This study used to address the most organized information about clinical demonstration and epidemiological impacts and the new pandemic zoonotic disease called corona virus. Background: The new respiratory virus known as corona (COVID-19) first originated in China at Wuhan, and rapidly spreading to all worldwide continents. The common cold, SARS, MERS and COVID-19 are types of corona viruses, and most people get infected with one or more of these viruses at some point in their lives. COVID-19 is viruses known for containing strains of lethal diseases in mammals and birds, its infections rate is doubling at every six days, infecting large number of people, its name is given from the protrude spikes surfaces, infect the respiratory tract of animals and human, transmit via droplets and contact. Objectives: The objectives of this study is to address scientific information’s about zoonotic disease called COVID-19, its clinical display like symptoms, ways of transmission, prevention methods, epidemiology and complications. Methods: Observing what is happening in the world, and collecting epidemiological data from WHO about COVID-19, organizing and rewrite in scientific methods. Results and Conclusion: Zoonotic diseases are diseases first transmit from infected animal to humans, animals such as bat, rat, pig, insects, fish, etc. The novel COVID-19 have been first originated in Wuhan from seafood sale market of sells fish, bats, snakes and pangolins and highly spreading globally. It is a pandemic zoonotic disease, infecting every individual of human being at any age, sex, race, religions, lifestyle, educational level, etc. Its similar symptoms with other corona viruses type such as strong fever, high elevated body temperature, dry cough, muscle fatigue, breathing difficulties, etc and also less common symptoms includes coughing mucus or blood, headaches, diarrhea, and kidney failure. In addition, as the disease progresses, patients approach with pneumonia, inflames the lungs and causes alveoli to fill with fluid and this can be detected by an X-ray. Its primary ways of transmission includes respiratory droplets from coughing and sneezing of fluid produced by infected individuals, touching contaminated surfaces, hands and objects with our hands then our mouth, nose and eye. Based on worldwide epidemiological data, more than 2.8 million people were infected, of which about 200,000 were died within 100 days, whereas, about 25 million people were infected, of which more than 846,000 were died within 220 days and also it creates negative economic impacts especially in developing countries. However, till now there is no recognized therapeutic against corona viruses, therefore advisable prevention methods are washing our hands regularly with soap, use hand sanitizer properly, during coughing and sneezing use inside of our elbow, stop handshaking with anyone, stay at home to limit social co