scholarly journals Assessment of the Remineralisation Products Efficiency in Incipient Caries Lesions Adjacent to the Fixed Orthodontic Appliances

2019 ◽  
Vol 70 (8) ◽  
pp. 2873-2878
Author(s):  
Galina Pancu ◽  
Gianina Iovan ◽  
Simona Stoleriu ◽  
Nicoleta Tofan ◽  
Antonia Moldovanu ◽  
...  
Keyword(s):  
Orthodontic Appliances ◽  
Study Group ◽  
Orthodontic Therapy ◽  
Fixed Orthodontic Appliances ◽  
Incipient Caries ◽  
Group 2 ◽  
Mouth Rinsing ◽  
Caries Lesions ◽  
Control Samples ◽  
Group 1

The aim of the study is to asses, by using microhardness technique, the remineralization effect of some products used in the treatment of early dental caries adjacent to fixed orthodontic appliances. The study was performed on a group of 32 patients receiving fixed orthodontic therapy. The patients were randomly divided in two groups, accordingly to the administered preventive protocol: in group 1 (control) toothpaste Splat Professional Biocalcium (without fluoride) was applied twice a day; in group 2 (study group) toothpaste and mouthwash Vitis anticaries with natrium monofluorophosphate 1450 ppm F, respectively 226 ppm F, twice a day were used. After 60 days, the extraction of premolars was made and the preparation of the samples was done. The microhardness analysis was performed using the device CV 400 DAT (Namicon). The analysis of the results found lower microhardness for the samples submitted to brushing with fluoridated toothpaste and rinsing with fluoridated mouthwash solution, comparing to control (samples submitted only to brushing with non-fluoridated toothpaste). The conclusions of this study confirm the effectiveness of a proper prophylactic protocol (toothbrushing with fluoridated toothpaste, mouth rinsing with fluoridated mouthwashes) associated to the fixed orthodontics therapy, in the prevention of the early enamel demineralization onset adjacent to brackets.

scholarly journals Antimicrobial resistance of bacterial strains in patients undergoing orthodontic treatment with and without fixed appliances

2021 ◽  
Author(s):  
Bruno Andrade Pellissari ◽  
Gabriela Sergini Pereira Sabino ◽  
Roberto Nepomuceno de Souza Lima ◽  
Rogério Heládio Lopes Motta ◽  
Selly Sayuri Suzuki ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Orthodontic Treatment ◽  
Bacterial Resistance ◽  
Control Group ◽  
Orthodontic Appliances ◽  
Bacterial Strains ◽  
Fixed Orthodontic Appliances ◽  
Fixed Appliances ◽  
Group 2 ◽  
Group 1

ABSTRACT Objectives To identify microorganisms isolated from patients wearing fixed orthodontic appliances and to evaluate the resistance of isolated bacterial strains to different antimicrobials. Materials and Methods Seventeen healthy patients wearing a fixed orthodontic appliance (group 1) and six nonwearers (group 2, control group) were evaluated. The biofilm that formed around the orthodontic brackets was collected, and the samples were then plated in a chromogenic medium (chromIDT, bioMérieux). Colony-forming units (CFUs) were isolated and inoculated in blood-agar medium. Automated biochemical tests (VITEK 2, bioMérieux) were carried out to identify the genus and species of the microorganisms and the resistance provided by 43 drugs (37 antibacterial and 6 antifungal). Results The most prevalent microbial genera identified in group 1 were Streptococcus (24.0%), Staphylococcus (20.0%), Enterobacter (12.0%), Geobacillus (12.0%), and Candida (12.0%), and the most frequent species were Enterobacter cloacae complex (13.6%) and Staphylococcus hominis (13.6%). In group 2, the most prevalent genera were Streptococcus (57.1%), Staphylococcus (14.2%), Sphingomonas (14.2%), and Enterobacter (14.2%). With regard to antimicrobial resistance, 14 of 19 (74%) isolated bacterial strains were found to be resistant to at least 1 of the tested antimicrobials. Conclusions The findings of the present study suggest that patients undergoing orthodontic treatment with fixed appliances have a more complex biofilm with a higher level of bacterial resistance.

scholarly journals Clinical and Microbiological Evaluation of Stabilised Periodontal Patients Undergoing Early Stage of Orthodontic Treatment

2020 ◽  
Vol 15 (2) ◽  
pp. 96-107
Author(s):  
Asma Alhusna Abang Abdullah ◽  
Keyword(s):  
Orthodontic Treatment ◽  
Pathogenic Bacteria ◽  
Prospective Clinical Study ◽  
Orthodontic Appliances ◽  
Oral Microbiota ◽  
Periodontal Health ◽  
Fixed Orthodontic Appliances ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1

Orthodontic treatment may affect the equilibrium of oral microbiota which plays a major role in aetiology of periodontal disease. This prospective clinical study aimed to assess the periodontal health and microbiological profile of healthy (Group 1) and stabilised periodontal (Group 2) patients throughout three months of orthodontic treatment. Upper and lower fixed orthodontic appliances were bonded. Periodontal health was assessed using plaque score (PS), bleeding on probing (BOP) and pocket depth (PD). 29 sites were taken for subgingival plaque sampling. Plaque samples were inoculated on Trypticase Soy Blood Agar (TSBA) and Trypticase Soy Bacitracin Vancomycin (TSBV) agar for assessment of aerobe, anaerobe, black pigmented bacteria (BPB) and Aggregatibacter actinomycetemcomitans. All the measurements were taken before bonding (T0), 1 week (T1), 1 month (T2) and 3 months post-bonding (T3). Generally, periodontal health in both groups were almost similar. After 1 week, the number of aerobes was significantly higher in Group 1 (88%) while the anaerobes were significantly higher in Group 2 (45%). A. actinomycetemcomitans was higher in Group 1 at T0 and T1 but was significantly higher in Group 2 at T3. BPB was minimal at all time with no significant difference. Thus, during the first 3-month of orthodontic treatment, there were significant changes in the number of aerobes-anaerobes in both healthy and stabilised periodontal patients. Pathogenic bacteria would increase during early treatment of orthodontics.

Retention period in children with crossbite

2021 ◽  
Vol 21 (2) ◽  
pp. 118-121
Author(s):  
V. M. Vodolatsky ◽  
R. S. Makatov
Keyword(s):  
Orthodontic Treatment ◽  
Orthodontic Appliances ◽  
Retention Period ◽  
Fixed Orthodontic Appliances ◽  
Transversal Plane ◽  
Group 2 ◽  
Design Characteristics ◽  
Group 1

Relevance. Crossbite is a deformation of the dentoskeletal system in the horizontal (transversal) plane, and it results from a discrepancy between the width of the upper and lower dental arches in the anterior or posterior dentition.Crossbite can arise as an isolated condition, and then it is an independent de-formation of the dentoskeletal system. In some cases, a crossbite is combined with a wrong arch-to-arch relationship in the sagittal and vertical planes.The aim was to analyze the duration of the retention period in children with crossbite after the orthodontic treatment.Materials and methods. We orthodontically treated 18 children with crossbite aged 7 to 18 years. All patients were divided into 2 groups. Group 1 included 14 children from 7 to 14 years old with unilateral crossbite (right-sided – 6, left-sided – 8). Group 2 included 4 children from 9 to 18 years old with bilateral crossbite. All 18 children had a buccal crossbite. All patients underwent orthodontic treatment with removable and fixed orthodontic appliances.Results. The retention period after the orthodontic treatment of crossbite lasted 6-9 months.Conclusions. The analysis demonstrated that the retention period after the orthodontic treatment in children with crossbite averaged 6-9 months. The design characteristics of the or-thodontic appliances did not affect the duration of the retention period in children with crossbite.

scholarly journals Obstructive sleep apnea and CPAP therapy alter distinct transcriptional programs in subcutaneous fat tissue

SLEEP ◽  
2019 ◽  
Vol 43 (6) ◽  
Author(s):  
Sina A Gharib ◽  
Amanda L Hurley ◽  
Michael J Rosen ◽  
James C Spilsbury ◽  
Amy E Schell ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Subcutaneous Adipose Tissue ◽  
Subcutaneous Fat ◽  
Study Group ◽  
Cpap Therapy ◽  
Obstructive Sleep ◽  
Group 2 ◽  
Subcutaneous Adipose ◽  
Group 1

Abstract Obstructive sleep apnea (OSA) has been linked to dysregulated metabolic states, and treatment of sleep apnea may improve these conditions. Subcutaneous adipose tissue is a readily samplable fat depot that plays an important role in regulating metabolism. However, neither the pathophysiologic consequences of OSA nor the effects of continuous positive airway pressure (CPAP) in altering this compartment’s molecular pathways are understood. This study aimed to systematically identify subcutaneous adipose tissue transcriptional programs modulated in OSA and in response to its effective treatment with CPAP. Two subject groups were investigated: Study Group 1 was comprised of 10 OSA and 8 controls; Study Group 2 included 24 individuals with OSA studied at baseline and following CPAP. For each subject, genome-wide gene expression measurement of subcutaneous fat was performed. Differentially activated pathways elicited by OSA (Group 1) and in response to its treatment (Group 2) were determined using network and Gene Set Enrichment Analysis (GSEA). In Group 2, treatment of OSA with CPAP improved apnea-hypopnea index, daytime sleepiness, and blood pressure, but not anthropometric measures. In Group 1, GSEA revealed many up-regulated gene sets in OSA subjects, most of which were involved in immuno-inflammatory (e.g. interferon-γ signaling), transcription, and metabolic processes such as adipogenesis. Unexpectedly, CPAP therapy in Group 2 subjects was also associated with up-regulation of several immune pathways as well as cholesterol biosynthesis. Collectively, our findings demonstrate that OSA alters distinct inflammatory and metabolic programs in subcutaneous fat, but these transcriptional signatures are not reversed with short-term effective therapy.

scholarly journals Efficacy of azoximer bromide in the treatment of hospitalized patients with moderate to severe community-acquired pneumonia

2021 ◽  
pp. 106-117
Author(s):  
S. K. Zyryanov ◽  
O. I. Butranova ◽  
A. V. Ershov ◽  
Z. Sh. Manasova
Keyword(s):  
Combination Therapy ◽  
Community Acquired Pneumonia ◽  
Hospitalized Patients ◽  
Study Group ◽  
Therapy Regimen ◽  
Duration Of Hospital Stay ◽  
Comparator Group ◽  
Group 2 ◽  
Severe Community Acquired Pneumonia ◽  
Group 1

Introduction. The high incidence of community-acquired pneumonia and the high complication rates in the cases of severe pneumonia actualize the search for new pharmacotherapy tools to improve the effectiveness of standard patient management regimens. A high level of severe inflammatory response underlies the high risk for developing septic complications of pneumonia, along with impaired immune responses.The aim is to evaluate the efficacy of azoximer bromide introduction in the combination therapy regimen for hospitalized patients with moderate to severe community-acquired pneumonia.Materials and methods. A prospective, open label, parallel group, randomized study comparing the efficacy of azoximer bromide introduction in the combination therapy of hospitalized patients with moderate to severe community-acquired pneumonia was conducted at the premises of Federal Scientific and Clinical Center for Reanimatology and Rehabilitation. 30 patients were included in the study group and 37 patients in the comparator group. The baseline characteristics were comparable in both groups. Results. The azoximer bromide introduction in the combination therapy of patients with community-acquired pneumonia led to a statistically significant reduction in the duration of hospital stay (Me (LQ; HQ): 9 (8; 10) days for the study group and 13 (10; 14) days for the comparator group, (p = 0.000078), duration of ICU stay (Me (LQ; HQ) 2 days (1.5; 2.5) and 5 days (5.0; 6.0), respectively, (p = 0.00001), the duration of febrile fever 5 (± 0.6) days versus 10 (± 1.2) days (p = 0.0000), the incidence of acute respiratory failure (13.33% in group 1 versus 37.84% in group 2, p = 0.024) and septic shock (10% in group 1 versus 32.43% in group 2, p = 0.0285).Conclusions. The azoximer bromide introduction in the standard therapy regimen for patients with community-acquired pneumonia allowed to reduce the duration of hospital stay, the duration of ICU stay, the length of febrile fever, the incidence of septic shock and respiratory failure. The possible mechanisms of action may include a reduction of the severe inflammatory reactions and an optimization of the patient's immune response to the infectious process.

scholarly journals EFFECT OF BROMELAIN AND ARNICA COMBINATION ON PERIORBITAL EDEMA AND ECCHYMOSIS IN SEPTORHINOPLASTY

2021 ◽  
Author(s):  
ONER SAKALLIOGLU ◽  
EMRAH GÜLMEZ ◽  
YAVUZ SULTAN SELIM YILDIRIM ◽  
HASAN CETINER ◽  
SERTAC DUZER ◽  
...  
Keyword(s):  
Topical Administration ◽  
Control Group ◽  
Study Group ◽  
Periorbital Edema ◽  
Eyelid Edema ◽  
Group 2 ◽  
Group 1

Purpose: The aim of this study to investigate the effect of bromelain-arnica gel combination on periorbital edema and ecchymosis seen after open septorhinoplasty. Methods: Sixty patients who performed open septorhinoplasty with osteotomies were included to the study. These patients were allocated into two groups: in group 1, 30 patients as control and in group 2, 30 patients as study group who were treated with topical bromelain-arnica gel after surgery. Scoring of eyelid edema and peroirbital ecchymosis were evaluated on the first, third and seventh postoperative days using scale of 0 to 4 used by observers. Results: We observed that the administration of topical bromelain-arnica gel after surgery was effective clinically and statistically in decreasing the score of both edema and ecchymosis in open septorhinoplasty with ostetomies. In group 2 patients, periorbital edema and ecchymosis scores were significantly lower compared to control group (p < 0.05). Conclusions: Our results support that topical administration of bromelain and arnica gel combination provided both clinically and statistically significant reduction in periorbital edema and ecchymosis following septorhinoplasty.

scholarly journals Antiamoebic Chemoprophylaxis Using Quinfamide in Children: A Comparative Study

2002 ◽  
Vol 2 ◽  
pp. 1070-1078 ◽  
Author(s):  
Nicolas Padilla ◽  
Rosalinda Diaz ◽  
Alfonso Alarcon ◽  
Roberto Barreda
Keyword(s):  
Primary Schools ◽  
Personal Hygiene ◽  
Study Group ◽  
Three Samples ◽  
Stool Samples ◽  
Group 3 ◽  
Group 2 ◽  
Study Participants ◽  
Prospective Longitudinal ◽  
Group 1

This study sought to examine whether the administration of quinfamide at 3- or 6-month intervals diminished the frequency ofEntamoeba histolyticacysts in stool samples compared to controls. The prospective, longitudinal, randomized, single-blind study examined children from six primary schools in Celaya and Neutla, Guanajuato. Of the 1,524 students in these schools, we selected participants for the study as follows: Children were included in the study if their parents agreed in writing to the study and if the children demonstrated evidence ofE. histolyticacysts after a parasitoscopic analysis by concentration (PSC) in three samples over consecutive days using Faust’s method. Those included in the study received a single 4.3-g/kg dose of quinfamide, and we performed PSC on days 5, 6, and 7 following dose administration to examine whether quinfamide had affected the presence of the cysts. The study participants who tested negative for cysts were divided into three groups: Group 1 had 102 patients who underwent quinfamide treatment and three CPS analyses after the 12 months of the study; Group 2 had 98 subjects who underwent the quinfamide treatment and three CPS analyses at months 3, 6, 9, and 12 after their entrance into the study; and Group 3 had 102 patients, who underwent the quinfamide treatment and series of three CPS analyses at months 6 and 12 of the study. All participants received the dose of quinfamide after providing stool samples and after a clinical gastrointestinal history was obtained. Further clinical gastrointestinal data were collected 5 days after the quintamide dose was administered. We used EpiInfo 6.0 for statistical analysis, calculatingX2andpvalues for the clinical data and the CPS data after the 12 months concluded. Of the initial samples of 1,524 subjects, 308 (20.2%) had Entamoebic cysts. Of these, six were further eliminated because they did not meet the inclusion requirements. At the conclusion of the study, Group 1 presented with 37.6% of subjects still testing positive for cysts; of Group 2, 12.5% tested positive; and in Group 3, 23.5% of participants tested positive for cysts (X2= 16.8; df = 2;p= 0.0002). For comparisons of groups 1 and 2 and 1 and 3,p> 0.05. We conclude that antiamoebic chemoprophylaxis can be a choice for control of amoebic infection where personal hygiene and food consumption habits are not improving.

Cytomorphometric and Morphological Analysis in Women with Trichomonas vaginalis Infection: Micronucleus Frequency in Exfoliated Cervical Epithelial Cells

2015 ◽  
Vol 59 (3) ◽  
pp. 258-264 ◽  
Author(s):  
Zehra Safi Oz ◽  
Banu Doğan Gun ◽  
Mustafa Ozkan Gun ◽  
Sukru Oguz Ozdamar
Keyword(s):  
Epithelial Cells ◽  
Trichomonas Vaginalis ◽  
Control Group ◽  
Study Group ◽  
Control Groups ◽  
The Mean ◽  
The Difference ◽  
Group 2 ◽  
And Control ◽  
Group 1

Objectives: The aim of this study was to explore the cytomorphometric and morphological effects of Trichomonas vaginalis in exfoliated epithelial cells. Study Design: Ninety-six Pap-stained cervical smears were divided into a study group and two control groups as follows: T. vaginalis cases, a first control group with inflammation, and a second control group without inflammation. Micronucleated, binucleated, karyorrhectic, karyolytic, and karyopyknotic cells and cells with perinuclear halos per 1,000 epithelial cells were counted. Nuclear and cellular areas were evaluated in 70 clearly defined cells in each smear using image analysis. Results: The frequencies of morphological parameters in the T. vaginalis cases were higher than the values of the two control groups, and the difference among groups was found to be significant (p < 0.05). The nuclear and cytoplasmic areas of epithelial cells were diminished in patients with trichomoniasis. The mean nucleus/cytoplasm ratio in T. vaginalis patients was higher than the value in the control groups, and the difference between the study group and control group 1 was significant. However, there was no statistically significant increase between the study group and control group 2. Conclusions:T. vaginalis exhibited significant changes in the cellular size and nuclear structure of the cells. The rising frequency of micronuclei, nuclear abnormalities, and changing nucleus/cytoplasm ratio may reflect genotoxic damage in trichomoniasis.

Caries-Preventive Effects of Fluoride-Releasing Materials

1995 ◽  
Vol 9 (4) ◽  
pp. 377-383 ◽  
Author(s):  
T. Büyükyilmaz ◽  
B. Øgaard
Keyword(s):  
Clinical Studies ◽  
Antimicrobial Agents ◽  
Orthodontic Appliances ◽  
Clinical Effects ◽  
Bonding Agents ◽  
Model Studies ◽  
Fixed Orthodontic Appliances ◽  
Caries Model ◽  
Orthodontic Patients ◽  
Caries Lesions

The plaque-retentive properties of fixed orthodontic appliances result in a severe challenge on surfaces generally not susceptible to caries. Lesions may develop within a month in the absence of fluoride, and clinical studies have shown that from 50 to 75% of orthodontic patients develop decalcifications on labial surfaces during treatment. Fluoride mouthrinses reduce the occurrence, although compliance is often poor. Orthodontic bonding agents and cements releasing fluoride, which reduce the need for cooperation, have been introduced. Few clinical studies have been done to prove the cariostatic properties of fluoride-releasing materials in orthodontics. In short-term caries model studies, glass ionomers and a glass filler containing light-cured adhesive that releases relatively large amounts of fluoride have shown cariostatic properties. However, during severe challenges such as occur with orthodontic appliances, fluoride alone has limited cariostatic properties. The combination of fluoride with antimicrobial agents, and the use of acidic fluoride solutions depositing acid-resistant coatings of calcium fluoride and titanium have shown to give better clinical effects than fluoride alone during extreme conditions. Fluoride-releasing materials may therefore be considered as useful supplements to these procedures.

scholarly journals Stability in Dental Changes in RME and SARME: A 2-Year Follow-up

2009 ◽  
Vol 79 (2) ◽  
pp. 207-213 ◽  
Author(s):  
Oral Sokucu ◽  
H. Huseyin Kosger ◽  
A. Altug Bıcakci ◽  
Hasan Babacan
Keyword(s):  
Orthodontic Treatment ◽  
Rapid Maxillary Expansion ◽  
Study Group ◽  
Maxillary Expansion ◽  
Patient Groups ◽  
Group 2 ◽  
Maxillary Arch ◽  
Group 1 ◽  
Dental Casts

Abstract Objective: To compare the effects of rapid maxillary expansion (RME) and surgically assisted rapid maxillary expansion (SARME) on dentoalveolar structures following orthodontic treatment, as well as stability at 2-year follow-up. Materials and Methods: Two groups of subjects were used in the study. Group 1 consisted of 14 subjects (mean age, 12.7 ± 1.4 years) who were treated with RME, and Group 2 consisted of 13 subjects (mean age, 18.5 ± 2.3 years) who were treated with SARME. In both groups, all cases had a maxillary width deficiency with bilateral crossbites. Maxillary dental casts were available at three different intervals: pretreatment (T1), after orthodontic treatment (T2), and at follow-up recall (T3). Intermolar and interpremolar width, palatal height, and maxillary arch depth and length were assessed from maxillary dental casts. Results: Treatment by RME and SARME produced significant increases in intermolar and interpremolar width and maxillary arch length after expansion (T2) (P &lt; .05). The amount of relapse was not significantly different 2 years after treatment (P &gt; .05). Conclusions: Although age ranges of the patient groups are different, the dentoalveolar responses of RME and SARME were similar after orthodontic treatment. (Angle Orthod. 2009:79; )

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