Optimizing outcome and quality of life for mesenteric ischemia patients by improving diagnostic and treatment strategies

Nanotechnology: its application in treating Neurodegenerative diseases

CNS & Neurological Disorders - Drug Targets ◽

10.2174/1871527319666200916121515 ◽

2020 ◽

Vol 19 ◽

Author(s):

Falaq Naz ◽

Yasir Hasan Siddique

Keyword(s):

Quality Of Life ◽

Neurodegenerative Diseases ◽

Blood Brain Barrier ◽

Huntington Disease ◽

Treatment Strategies ◽

Present Review ◽

Brain Barrier ◽

Treatment Level ◽

Blood Brain

: Neurodegenerative diseases including Alzheimer’s, Parkinson’s and Huntington disease are have serious concern due to its effect on the quality of life of affected persons. Neurodegenerative diseases have some limitations for both diagnostic as well as at treatment level. Introducing nanotechnology, for the treatment of these diseases may contribute significantly in solving the problem. There are several treatment strategies for the neurodegenerative diseases, but their limitations are the entry into the due to the presence of the blood-brain barrier (BBB). The present review highlights the application of nanotechnology during last 20 years for the treatment of neurodegenerative diseases.

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Predictive factors of quality of life in temporal and extratemporal lobe epilepsy: association with affective temperament profiles and psychiatric comorbidities

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x-anp-2020-0437 ◽

2021 ◽

Vol 79 (9) ◽

pp. 799-807

Author(s):

Sehnaz Basaran ◽

Halil İbrahim Tas

Keyword(s):

Quality Of Life ◽

Depressive Symptoms ◽

Predictive Factors ◽

Focal Epilepsy ◽

Short Form ◽

Linear Regression Analysis ◽

Treatment Strategies ◽

Affective Temperaments ◽

Sf 36

ABSTRACT Background: Investigating predictive factors of reduced quality of life (QOL) of patients and their association with focal epilepsy can improve management and treatment strategies. Objective: This study aimed to investigate the relationship between affective temperaments, depression, anxiety, disease characteristics, and QOL and to explore the predictors of QOL in patients with temporal lobe epilepsy (TLE) and extratemporal lobe epilepsy (ETLE). Methods: A total of 50 patients with TLE, 51 patients with ETLE, and 70 controls were enrolled. Affective temperaments were evaluated using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A). QOL was assessed by the Short-Form Health Survey (SF-36). Beck Depression Inventory and Beck Anxiety Inventory were used to explore depression and anxiety severity, respectively. Results: Compared with the controls, patients with TLE and ETLE had significantly higher scores on all TEMPS-A scales, except on hyperthymic temperament. All the SF-36 subscale scores were lower in the TLE and ETLE groups. Linear regression analysis revealed that depressive symptoms, anxiety, depressive and irritable temperament, and seizure frequency were significant predictors of QOL in TLE. Patients with ETLE with temperamental disturbances, depressive symptoms, and polytherapy had a poorer QOL. Conclusions: Affective temperaments, psychiatric disorders, and clinical factors may predict impaired QOL in patients with TLE and ETLE. Further studies are needed to identify predictors of QOL in various epilepsy subtypes.

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Physical activity in secondary stroke prevention

Swiss Sports & Exercise Medicine ◽

10.34045/ssem/2019/33 ◽

2019 ◽

Vol 67 (4) ◽

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Activities Of Daily Living ◽

Brain Function ◽

Stroke Prevention ◽

Daily Living ◽

Recurrent Stroke ◽

Treatment Strategies ◽

Secondary Stroke Prevention

After having a stroke the main challenges are reducing the risk of recurrent stroke, improving impaired brain function, quality of life, independence in activities of daily living and reintegration into the community. [1] Lesion-induced impairment of brain function also has, besides its effects on e.g. motor, sensory, visual and speech function, an influence on e.g. cognition and mood, all of which are determinants of post-stroke physical activity. The evidence for a benefit of physical activity in secondary stroke prevention is increasing and treatment strategies aimed at factors which are limiting physical activity are more and more recognized.

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Treatment strategies for chemotherapy-induced peripheral neuropathy: potential role of exercise

Oncology Reviews ◽

10.4081/oncol.2010.117 ◽

2011 ◽

Vol 4 (2) ◽

pp. 117

Author(s):

Karen Y. Wonders ◽

Beverly S. Reigle ◽

Daniel G. Drury

Keyword(s):

Quality Of Life ◽

Peripheral Neuropathy ◽

Cancer Patients ◽

Lifestyle Modification ◽

Treatment Strategies ◽

Moderate Intensity ◽

Moderate Intensity Exercise ◽

Exercise Rehabilitation

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting effect of cancer therapy that often has negative implications on a patient’s quality of life. The pain associated with CIPN has long been recognized as one of the most difficult types of pain to treat. Historically, much effort has been made to explore pharmacological therapies aimed at reducing symptoms of CIPN. While many of these agents provide a modest relief in the symptoms of peripheral neuropathy, many have been shown to have additional negative side effects for cancer patients. Therefore, the authors suggest exercise rehabilitation as one lifestyle modification that may positively impact the lives of patients with CIPN. To our knowledge, there are currently no published clinical trials examining the role of exercise in preserving neurological function following chemotherapy. However, investigations using low-to-moderate intensity exercise as an intervention in patients with diabetic peripheral neuropathy and hereditary motor and sensory neuropathies have produced promising results. Given that cancer patients appear to tolerate exercise, it seems plausible that exercise rehabilitation could be used as an effective strategy to minimize CIPN-induced detriments to quality of life.

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Survival Augmented Patient Preference Incorporated Reinforcement Learning to Evaluate Tailoring Variables for Personalized Healthcare

Stats ◽

10.3390/stats4040046 ◽

2021 ◽

Vol 4 (4) ◽

pp. 776-792

Author(s):

Yingchao Zhong ◽

Chang Wang ◽

Lu Wang

Keyword(s):

Quality Of Life ◽

Patient Preference ◽

Treatment Strategies ◽

Treatment Decision ◽

Personalized Treatment ◽

Model Framework ◽

Q Learning ◽

Treatment Decision Making ◽

Weighted Utility

In this paper, we consider personalized treatment decision strategies in the management of chronic diseases, such as chronic kidney disease, which typically consists of sequential and adaptive treatment decision making. We investigate a two-stage treatment setting with a survival outcome that could be right censored. This can be formulated through a dynamic treatment regime (DTR) framework, where the goal is to tailor treatment to each individual based on their own medical history in order to maximize a desirable health outcome. We develop a new method, Survival Augmented Patient Preference incorporated reinforcement Q-Learning (SAPP-Q-Learning) to decide between quality of life and survival restricted at maximal follow-up. Our method incorporates the latent patient preference into a weighted utility function that balances between quality of life and survival time, in a Q-learning model framework. We further propose a corresponding m-out-of-n Bootstrap procedure to accurately make statistical inferences and construct confidence intervals on the effects of tailoring variables, whose values can guide personalized treatment strategies.

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Short Review On Varicose Vein And Its Management

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v12i1.4190 ◽

2021 ◽

Vol 12 (1) ◽

pp. 832-836

Author(s):

Pranav N ◽

Anila K N ◽

Riju.R.Menon

Keyword(s):

Quality Of Life ◽

Varicose Vein ◽

Inflammatory Responses ◽

Early Stage ◽

Treatment Strategies ◽

Short Review ◽

Disease Diagnosis ◽

Treated Group ◽

Severe Condition

A varicose vein is a condition which affects a large number of people in Western countries and India especially, the northern areas. For curing this proper disease diagnosis, sufficient care for patient and treatment strategies are required, to control the symptoms and signs of varicose vein, the flavonoid group of drugs have been widely used for many years. Under this group, Daflon is the most potent and efficient drug which can be used. This enhances the bioavailability and absorption from the gastrointestinal area. Improved quality of patient's life and efficacy makes this drug therapy more potent and significant. Some of the clinical studies have shown its better action for increased venous tone, lymphatic drainage, decreases cosmetic disfigurement, inflammatory responses occur in microcirculation, protection from free radicals and improved quality of life and efficacy. When compared with other available drugs like Polidocanol, Sotradecol, Asclera, Varithena, Sodium tetradecyl sulfate etc. .clinical benefits of Daflon is more. This drug is useful in the early stage and can be used in severe condition along with sclerotherapy, compression treatment and surgery. Increased patient’s quality of life and increased efficacy were observed in Daflon treated group. Thus it is efficacious as a standard therapy alone and also in combination with other conservative treatment.

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Quality of life and costs for different treatment strategies for rheumatoid arthritis

Expert Review of Pharmacoeconomics & Outcomes Research ◽

10.1586/14737167.5.4.395 ◽

2005 ◽

Vol 5 (4) ◽

pp. 395-410 ◽

Cited By ~ 2

Author(s):

Paco MJ Welsing ◽

Wietske Kievit ◽

Roland FJM Laan ◽

Johan L Severens

Keyword(s):

Quality Of Life ◽

Rheumatoid Arthritis ◽

Treatment Strategies

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Key Factors Contributing to Quality of Life for Breast Cancer Patients in Latvia: Supplementing Quantitative Surveys with Qualitative Interviews

Acta Chirurgica Latviensis ◽

10.2478/v10163-012-0001-0 ◽

2012 ◽

Vol 12 (1) ◽

pp. 3-10 ◽

Cited By ~ 1

Author(s):

Agnese Dzērvīte ◽

Maruta Pranka ◽

Tana Lace ◽

Ritma Rungule ◽

Edvins Miklasevics ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Patients ◽

Qualitative Interviews ◽

Treatment Strategies ◽

Well Being ◽

University Hospital ◽

Breast Cancer Patients ◽

Key Factors

Summary Introduction. Health related quality of life is a much debated topic in medicine with much quantitative and qualitative research contributing to the understanding of how to improve the lives of patients, yet little has been published in relation to the quality of life of Latvian breast cancer patients. Aim of the Study. To gather base measurements of subjective and objective quality of life factors for breast cancer patients in Latvia and discover which key factors contribute most to quality of life of Latvian breast cancer patients at the start of treatment. Materials and Methods. This paper presents data collected from April 2010 to June 2011 at the Pauls Stradins Clinical University hospital on key factors influencing quality of life for breast cancer patients: health and physical well-being; state of surroundings and environment; social support and functionality; financial state, employment and leisure. Quantitative survey material has been supplemented with insight from qualitative in-depth interviews to better explain the objective and subjective implications for breast cancer patients’ quality of life. Results. Interviewed breast cancer patients rated their quality of life as being average or good at the beginning of treatment. Negative factors contributing to lowered quality of life were mainly linked to patient financial, social and emotional state at the first weeks of treatment and correspond to previous research done in Latvia on quality of life issues. Conclusions. Further follow-up surveys will contribute to the evaluation of breast cancer patients’ needs while undergoing treatment to further improve treatment strategies, especially if validated quality of life measurement surveys were to be implemented in Latvian hospitals.

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How I Treat High-risk Multiple Myeloma

Blood ◽

10.1182/blood.2020008733 ◽

2021 ◽

Author(s):

Elena Zamagni ◽

Simona Barbato ◽

Michele Cavo

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Multiple Myeloma ◽

Clinical Trials ◽

High Risk ◽

Tumor Biology ◽

Treatment Strategies ◽

Specific Drug ◽

Improve Quality

Survival of multiple myeloma (MM) has significantly improved over the last decade; however, a composed group of patients (15-20%), named high-risk (HR) MM, still experience reduced survival. Both tumor biology and suboptimal/absent responses to therapy may underlie HR definition and a clear uniform identification of risk factors is crucial for a proper management of these patients. In biologic-HRMM, MRD negativity attainment and sustain, inside and outside BM, should be the primary goal and therapy should be adapted in patients with frailty to reduce toxicity and improve quality of life. MM treatment has traditionally been tailored on age and more recently frailty or comorbidities, but very rarely on the biology of the disease, mainly because of the lack of a clear benefit derived from a specific drug/combination, inhomogeneity in HR definition and lack of data coming from prospective, properly designed clinical trials. Some attempts have been successfully made recently in this direction. In this review, we are discussing the current different definitions of HR and the need for a consensus, the results of available trials in HR patients and the way through risk-adapted treatment strategies. For this purpose, we are proposing several clinical cases of difficult-to-treat patients throughout different treatment phases.

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