl, and MgSO4 had the highest antibacterial activities at concentrations of 64.8, 1.84, and 0.08 g L−1, respectively. The data also showed that the optimal fermentation conditions for the antibacterial material production of GBacillus-9 were as follows: Inoculum volume of 5%, initial pH of 7.0, temperature of 36 °C, rotating speed of 180 rpm, and fermentation time of 10 h. The optimal fermentation medium and conditions achieved to improve the yield of antibacterial materials for GBacillus-9 can enhance the process of developing biological additives derived from GBacillus-9.

Synthesis and Antibacterial Activity of some New Quinoxaline-1,4-Dioxide Derivatives

2013 ◽  
Vol 634-638 ◽  
pp. 1376-1379 ◽  
Author(s):  
Zhi Jun Xin ◽  
Jian Ping Liang ◽  
Xue Hu Li ◽  
Lei Tao ◽  
Xi Hong Lu
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Agents ◽  
Good Antibacterial Activity ◽  
Low Toxicity ◽  
New Compounds

As a continuation of our research and with the aim of obtaining new antibacterial agents which can improve the current chemotherapeutic antibacterial treatments, a series of quinoxaline-1,4-di-N-oxide derivatives were synthesized and evaluated for antibacterial activity against bacterial growing in macrophages in vitro. The results indicate that the new compounds exhibited a good antibacterial activity. Also, the potency and low toxicity of these compounds make them valid leads for synthesizing new compounds that possess better activity.

Effect of Rare Earth Oxides on Properties of Nano Antibacterial Ceramic Glaze

2020 ◽  
Vol 852 ◽  
pp. 139-149
Author(s):  
Guang Fu Liu
Keyword(s):  
Rare Earth ◽  
Thermal Shock Resistance ◽  
Antibacterial Agents ◽  
Antibacterial Effect ◽  
Rare Earth Oxide ◽  
Rare Earth Oxides ◽  
Antibacterial Materials ◽  
Ceramic Glaze ◽  
Good Antibacterial Activity ◽  
Shock Resistance

This topic is based on the research and development of inorganic silver-loaded antibacterial materials with good antibacterial activity, and the preparation of silver-loaded calcium carbonate inorganic nano-antibacterial agents by redox reaction. At the same time, the mixed rare earth oxide was added to the ceramic glaze containing silver nano antibacterial agent, and the nano antibacterial building sanitary ceramics were prepared by firing at 1180 °C in an oxidizing atmosphere. This experiment investigated the effect of adding mixed rare earth oxides on the quality and properties of glaze. Experiments show that the new glaze has stronger antibacterial effect than the nano antibacterial glaze without mixed rare earth oxide, and the glaze quality is good. After adding 0.5 wt% of mixed rare earth oxide, the whiteness, abrasion resistance, hardness and thermal shock resistance of the glaze were significantly improved.This topic is based on the research and development of inorganic silver-loaded antibacterial materials with good antibacterial activity, and the preparation of silver-loaded calcium carbonate inorganic nano-antibacterial agents by redox reaction. At the same time, the mixed rare earth oxide was added to the ceramic glaze containing silver nano antibacterial agent, and the nano antibacterial building sanitary ceramics were prepared by firing at 1180 °C in an oxidizing atmosphere. This experiment investigated the effect of adding mixed rare earth oxides on the quality and properties of glaze. Experiments show that the new glaze has stronger antibacterial effect than the nano antibacterial glaze without mixed rare earth oxide, and the glaze quality is good. After adding 0.5 wt% of mixed rare earth oxide, the whiteness, abrasion resistance, hardness and thermal shock resistance of the glaze were significantly improved.

scholarly journals Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine

2020 ◽  
Author(s):  
Jun He ◽  
Xue-Mei Tang ◽  
Ting-Ting Liu ◽  
Feng Peng ◽  
Qing Zhou ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Agents ◽  
Research Direction ◽  
Antibacterial Activities ◽  
Maximal Effect ◽  
Bacterial Surface ◽  
Good Antibacterial Activity ◽  
Bacterial Structure ◽  
Scanning Electron ◽  
Better Than

Abstract Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacterial activity against Xanthomonas oryzaepv. oryzae (Xoo), Xanthomonas axonopodispv. citri (Xac) and Ralstonia solanacearum (Rs). Among them, compounds 4m and 4p revealed excellent antibacterial activities against Rs with a concentration for 50% of maximal effect (EC50) value of 4 and 4 μg/mL, which were better than the control drugs bismerthiazol (13 μg/mL) and thiodiazole-copper (185 μg/mL). As observed using scanning electron microscope (SEM), these compounds act by causing folding and deformation of the bacterial surface, resulting in incomplete bacterial structure, so as to achieve the goal of bacteriostasis. The myricetin derivatives synthesized are expected to guide the research direction of new antibacterial agents.

Synthesis, Characterization and Antimicrobial Activity of 4-Substituted-Benzylpiperazinyl Methanone Derivatives

2017 ◽  
Vol 10 (2) ◽  
pp. 3684-3687
Author(s):  
Mahesh Chidara ◽  
Satla Shobha Rani
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Mass Spectral Data ◽  
Future Studies ◽  
Mass Spectral ◽  
E Coli ◽  
H Nmr ◽  
Good Antibacterial Activity

Novel antibacterial compounds are needed to combat the emerging bacterial infections. In this study, synthesis of 4-substituted benzylpiperazin-1-yl methanone derivatives was carried out by 4-substituted benzyl chloride (I) with piperazine in presence of ethanol to obtain 4-substituted benzylpiperazines (II). Benzylpiperazines (II) was condensed with different substituted esters in presence of diluted acid to produce title compounds (IIIa–e, IVa-e and Va-e). All the title compounds were screened for possible antibacterial activity against P. Vulgaris, S. Aureas, E. Coli, B. Subtillus and antifungal activity against Altenaria, Culvalaria, C. Albicans and A. Niger. Among the compounds synthesized IVb, IVd and IVf demonstrated good antibacterial activity; IVb, IVc, and IVe showed good antifungal activity. The activities of the synthesized compounds are compared with the standard and other test compounds. The structures of synthesized compounds were established by elemental analysis, IR, H NMR and Mass spectral data. Future studies will confirm their efficacy and utility as antibacterial agents. 

Large-scale High-throughput Screening Revealed 5'-(carbonylamino)-2,3'- bithiophene-4'-carboxylate as Novel Template for Antibacterial Agents

2020 ◽  
Vol 17 (5) ◽  
pp. 716-724
Author(s):  
Yan A. Ivanenkov ◽  
Renat S. Yamidanov ◽  
Ilya A. Osterman ◽  
Petr V. Sergiev ◽  
Vladimir A. Aladinskiy ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
High Throughput ◽  
High Throughput Screening ◽  
Large Scale ◽  
Antibacterial Agents ◽  
Sos Response ◽  
Luciferase Assay ◽  
Translational Machinery ◽  
E Coli ◽  
New Class

Background: The key issue in the development of novel antimicrobials is a rapid expansion of new bacterial strains resistant to current antibiotics. Indeed, World Health Organization has reported that bacteria commonly causing infections in hospitals and in the community, e.g. E. Coli, K. pneumoniae and S. aureus, have high resistance vs the last generations of cephalosporins, carbapenems and fluoroquinolones. During the past decades, only few successful efforts to develop and launch new antibacterial medications have been performed. This study aims to identify new class of antibacterial agents using novel high-throughput screening technique. Methods: We have designed library containing 125K compounds not similar in structure (Tanimoto coeff.< 0.7) to that published previously as antibiotics. The HTS platform based on double reporter system pDualrep2 was used to distinguish between molecules able to block translational machinery or induce SOS-response in a model E. coli system. MICs for most active chemicals in LB and M9 medium were determined using broth microdilution assay. Results: In an attempt to discover novel classes of antibacterials, we performed HTS of a large-scale small molecule library using our unique screening platform. This approach permitted us to quickly and robustly evaluate a lot of compounds as well as to determine the mechanism of action in the case of compounds being either translational machinery inhibitors or DNA-damaging agents/replication blockers. HTS has resulted in several new structural classes of molecules exhibiting an attractive antibacterial activity. Herein, we report as promising antibacterials. Two most active compounds from this series showed MIC value of 1.2 (5) and 1.8 μg/mL (6) and good selectivity index. Compound 6 caused RFP induction and low SOS response. In vitro luciferase assay has revealed that it is able to slightly inhibit protein biosynthesis. Compound 5 was tested on several archival strains and exhibited slight activity against gram-negative bacteria and outstanding activity against S. aureus. The key structural requirements for antibacterial potency were also explored. We found, that the unsubstituted carboxylic group is crucial for antibacterial activity as well as the presence of bulky hydrophobic substituents at phenyl fragment. Conclusion: The obtained results provide a solid background for further characterization of the 5'- (carbonylamino)-2,3'-bithiophene-4'-carboxylate derivatives discussed herein as new class of antibacterials and their optimization campaign.

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