scholarly journals Cancer/testis antigen, Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers

2020 ◽  
Vol 26 (4) ◽  
pp. 424-432
Author(s):  
Akiko Shida ◽  
Takashi Fukuyama ◽  
Nobue Futawatari ◽  
Haruki Omiya ◽  
Yoshinobu Ichiki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Testis Antigen ◽  
Cancer Antigen ◽  
Gastric Cancers ◽  
Cancer Testis

scholarly journals Detection of Kita-Kyushu Lung Cancer Antigen-1, a Cancer/testis Antigen, in the stomach closer to the cancerous condition.

2020 ◽  
Author(s):  
Takashi Fukuyama ◽  
Toshikazu Otsuka ◽  
Nobue Futawatari ◽  
Kumiko Tahara ◽  
Masaaki Watanabe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Lung Cancer ◽  
Helicobacter Pylori ◽  
Cancer Testis Antigen ◽  
Cancer Antigen ◽  
Exact Test ◽  
Cancer Prediction ◽  
Precancerous Condition ◽  
Cancer Testis

Abstract Background: Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) and is an attractive target for immunotherapy. An earlier study from our group demonstrated frequent KK-LC-1 expression in gastric cancers (GC) and non-tumor sites of the stomach carrying a tumor. Additionally, there was a correlation to Helicobacter pylori (Hp) infection. Currently it remains unclear whether KK-LC-1 is expressed in stomachs without gastric cancer.Methods: In the present study, we investigated differences in KK-LC-1 gene expression at non-tumor sites of stomachs with or without a tumor from 118 GC patients and 115 non-GC patients. Fisher’s exact test was used for the statistical analyses.Results: Our results show that KK-LC-1 gene expression was detected in 77% of non-tumor sites in stomachs with a tumor. Such findings were significantly higher than in stomachs without a tumor (7%, P <0.0001). All patients with KK-LC-1 expression at non-tumor sites of their stomachs without tumors carried Hp.Conclusions: KK-LC-1 appears to be detected in the stomach’s precancerous condition, but not in an atrophic stomach with Hp. KK-LC-1 may be a useful marker for gastric cancer prediction.

scholarly journals HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL

2008 ◽  
Vol 123 (11) ◽  
pp. 2616-2625 ◽  
Author(s):  
Michiko Harao ◽  
Shinya Hirata ◽  
Atsushi Irie ◽  
Satoru Senju ◽  
Tetsuya Nakatsura ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Division ◽  
Cell Division Cycle ◽  
Cancer Testis Antigen ◽  
Ctl Epitopes ◽  
Cancer Testis

Overexpression of cancer‐testis antigen melanoma‐associated antigen A1 in lung cancer: A novel biomarker for prognosis, and a possible target for immunotherapy

2018 ◽  
Vol 234 (7) ◽  
pp. 12080-12086 ◽  
Author(s):  
Azar Fanipakdel ◽  
Mehdi Seilanian Toussi ◽  
Faezeh Rezazadeh ◽  
Nema Mohamadian Roshan ◽  
Seyed Alireza Javadinia
Keyword(s):  
Lung Cancer ◽  
Cancer Testis Antigen ◽  
Cancer Testis

Serum levels of the cancer-testis antigen POTEE and its clinical significance in non-small cell lung cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e22213-e22213
Author(s):  
Qi Wang ◽  
Xuefei Li ◽  
Shengxiang Ren ◽  
Ningning Cheng ◽  
Weijing Cai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Clinical Significance ◽  
Cell Lung Cancer ◽  
Serum Levels ◽  
Small Cell ◽  
Cancer Testis Antigen ◽  
Small Cell Lung ◽  
Cancer Testis
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