scholarly journals The evolution of neuropsychiatric symptoms during treatment for hyperthyroidism

2021 ◽  
Vol 16 (2) ◽  
pp. 273-278
Author(s):  
Oana-Maria NICOLA (MARIOARA) ◽  
◽  
Alice Elena GHENEA ◽  
Cristina-Nicoleta VLĂDOIANU ◽  
Valentin CARLIG ◽  
...  
Keyword(s):  
Neuropsychiatric Symptoms ◽  
Antithyroid Drug ◽  
T Test ◽  
Chi Square ◽  
Antithyroid Drug Therapy ◽  
Significant Difference ◽  
Hamd Score ◽  
Chi Square Test ◽  
Student’S T ◽  
Student’S T Test

Introduction. The link between the action of thyroid hormones and neurological, cognitive and affective function is well known. The aim of the study is to evaluate the changes of hormone’s value and symptoms at hyperthyroid patients after 6 months and 1 year of treatment. Materials and methods. In our study, we enrolled 80 patients with hyperthyroidism (new cases) and we asked them to fill out a questionnaire three times: first time was when they were into a thyrotoxic state (before the antithyroid drug therapy – ATD) and after that during ATD treatment (when they were into an euthyroid state after 6-12 months of treatment, average 7 months). Results. There is no statistically significant difference between the ages of the study and control groups (p Student’s t -test = 0.207 > 0.005), nor between the distributions according to gender (p Chi square test = 0.827) or area of residence (p Chi square test = 0.820). For HAMD score, there is highly significant differences (p < 0.001) before treatment, a statistically significant difference after 6 months (p Student’s t-test = 0.015 < 0.05), and no statistically significant difference after 1 year. Conclusion. Depression and anxiety were improved following thyroid function normalization in hyperthyroidism.

scholarly journals Effect of Use of Ambulance as Emergency Medical Service in Patients of ST-Elevation Myocardial Infarction

2021 ◽  
Vol 2 (3) ◽  
pp. 4
Author(s):  
Majid Bashir ◽  
Kubra Maryam ◽  
Nazeer Ahmed ◽  
Tariq Mehmood ◽  
Adnan Aslam
Keyword(s):  
Myocardial Infarction ◽  
St Elevation Myocardial Infarction ◽  
Base Line ◽  
Chi Square ◽  
Level Of Satisfaction ◽  
Significant Difference ◽  
Chi Square Test ◽  
St Elevation ◽  
Student’S T ◽  
Student’S T Test

Objective: To study the frequency of ambulance utilization by the St-elevation Myocardial Infarction patients toreach hospital, perception of ambulance users about the facilities available in the ambulance, and evaluate theclinical outcomes of STEMI between ambulance users and non-users.Study Design: Cross-section survey-based study.Place and Duration of Study: The study was carried out in the Department of Cardiology at Chaudry Pervaizth th Elahi Institute of Cardiology (CPEIC) Multan from 14 April 2020 to 14 September 2020.Materials and Methods: Patients with the diagnosis of STEMI were included in the study and were classifiedinto two groups' ambulance and non-ambulance users, to reach the facility. Patients' demographics, initialpresenting symptoms, availability of ambulance, and time to reach the hospital were recorded. Moreover, theywere followed for complication during their stay and base line laboratory indicators. Ambulance users werealso evaluated for their perception about availability of medical services in the ambulance. The data collectedfrom both of the groups were compared through student's t-test and chi-square test. Statistical value less than0.05 was considered as significant.Results: Out of 300 patients, 32.6% were ambulance users while 67.4% were non-ambulance user. Nosignificant difference was found in age, gender, underlying comorbidity, and initial presenting symptomsbetween two groups. Majority of ambulance users (74%) arrived in less than 45minutes. Differentcomplications were recorded but no significant difference was found between two groups. Majority ofambulance users 31.5% were neutral about the level of satisfaction for ambulance facilities.Conclusion: Frequency of ambulance utilization by STEMI patients is not only low in Pakistan, but ambulancesystem is also not successful in producing significant change in clinical outcomes. Therefore an awarenesscampaign along with ambulance improvement campaigns should be launched to bring a meaningful change.

Statistical Inference

2017 ◽  
pp. 114-139
Keyword(s):  
Statistical Inference ◽  
Random Sample ◽  
T Test ◽  
Entire Population ◽  
Inferential Statistics ◽  
Chi Square ◽  
Whitney Test ◽  
Chi Square Test ◽  
Student’S T ◽  
Student’S T Test

Statistical inference allows drawing conclusions from data. These analyses use a random sample of data taken from a population to describe and make inferences about the population. Inferential statistics are valuable when it is not convenient or possible to examine each member of an entire population. In this chapter, some concepts like ANOVA, Student's t-test, Chi-Square test, Mann-Whitney test and Kruskal-Wallis test will be presented. Given the insight of a particular phenomenon, after reading this chapter, the analyst will be able to, from that knowledge, infer possible new results.

scholarly journals Η διακύμανση των μεταβολικών παραμέτρων πριν και μετά εφαρμογή CPAP σε ασθενείς με υπνοαπνοϊκό σύνδρομο

2015 ◽  
Author(s):  
Καταλίν Φέκετε
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
T Test ◽  
Chi Square ◽  
Chi Square Test ◽  
Student’S T ◽  
Paired T Test ◽  
Student’S T Test

Το Σύνδρομο Αποφρακτικών Απνοιών-Υποπνοιών στον ύπνο (ΣΑΑΥΥ) έχει συσχετιστεί με την παρουσία αυξημένης δραστηριότητας του συμπαθητικού συστήματος, ενδοκρινικών διαταραχών και μεταβολικών ανωμαλιών. Ο σκοπός της μελέτης ήταν να διερευνήσει: την πιθανή επίδραση του ΣΑΑΥΥ στον μεταβολικό ρυθμό ηρεμίας (ΜΡΗ) όπως αυτός μετράται αμέσως προ και μετά τον νυχτερινό ύπνο, την επίδραση εφ’ άπαξ εφαρμογής συσκευής ρινικής continuous positive airway pressure (CPAP) στη μεταβλητότητα του ΜΡΗ μεταξύ ασθενών με ΣΑΑΥΥ και τον επιπολασμό του μεταβολικού συνδρόμου, μεταξύ ασθενών με ΣΑΑΥΥ και μαρτύρων χωρίς ΣΑΑΥΥ. Πρόκειται για μια ενσωματωμένη σε κοόρτη μελέτη ασθενών και μαρτύρων. Συγκροτήθηκαν δύο ομάδες: η ομάδα των αρρένων ασθενών με ΣΑΑΥΥ και η όμοια σε φύλο και ηλικία ομάδα των μαρτύρων, δηλαδή των ατόμων χωρίς ΣΑΑΥΥ. Και οι δύο ομάδες υπεβλήθησαν σε ανθρωπομετρικές μετρήσεις, πολυκαταγραφική μελέτη ύπνου και μέτρηση του ΜΡΗ με έμμεση θερμιδομετρία προ και μετά του ύπνου. Οι ασθενείς με ΣΑΑΥΥ επανέλαβαν τις μετρήσεις του ΜΡΗ προ και μετά την εφ’ άπαξ εφαρμογή συσκευής CPAP. Ο ΜΡΗ συγκρίθηκε προ και μετά ύπνου σε κάθε ομάδα χρησιμοποιώντας το paired t-test κατά ζεύγη ανάλυση ή το βαθμονομημένη δοκιμασία κατά Wilcoxon, ανάλογα με την κανονικότητα ή μη της κατανομής των μεταβλητών. Οι συγκρίσεις μεταξύ των ομάδων ασθενών-μαρτύρων και μεταξύ των σταδίων βαρύτητας του ΣΑΑΥΥ πραγματοποιήθηκε με χρήση του Student’s t-test ή του Mann-Whitney U test, για τις συνεχείς μεταβλητές και με το Chi-square test για τις κατηγορικές μεταβλητές. Ο επιπολασμός του μεταβολικού συνδρόμου ήταν σημαντικά υψηλότερος μεταξύ των ασθενών σε σύγκριση με τους μάρτυρες και σημαντικά υψηλότερος μεταξύ των ασθενών με μέτριο ή βαρύ. Σε ασθενείς με ΣΑΑΥΥ ο ΜΡΗ μετρούμενος προ και μετά του ύπνου ήταν σημαντικά διαφορετικός. Επιπλέον ανάλυση ανέδειξε ότι οι διαφορές στον ΜΡΗ προ και μετά του ύπνου ήταν στατιστικά σημαντικές μεταξύ των ασθενών με μέσης βαρύτητας και βαρύ σύνδρομο, αλλά όχι μεταξύ αυτών με ήπιο σύνδρομο. Μεταξύ των μαρτύρων δεν παρατηρήθηκαν στατιστικά σημαντικές διαφορές στις τιμές του ΜΡΗ προ και μετά του ύπνου. Έπειτα από εφ’ άπαξ εφαρμογή ρινικής CPAP οι ασθενείς με επαρκή ανταπόκριση σε αυτό παρουσίασαν παρόμοιες τιμές ΜΡΗ προ και μετά του ύπνου. Αντίθετα, οι ασθενείς με μη επαρκή ανταπόκριση, οι διαφορές στις τιμές του ΜΡΗ προ και μετά ύπνου, παρέμειναν στατιστικά σημαντικές. Το μεταβολικό σύνδρομο είναι μια συνήθης μεταβολική διαταραχή μεταξύ ασθενών με ΣΑΑΥΥ και ειδικότερα μεταξύ αυτών με βαρύτερη νόσο. Οι ασθενείς με μέτριας βαρύτητας ή βαρύ ΣΑΑΥΥ παρουσιάζουν στατιστικά σημαντικές διαφοροποιήσεις στην τιμή του ΜΡΗ προ και μετά του νυχτερινού ύπνου, σε σύγκριση τόσο με τους ασθενείς με ήπιο σύνδρομο, όσο και με τους μάρτυρες χωρίς ΣΑΑΥΥ. Η εφ’ άπαξ χορήγηση ρινικής CPAP εξαλείφει τις διαφοροποιήσεις στις μετρήσεις του ΜΡΗ προ και μετά ύπνου μεταξύ των ασθενών με επαρκή ανταπόκριση στη θεραπεία, αλλά όχι μεταξύ των υπολοίπων.

scholarly journals Ανοσολογική διερεύνηση των παιδιών με κοιλιοκάκη

2014 ◽  
Author(s):  
Μαρουδιά Κρίνη
Keyword(s):  
Logistic Regression ◽  
T Test ◽  
Odds Ratios ◽  
Chi Square ◽  
Exact Test ◽  
Fisher's Exact Test ◽  
Fisher’S Exact Test ◽  
Chi Square Test ◽  
Student’S T ◽  
Student’S T Test

Σκοπός της παρούσας διδακτορικής διατριβής ήταν να διερευνήσει την κατανομή των HLA-DRB1, DQA1 και DQB1 αλληλομόρφων γονιδίων, των απλοτύπων και γονοτύπων στον ελληνικό παιδιατρικό πληθυσμό με κοιλιοκάκη, σε σύγκριση με τους υγιείς μάρτυρες, και να αξιολογήσει την επίδραση των HLA τάξης ΙΙ γονιδίων στην επιδεκτικότητα της νόσου. Παράλληλα, αναζητήθηκαν συσχετίσεις του HLA-γενετικού υποστρώματος των ασθενών με τα κλινικά, επιδημιολογικά, ορολογικά και ιστολογικά χαρακτηριστικά της νόσου.Μελετήθηκαν 118 παιδιά με κοιλιοκάκη ελληνικής καταγωγής. Oι συμπτωματικοί ασθενείς ταξινομήθηκαν σε 3 ομάδες ως εξής: ομάδα Α = DQB1*02 ομοζυγώτες, ομάδα Β = DQB1*02 ετεροζυγώτες και ομάδα Γ = DQB1*02 αρνητικοί ασθενείς. Ως ομάδα ελέγχου, για τη σύγκριση των αποτελεσμάτων της HLA τυποποίησης των ασθενών, χρησίμευσε η HLA τυποποίηση 120 υγιών ατόμων, δοτών αίματος και μυελού των οστών, μη συγγενών μεταξύ τους, ελληνικής καταγωγής και εθνικότητας. Η γονιδιακή HLA τυποποίηση πραγματοποιήθηκε με τις μεθόδους PCR-SSP και PCR-SSO. Η στατιστική ανάλυση περιελάμβανε τα Pearson’s Chi-Square test, Fisher’s exact test, Student’s t-test, Mann-Whitney και Kruskal-Wallis test. Ο βαθμός τη σχέσης ελέγχθηκε με ακριβή λογιστική παλινδρόμηση (exact logistic regression) και παρουσιάστηκε ως λόγος σχετικών πιθανοτήτων (odds ratios, OR). Tα αποτελέσματα έδειξαν στατιστικά αυξημένη συχνότητα των HLA-DQB1*02:01, DQB1*02:02, DQA1*02:01, DQA1*05:01, DRB1*03 και DRB1*07 και στατιστικά μειωμένη συχνότητα των HLA-DQB1*03:01, DQB1*05:01, DQB1*05:02, DQA1*01:01, DQA1*01:02, DQA1*01:04, DQA1*05:05, DRB1*01 και DRB1*16 στους ασθενείς σε σύγκριση με τους υγιείς μάρτυρες. Σε επίπεδο απλοτύπων, ο κύριος συσχετιζόμενος με την κοιλιοκάκη απλότυπος ήταν ο DR3-DQ2 και ακολούθησε ο DR7-DQ2. Το 95,8% των ασθενών με κοιλιοκάκη εκφράζει το DQ2 ή/και το DQ8 μόριο. Μόνο ένας στους 118 ασθενείς, που αντιστοιχεί σε πιθανότητα 0,8%, δεν εκφράζει κανένα από τα συσχετιζόμενα με την κοιλιοκάκη αλλήλια και είναι DQ2/DQ8/DQA1*05/DQB1*02 - αρνητικός. Τα αποτελέσματα της μελέτης έδειξαν μια στατιστικά σημαντική διαφορά στον τίτλο των ΕΜΑ αντισωμάτων μεταξύ των ομάδων Α και Γ. Αναλυτικά, οι τίτλοι των ΕΜΑ αντισωμάτων είναι σημαντικά υψηλότεροι στους HLA-DQB1*02 ομοζυγώτες σε σχέση με τους HLA-DQB1*02 αρνητικούς ασθενείς, γεγονός που πιθανόν να αντανακλά μια HLA-DQB1*02 δοσοεξαρτώμενη επίδραση στον τίτλο των ΕΜΑ αντισωμάτων.Συμπερασματικά, η παρούσα διατριβή περιγράφει για πρώτη φορά στον ελληνικό παιδιατρικό πληθυσμό τη συχνότητα εμφάνισης των HLA τάξης ΙΙ αλληλομόρφων γονιδίων, απλοτύπων και γονοτύπων, και επιβεβαιώνει τη συμβολή των HLA τάξης ΙΙ γονιδίων στη γενετική προδιάθεση της νόσου. Επιπλέον, παρέχει στοιχεία που υποδηλώνουν μια πιθανή HLΑ-DQB1*02 δοσοεξαρτώμενη επίδραση στον τίτλο των ΕΜΑ αντισωμάτων.

The Influence of Age and Gender on Mandibular Indices among the Libyan Population

2019 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Negative Correlation ◽  
Bone Mineralization ◽  
Age Groups ◽  
T Test ◽  
Chi Square ◽  
Age And Gender ◽  
Significant Difference ◽  
Chi Square Test ◽  
And Gender ◽  
Libyan Population

Radiographic Mandibular Indices serve as easy and relatively cheap tools for evaluating bone mineralization. Objectives: To examine the effect of age and gender on three mandibular indices: the panoramic mandibular index (PMI), the mandibular ratio (MR) and the mandibular cortical index (MCI), among Libyan population. Methods: The three indices were measured on 317 digital (OPGs) of adult humans (155 males, 162 females). The sample was divided into six age groups (from 18-25 years through 56-65 years). The measurements were analyzed for interactions with age and sex, using SPSS (Statistical Package for Social Studies) software version no. 22. The tests employed were two way ANOVA, the unpaired T-test and chi-square test. Results: The mean PMI fluctuated between 0.37 s.d. 0.012 and 0.38 s.d. 0.012. among the sixth age groups. One-way ANOVA statistical test revealed no significant of age on PMI. On the other hand gender variation has effect on PMI, since independent sample t-test disclosed that the difference between the male and female PMI means statistically significant. ANOVA test showed that the means of MR among age groups showed a negative correlation i.e. MR mean declined from 3.01 in 18-25 age groups to 2.7 in 55-65 age groups. In contrary, the gender showed no effect on MR according two sample t-test at p> 0.05. In regards with MCI, statistical analysis showed that it affected by age that is C1 was decreasing by age while C2 and C3 were increased by age. Using chi square test the result indicated that there is a significant difference among the different age group and the two genders in MCI readings. Conclusion: PMI was influenced significantly by age but minimally by the gender. MR is not affected by gender but has a negative correlation with age. MCI is affected by both age and gender

scholarly journals Effect of ondansetron on spinal induced hypotension in caesarean deliveries

2020 ◽  
Vol 8 (4) ◽  
pp. 193-199
Author(s):  
Pujan Balla ◽  
Anil Shrestha ◽  
Ninadini Shrestha ◽  
Navindra Bista ◽  
Moda Nath Marhatta
Keyword(s):  
Spinal Anesthesia ◽  
Elective Caesarean Section ◽  
P Value ◽  
Chi Square ◽  
Induced Hypotension ◽  
Intergroup Comparison ◽  
Chi Square Test ◽  
The Mean ◽  
Student’S T ◽  
Student’S T Test

Background: Spinal anesthesia is the preferred technique of anesthesia employed for caesarean sections. However, it is very often complicated by hypotension. Different drugs and techniques have been used to prevent the hypotension induced by spinal anesthesia. In this study, the effect of ondansetron on the prevention of hypotension after spinal anesthesia was evaluated. Objectives: To determine the effect of prophylactic ondansetron on prevention of spinal induced hypotension in elective caesarean section. Methodology: Eighty-six parturients planned for elective caesarean deliveries were randomized into two groups of 43 each. Group O received Ondansetron 4 mg (4 ml) and Group S received Normal Saline (4 ml) intravenously 10 minutes prior to spinal anesthesia. Blood pressure, heart rate, phenylephrine requirements, occurrence of nausea and vomiting and APGAR scores of neonates were compared between the groups. Hemodynamic data was analyzed using Student’s t-test for intergroup comparison and ANOVA was used for intragroup comparison. Categorical data was analyzed using Pearson Chi-Square test. For all determinants, p-value <0.05 was considered significant. Results: Occurrence of hypotension in Group O (20.9 %) was significantly lower than in Group S (72.1%) (p < 0.05). The mean arterial pressure was significantly higher in Group O at 2, 6, 8, 12 and 14 minutes (p < 0.05). The use of phenylephrine (37.21 mcg vs. 146.51 mcg, p < 0.05) and occurrence of nausea (11.6%, vs. 41.9% p < 0.002) was significantly lower in ondansetron group. Conclusion: Ondansetron is effective in preventing spinal induced hypotension in elective caesarean sections.

scholarly journals Fishery regulamentation or ethnoknowledge? The dilemma of the management of the mapará fisheries on the lower Tocantins river in northern Brazil

2021 ◽  
Vol 10 (11) ◽  
pp. e131101118963
Author(s):  
Esther Mirian Cardoso ◽  
Paulo Allison Costa da Mata ◽  
Matheus dos Santos Souza ◽  
Maria Clara Pinheiro de Souza ◽  
Victoria Isaac
Keyword(s):  
Socioeconomic Development ◽  
Economic Importance ◽  
Chi Square ◽  
Great Economic Importance ◽  
Chi Square Test ◽  
Northern Brazil ◽  
The Mean ◽  
Tocantins River ◽  
Student’S T ◽  
Student’S T Test

The fishery of mapará (Hypophthalmus marginatus) is of great economic importance in the Amazon region. Despite this, it is observed that the current norms of management disagree with the ethnoknowledge of fishermen of the Tocantins river. Therefore, there are many seizures and fines in the Tocantins Low region. This work appeared as a demand of the fishermen of the region and had as purpose to test the pertinence of the fishing legislation on the capture of the species and to provide subsidies for the adaptation of the norms to the local reality. For this, a mapará fishery was taken on the Pindobal Grande river, in the municipality of Igarapé-Miri, in the state of Pará. A sample of the captured individuals was collected, and identification, sexing and biometry were done. Fishing was described, and the sex ratio tested with the Chi-Square test and the mean length differences between the sexes with the Student's t-test. The results were compared with current legislation and literature data. The captured mapará individuals were mostly above 30 cm, as determined by legislation. It is concluded that, despite using a network that is prohibited, the capture of the species in the region acts selectively, due to the ethno-cognition and the fisherman's action ("taleiro"). Therefore, it is necessary that the legislation be revised, seeking the reconciliation between the conservation of ecosystems, the traditional knowledge and the socioeconomic development of the region.

scholarly journals Sports potential modeling of young basketball players: a preliminary analysis

2019 ◽  
Vol 21 ◽  
Author(s):  
Dilson Borges Ribeiro Junior ◽  
Jeferson Macedo Vianna ◽  
André de Assis Lauria ◽  
Emerson Filipino Coelho ◽  
Francisco Zacaron Werneck
Keyword(s):  
Adult Height ◽  
High Potential ◽  
Basketball Players ◽  
Chi Square ◽  
Chi Square Test ◽  
Student’S T ◽  
The Relationship ◽  
Student’S T Test ◽  
Adult Stature

Abstract The aims of this study were: 1) to evaluate the sports potential of young basketball players; 2) to identify variables that discriminate sports potential assessed by coaches; 3) to verifythe relationship between classification of the multidimensional profile of athletes and classification of the sports potential by coaches. Sixty-two young basketball players aged 15.6±1.1 years from U-15 (n = 24) and U-17 (n = 38) categories participated in the study. A test battery was applied to evaluate sports potential indicators: 1) anthropometric; 2) physicomotor; 3) psychological;4) skills;5) socio-environmental;6) maturational and 7) sports potential.Clusteranalysis was performed in three groups: high, medium and low potential. Student’s t-test was used for the comparison between athletes evaluated by the coach as excellent and the others and the Chi-Square test to verify the relationship between sports potential classifications. It was observed that in the high-potential group, athletes were chronologically older, with higher % predicted adult height (PMS), competitive and determined sports orientation, higher body size, lower skinfold summation, and greater physicomotor performance. In comparison with other athletes, high-potential basketball players presented higher stature, wider wingspan,longer limb length, greater predicted adult stature and higher Z score of the % PMS. It could be concluded that the multidimensional approach was useful for the evaluation of the sports potential of young basketball players, requiring the use of multidimensional variables, in addition to coaches’ opinion regarding the potential of their athletes.

scholarly journals THE RELIABILITY OF THE BOLTON RATIO WHEN APPLIED TO THE INDONESIAN POPULATION

2017 ◽  
Vol 10 (10) ◽  
pp. 176
Author(s):  
Joko Kusnoto
Keyword(s):  
T Test ◽  
Tooth Size ◽  
Crown Width ◽  
Indonesian Population ◽  
Significant Difference ◽  
The Mean ◽  
Anterior Ratio ◽  
Overall Ratio ◽  
Student’S T ◽  
Student’S T Test

  Objective: The objective of this study is to determine whether Bolton ratio can be applied clinically to the Indonesian population and to determine a more suitable Bolton ratio for the Indonesian population.Methods: This study was conducted on 120 readily available study models of treated cases comprising 37 males and 83 females. Two investigators separately measured the mesiodistal crown width of maxillary and mandibular tooth on each study model using sliding calipers. According to Bolton’s method, the overall and anterior ratios from each sample were calculated and the mean was generated. Using Student’s t-test with a 95% confidence interval, the investigators compared whether there is a significant difference between the ratio from Bolton’s samples and the ratio from the Indonesian samples.Results: The result of this study showed that, for Indonesian samples, the overall ratio is 89.7±2.05, while the anterior ratio is 76.4±2.76. Student’s t-test showed that there is a statistically significant difference (p<0.05) between the results of this study and that of Bolton’s study for both the anterior and overall ratios.Conclusion: It can be concluded that there is a difference between Indonesian population and Caucasian population in tooth size and Bolton ratio value. Therefore, original Bolton ratio value cannot be used as an accurate diagnostic tool for Indonesian population.

Combination Therapy Of Tadalafil And Pentoxifylline In Severe Erectile Dysfunction; A Prospective Randomized Trial

2015 ◽  
Vol 87 (8) ◽  
Author(s):  
Santosh Kumar ◽  
Rajesh Roat ◽  
Swati Agrawal ◽  
Kumar Jayant ◽  
Ravimohan S. Mavuduru ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Combination Therapy ◽  
Erectile Function ◽  
T Test ◽  
P Value ◽  
Chi Square ◽  
Significant Difference ◽  
Chi Square Test ◽  
Group A ◽  
Group B

Abstractwas to assess efficacy of Tadalafil alone versus Tadalafil plus Pentoxifylline in the treatment of erectile dysfunction by using self administered IIEF-5 questionnaire.Two hundred and thirty seven patients presenting with ED at andrology OPD were evaluated for ED by a self administered IIEF (International Index of Erectile Function) questionnaire. Patients were systematically randomized by computer generated random table into two groups groups namely, group A: Tadalafil only group, group B: combination of Tadalafil + Pentoxifyl-line. All the patients were re-assessed by IIEF-5 questionnaire after 8 weeks of medical therapy. Statistical analysis was performed using student’s unpaired t-test, paired t-test, chi square test. p-value < 0.05 was considered statistically significant.Two hundred and thirty seven patients were included in the present study, in group A: 92 patients (78.6%) showed improvement in their IIEF score after 8 weeks of tadalafil treatment. While in group B, overall 104 patients(86.6%) showed improvement after combination of Tadalafil and Pentoxifylline. There was a statistically significant difference of percentage change in IIEF score was seen in group B (group A 90.7±15.2%, group B 95.6±13.4%; p value – 0.014). We found this difference even more statistically significant in patients with severe ED (group A 72.7±47.2%, group B 132.3±54.3%; p value – 0.000). There was no significant difference in between the two groups with regards to occur-rence of side effects.Both tadalafil and combination of Tadalafil + Pentoxifylline improve erectile function in patients of ED. Patients with severe ED showed much significant improvement in erectile function with combination therapy.

Sign in / Sign up

Export Citation Format

Share Document