scholarly journals Preoperative management in Hirschsprung’s congenital megacolon

2015 ◽  
Vol 10 (3) ◽  
pp. 276-280
Author(s):  
Simona-Gabriela TUDORACHE ◽  
◽  
Cătălin CHIRIAC-BABEI ◽  
Toli PĂTRĂNCUŞ ◽  
Laura NICULESCU ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Average Length ◽  
Treatment Plan ◽  
Congenital Megacolon ◽  
Group I ◽  
Definitive Operation ◽  
Group Ii ◽  
Pull Through ◽  
Definitive Surgery ◽  
Time Of Operation

Introduction. Hirschsprung’s congenital megacolon is a challenge in terms of diagnosis and a proper treatment plan. If, in terms of the final operation there have been described various techniques and done studies that followed postoperative complications, regarding tracking and treatment previous to the intervention there is little documentation available. Material and methods. The study is retrospective and includes a group of 31 patients diagnosed and treated in the “Grigore Alexandrescu” Children’s Emergency Hospital between 2010-2014. The group of patients was divided into two groups: Group I – patients who underwent diverting stomy before pull through and group II – without diverting stomy, who received preoperative nursing. The main parameters followed were: the frequency rate of enterocolitis and number of hospitalizations before the definitive operation. The second parameter followed is the patients age at the time of the pull through, patients were followed until definitive surgery. Data was collected from the hospital information system – Hippocrates, the clinical charts and the operation room registry of surgery and were processed using SPSS version 22.0. Results. From group I, 10 patients (32.3%) had at least one episode of enterocolitis before definitive surgery, compared with only 3 patients (9.7%) in group II. Analyzing the data, we fi nd that patients in group I have on average 4 more hospitalizations than those in group II. The average length hospitalization was 21 days for group I and 7 days for group II. The age at the time of operation ranged between 2 and 72 months in the whole group, with an average of 8 months for patients in group II and 21 months in the first group. The average duration of observation of the patients was 3 months for group I and 16 months for the second group. Conclusion. In the group with diverting stomy, infectious episodes are more frequent and the number of hospitalizations before the pull through is bigger. If frozen histopathological examination is available one stage pull through is considered the best option, exception beeing when there is an absolute indication for diverting stomy.

scholarly journals The Effect of Intratesticular Injection of Human Adipose-Derived Stem Cell (hADSC) on Testicular Oxidative Stress and Spermatogenesis Process in the Varicocele Rat Model

2021 ◽  
Author(s):  
Safendra Siregar ◽  
Bambang Sasongko Noegroho ◽  
Ricky Adriansjah ◽  
Akhmad Mustafa ◽  
Ananta Bonar
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Wistar Rats ◽  
Histopathological Examination ◽  
Therapy Group ◽  
Intervention Group ◽  
Testicular Tissue ◽  
Control Group ◽  
Group I ◽  
Group Ii

Abstract Introduction: Varicocele is the predominant cause of male infertility and was found in 19% - 41% of men with primary infertility and 45% - 81% of men with secondary infertility. Human adipose Derived Stem Cells (hADSC) can suppress oxidative stress in some oxidative injury model. Therefore, this study would like to investigate the effect of intratesticular hADSC injection on MDA level and spermatogenesis process by histopathological examination in the varicocele rat model.Method: This is an experimental study. A total sampling of 9 male Wistar rats were divided into three groups. Group I consist of 1 Wistar rats without any treatment or model (sham group), group II consist of 4 Wistar rats with varicocele model without hADSC therapy (control group), and group III consist of 4 Wistar rats with varicocele model and were given injections of 1.0x106 hADSC cells intratesticularly 30 days after model was made (therapy group). Testicular tissue was harvested for evaluation. Results: In all varicocele model rats (group II and III), the result of MDA level in therapy group (2.53 mol/liter) was significantly lower than the MDA level in control group (4.43 mol/liter) (p = 0.01). On histopathological examination, the average Johnson's Score in the therapy and control group was 9,77 and 9,18, respectively. The analysis showed Johnson’s score in the intervention group was significantly higher (p = 0.018). Conclusion: Intratesticular injection of hADSC can help reduce MDA levels and improve spermatogenesis process, which is damaged by varicoceles.

scholarly journals Effectiveness of capsaicin containing dried habanero pepper extract in the treatment of primary hepatic cancer in geriatric dogs

2018 ◽  
Vol 74 (1) ◽  
pp. 5976-2018
Author(s):  
PIOTR DĘBIAK ◽  
DAGMARA GADOMSKA* ◽  
ANNA ŚMIECH ◽  
JERZY ZIĘTEK ◽  
PAWEŁ ŁYP ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Histopathological Examination ◽  
Hepatic Cancer ◽  
Liver Tumours ◽  
Group I ◽  
Average Survival ◽  
Habanero Pepper ◽  
Long Time ◽  
Group Ii ◽  
Alternative Medications

The study was aimed at the preliminary clinical assessment of the anti-cancer efficacy of a dietary supplement based on the extract of habanero peppers containing capsaicin in dogs with primary hepatic cancer. 24 dogs with primary hepatic cancer, divided into two groups, were followed up during the study. Group I included 16 dogs receiving a dietary supplement based on capsaicin-containing habanero peppers, while group II consisted of 8 dogs that did not receive any veterinary treatment. The dogs were subjected to clinical examination, ultrasound imaging as well as biochemical and haematological analyses. Patient survival was determined in both groups. An autopsy was performed in all animals that died or were euthanised, and tumour samples were collected for histopathological examination, on the basis of which the type of neoplasm was finally determined. Survival of dogs in group I ranged from 54 to 285 days (178.6 days on average). Survival of dogs in group II was 32-128 days (76.5 days on average). In none of the dogs classified to group I that had single tumours did the size of the lesion increase during supplement administration, and in the case of two dogs that were receiving the preparation for a long time (188 and 285 days), their liver tumours actually shrank. In all dogs from group II that had single tumours, the size of the lesions increased in the course of the observation. The preliminary clinical observations by the authors indicate that the capsaicin-containing habanero pepper extract exhibits favourable effects on liver tumours in dogs and is well tolerated by the animals, thus the obtained results are a good sign for future studies on alternative medications used in dog oncology..

scholarly journals Biochemical and Histopathological Effects on Liver Profile due to Acute and Subacute Oral Toxicity of Somina on Rats

2021 ◽  
Vol 9 (1) ◽  
pp. 76-81
Author(s):  
Aisha Azmat ◽  
Muhammad Ahmed
Keyword(s):  
Oral Administration ◽  
Histopathological Examination ◽  
Treated Group ◽  
Control Group ◽  
Histopathological Analysis ◽  
Oral Toxicity ◽  
Toxicological Effect ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Background: Limited research studies are reported regarding the toxicological effect of different herbal medicine already used in different countries. Objective: This research study was planned to examine the changes in liver (biochemical and histological) associated with oral administration of somina (acute and sub-acute) in rats. Methodology: Group– I served as control (saline), while other groups (II, III) were daily treated with somina at different doses of 0.285g/kg (group – II), 10g/kg/day (group – III), for 14 (set I), 21 (set II), and 30 (set III) consecutive days.  Each group contains 12 rats. During the study period, signs and behavioral changes, mortality, were observed. At the end of study period, blood sample was drawn directly from heart, for the estimation of liver enzymes: Bilirubin (BIL), alkaline phosphatase (ALP), serum glutamic pyruvic transferase (SGPT), aspartate aminotransferase (SGOT), Albumin (ALB) and total protein (TP). The liver was carefully dichotomized, weighed, and further processed for histopathological analysis. Results: Herbal drug somina was claimed to be practically non-toxic as in rats no mortality was recorded after the oral administration of somina (14, 21 and 30 consecutive days). Liver profile showed non-significant changes in treated group- II and III (P > 0.05), as compared to the control (group- I). The histopathological examination did not reveal any deteriorative effect. Conclusion: It was concluded that oral administration of somina did not produce any significant detrimental effects on rat liver (biochemical and histopathological parameters), even at doses of 10g/kg/day indicating its safe use.

scholarly journals 901 Management, Complications and Neurological Outcomes of Aneurysmal Subarachnoid Haemorrhage in Elderly Patients

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
P H Cheng ◽  
H N Simms ◽  
A Abouharb
Keyword(s):  
Subarachnoid Haemorrhage ◽  
Average Length ◽  
Low Grade ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Complication Rates ◽  
Elderly Age ◽  
Group Iii ◽  
Neurological Outcomes ◽  
Group I ◽  
Group Ii

Abstract Aim To study the management of aneurysmal subarachnoid haemorrhage (aSAH) and compare neurological outcomes in different elderly age groups. Method A retrospective cohort study. aSAH patients with age 60 and above admitted to Royal Victoria Hospital Belfast between 2015 to 2019 were enrolled, and divided into 3 sub-groups, age 60 – 69 (Group I), age 70 – 79 (Group II) and age >80 (Group III). Patient characteristics and clinical courses were compared, including co-morbidities, WFNS grades, interventions, complications and neurological outcomes at follow up. Results 158 patients were included, with 104 in Group I, 49 in Group II and 5 in Group III. Despite Group III patients presented with only WFNS grade 1 & 2, mortality increased exponentially with age from 9.6% to 12.2% to 40% across 3 sub-groups. There was also a linear increase in average length of stay (LOS) from 21 to 24 days. 81 Group I patients (77.9%) developed complications and 38 patients (77.6%) in Group II. In Group III, 3 patients (60%) developed complications when 2 other patients did not survive. Most common complications were hydrocephalus (46.2%) and hospital acquired infections 36.7%). Conclusions Our study suggests patients with age >80 had less favourable neurological outcomes despite having low grade aSAH at presentation and received similar intervention. Average LOS in hospital also increased with age. Similar complication rates were noticed in all groups. Comparing our data with other neurosurgical units in UK and Ireland will provide further information in managing elderly aSAH patients and facilitate risk stratification when considering those patients for intervention.

scholarly journals Impact of the covid pandemic on admission for acute heart disease in a level II coronary unit

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
AM Campos Pareja ◽  
L Garcia Riesco ◽  
M Frutos Lopez ◽  
J Nevado Portero ◽  
M Villa Gil Ortega
Keyword(s):  
Heart Disease ◽  
Length Of Stay ◽  
Ischemic Heart Disease ◽  
Average Length ◽  
Ischemic Heart ◽  
Average Length Of Stay ◽  
Group I ◽  
Level Ii ◽  
Acute Ischemic Heart Disease ◽  
Group Ii

Abstract Funding Acknowledgements Type of funding sources: None. Purpose and Methods The Covid-19 pandemic has led to an increase in demand for Critical Patient Care Units. For this reason, level III Coronary Units have become a very valuable resource in the care of seriously ill patients, especially those due to covid. Level II Coronary Units could have assumed a greater number of acute heart patients, especially coronary, during the pandemic in hospitals that have coronary units of different levels.  Our objective has been to compare the profile of patients who have been admitted to our level II Coronary Unit, retrospectively analyzing and comparing the demographic data and the reason for admission of the patients who were admitted between March and November 2019 (group I) with those who did so between the same months of 2020 (group II).  Results   Group I patients were 518 patients compared to 625 in group II. There was no difference between the age of the patients admitted (65.2 + 13 vs 65.1 + 13.8 years old). In the covid period, there were no significant differences between the classic risk factors, such as hypertension, diabetes or dyslipidemia. There was a higher percentage of smoking among the patients. During the pandemic, the patients admitted had significantly less history of previous heart disease (40.2% vs 78%). There has been a significant increase in admissions for acute ischemic heart disease in our unit (60% vs 13.8% the previous year), at the expense of Acute coronary syndrome with ST elevation (STEMI), with a downward trend in pathologies such as arrhythmias (13.5% in 2020 vs 20.6% in 2019) and acute heart failure (11.1% in 2020 vs 12.1% in 2019).  The average length of stay during the Covid-19 period was significantly shorter, 2.7 days, compared to 3.3 days in the 2019 period, at the expense of a higher turnover rate in the Unit (79.42 vs 74, 09). During the covid period, there were 36.67% more discharge.  Conclusions  During the Covid-19 pandemic, a significant increase in acute ischemic heart disease (STEMI) has been observed in our level II Coronary unit, which is responsible for the greater number of discharges and the decrease in our average length of stay. This has allowed level III Coronary Units the ability to assume the excess of patients in need of intensive care that has been significantly increased by the Covid-19 pandemic

scholarly journals IN VIVO INVESTIGATION OF BOVINE CUTANEOUS PAPILLOMATOSIS WITH HOMEOPATHIC PREPARATIONS

2012 ◽  
Vol 3 (2) ◽  
pp. 114-116
Author(s):  
MG Hossain ◽  
MG Haider ◽  
MR Khan ◽  
EH Chowdhury ◽  
MM Hossain
Keyword(s):  
Untreated Control ◽  
Histopathological Examination ◽  
Control Group ◽  
Group Iii ◽  
Concurrent Use ◽  
Group I ◽  
Cellular Necrosis ◽  
Group Ii ◽  
Control Group Group

This investigation was carried out to determine the effects of thuza and antim crud (Homeopathic preparations) on bovine cutaneous papillomatosis/wart. Nine calves of one to two and a half years age and of both sexes affected with cutaneous papillomatosis were randomly divided into three equal groups (group I, group II and group III) for this experiment from March 2002 to February 2003. Each calf of group I was first administered with 15 globules sulphur with a potency of 200-power once orally. This was followed after 7 days with 50M (M = 1000-power) thuza at the dose rate of 10 globules twice daily orally for a period of three weeks. The calves of group II were administered with sulphur and antim crud at the same dose, potency, route and duration, respectively and the calves of group III were kept as untreated control. Papilloma tissues were collected prior to treatment and at the sixth week of treatment and they were subjected to histopathological examination. Thuza and antim crud with concurrent use of sulphur were found effective in curing bovine cutaneous papillomatosis with a rate of 66.66% (4/6). Little or no reduction in size of the papillomas was observed within the first two weeks of treatment in both the treated groups (group I and group II). Thereafter, miniature size sessile and pedunculated papillomas started drying with the gradual reduction in size that fell leaving hairless areas at the end of fourth week. By the eighth week there was complete cure of papillomas. One calf of each treated groups (group I and group II) affected with large papillomas (5 X 7 cm) were not completely cured. Microscopic examination of regressive papillomas at sixth week of treatment showed cellular necrosis. Growth recurrence was not observed within one month of recovery. In the untreated control group (group III), the number and size of papillomas increased. Therefore, this line of treatment may be practiced for the treatment of bovine papillomatosis.

Association of Hyperhomocysteinemia with Early Onset Atherosclerotic Peripheral Arterial Occlusive Diseases

2021 ◽  
Vol 13 (2) ◽  
pp. 120-127
Author(s):  
Md Shamim Reza ◽  
AM Asif Rahim ◽  
AHM Bashar ◽  
M Shahidul Islam ◽  
SAN Alam
Keyword(s):  
Early Onset ◽  
Homocysteine Level ◽  
Histopathological Examination ◽  
Serum Homocysteine ◽  
Group I ◽  
Arterial Occlusive Diseases ◽  
Total Homocysteine ◽  
Group Ii ◽  
Peripheral Arterial ◽  
Plasma Total Homocysteine

Background: Homocysteine is increasingly recognized as an independent risk factor for vascular disease specially peripheral arterial occlusive diseases. In the present study, an attempt was made to find out the association between the raised fasting plasma total homocysteine level and early onset atherosclerotic peripheral arterial occlusive diseases (PAOD). Methods: In this prospective observational study a total of 50 study subjects were included. All patients were clinically and angiographically documented for atherosclerotic PAOD. All patients underwent surgical intervention as well as estimation of serum total homocysteine level. Arterial segment was sent for histopathological examination to find out whether atherosclerosis was present or not. Patients were divided into two groups- Group-1 included patients of 20-40 years of age and group-II included those of 41-60 years of age. The groups were compared to see association between elevated level of plasma homocysteine and atherosclerotic peripheral arterial occlusive diseases in elderly as well as in early age. Results: 41 (82%) patients were male and 9 (18%) patients were female. Serum homocysteine level was higher in group I than group II (71.4% vs. 40.9%). Besides, the level of mean serum homocysteine level was significantly (p=0.02) higher in group I than group II (21.18±9.53 vs. 17.24±8.92 μmol/L). Conclusion: In conclusion, this study suggests that serum homocysteine has an association with early onset atherosclerotic PAOD. Therefore, a raised serum homocysteine level can be used as an independent biochemical predictor of early onset atherosclerotic PAOD. Cardiovasc. j. 2021; 13(2): 120-127

scholarly journals Perbandingan Efektivitas Terapi Zink dengan Tanpa Zink Pada Pasien Diare Anak Rawat Inap Di RSD Idaman Kota Banjarbaru

2019 ◽  
Vol 6 (1) ◽  
pp. 64
Author(s):  
Helmina Wati ◽  
Satrio Wibowo Rahmatullah ◽  
Muhamad Hepriatna
Keyword(s):  
Standard Therapy ◽  
Research Method ◽  
Pediatric Patients ◽  
Average Length ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Cross Sectional ◽  
Group I ◽  
Group Ii ◽  
Zinc Supplements

ABSTRAK             Diare merupakan masalah utama  kesehatan masyarakat, WHO dan UNICEF merekomendasikan penatalaksanaan diare pada pasien anak dengan penambahan suplemen zink. penelitian ini bertujuan untuk mengetahui perbandingan efektivitas terapi Zink dengan Tanpa zink terhadap pasien anak di rawat inap rumah sakit Idaman Banjarbaru. metode penelitian menggunakan dekriptif cross sectional dengan studi retrospektif. penelitian ini menggunakan 2 kelompok yaitu kelompok I, pasien yang mendapatkan terapi standar tanpa diberikan zink, kelompok II, pasien yang mendapatkan terapi standar dengan pemberian zink. hasil penelitian menunjukkan bahwa rata-rata lama waktu diare pada kelompok I selama 3 hari dibandingkan dengan kelompok II selama 4.4 hari. Hasil Spps menyatakan bahwa terdapat perbedaan yang signifikan antara kelompok I dan kelompok II (p<0,05). Kata kunci : Diare, Zink, tanpa Zink  ABSTRACT Diarrhea is a major public health problem, WHO and UNICEF recommend management of diarrhea in pediatric patients with the addition of zinc supplements. This study aims to determine the comparison of the effectiveness of Zink therapy with no zinc on pediatric patients inpatient in Banjarbaru ideal hospital. The research method uses cross sectional descriptive with a retrospective study. This study used 2 groups, group I, patients who received standard therapy without zinc, group II, patients who received standard therapy with zinc. The results showed that the average length of time for diarrhea in group I was 3 days compared to group II for 5 days. The Spps results stated that there were significant differences between group I and group II (p <0.05). Keyword: Diarrea, Zink, Without Zink 

scholarly journals MODIFIED ALVARADO SCORE

2010 ◽  
Vol 17 (04) ◽  
pp. 546-550
Author(s):  
SYED WARIS ALI SHAH ◽  
CHAUDHRY AHMED KHAN ◽  
SIKANDER ALI MALIK ◽  
AHMED WAQAS ◽  
AJMEL MUNIR TARRAR ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Histopathological Examination ◽  
Military Hospital ◽  
P Value ◽  
Alvarado Score ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Negative Appendicectomy ◽  
Modified Alvarado Score

objective: To compare the frequency of inflamed appendix in suspected patients of acute appendicitis having Modified Alvarado Score (MAS) of 7 or more with patients having MAS of 6 or below. Design: Comparative cross sectional study. Place and duration of study: The study was carried out at Surgical Departments of Combined Military Hospital (CMH) and Military Hospital (MH) Rawalpindi from April 2006 to April 2007. Material and Methods: This study involved 100 patients who were operated with provisional diagnosis of acute appendicitis. Preoperatively MAS of each patient was calculated and the patients were divided in two groups. Group-I had MAS of 7 or more while Group-II had MAS of 6 or below. Postoperatively appendices of all the patients were sent for histopathological examination and its result regarding presence or absence of acute appendicitis was then compared with MAS of respective group. Results: (a) Group-I:- A total of 72 patients with 64(88.9%) positive inflamed appendices on histology. Negative appendicectomy rate 8(11.1%), (b) Group-II:- A total of 28 patients with 8(28.6) positive inflamed appendices. Negative appendicectomy rate 20(71.4%). There is statistical significant difference of positive appendicectomy rate between two groups with (p-value<0.001). Conclusion: Frequency of inflamed appendix is more in patients having MAS of seven orabove. The number of negative appendicectomies can be reduced by using MAS in clinical practice.

Sonoelastography in differentiation of benign and malignant testicular lesion in dogs

2014 ◽  
Vol 17 (3) ◽  
pp. 487-491 ◽  
Author(s):  
K. Glińska-Suchocka ◽  
M. Jankowski ◽  
K. Kubiak ◽  
J. Spużak ◽  
S. Dzimira
Keyword(s):  
Histopathological Examination ◽  
Interstitial Cells ◽  
Ultrasonographic Examination ◽  
High Stiffness ◽  
Group I ◽  
Testicular Interstitial Cells ◽  
Testicular Lesions ◽  
Low Stiffness ◽  
Group Ii ◽  
Screening Diagnostics

AbstractPresent study aimed to evaluae the elasticity of tumorous testicular lesions and usefulness of the elastographic examination for diagnosing lesions in the testes. The study was carried out on nine dogs in which tumorous testicular lesions had been found in the ultrasonographic examination. In all the animals examined, the elastographic examination of the lesions was performed and then castration and the histopathological examination of specimens in order to determine the type of the changes. On the basis of the results of the histopathological examination the dogs were divided into two groups: group I - consisted of three dogs in which nonneoplastic testicular lesions were found and group II comprised six dogs in which neoplasic lesions that began in testicular interstitial cells (Leydigoma) were detected. The lesions observed in dogs of group I showed low stiffness (average 11.25 kPa, range 6.1 to 16.4 kPa), whereas the lesions found in dogs of group II were characterized by high stiffness (average 91.85 kPa, range 52.3 to 131.4 kPa). On the basis of a scale proposed by Goodie et al. (2012), the lesions in group I were in the range of SC1,and in turn, the lesions in group II were in the range of SC 3 inverted. Based on the results obtained, it can be stated that the sonoelastographic examination is useful method for the screening diagnostics of testicular lesions.

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