scholarly journals HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL

2008 ◽  
Vol 123 (11) ◽  
pp. 2616-2625 ◽  
Author(s):  
Michiko Harao ◽  
Shinya Hirata ◽  
Atsushi Irie ◽  
Satoru Senju ◽  
Tetsuya Nakatsura ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Division ◽  
Cell Division Cycle ◽  
Cancer Testis Antigen ◽  
Ctl Epitopes ◽  
Cancer Testis

scholarly journals Possible Molecular Mechanisms for the Roles of MicroRNA-21 Played in Lung Cancer

2019 ◽  
Vol 18 ◽  
pp. 153303381987513 ◽  
Author(s):  
Qiang Wang ◽  
Linyou Zhang
Keyword(s):  
Lung Cancer ◽  
Transcription Factor ◽  
Cell Division ◽  
A549 Cells ◽  
Group Versus ◽  
Negative Control ◽  
Replication Initiation ◽  
Cell Division Cycle ◽  
Initiation Factor ◽  
Control Group

Background: We aimed to find the possible molecular mechanisms for the roles of microRNA-21 underlying lung cancer development. Methods: MicroRNA-21-5p inhibitor was transfected into A549 cells. Total RNA was isolated from 10 samples, including 3 in control group (A549 cells), 3 in negative control group (A549 cells transferred with microRNA-21 negative control), and 4 in SH group (A549 cells transferred with microRNA-21 inhibitor), followed by RNA sequencing. Then, differentially expressed genes were screened for negative control group versus control group, SH group versus control group, and SH group versus negative control group. Functional enrichment analyses, protein–protein interaction network, and modules analyses were conducted. Target genes of hsa-miR-21-5p and transcription factors were predicted, followed by the regulatory network construction. Results: Minichromosome maintenance 10 replication initiation factor and cell division cycle associated 8 were important nodes in protein–protein interaction network with higher degrees. Cell division cycle associated 8 was enriched in cell division biological process. Furthermore, maintenance 10 replication initiation factor and cell division cycle associated 8 were significantly enriched in cluster 1 and micro-RNA-transcription factor-target genes regulating network. In addition, transcription factor Dp family member 3 (transcription factor of maintenance 10 replication initiation factor and cell division cycle associated 8) and RAD21 cohesin complex component (transcription factor of maintenance 10 replication initiation factor) were target genes of hsa-miR-21-5p. Conclusions: Micro-RNA-21 may play a key role in lung cancer partly via maintenance 10 replication initiation factor and cell division cycle associated 8. Furthermore, microRNA-21 targeted cell division cycle associated 8 and then played roles in lung cancer via the process of cell division. Transcription factor Dp family member 3 and RAD21 cohesin complex component are important transcription factors in microRNA-21-interfered lung cancer.

scholarly journals Detection of Kita-Kyushu Lung Cancer Antigen-1, a Cancer/testis Antigen, in the stomach closer to the cancerous condition.

2020 ◽  
Author(s):  
Takashi Fukuyama ◽  
Toshikazu Otsuka ◽  
Nobue Futawatari ◽  
Kumiko Tahara ◽  
Masaaki Watanabe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Lung Cancer ◽  
Helicobacter Pylori ◽  
Cancer Testis Antigen ◽  
Cancer Antigen ◽  
Exact Test ◽  
Cancer Prediction ◽  
Precancerous Condition ◽  
Cancer Testis

Abstract Background: Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) and is an attractive target for immunotherapy. An earlier study from our group demonstrated frequent KK-LC-1 expression in gastric cancers (GC) and non-tumor sites of the stomach carrying a tumor. Additionally, there was a correlation to Helicobacter pylori (Hp) infection. Currently it remains unclear whether KK-LC-1 is expressed in stomachs without gastric cancer.Methods: In the present study, we investigated differences in KK-LC-1 gene expression at non-tumor sites of stomachs with or without a tumor from 118 GC patients and 115 non-GC patients. Fisher’s exact test was used for the statistical analyses.Results: Our results show that KK-LC-1 gene expression was detected in 77% of non-tumor sites in stomachs with a tumor. Such findings were significantly higher than in stomachs without a tumor (7%, P <0.0001). All patients with KK-LC-1 expression at non-tumor sites of their stomachs without tumors carried Hp.Conclusions: KK-LC-1 appears to be detected in the stomach’s precancerous condition, but not in an atrophic stomach with Hp. KK-LC-1 may be a useful marker for gastric cancer prediction.

Overexpression of cancer‐testis antigen melanoma‐associated antigen A1 in lung cancer: A novel biomarker for prognosis, and a possible target for immunotherapy

2018 ◽  
Vol 234 (7) ◽  
pp. 12080-12086 ◽  
Author(s):  
Azar Fanipakdel ◽  
Mehdi Seilanian Toussi ◽  
Faezeh Rezazadeh ◽  
Nema Mohamadian Roshan ◽  
Seyed Alireza Javadinia
Keyword(s):  
Lung Cancer ◽  
Cancer Testis Antigen ◽  
Cancer Testis

scholarly journals Cell division cycle 20 overexpression predicts poor prognosis for patients with lung adenocarcinoma

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769223 ◽  
Author(s):  
Run Shi ◽  
Qi Sun ◽  
Jing Sun ◽  
Xin Wang ◽  
Wenjie Xia ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Division ◽  
Lung Adenocarcinoma ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Size ◽  
Poor Prognosis ◽  
Small Cell ◽  
Cell Division Cycle ◽  
Small Cell Lung

The cell division cycle 20, a key component of spindle assembly checkpoint, is an essential activator of the anaphase-promoting complex. Aberrant expression of cell division cycle 20 has been detected in various human cancers. However, its clinical significance has never been deeply investigated in non-small-cell lung cancer. By analyzing The Cancer Genome Atlas database and using some certain online databases, we validated overexpression of cell division cycle 20 in both messenger RNA and protein levels, explored its clinical significance, and evaluated the prognostic role of cell division cycle 20 in non-small-cell lung cancer. Cell division cycle 20 expression was significantly correlated with sex (p = 0.003), histological classification (p < 0.0001), and tumor size (p = 0.0116) in non-small-cell lung cancer patients. In lung adenocarcinoma patients, overexpression of cell division cycle 20 was significantly associated with bigger primary tumor size (p = 0.0023), higher MKI67 level (r = 0.7618, p < 0.0001), higher DNA ploidy level (p < 0.0001), and poor prognosis (hazard ratio = 2.39, confidence interval: 1.87–3.05, p < 0.0001). However, in lung squamous cell carcinoma patients, no significant association of cell division cycle 20 expression was observed with any clinical parameter or prognosis. Overexpression of cell division cycle 20 is associated with poor prognosis in lung adenocarcinoma patients, and its overexpression can also be used to identify high-risk groups. In conclusion, cell division cycle 20 might serve as a potential biomarker for lung adenocarcinoma patients.

Serum levels of the cancer-testis antigen POTEE and its clinical significance in non-small cell lung cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e22213-e22213
Author(s):  
Qi Wang ◽  
Xuefei Li ◽  
Shengxiang Ren ◽  
Ningning Cheng ◽  
Weijing Cai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Clinical Significance ◽  
Cell Lung Cancer ◽  
Serum Levels ◽  
Small Cell ◽  
Cancer Testis Antigen ◽  
Small Cell Lung ◽  
Cancer Testis
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