Maternal antibiotic prophylaxis affects Bifidobacterium spp. counts in the human milk, during the first week after delivery

2019 ◽  
Vol 10 (2) ◽  
pp. 155-163 ◽  
Author(s):  
M. Padilha ◽  
J.M. Iaucci ◽  
V.P. Cabral ◽  
E.M.A. Diniz ◽  
C.R. Taddei ◽  
...  
Keyword(s):  
Human Milk ◽  
Antibiotic Prophylaxis ◽  
University Hospital ◽  
Medium Term ◽  
Short Term ◽  
Milk Samples ◽  
Total Dna ◽  
The University ◽  
The Impact ◽  
Total Bacteria

Human milk is an important source of microorganisms for infant gut colonisation. Although the maternal antibiotic prophylaxis is an important strategy to prevent maternal/neonatal sepsis, it has to be investigated how it may affect the human milk microbiota, especially the genus Bifidobacterium, which has been associated to health benefits. Here, we investigated the impact of the maternal antibiotic prophylaxis on the human milk Bifidobacterium spp. and total bacteria counts, in the first week (short-term) and first month (medium-term) after delivery. Human milk samples were collected from 55 healthy lactating women recruited from the University Hospital of the University of São Paulo at days 7±3 and 30±4 after vaginal delivery. Twenty one volunteers had received maternal antibiotic prophylaxis (MAP group) and 34 had not received MAP (no-MAP group) during or after labour. Total DNA was isolated from milk samples, and the bacterial counts were estimated by quantitative PCR (qPCR). We found lower levels of Bifidobacterium in the MAP group in the first week after delivery (median = 2.1 vs 2.4 log of equivalent cells/ml of human milk, for MAP and no-MAP groups, respectively; P=0.01), although there were no statistical differences in total bacteria count. However, no differences were found in Bifidobacterium counts between the groups at day 30±4 (median = 2.5 vs 2.2 log of equivalent cells/ml of human milk, for MAP and no-MAP groups, respectively; P=0.50). Our results suggest that MAP has a significant impact on Bifidobacterium counts in human milk, reducing this population in the first week after delivery. However, throughout the first month after delivery, the Bifidobacterium counts tend to recover, reaching similar counts to those found in no-MAP group at day 30±4 after delivery.

scholarly journals Impacto de la ecografía volumétrica portátil en el sondaje vesical por retención urinaria en una unidad de medicina interna

2019 ◽  
Vol 19 (1) ◽  
pp. 42-62
Author(s):  
David Guadarrama Ortega ◽  
Raquel Díaz Díaz ◽  
María Aránzazu Martín Hernández ◽  
María Teresa Peces Hernández ◽  
Jonatan Vallejo Paredes ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Urinary Retention ◽  
Medical Record ◽  
Electronic Medical Record ◽  
University Hospital ◽  
Urinary Catheterization ◽  
Short Term ◽  
The University ◽  
The Impact ◽  
De Medicina

Objetivo: Estimar el impacto que el uso de ecógrafo vesical tiene en los sondajes vesicales por sospecha de retención urinaria de una unidad de Medicina interna.Metodología: Estudio de cohortes retrospectivas, comparando la cohorte expuesta a la disponibilidad del ecógrafo vesical, con la no expuesta el año previo. Se analizan todos los registros en la Historia Clínica Electrónica (HCE) de sondajes vesicales permanentes de corta duración en pacientes adultos que ingresaron en la unidad de hospitalización de Medicina Interna del Hospital Universitario Fundación Alcorcón (HUFA) durante los años 2015 y 2016. Se estima la frecuencia de retención urinaria como causa del sondaje después de la incorporación del dispositivo en la unidad y se compara con la frecuencia en sondajes durante el mismo periodo del año anterior en la misma unidad. Se estima el impacto que disponer de este dispositivo tiene en la frecuencia de retención urinaria como motivo del sondaje.Resultados: Se incluyen 134 sondajes en 113 pacientes, 62 en el grupo sin ecógrafo y 72 en el grupo con ecógrafo. La frecuencia de sondajes por retención se reduce del 47.5% al 21.4% después de introducir el ecógrafo en la unidad. Esto supone una reducción del 50% (RR ajustado= 0.48; IC95%:0.27-0.84, p=0.01) en la frecuencia de sondaje vesical por sospecha de retención urinaria. Aim: To estimate the impact of the use of portable bladder volumetric ultrasound on bladder catheterization due to suspicion of urinary retention in an internal medicine unit. Methodology: Study of retrospective cohorts, comparing the cohort exposed to the availability of bladder ultrasound, with the not exposed the previous year. All records in the Electronic Medical Record (EHR) of short-term permanent bladder catheters in adult patients admitted to the Internal Medicine hospitalization unit of the University Hospital Fundación Alcorcón (HUFA) during the years 2015 and 2016 were analyzed. The urinary retention frequency is estimated as the cause of the catheterization after the device has been incorporated into the unit and compared with the frequency of catheterization during the same period of the previous year in the same unit. It is estimated that the impact of having this device on the urinary retention frequency is the reason for the catheterization. Results: 134 catheters are included in 113 patients, 62 in the group without ultrasound and 72 in the group with ultrasound. The frequency of catheterizations due to retention is reduced from 47.5% to 21.4% after introducing the ultrasound unit into the unit. This represents a 50% reduction (adjusted RR=0.48; CI95%:0.27-0.84, p=0.01) in the frequency of urinary catheterization for suspected urinary retention.

scholarly journals Impact of the COVID-19 pandemic and its related psychological effect on orthopedic surgeries conducted in different types of hospitals in Taiwan

2021 ◽  
Vol 29 (1) ◽  
pp. 230949902199607 ◽  
Author(s):  
Chia-Lung Shih ◽  
Peng-Ju Huang ◽  
Hsuan-Ti Huang ◽  
Chung-Hwan Chen ◽  
Tien-Ching Lee ◽  
...  
Keyword(s):  
Community Hospital ◽  
University Hospital ◽  
Total Knee Arthroplasties ◽  
Peak Period ◽  
Number Of Patients ◽  
Total Knee ◽  
Investigation Period ◽  
Orthopedic Diseases ◽  
The University ◽  
The Impact

Aim: Taiwan’s response to the coronavirus disease 2019 (COVID-19) differed in that it successfully prevented the spread without having to shutdown or overburden medical services. Patients’ fear regarding the pandemic would be the only reason to reduce surgeries, so Taiwan could be the most suitable place for research on the influence of psychological factors. This study aimed to assess the impact of patients’ fear on orthopedic surgeries in Taiwan amid the peak period of the COVID-19 pandemic. Patients and Methods: The investigation period included the COVID-19 pandemic (March 2020 to April 2020) and the corresponding period in the previous year. The following data on patients with orthopedic diseases were collected: outpatient visits, hospital admission, and surgical modalities. Results: The COVID-19 pandemic led to a 22%–29% and 20%–26% reduction in outpatients, 22%–27% and 25%–37% reduction in admissions, and 26%–35% and 18%–34% reduction in surgeries, respectively, at both hospitals. The weekly mean number of patients was significantly smaller during the COVID-19 pandemic for all types of surgery and elective surgeries at the university hospital, and for all types of surgery, elective surgeries, and total knee arthroplasties at the community hospital. Further, patients visiting the community hospital during the pandemic were significantly younger, for all types of surgery, elective surgeries, and total knee arthroplasties. Conclusions: The reduction in orthopedic surgeries in Taiwan’s hospitals during COVID-19 could be attributed to patients’ fear. Even without restriction, the pandemic inevitably led to a reduction of about 20%–30% of the operation volume.

scholarly journals Longitudinal Changes in the Concentration of Major Human Milk Proteins in the First Six Months of Lactation and Their Effects on Infant Growth

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1476
Author(s):  
Jian Zhang ◽  
Ai Zhao ◽  
Shiyun Lai ◽  
Qingbin Yuan ◽  
Xiaojiang Jia ◽  
...  
Keyword(s):  
Human Milk ◽  
Maternal Education ◽  
Mode Of Delivery ◽  
Milk Proteins ◽  
Protein Composition ◽  
Infant Growth ◽  
Term Infants ◽  
Longitudinal Changes ◽  
Milk Samples ◽  
The Impact

Our knowledge related to human milk proteins is still limited. The present study determined the changes in multiple human milk proteins during the first six months of lactation, investigated the influencing factors of milk proteins, and explored the impact of milk proteins on infant growth. A total of 105 lactating women and their full-term infants from China were prospectively surveyed in this research. Milk samples were collected at 1–5 days, 8–14 days, 1 month, and 6 months postpartum. Concentrations of total protein and α-lactalbumin were measured in all milk samples, and concentrations of lactoferrin, osteopontin, total casein, β-casein, αs−1 casein, and κ-casein were measured in milk from 51 individuals using ultra performance liquid chromatography coupled with mass spectrometry. The concentration of measured proteins in the milk decreased during the first six months of postpartum (p-trend < 0.001). Maternal age, mode of delivery, maternal education, and income impacted the longitudinal changes in milk proteins (p-interaction < 0.05). Concentrations of αs−1 casein in milk were inversely associated with the weight-for-age Z-scores of the infants (1 m: r −0.29, p 0.038; 6 m: r −0.33, p 0.020). In conclusion, the concentration of proteins in milk decreased over the first six months postpartum, potentially influenced by maternal demographic and delivery factors. Milk protein composition may influence infant weights.

scholarly journals The impact of University of Žilina´s employees on regional development

2017 ◽  
Vol 5 (2) ◽  
pp. 21-24
Author(s):  
Lucia Možuchová ◽  
◽  
Lucia Gašperová ◽  
Mária Rostášová ◽  
Dorota Jelonek
Keyword(s):  
Regional Development ◽  
Strong Impact ◽  
University Staff ◽  
Short Term ◽  
Total Size ◽  
Diverse Range ◽  
Registered Office ◽  
The University ◽  
The Impact ◽  
The City

The university is an important part of the region's infrastructure and has the potential to initiate changes and transform the economy into a diverse range. The presence of a university in a host city or region has a strong impact on regional development. Universities are usually among the largest employers in the city. Their employees, students and visitors spend some of their finances in this city, which have an impact on local and regional economic development. The total size of the impact of university varies depending on the size of the university and the characteristics of the local and regional economy. The primary aim of the contribution is identification of the selected short-term impacts of the University of Žilina to the city and region, where it has its registered office. To achieve the stated goal, primary research was carried out primarily focused on the economic impact of university staff on the development of the Žilina´s region.

scholarly journals Impact of ERAS compliance on the delay between surgery and adjuvant chemotherapy in hepatobiliary and pancreatic malignancies

2020 ◽  
Vol 405 (7) ◽  
pp. 959-966
Author(s):  
Pénélope St-Amour ◽  
Pascal St-Amour ◽  
Gaëtan-Romain Joliat ◽  
Aude Eckert ◽  
Ismail Labgaa ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Enhanced Recovery ◽  
Young Patients ◽  
University Hospital ◽  
Colorectal Metastases ◽  
Liver Malignancies ◽  
Study Population ◽  
Eras Protocol ◽  
The University ◽  
The Impact

Abstract Background Multidisciplinary approach with adjuvant chemotherapy is the key element to provide optimal outcomes in pancreas and liver malignancies. However, post-operative complications may increase the interval between surgery and chemotherapy with negative oncologic effects. Hypothesis and study aim The aim of the study was to analyse whether compliance to Enhanced Recovery After Surgery (ERAS) pathway was associated with decreased interval to adjuvant chemotherapy. Methods Retrospective analysis of all consecutive ERAS patients with surgery for hepatobiliary or pancreatic malignancies at the University Hospital of Lausanne between 2012 and 2016. Multivariate analysis was performed to assess the impact of ERAS compliance on time to chemotherapy. Results A total of 133 patients with adjuvant chemotherapy were included (n = 44 liver and n = 89 pancreatic cancer). Median compliance to ERAS was 61% (IQR 55–67) for the study population, and median delay to chemotherapy was 49 days (IQR 39-61). Overall, compliance ≥ 67% to ERAS induced a significant reduction in the interval between surgery and chemotherapy for young patients (< 65 years old) with or without severe comorbidities (reduction of 22 and 10 days, respectively). High compliance in young ASA3 patients with liver colorectal metastases was associated with an increase of 481 days of DFS. Conclusions ERAS compliance ≥ 67% tends to be associated with a reduction in the delay to adjuvant chemotherapy for young patients with hepatobiliary and pancreatic malignancies. More prospective studies with strict adhesion to the ERAS protocol are needed to confirm these results.

scholarly journals The impact of teaching computational astronomy on the development of students' computer skills

2019 ◽  
Vol 200 ◽  
pp. 02001 ◽  
Author(s):  
Afrodita L. Boldea
Keyword(s):  
Professional Training ◽  
Web Design ◽  
Research Area ◽  
Short Term ◽  
Approach To Learning ◽  
Isaac Newton ◽  
La Palma ◽  
Teaching Learning ◽  
The University ◽  
The Impact

Some blended methods of teaching-learning were successfully used in teaching the astronomy and astrometry of asteroids to students in Computer Sciences at the University of Craiova, using real astronomical data about celestial objects from our Solar System, obtained from the Astronomical Observatory Isaac Newton (La Palma, Spain). The students were asked to develop some small scripts in order to facilitate the detection and the analysis of data for new discovered asteroids, a request that improved their capacities to understand and apply various modern concepts of Computer Graphics, Data Base and Web design. This approach to learning brings new challenges for the students, new opportunities for the process of professional training in Computer Sciences and provided good result in very short term, the students acquiring very fast the necessary skills to approach both the professional level of Web programming and the modern research area of Computational Astronomy.

Performance Funding Policy Effects on Community College Outcomes: Are Short-Term Certificates on the Rise?

2017 ◽  
Vol 46 (1) ◽  
pp. 3-39 ◽  
Author(s):  
Amy Y. Li ◽  
Alec I. Kennedy
Keyword(s):  
Postsecondary Education ◽  
Performance Metrics ◽  
State Level ◽  
Cost Effective ◽  
Performance Funding ◽  
Funding Policy ◽  
Level Control ◽  
Medium Term ◽  
Short Term ◽  
The Impact

Objective: Performance funding (PF) policies allocate a portion of state funding to colleges based on student outcomes. This study is the first to account for policy type and design differences, and explores the impact of performance funding on three levels of credential completions: short-term certificates, medium-term certificates, and associate’s degrees. Method: We create a panel dataset of 751 two-year colleges from years 1990 to 2013 using data from the Integrated Postsecondary Education Data System. We conduct a series of analyses using difference-in-differences with the inclusion of college- and state-level control variables. Results: We find that, on average, performance funding produces no significant changes in completions of any of the three credentials. Policy types characterized by a greater proportion of funding tied to the base budget, mission differentiation in performance metrics, inclusion of underrepresented student metrics, and longer periods of operating years produce an increase in short-term certificates, no significant change in medium-term certificates, and a decrease in associate’s degrees. Contributions: This study’s findings suggest that because awarding more short-term certificates is a relatively quick and cost-effective way to capture performance funds, colleges might be engaging in a path of least resistance by churning out short-term certificates and redirecting focus away from associate’s degrees, which is concerning given that short-term certificates generally offer limited labor market benefits compared to medium-term certificates and associate’s degrees. Our results also underscore the importance of policy designs in explaining differential impacts on credential completion.

Therapeutic administration of enrofloxacin in mice does not select for fluoroquinolone resistance inCampylobacter jejuni

2018 ◽  
Vol 64 (10) ◽  
pp. 681-694 ◽  
Author(s):  
G. Douglas Inglis ◽  
Sarah J.M. Zaytsoff ◽  
L. Brent Selinger ◽  
Eduardo N. Taboada ◽  
Richard R.E. Uwiera
Keyword(s):  
Inhibitory Concentration ◽  
Subcutaneous Administration ◽  
Fluoroquinolone Resistance ◽  
Short Term ◽  
Resistance Development ◽  
Antibiotic Duration ◽  
Cell Densities ◽  
The Impact ◽  
Therapeutic Administration ◽  
Total Bacteria

Enrofloxacin is registered for therapeutic use in beef cattle to treat bovine respiratory disease in Canada. A murine model was used to experimentally examine the impact of therapeutic administration of enrofloxacin on fluoroquinolone resistance development in Campylobacter jejuni. Administration of enrofloxacin to mice via subcutaneous injection or per os routes resulted in equivalent levels of bioactive enrofloxacin within the intestine, but bioactivity was short-lived (<48 h after cessation). Enrofloxacin administration did not affect densities of total bacteria, Firmicutes, or Bacteroidetes in digesta and had modest impacts on densities of Enterobacteriaceae. All mice inoculated with C. jejuni NCTC 11168 became persistently colonized by the bacterium. Enrofloxacin reduced C. jejuni cell densities within the cecal and colonic digesta for all treatments, and densities shed in feces as a function of antibiotic duration. None of the C. jejuni isolates recovered from mice after administration of enrofloxacin (n = 260) developed resistance to ciprofloxacin regardless of method or duration of administration. Furthermore, only modest shifts in the minimum inhibitory concentration of the isolates by treatment were noted. The study findings indicate that the risk posed by short-term subcutaneous administration of enrofloxacin for the development of fluoroquinolone resistance in mammals is low.

scholarly journals Assessing the Impact of Disruptive Events on Port Performance and Choice: The Case of Gothenburg

2021 ◽  
Vol 9 (2) ◽  
pp. 145
Author(s):  
Martin Svanberg ◽  
Henrik Holm ◽  
Kevin Cullinane
Keyword(s):  
Performance Metrics ◽  
Automatic Identification ◽  
Identification System ◽  
Container Port ◽  
Medium Term ◽  
Short Term ◽  
Labour Dispute ◽  
Container Ports ◽  
The Impact ◽  
The Relationship

This paper assesses the impact of a major disruptive event at the port of Gothenburg, Scandinavia’s largest container port. Automatic Identification System (AIS) data is analyzed, in combination with official port statistics on container handling in the four main container ports in Sweden, from 2014–2018. Particular attention is paid to the relationship between container volumes handled and calculated performance metrics at the specific times of the intense labour dispute at the port of Gothenburg during the periods Q2 (2016) and Q4 (2016)–Q2 (2017). The paper concludes that the decline in container volumes handled at Gothenburg over the period is specifically due to fewer ships calling at the port following each of the intense periods of the labour dispute. It is also concluded that the effect on competitor ports in the region were significant in terms of both increased volumes of gateway container traffic and the resulting short-term and medium term impacts on both port user profiles and port efficiency levels.

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