Endocrine Comorbidities in Patients with Psoriatic Arthritis: A Population-based Case-controlled Study

2017 ◽  
Vol 44 (6) ◽  
pp. 786-790 ◽  
Author(s):  
Amir Haddad ◽  
Ron Ilan Ashkenazi ◽  
Haim Bitterman ◽  
Ilan Feldhamer ◽  
Sari Greenberg-Dotan ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Multivariable Analysis ◽  
Population Based ◽  
Cross Sectional Study ◽  
Controlled Study ◽  
Control Group ◽  
Cushing Disease ◽  
Cross Sectional ◽  
Addison Disease ◽  
Multivariable Regression

Objective.To investigate endocrine comorbidities in patients with psoriatic arthritis (PsA).Methods.A retrospective, cross-sectional study was performed with the database of Clalit Health Services, the largest healthcare provider in Israel, between 2002 and 2014. Patients with PsA were identified and matched by age and sex to healthy controls. The following morbidities were analyzed: hypo/hyperthyroidism, hypo/hyperparathyroidism, hyperprolactinemia, Cushing disease, Addison disease, diabetes insipidus, diabetes mellitus (DM), pituitary adenoma, acromegaly, and osteoporosis. Descriptive statistics were applied. The associations between PsA and endocrine comorbidities were analyzed by univariable and multivariable analysis.Results.The study included 3161 patients with PsA, 53.4% women, mean age 58.4 ± 15.4 years, and 31,610 controls. Comparative analyses yielded higher proportion of hypothyroidism (12.7% vs 8.6%, p < 0.0001), Cushing disease (0.3% vs 0.1%, p < 0.0001), osteoporosis (13.2% vs 9.1%, p < 0.0001), and DM (27.9% vs 20.7%, p < 0.0001) in the PsA group compared with the control group. In the multivariable regression analysis, the following diseases were more frequent in the PsA group: hypothyroidism (OR 1.61, 95% CI 1.47–1.81), DM (OR 1.35, 95% CI 1.18–1.42), Cushing disease (OR 3.96, 95% CI 1.67–9.43), and osteoporosis (OR 1.56, 95% CI 1.37–1.78).Conclusion.PsA is associated with a high frequency of hypothyroidism, osteoporosis, DM, and Cushing disease. Awareness of these comorbidities may help physicians provide the optimal medical care to patients with PsA.

scholarly journals Higher prevalence of psoriatic arthritis in the adult population in Spain? A population-based cross-sectional study

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0234556
Author(s):  
Antonio Romero Pérez ◽  
Rubén Queiro ◽  
Daniel Seoane-Mato ◽  
Eduard Graell ◽  
Eugenio Chamizo ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Adult Population ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Burden and Disease Characteristics of Patients with Psoriatic Arthritis: A Population-based Cross-sectional Study

2019 ◽  
Vol 46 (7) ◽  
pp. 716-720 ◽  
Author(s):  
Hasan G. Tekin ◽  
Jashin J. Wu ◽  
Russel Burge ◽  
Julie Birt ◽  
Alexander Egeberg
Keyword(s):  
Psoriatic Arthritis ◽  
Population Based ◽  
Cross Sectional Study ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Considerable Proportion ◽  
Antiinflammatory Drugs ◽  
Cross Sectional ◽  
Disease Characteristics ◽  
Systemic Corticosteroids ◽  
Comorbid Diseases

Objective.To describe the prevalence and treatment regimes, disease characteristics, and comorbid diseases among patients with psoriatic arthritis (PsA) in Denmark.Methods.All Danish individuals aged ≥ 18 years with rheumatologist-diagnosed PsA were linked in nationwide administrative registers.Results.Among 4.7 million individuals in Denmark, 10,577 patients with PsA had been diagnosed by a rheumatologist. A female predominance (54.5–59.8%) was seen among patients with PsA, and about half of the patients (53.0%) had received no treatment or treatment only with nonsteroidal antiinflammatory drugs/systemic corticosteroids, while 32.9% had received nonbiological disease-modifying antirheumatic drugs (DMARD) and 14.1% had been treated with biologicals. Cutaneous psoriasis was recorded in 66.2–72.3% of patients with PsA, and patients with severe PsA had the highest prevalences of distal interphalangeal arthropathy, spondylitis, and arthritis mutilans. Smoking and comorbid diseases such as hypertension, diabetes, depression, and anxiety were seen frequently in patients with PsA, but did not significantly differ across severities of PsA.Conclusion.Disease burden appeared to be significant in patients with PsA across all severities. A considerable proportion of patients with PsA did not receive active antipsoriatic treatment, and about 1 out of 3 patients was not diagnosed with psoriasis. Cutaneous symptoms of psoriasis in patients with PsA might be either underreported or undertreated.

scholarly journals Perceived loneliness among home-dwelling older adults with and without memory disorder: A population-based study

2018 ◽  
Vol 39 (2) ◽  
pp. 76-84
Author(s):  
Minnaleena Ollanketo ◽  
Raija Korpelainen ◽  
Timo J Jämsä ◽  
Maarit Kangas ◽  
Heli Koivumaa-Honkanen ◽  
...  
Keyword(s):  
Older Adults ◽  
Perceived Stress ◽  
Healthcare Services ◽  
Population Based ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Memory Disorder ◽  
Emotional Loneliness ◽  
With Memory

The aim of this population-based cross-sectional study was to describe and compare the prevalence and features of perceived loneliness among home-dwelling older adults with ( n = 129) and without ( n = 244) memory disorder. The latter group was randomly resampled from 789 respondents stratified by age to obtain a standardized control group. Loneliness was assessed using the six-item De Jong Gierveld Loneliness Scale, and perceived stress using Cohen, Kamarck and Mermelstein’s 10-item Perceived Stress Scale. Results show that severe loneliness was common among the home-dwelling older adults, especially those with memory disorder, who also perceived stress more frequently than those without memory disorder. Both groups, but again more frequently those with memory disorder, were more likely to be emotionally than socially lonely. Thus, when planning social and healthcare services and interventions to mitigate loneliness among older adults living at home, memory problems and emotional loneliness require particular consideration.

scholarly journals The Impact of Testicular Loss on The Psychopathology of Young Patients: Population-Based Analysis Of 4 Million Examinees of Manpower Administration Database

2016 ◽  
Vol 9 (1) ◽  
pp. 147-147
Author(s):  
S. Lee ◽  
◽  
J. Kim ◽  
K. Moon ◽  
J. Park ◽  
...  
Keyword(s):  
Young Patients ◽  
Final Analysis ◽  
Population Based ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Abnormal Rate ◽  
The Military ◽  
The Impact

Objective: Patients of hypogonadism have high risk of depression and anxiety with impaired quality of life but the psychopathological impact of testicular loss without hypogonadism is rarely reported. We studied the impact of unilateral or bilateral testicular loss on psychopathology. Design and Method: We retrospectively analyzed 4 million cases of Manpower Administration (MA) database for the evaluation of the psychopathological status of men with testicular loss. For screening psychopathological status, we used the Military Multiphasic Personality Inventory (MMPI). The examinees of testicular loss were defined at least 50% decrease of testicular volume at CT scan. The examinees without severe medical disability were classified as normal control group. The abnormal result of MMPI scale was defined as a score more than one standard deviation. Results: In this cross-sectional study, total 3932 unilateral testicular absent examinees (UTAE) and 203 bilateral testicular absent examinees (BTAE) were screened. After exclusion of examinees with abnormal response, total 3562 UTAEs and 171 BTAEs were included for final analysis. The abnormal rate of anxiety (15.5% vs. 9.5%), depression (18.3% vs. 10.6%), somatization (18.6% vs 8.7%) and personality disorder (16.8% vs. 13.7%) were higher in UTAE group than matched control. The abnormal rate of depression (18.3% vs. 15.8%) and somatization (18.6% vs. 12.6%) in UTAE group were even higher than in BTAE group. Conclusions: Our population based study suggests young patients with testicular loss are psychopathological vulnerable condition. More active psychopathological screening is indicated for young testicular loss patients.

Occurrence and risk factors of uveitis in juvenile psoriatic arthritis: Data from a population-based nationwide study in Germany

2022 ◽  
pp. jrheum.210755
Author(s):  
Karoline Walscheid ◽  
Kai Rothaus ◽  
Martina Niewerth ◽  
Jens Klotsche ◽  
Kirsten Minden ◽  
...  
Keyword(s):  
Risk Factors ◽  
Psoriatic Arthritis ◽  
Early Onset ◽  
Late Onset ◽  
Multivariable Analysis ◽  
Population Based ◽  
Ocular Involvement ◽  
Cross Sectional ◽  
Dmard Treatment ◽  
Clinical Difference

Objective Data on uveitis in juvenile psoriatic arthritis (JPsA), a category of juvenile idiopathic arthritis (JIA), are scarce. We describe prevalence and risk factors for JPsA-associated uveitis (JPsA-U). Methods Cross-sectional data from the National Pediatric Rheumatological Database (from 2002 to 2014) were used to characterize JPsA-U and assess risk factors for uveitis development. Results Uveitis developed in 6.6% of 1862 JPsA patients. JPsA-U patients were more frequently female (73.0 vs 62.9%, p=0.031), ANA positive (60.3 vs 37.0%, p<0.001), younger at JPsA onset (5.3 ± 4.1 vs 9.3 ± 4.4 years, p<0.001), and received DMARD (disease modifying antirheumatic drug) treatment significantly more frequently than JPsA patients without uveitis. On multivariable analysis of a subgroup of 655 patients, mean cJADAS during study documentation was significantly associated with uveitis development. Children with early onset of JPsA were significantly more frequently ANA positive (48.4% vs 35.7% for those younger than 5 years at JPsA onset versus those aged 5 years and older, p<0.001), less often affected by skin disease (55.3% vs 61.0%, p=0.032), but more frequently by uveitis (17.3% vs 3.8%, p<0.001), and required DMARD treatment more frequently (52.9% vs 43.8%, p<0.001). Conclusion The characteristics of JPsA patients developing uveitis are similar to those of patients with uveitis in other JIA categories, such as oligoarticular JIA. Especially those children with early onset of JPsA seem to be at a higher risk for ocular involvement. Our data support the notion of a major clinical difference between those patients with early versus late onset of JPsA.

scholarly journals Flow cytometry evaluation of CD14/CD16 monocyte subpopulations in systemic sclerosis patients: a cross sectional controlled study

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Laiana Schneider ◽  
Natália Aydos Marcondes ◽  
Vanessa Hax ◽  
Isadora Flesch da Silva Moreira ◽  
Carolina Yuka Ueda ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Systemic Sclerosis ◽  
Inflammatory Diseases ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Controlled Study ◽  
Control Group ◽  
Blood Monocytes ◽  
Cross Sectional ◽  
Monocyte Subpopulations

Abstract Background Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by vasculopathy and fibrosis, which can be subclassified into diffuse cutaneous (dSSc) and limited cutaneous (lSSc) subtypes. Previous studies suggest that an increase in monocytes can be a hallmark of various inflammatory diseases, including SSc. Our aim was to evaluate circulating blood monocyte subpopulations (classical, intermediate and non-classical) of SSc patients and their possible association with disease manifestations. Methods Fifty consecutive patients fulfilling the 2013 ACR/EULAR classification criteria for SSc were included in a cross-sectional study. Monocyte subpopulations were identified based on their expression of CD64, CD14 and CD16, evaluated by flow cytometry, and were correlated with the clinical characteristics of the patients; furthermore, the expression of HLA-DR, CD163, CD169 and CD206 in the monocytes was studied. Thirty-eight age- and sex-matched healthy individuals were recruited as a control group. Results SSc patients had an increased number of circulating peripheral blood monocytes with an activated phenotypic profile compared to healthy subjects. Absolute counts of CD16+ (intermediary and non-classical) monocyte subpopulations were higher in SSc patients. There was no association between monocyte subpopulations and the clinical manifestations evaluated. Conclusion We identified higher counts of all monocyte subpopulations in SSc patients compared to the control group. There was no association between monocyte subpopulations and major fibrotic manifestations. CD169 was shown to be more representative in dSSc, being a promising marker for differentiating disease subtypes.

scholarly journals A comparison of clinical examination and ultrasound enthesitis indices in patients with psoriatic arthritis, adjusted for concomitant fibromyalgia

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110038
Author(s):  
Mark Sapsford ◽  
Jobie Evans ◽  
Gavin Clunie ◽  
Deepak Jadon
Keyword(s):  
Psoriatic Arthritis ◽  
Clinical Examination ◽  
Cross Sectional Study ◽  
Regression Analyses ◽  
Sectional Study ◽  
Single Centre ◽  
Cross Sectional ◽  
Multivariable Regression ◽  
Multivariable Analyses ◽  
Research Consortium

Objectives: To: (a) determine the extent of ultrasound (US)-detected peripheral enthesitis in a cohort of patients with psoriatic arthritis (PsA); (b) compare this with three clinical examination (CE) enthesitis indices; and (c) determine the effect of concurrent fibromyalgia on the evaluation of enthesitis. Methods: A prospective single-centre cross-sectional study of consecutive outpatients with established PsA undergoing clinical examination for enthesitis and US examination for inflammatory and structural lesions of enthesitis. Multivariable analyses tested for association between US scores, CE enthesitis indices and influence of concurrent fibromyalgia. Results: A total of 106 patients were assessed. Of these, 91/106 (85.8%) had CE enthesitis and 105/106 (99.1%) had ⩾1 US feature of enthesitis. There was a moderate correlation between US entheseal inflammation and both the Leeds Enthesitis Index (LEI) (Spearman rank, r = 0.36) and Spondyloarthritis Research Consortium of Canada Enthesitis Index (SPARCC) ( r = 0.44). US entheseal damage did not correlate with CE enthesitis indices. Twenty-eight (26.4%) patients were classified as having concurrent fibromyalgia, in whom multivariable regression analyses demonstrated no correlation between US scores and CE enthesitis indices. PsA patients without fibromyalgia demonstrated a statistically significant association between both LEI ( r = 0.48, p < 0.0001) and SPARCC ( r = 0.62, p < 0.0001) and US entheseal inflammation. Conclusion: There is a moderate association between US entheseal inflammation, but not damage, and CE enthesitis indices in patients with PsA. The presence of concurrent fibromyalgia is linked with higher CE enthesitis scores, without an increase in US inflammation, suggesting that CE enthesitis indices should be used/interpreted with caution in these patients. Imaging, including US, should be the preferred modality to detect enthesitis in PsA patients with concurrent fibromyalgia.

scholarly journals Prevalence and correlates of elevated HbA1c in rural Zambia: A population-based cross-sectional study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
Y Tateyama ◽  
T Techasrivichien ◽  
P M Musumari ◽  
M Macwan’gi ◽  
R Zulu ◽  
...  
Keyword(s):  
Gender Difference ◽  
Alcohol Intake ◽  
Multivariable Analysis ◽  
Population Based ◽  
Cross Sectional Study ◽  
Health Interventions ◽  
Sub Saharan Africa ◽  
Rural Residents ◽  
Cross Sectional ◽  
Cooking Oil

Abstract Background Diabetes mellitus (DM) poses a serious challenge to the health systems in sub-Saharan Africa. In Zambia, the estimated prevalence of DM among adults was 4.2% in 2016. However, little is known about its magnitude among the rural population. To address this gap, we investigated the prevalence of DM and its correlates among rural residents in Zambia. Methods In 2016, we recruited 690 rural residents aged 25-64 of Mumbwa district by multistage, clustered, household sampling. Questionnaire survey was conducted along with anthropometric and biological measurements including HbA1c. Data analysis was adjusted for complex sampling. Results The prevalence of elevated HbA1c (≥5.7) was 41% (Men 34%, Women 48%). DM, defined as HbA1c ≥ 6.5%, was present in 2.6% of the participants. Sixteen percent of men and 37% of women were overweight or obese (BMI≥25). In multivariable analysis, high cooking oil intake and obesity (BMI≥30) were associated with higher odds of elevated HbA1c (adjusted odds ratio [AOR]=1.76 and 3.30), but the association was inverse for alcohol intake (AOR≈0.55). By gender, obesity was positively associated with an elevated HbA1c in both genders (AOR= men 6.57, women 2.11). Secondary education was inversely (AOR=0.52), and high sugar intake was positively (AOR=1.66) associated with elevated HbA1c in men. Older age and high cooking oil intake were positively associated (AOR=1.89 and 2.14), and alcohol intake (AOR=0.46) was inversely associated with elevated HbA1c in women. Conclusions More than 40% of rural residents in Zambia had elevated HbA1c. The risk factor profile was different between genders. Obesity increased the odds of elevated HbA1c in both genders, but the odds was disproportionately higher in men than in women. The reasons for such gender difference remain unknown, but we speculate that it might be explained by the early onset of obesity in women. Such gender difference should be addressed in health interventions in this population. Key messages Over 40% of rural residents in Zambia are at risk of prediabetes or diabetes. Health interventions should address the gender difference in the risk of elevated HbA1c.

scholarly journals Chronic joint symptoms in adults: A population-based study

2017 ◽  
Vol 63 (7) ◽  
pp. 575-582
Author(s):  
Silvia Helena de Oliveira Morais ◽  
Wellington Segheto ◽  
Danielle Cristina Guimarães da Silva ◽  
France Araújo Coelho ◽  
Vanessa Guimarães Reis ◽  
...  
Keyword(s):  
Adult Population ◽  
Multivariable Analysis ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sampling Scheme ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
Joint Symptoms ◽  
Heavy Work ◽  
The City

Summary Objective: To analyze factors associated with chronic joint symptoms (CJS) in adults. Method: A population-based, cross-sectional study was performed with a sample of 1,217 adults aged between 20 and 59 years, in the city of Viçosa, in 2014. The sampling process was performed by conglomerates and sample was selected using a two-stage cluster-sampling scheme. First, 30 of the 99 census tracts of Viçosa were randomly selected using a random sampling scheme, without replacement. Household questionnaires were applied to obtain CJS data, sociodemographic conditions, behavioral factors and health status. Multivariable analysis was conducted using Poisson regression, adjusted for the sampling design effect, using the svy commands in Stata software. Results: Prevalence of CJS totaled 31.27%, significantly higher in women (18.45). Age ranges 40-49 (PR 1.50; 95CI 1.16-1.92) and 50-59 years (PR 1.55; 95CI 1.07-2.25); overweight (PR 1.60; 95CI 1.28-2.00); obesity (PR 1.60; 95CI 1.11-2.29); and those who self-reported performing heavy work (PR 1.27; 95CI 1.09-1.48) showed higher prevalences of CJS. Conclusion: Women and individuals who were older, overweight and performing heavy work had a higher risk of CJS in this adult population residing in Viçosa, MG, Brazil.

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