scholarly journals Artificial Reproductive Technology – A Risk Factor for Retinopathy of Prematurity

2018 ◽  
Vol 6 (11) ◽  
pp. 2245-2249 ◽  
Author(s):  
Kalina Trifonova ◽  
Kiril Slaveykov ◽  
Hristo Mumdzhiev ◽  
Dimitar Dzhelebov
Keyword(s):  
Risk Factor ◽  
Retinopathy Of Prematurity ◽  
Risk Group ◽  
Meta Analysis ◽  
Fold Increase ◽  
Reproductive Technology ◽  
Premature Babies ◽  
Background Retinopathy ◽  
Significant Pathology ◽  
Artificial Reproductive Technology

BACKGROUND: Retinopathy of Prematurity (ROP) is a potentially blinding vasoproliferative disease in premature babies. The presentation and course of ROP are determined by a complex interaction of a series of risk factors, including artificial reproductive technology (ART). AIM: To analyse and combine the information relating ART as an independent risk factor for retinopathy of prematurity. METHODS AND MATERIAL: The article is systematic review and meta-analysis using RevMan 5. Pubmed, Scopus and Medline were searched for articles from 1990 to 2018. RESULTS: Studies suggest that ROP is observed more frequently in ART children. They are more likely to be premature and of low birth weight than those conceived naturally. Results vary from just a tendency to a five-fold increase in risk to develop ROP in ART babies. At the same time, they might develop ROP later, and more mature newborns might be affected. CONCLUSION: The data relating ART as a risk factor for ROP is inconclusive, but most studies show at least a tendency. The ART newborns need to be considered as a risk group for ROP and observed with greater suspicion. Even more mature ART newborns might need to be screened in order not to miss any significant pathology.

scholarly journals Is Artificial Reproductive Technology a Risk Factor for Retinopathy of Prematurity Independent of the Generation of Multiple Births?

2016 ◽  
Vol 27 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Lucy Barker ◽  
Catey Bunce ◽  
Shahid Husain ◽  
Gill G.W. Adams
Keyword(s):  
Risk Factor ◽  
Retinopathy Of Prematurity ◽  
Reproductive Technology ◽  
Multiple Births ◽  
Considerable Proportion ◽  
Multiple Birth ◽  
Retrospective Audit ◽  
Significant Difference ◽  
Artificial Reproductive Technology ◽  
Rop Screening

Purpose There is some debate regarding whether artificial reproductive technology (ART) constitutes an independent risk factor for retinopathy of prematurity (ROP). We wanted to assess the prevalence of ART in multiple birth infants seen for ROP screening and whether or not ROP was identified or treated, in order to evaluate whether ART contributes a risk factor for ROP independent of the generation of multiple births. Methods A retrospective audit was performed of all multiple birth babies admitted to a tertiary neonatal unit who met the UK ROP screening criteria (<32 weeks gestational age [GA] and/or <1,501 g birthweight [BW]). Results A total of 205 babies met our criteria, of whom 87.3% were twins. A total of 39.5% were born following ART. A total of 30.5% of the non-ART group developed ROP vs 34% of the ART group (p = 0.837). Stage 3 ROP developed in 5.1% of non-ART babies and 6% of ART babies. A total of 8.5% of non-ART babies and 10% of ART babies required treatment for ROP. Logistic regression demonstrated that ART was not independently associated with development of ROP. Conclusions Artificial reproductive technology multiple birth babies make up a considerable proportion of the ROP screening burden and their number is likely to increase as ART is increasingly available and utilized. We found no significant difference between the numbers of babies developing ROP in the ART vs non-ART groups, but the numbers are small. The estimated odds of developing ROP are slightly higher in the ART babies, so our data do not rule out a possible association.

Chorioamnionitis as a Risk Factor for Retinopathy of Prematurity: A Systematic Review and Meta-Analysis

Neonatology ◽  
2014 ◽  
Vol 105 (3) ◽  
pp. 189-199 ◽  
Author(s):  
Souvik Mitra ◽  
Dagfinn Aune ◽  
Christian P. Speer ◽  
Ola Didrik Saugstad
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Retinopathy Of Prematurity ◽  
Meta Analysis

scholarly journals Chorioamnionitis as a risk factor for retinopathy of prematurity: an updated systematic review and meta-analysis

2018 ◽  
Author(s):  
Eduardo Villamor-Martinez ◽  
Giacomo Cavallaro ◽  
Genny Raffaeli ◽  
Owais M. M. Mohammed Rahim ◽  
Amro M. T. Ghazi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Birth Weight ◽  
Retinopathy Of Prematurity ◽  
Very Low Birth Weight ◽  
Meta Analysis ◽  
Primary Data ◽  
Significant Positive Association ◽  
Severe Stage

AbstractThe role of chorioamnionitis (CA) in the development of retinopathy of prematurity (ROP) is difficult to establish, because CA-exposed and CA-unexposed infants frequently present different baseline characteristics. We performed an updated systematic review and meta-analysis of studies reporting on the association between CA and ROP. We searched PubMed and EMBASE for relevant articles. Studies were included if they examined preterm or very low birth weight (VLBW, <1500g) infants and reported primary data that could be used to measure the association between exposure to CA and the presence of ROP. Of 748 potentially relevant studies, 50 studies met the inclusion criteria (38,986 infants, 9,258 CA cases). Meta-analysis showed a significant positive association between CA and any stage ROP (odds ratio [OR] 1.39, 95% confidence interval [CI] 1.11 to 1.74). CA was also associated with severe (stage ≥3) ROP (OR 1.63, 95% CI 1.41 to 1.89). Exposure to funisitis was associated with a higher risk of ROP than exposure to CA in the absence of funisitis. Additional meta-analyses showed that infants exposed to CA had lower gestational age (GA) and lower birth weight (BW). Meta-regression showed that lower GA and BW in the CA-exposed group was significantly associated with a higher risk of ROP. In conclusion, our study confirms that CA is a risk factor for developing ROP. However, part of the effects of CA on the pathogenesis of ROP may be mediated by the role of CA as an etiological factor for very preterm birth.

scholarly journals Chorioamnionitis as a risk factor for retinopathy of prematurity: An updated systematic review and meta-analysis

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205838 ◽  
Author(s):  
Eduardo Villamor-Martinez ◽  
Giacomo Cavallaro ◽  
Genny Raffaeli ◽  
Owais M. M. Mohammed Rahim ◽  
Silvia Gulden ◽  
...  
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Retinopathy Of Prematurity ◽  
Meta Analysis

scholarly journals Association between Artificial Reproductive Technology and Retinopathy of Prematurity

2021 ◽  
Vol 9 (B) ◽  
pp. 6-11
Author(s):  
Kiril Slaveykov ◽  
Kalina Trifonova ◽  
Hristo Mumszhiev
Keyword(s):  
Retinopathy Of Prematurity ◽  
Neonatal Intensive Care ◽  
Newborn Infants ◽  
Significant Risk ◽  
Reproductive Technology ◽  
Reproductive Age ◽  
University Hospital ◽  
Screening Criteria ◽  
Logistic Regression Models ◽  
Artificial Reproductive Technology

BACKGROUND: Infertility is an increasingly common health problem which affects approximately 10% of the women in reproductive age. Artificial reproductive technology (ART), which is the modern solution to infertility, unfortunately has been linked to increased prevalence of prematurity and low birth weight (BW) in the newborn. That’s why ART infants make up a considerable portion of the retinopathy of prematurity (ROP) screening burden, which is likely to increase, as ART becomes increasingly available and utilized. AIM: The aim of the study was to assess the association between ART and the development of ROP. MATERIALS AND METHODS: Retrospective analysis of preterm infants screened for ROP at the Neonatal Intensive Care Unit in the University Hospital â€oeProf. Dr. Stoyan Kirkovich” Stara Zagora, Bulgaria, by single factor and multifactor logistic regression models. RESULTS: During a 4-year period (2016–2019), 419 infants, meeting the screening criteria, were admitted in the ward. Out of them, 265 were conceived naturally and 154 through ART. Thirty-two (7.6%) children required laser treatment for ROP, among which 15 (46.87%) were conceived naturally and 17 (53.12%) by ART. Multifactor analyses proves BW (odds ratio [OR] 0.99; confidence interval [CI], 0.98–0.99; p = 0.008) and gestational age (GA) (OR 0.296; 95% CI 0.09–0.88; p = 0.029) as significant risk factors for severe ROP, requiring treatment. CONCLUSION: ART is a risk factor for ROP due to its association with lower BW and GA of the newborn infants, rather than directly increasing the possibility for it. Nevertheless, there is a pronounced trend for more severe ROP to develop in ART children, when compared to naturally conceive in the same weight group.

scholarly journals Caesarean section in pregnancies conceived by assisted reproductive technology: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nakeisha A. Lodge-Tulloch ◽  
Flavia T. S. Elias ◽  
Jessica Pudwell ◽  
Laura Gaudet ◽  
Mark Walker ◽  
...  
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Caesarean Section ◽  
Assisted Reproductive Technology ◽  
Intracytoplasmic Sperm Injection ◽  
Meta Analysis ◽  
Fold Increase ◽  
Reproductive Technology ◽  
Vitro Fertilization

Abstract Background Caesarean section rates are higher among pregnancies conceived by assisted reproductive technology (ART) compared to spontaneous conceptions (SC), implying an increase in neonatal and maternal morbidity. We aimed to compare caesarean section rates in ART pregnancies versus SC, overall, by indication (elective versus emergent), and by type of ART treatment (in-vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), fresh embryo transfer, frozen embryo transfer) in a systematic review and meta-analysis. Methods We searched Medline, EMBASE and CINAHL databases using the OVID Platform from 1993 to 2019, and the search was completed in January 2020. The eligibility criteria were cohort studies with singleton conceptions after in-vitro fertilization and/or intracytoplasmic sperm injection using autologous oocytes versus spontaneous conceptions. The study quality was assessed using the Newcastle Ottawa Scale and GRADE approach. Meta-analyses were performed using odds ratios (OR) with a 95% confidence interval (CI) using random effect models in RevMan 5.3, and I-squared (I2) test > 75% was considered as high heterogeneity. Results One thousand seven hundred fifty studies were identified from the search of which 34 met the inclusion criteria. Compared to spontaneous conceptions, IVF/ICSI pregnancies were associated with a 1.90-fold increase of odds of caesarean section (95% CI 1.76, 2.06). When stratified by indication, IVF/ICSI pregnancies were associated with a 1.91-fold increase of odds of elective caesarean section (95% CI 1.37, 2.67) and 1.38-fold increase of odds of emergent caesarean section (95% CI 1.09, 1.75). The heterogeneity of the studies was high and the GRADE assessment moderate to low, which can be explained by the observational design of the included studies. Conclusions The odds of delivering by caesarean section are greater for ART singleton pregnancies compared to spontaneous conceptions. Preconception and pregnancy care plans should focus on minimizing the risks that may lead to emergency caesarean sections and finding strategies to understand and decrease the rate of elective caesarean sections.

scholarly journals Prevalence and Risk Factors for Retinopathy of Prematurity in China: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Qi Lumin ◽  
Gu Ziying ◽  
Sun Xincheng
Keyword(s):  
Risk Factors ◽  
Environmental Exposure ◽  
Retinopathy Of Prematurity ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Mainland China ◽  
Fixed Effects Model ◽  
Premature Babies ◽  
Meta Analyses ◽  
Rop Screening

Abstract Background The etiology of retinopathy of prematurity (ROP) is thought to be related to genetic susceptibility and environmental exposure factors. The purpose of this article was to estimate the prevalence of ROP in mainland China and to attempt to summarize the environmental risk factors for ROP in Chinese infants. Method We searched 9 databases for articles that were published before May 29, 2021, and studies describing the prevalence and risk factors for ROP in Chinese infants were included. The fixed-effects model and the random-effects model were applied to the effect sizes (ES) and their 95% confidence intervals (CIs) with I2≤50% and I2>50% in the heterogeneity tests, respectively. Results Twenty-two separate populations were included in the meta-analysis of the prevalence of ROP. The prevalence of ROP in mainland China was 9.284% (95% CI: 6.546-12.022%). It was negatively correlated with birth weight (BW) and gestational age (GA). Fifty independent meta-analyses were observed to be related to environmental exposure factors of ROP. Thirty of the 50 meta-analyses had results that were significant at p values less than 0.05. The first three risk factors with the largest combined effect size were GA≤34 w, bronchopulmonary dysplasia (BPD) and BW≤2,000 g. Conclusions Approximately one in ten immature infants suffered from ROP. More studies need to be included. Premature babies with diseases that cause hypoxia and irregular oxygen use should be paid more attention for ROP screening.

scholarly journals Caesarean Section in Pregnancies Conceived by Assisted Reproductive Technology: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Nakeisha A Lodge-Tulloch ◽  
Flavia T. S. Elias ◽  
Jessica Pudwell ◽  
Laura Gaudet ◽  
Mark Walker ◽  
...  
Keyword(s):  
Systematic Review ◽  
In Vitro Fertilization ◽  
Caesarean Section ◽  
Assisted Reproductive Technology ◽  
Intracytoplasmic Sperm Injection ◽  
Meta Analysis ◽  
Fold Increase ◽  
Reproductive Technology ◽  
Vitro Fertilization

Abstract Background: Caesarean section rates are higher among pregnancies conceived by assisted reproductive technology (ART) compared to spontaneous conceptions (SC), implying an increase in neonatal and maternal morbidity. We aimed to compare caesarean section rates in ART pregnancies versus SC, overall, by indication (elective versus emergent), and by type of ART treatment (in-vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), fresh embryo transfer, frozen embryo transfer) in a systematic review and meta‐analysis.Methods: We searched Medline, EMBASE and CINAHL databases using the OVID Platform from 1993-2019, and the search was completed in January 2020. The eligibility criteria were cohort studies with singleton conceptions after in-vitro fertilization and/or intracytoplasmic sperm injection using autologous oocytes versus spontaneous conceptions. The study quality was assessed using the Newcastle Ottawa Scale. Meta-analyses were performed using odds ratios (OR) with a 95% confidence interval (CI) using random effect models in RevMan 5.3, and I-squared (I2) test > 75% was considered as high heterogeneity.Results: 1750 studies were identified from the search of which 34 met the inclusion criteria. Compared to spontaneous conceptions, IVF/ICSI pregnancies were associated with a 1.93-fold increase of odds of caesarean section (95% CI 1.78, 2.09). When stratified by indication, IVF/ICSI pregnancies were associated with a 2.12-fold increase of odds of elective caesarean section (95% CI 1.63, 2.77) and 1.57-fold increase of odds of emergent caesarean section (95% CI 1.27, 1.95). Conclusions: The odds of delivering by caesarean section are greater for ART singleton pregnancies compared to spontaneous conceptions. Preconception and pregnancy care plans should focus on minimizing the risks that may lead to emergency caesarean sections and finding strategies to understand and decrease the rate of elective caesarean sections.

scholarly journals The Risk of Retinopathy of Prematurity in the Infants following Assisted Reproductive Technology: A Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Lixiong Gao ◽  
Weiyang Shao ◽  
Na Li ◽  
Chunyu Tian ◽  
Hongzhen Jia ◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Retinopathy Of Prematurity ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Reproductive Technology ◽  
Cochrane Library ◽  
Large Sample Size ◽  
Stage 1 ◽  
Risk Of Retinopathy

Currently, the use of assisted reproductive technology (ART) is increasing. Because of the poor prognosis of retinopathy of prematurity (ROP), the association between ART and the ROP has been explored in several studies, but the result was still inconclusive. Conducting a meta-analysis, we evaluated the risk of ROP in relation to the ART. Subgroup analysis as well as groups with different embryo numbers and different ROP stages was further analyzed. The PubMed, Embase, and Cochrane Library databases were searched for studies recording data about both the use of ART and ROP occurrence simultaneously. Odds ratios (ORs) and 95% confidence interval (95%CI) were calculated to analyze the association by using random- or fixed-effect models based on heterogeneity test. In total 15 observational studies containing 10392 ART cases and 39474 spontaneous conception cases were included. Results showed that there was a significant association between the use of ART and ROP occurrence in the offspring (OR = 1.34, 95% CI: 1.05 to 1.73, P = 0.02). With subgroup analysis, we found that the influence actually came from a subgroup of ART, the in vitro fertilization (IVF). Moreover, there was a significant association between ART and ROP in singletons. Though insignificant, the ORs were larger than 1 in the analysis between ART and stage 1 and 2 ROP. But ART showed significant association with stage 3 ROP. Our study preliminarily indicated that the use of IVF was associated with higher risk of ROP occurrence. And ART is more likely to result in severe ROP and ROP in singletons. Further specific, high-quality studies with large sample size are still needed to draw more precise conclusion.

Sign in / Sign up

Export Citation Format

Share Document