Risk Factors on Severity of Blood Pressure among Pregnant Women with Pregnancy Induced Hypertension (PIH) in Hilly areas of Uttarakhand

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Pregnant Women ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension

Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

2020 ◽  
Vol 15 (3) ◽  
pp. 227-239 ◽  
Author(s):  
Hader I. Sakr ◽  
Akef A. Khowailed ◽  
Reham S. Al-Fakharany ◽  
Dina S. Abdel-Fattah ◽  
Ahmed A. Taha
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Urate ◽  
Interleukin 1Β ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

Incidence of Pregnancy Induced Hypertensive Women and its Associated Factors

2021 ◽  
Vol 15 (12) ◽  
pp. 3307-3309
Author(s):  
Samia Saifullah ◽  
Maryam Shoaib ◽  
Muhammad Sohail Tareen ◽  
Nosheen Sikander Baloch
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Renal Diseases ◽  
Pregnancy Induced Hypertension ◽  
Cross Sectional ◽  
Induced Hypertension ◽  
Keywords Pregnancy

Background: Pregnancy induced hypertension is a fetal disease resulting into morbidity and mortality of female as well as its neonate. Objective: To find the incidence of pregnancy induced hypertension in Pakistani women. Study Design: Cross sectional study Place and Duration of the Study: Department of Obstetrics & Gynaecology, Sandeman Provincial Hospital, Quetta from 1st March 2019 to 31st March 2021. Methodology: Seven hundred and twenty eight females were identified with pregnancy induced hypertension from all the pregnant women attending the outdoor were enrolled. Each female was checked for their protein urea as well as systolic and diastolic blood pressure according to standard operating protocol. Socio-demographic, clinical and family history were documented. Results: Among all pregnant women, 150 were identified as pregnancy induced hypertensive with a 20.6% incidence of pregnancy induced hypertension. The mean value systolic blood pressure value was 144.3±5.2 and of diastolic as 83.1±5.2 in pregnancy induced hypertension women. Conclusion: Family history, obesity and renal diseases are the main factors associated with pregnancy induced hypertension with an incidence of 20.6% among pregnant women. Keywords: Pregnancy induced hypertension, Body mass index, Pregnant women, Hypertension

scholarly journals Direct laboratory evidence that pregnancy-induced hypertension might be associated with increased catecholamines and decreased renalase concentrations in the umbilical cord and mother’s blood

2019 ◽  
Vol 43 (2) ◽  
pp. 77-85
Author(s):  
Yakup Baykus ◽  
Sefer Ustebay ◽  
Rulin Deniz ◽  
Kader Ugur ◽  
Şeyda Yavuzkir ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Healthy Control ◽  
C 30 ◽  
Body Mass Indexes ◽  
Umbilical Cord Vein

Abstract Background Renalase (RNL) is a controversial enzyme as to whether it oxidizes catecholamines (CAs) (as is generally accepted) in the blood or not. CAs (dopamine [DPMN], epinephrine [EPI] and norepinephrine [NEPI]) are associated with hypertension, including pregnancy-induced hypertension, which occurs in 8–10% of all pregnancies. Therefore, the aim of the study was to compare CAs and renalase concentration in (i) normotensive controls (C), (ii) patients with preeclampsia (PE) and (iii) patients with severe preeclampsia (SPE), which is one of the well-known symptoms of hypertension. Methods This case-control study involved 90 women divided into three groups – 30 C, 30 PE and 30 SPE – whose age and body mass indexes (BMIs) were similar. A total of 270 blood samples (90 maternal samples, 90 umbilical cord artery samples and 90 umbilical cord vein samples) were obtained. CAs and RNL concentrations of the biological samples were measured by enzyme-linked immunosorbent assay (ELISA). Results Comparing the amounts of CAs, RNL and systolic blood pressure (SBP)/diastolic blood pressure (DBP) between healthy control pregnant women and pregnant women with PE and SPE (SBP/DBP was 120/80 mm Hg for C, above 140/90 mm Hg for PE and above 160/110 mm Hg for SPE), the levels of CAs were significantly increased whereas RNL was reduced. The correlation between SBP/DBP and the amount of RNL in pregnant women with PE and SPE was negative. Conclusions These novel results are evidence that hypertension seen in PE and SPE is directly related to increased levels of CAs and reduced RNL concentrations. The use of RNL preparations may be preferred in future to prevent maternal and perinatal morbidity and mortality due to pregnancy-induced hypertension.

Abnormalities of peripheral venous tone in women with pregnancy-induced hypertension

1986 ◽  
Vol 70 (2) ◽  
pp. 155-157 ◽  
Author(s):  
Karen Stainer ◽  
Rachel Morrison ◽  
C. Pickles ◽  
A. J. Cowley
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Inverse Correlation ◽  
The Other ◽  
Normal Blood ◽  
Pregnancy Induced Hypertension ◽  
Normal Blood Pressure ◽  
Venous Tone ◽  
Arterial Blood ◽  
Induced Hypertension

1. Forearm venous tone was measured in two groups of pregnant women: one group with pregnancy-induced hypertension and the other group with normal blood pressure. 2. The women with pregnancy-induced hypertension were venoconstricted in the forearm (P < 0.01) compared with the pregnant women with normal blood pressure. However, there was no difference in venous tone between the women with pregnancy-induced hypertension and nonpregnant women. 3. There was an inverse correlation between mean arterial blood pressure and forearm venous tone (r = −0.581, P < 0.001) for all the pregnant women studied. Further evaluation of peripheral venous tone may provide valuable information about the pathophysiology and treatment of women with pregnancy-induced hypertension.

The effects of posture on abnormalities of forearm venous tone in women with pregnancy-induced hypertension

1987 ◽  
Vol 73 (3) ◽  
pp. 267-269 ◽  
Author(s):  
Karen Stainer ◽  
C. Pickles ◽  
A. J. Cowley
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Blood Volume ◽  
Supine Position ◽  
Pregnancy Induced Hypertension ◽  
Central Blood Volume ◽  
Venous Tone ◽  
Induced Hypertension

1. Forearm venous tone was measured in the left lateral supine position and in response to passive leg elevation in a group of women with pregnancy-induced hypertension and compared with a group of normotensive pregnant women and a group of non-pregnant women. 2. The women with pregnancy-induced hypertension were venoconstricted in the supine position compared with the normal pregnant women (P < 0.002). There was no difference in forearm venous tone between the women with pregnancy-induced hypertension and the non-pregnant women. 3. In response to passive leg elevation the women with pregnancy-induced hypertension venodilated (P < 0.002) whereas there was no change in forearm venous tone in the normotensive pregnant women and the non-pregnant women. There was no change in blood pressure in any of the women after 35 min of leg elevation. 4. These results demonstrate that the abnormal venous vasoconstriction that occurs in women with pregnancy-induced hypertension in the supine position is corrected by passive leg elevation, a manoeuvre which leads to an increase in central blood volume.

scholarly journals Evaluation of the Relationship Between Types of Occupational Risk Factors and Pregnancy Induced Hypertension Among Iranian Employed Pregnant Women

2020 ◽  
Author(s):  
Nazanin Izadi ◽  
Omid Aminian ◽  
Pegah Estakhrian ◽  
Samaneh Akbarpour ◽  
Mahin Ahmadi Pishkuhi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Shift Work ◽  
Gestational Hypertension ◽  
Pregnancy Induced Hypertension ◽  
Related Factors ◽  
Cross Sectional ◽  
Occupational Risk Factors ◽  
Induced Hypertension ◽  
The Relationship

Gestational hypertension or pregnancy-induced hypertension is the emergence of hypertension in a pregnant women after 20 weeks of gestation. This study aimed to evaluate the job-related factors associated with pregnancy-induced hypertension. This cross-sectional study was conducted on 560 pregnant women who referred to the Nursing Clinic of Imam Khomeini Hospital in 2017; of all studied cases, 210 pregnant women with pregnancy-induced hypertension were selected as cases and 350 women without pregnancy-induced hypertension were selected as controls. The data on demographic characteristics, occupational characteristics, and ergonomic dangers were collected by the researchers. Finally, the relationship between job variables and the probability of developing hypertension in pregnant women was measured. The results of the logistic regression analysis showed that the variables of body mass index, fertility, shift work, and service works had a significant relationship with pregnancy-induced hypertension. Women with service work were 2.32 times more likely to develop hypertension than women with other types of jobs (P=0.013). The people who had a shift work were 2.28 times more likely to develop pregnancy-induced hypertension than those who did not have shift work. Based on the results of this study, there was no relationship between ergonomic risks and pregnancy-induced hypertension. It seems that due to the higher frequency of pregnancy-induced hypertension in highly demanding jobs, it is necessary to pay more attention to the assessment of related risk factors, such as psychological variables. © 2019 Tehran University of Medical Sciences. All rights reserved. Acta Med Iran 2019;57(7):430-434.

scholarly journals Rural and urban differences in blood pressure and pregnancy-induced hypertension among pregnant women in Ghana

2013 ◽  
Vol 9 (1) ◽  
pp. 59 ◽  
Author(s):  
Deborah van Middendorp ◽  
Augustinus Asbroek ◽  
Fred Bio ◽  
Anthony Edusei ◽  
Lyonne Meijjer ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Pregnancy Induced Hypertension ◽  
Rural And Urban ◽  
Induced Hypertension

scholarly journals Effect of low dose aspirin on maternal outcome in women at risk for developing pregnancy induced hypertension

2020 ◽  
Vol 9 (4) ◽  
pp. 1590
Author(s):  
Madhusmita Pradhan ◽  
Kishore S. V. ◽  
Jyotiranjan Champatiray
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Pregnant Women ◽  
Low Dose ◽  
Multiple Pregnancy ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Induced Hypertension

Background: Pre-eclampsia is not totally a preventable disease. It is found more related to chains of social ills such as poor maternal nutrition, limited or no antenatal care and poor reproductive education. However, some specific “high-risk” factors leading to pregnancy induced hypertension (PIH) may be identified in individuals which include and not limited to young and elderly primigravida, multiple pregnancy, diabetes, Rh incompatibility, new paternity, pre-existing vascular or renal disease, family history of hypertension, pre-eclampsia and eclampsia, obesity, thrombophilia. Low dose aspirin given in 2nd trimester in these high-risk women is anticipated to prevent the development of PIH.Methods: This prospective randomized controlled trial was conducted in the department of obstetrics and gynecology, SCB MC and Hospital, Cuttack during November 2018 to October 2019. Pregnant women between the gestational age of 13th to 28th weeks were screened for risk factors and included in this study. Low dose aspirin of 60 mg daily till delivery was given to pregnant women who consented to be a part of study randomly with the other group having placebo.Results: Protienuric hypertension was high in control group who did not receive aspirin. Low dose aspirin significantly reduces PIH in high-risk group (3.48% in case versus 23.52% in control). Low dose aspirin was not associated with significant increase in placental bleeding. Low dose aspirin was generally safe for the fetus and new born infant with no evidence of an increased likelihood of bleeding.Conclusions: Low dose aspirin has a definite role in the prevention of PIH in high risk pregnancy. Low dose aspirin reduces the incidence of PIH. Low dose aspirin can be considered a safe drug without any deleterious side effect for mother and the fetus. Benefits of prevention of PIH, justifies its administration in women at high risk.

scholarly journals The need for quality improvement in diagnosing pregnancy induced hypertension in Sri Lanka

2013 ◽  
Vol 2 (2) ◽  
pp. 55-60
Author(s):  
S Prathapan ◽  
P Fonseka ◽  
G Lindmark ◽  
R Prathapan ◽  
A Lokubalasooriya
Keyword(s):  
Blood Pressure ◽  
Sri Lanka ◽  
Pregnant Women ◽  
Medical Officer ◽  
Quality Of Services ◽  
Pregnancy Induced Hypertension ◽  
Cross Sectional ◽  
Induced Hypertension ◽  
Antenatal Clinics

Sri Lanka has shown relatively good maternal outcome indicators for a developing country. However, high maternal deaths from pregnancy induced hypertension and pre-eclamptic toxemia raise questions about the quality of detection and treatment at field antenatal clinics, which is the primary care setting for pregnant women. The objective of the study was to assess the quality of facilities and services provided at the field antenatal clinics to di-agnose pregnancy induced hypertension or pre-eclamptic toxemia. It was a cross-sectional study. This study was set in field antenatal clinics and was conducted in two stages based on the Lot Quality Assurance Sampling method. In the first stage 55 antenatal clinics were selected from 11 Medical officers of Health areas, and in the second stage 275 pregnant women were recruited from these 55 clinics. Quality of services and quality of facilities were assessed using observation checklists. The quality of facilities was better than the quality of services in the Colombo district. The quality of facilities was acceptable in all areas other than for the presence of the Medical Officer. The quality of services was unacceptable in all areas for history taking and examination. Investigation for urine albumin was also unacceptable in all the areas. The sensitivity for measuring the systolic blood pressure and the diastolic blood pressure were 57% (95% CI: 47.4%–66.8%) and 16.7% (95% CI: 9.4%–24%) respectively. Urgent steps should be taken to improve the quality of care in the substandard areas to reduce the leading cause of maternal mortality in Sri Lanka. DOI: http://dx.doi.org/10.3329/seajph.v2i2.15952 South East Asia J Public Health | Jul-Dec 2012 | Vol 2 Issue 2 | 55-60

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