scholarly journals BIOMECHANICS OF SUPERPARAMAGNETIC NANOPARTICLES FOR LASER HYPERTHERMIA

2020 ◽  
Vol 32 (01) ◽  
pp. 2050007
Author(s):  
Maryam Fatima ◽  
Ayesha Sohail ◽  
Khush Bakhat Akram ◽  
Lubna Sherin ◽  
Saad Ihsan Butt ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Magnetic Particles ◽  
Chemical Properties ◽  
Superparamagnetic Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Three Dimension ◽  
Hyperthermia Treatment ◽  
Proposed Model ◽  
Laser Hyperthermia ◽  
Graphene Nanocomposite

Nanoparticle hyperthermia treatment is progressing with the passage of time, and with the development in the field of hybrid nanoparticles synthesis. The transient heat transfer in magnetite–graphene nanocomposite in three dimension under conduction is studied during this research. The proposed model is simulated in finite element solver framework. Novel hybrid nanoparticles were synthesized. Their chemical properties and their heat transfer properties were examined. By mathematical modeling results, the effective hybrid nanoparticle is chosen that can be used as a drug in hyperthermia process. Current developments in nanotechnology have improved the ability to precisely modify the features and properties of MNPs for these biomedical applications. The accurate control on the magnetic properties of the particle is the key in hyperthermia applications. By these magnetic particles, wished temperature can be achieved for laser hyperthermia. In this paper, study is done for understanding the properties and novelty of the new nanoparticles. The merits and demerits of synthesized hybrid nanoparticles are also discussed either the composites can used as a drug or not.

scholarly journals Heat Transfer Modeling in Bone Tumour Hyperthermia Induced by Hydroxyapatite Magnetic Thermo-Seeds

2020 ◽  
Vol 14 (1) ◽  
pp. 77-89
Author(s):  
Fabio Fanari ◽  
Lorena Mariani ◽  
Francesco Desogus
Keyword(s):  
Heat Transfer ◽  
Numerical Models ◽  
Bone Tumour ◽  
Heat Transfer Process ◽  
Thermal Treatments ◽  
Hyperthermia Treatment ◽  
Theoretical Frameworks ◽  
Thermal Dynamics ◽  
Electromagnetic Power ◽  
Proposed Model

Background: Hyperthermia is an adjuvant oncologic thermal therapy. In the case of deep-seated bone cancers, the interstitial hyperthermia treatment can be performed using thermo-seeds, implanted biomaterial components that are able to convert external electromagnetic power into thermal one. Several magnetic biomaterials have been synthesized for thermal treatments of cancer. However, less attention has been paid to the modeling description of the therapy, especially when the bio-heat transfer process is coupled to the electromagnetic heating. Objective: In this work, a comparison between the available analytical and numerical models is presented. Methods: A non-linear multiphysics model is used to study and describe the performance of cylindrical magnetic hydroxyapatite thermo-seeds to treat residual cancer cells of bone tumours. Results: The thermal dynamics and treatment outcome are carefully evaluated. Under the exposure of a magnetic field of 30 mT, working at 300 kHz, it was found that magnetic hydroxyapatite implants with a size of 10 mm × 10 mm could increase the temperature above 42 °C for 60 min. Conclusion: The proposed model overcomes the limitations of the available theoretical frameworks, and the results reveal the relevancy of the implant geometry to the effectiveness of the hyperthermia treatment.

scholarly journals Numerical Analysis of Breast Cancer Cell with Gold Nanoparticles Necrosis by Laser Hyperthermia

2020 ◽  
Vol 10 (2) ◽  
pp. 138-144
Author(s):  
Shna A. Karim ◽  
Yousif M. Hassan
Keyword(s):  
Breast Cancer ◽  
Heat Transfer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Biological Tissues ◽  
Surrounding Tissue ◽  
Threshold Temperature ◽  
Cancer Tissue ◽  
Hyperthermia Treatment ◽  
Laser Hyperthermia

Laser hyperthermia treatment of cancer tissue is widely used in cancer treatment to destroy cancer cells. This study focus on the mechanisms of heat transfer in biological tissues to minimize damage to the tissues resulting from extra heat applied. The important feature of this method is heating of specific region to raise its temperature to a threshold temperature and destroying cancer cells without to destroy surrounding tissue. In this study, we have used the combinations of laser light and gold nanoparticles to investigate the influence of nanoparticles on the spatial distribution of temperature in the tumor and healthy tissues. Accurate simulations and solving Penne’s bio-heat transfer equation were used to solve and model the thermal tumor breast cancer in the presence of gold. Nanoparticles of some particular sizes and concentrations were selected. We would like here to stress that our attempt was a theoretical and computer model with some real and hypothesized parameters and homogeneous target. The results of this study help the doctors in the study for results of hyperthermia treatment before using it on the vivo by known the properties of the laser used and the properties of the breast tumor trying to reduce the damage of the treatment.

THE MECHANISM OF RAISING AND QUANTIFICATION OF SPECIFIC HEAT FLUX AT BOILING OF NANOFLUIDS IN FREE CONVECTION CONDITIONS

2017 ◽  
pp. 25-34
Author(s):  
V.N. Moraru
Keyword(s):  
Heat Transfer ◽  
Heat Flux ◽  
Heat Capacity ◽  
Specific Heat ◽  
Chemical Properties ◽  
Heating Surface ◽  
Physical Models ◽  
Superheated Liquid ◽  
Two Phase ◽  
Boiling Process

The results of our work and a number of foreign studies indicate that the sharp increase in the heat transfer parameters (specific heat flux q and heat transfer coefficient _) at the boiling of nanofluids as compared to the base liquid (water) is due not only and not so much to the increase of the thermal conductivity of the nanofluids, but an intensification of the boiling process caused by a change in the state of the heating surface, its topological and chemical properties (porosity, roughness, wettability). The latter leads to a change in the internal characteristics of the boiling process and the average temperature of the superheated liquid layer. This circumstance makes it possible, on the basis of physical models of the liquids boiling and taking into account the parameters of the surface state (temperature, pressure) and properties of the coolant (the density and heat capacity of the liquid, the specific heat of vaporization and the heat capacity of the vapor), and also the internal characteristics of the boiling of liquids, to calculate the value of specific heat flux q. In this paper, the difference in the mechanisms of heat transfer during the boiling of single-phase (water) and two-phase nanofluids has been studied and a quantitative estimate of the q values for the boiling of the nanofluid is carried out based on the internal characteristics of the boiling process. The satisfactory agreement of the calculated values with the experimental data is a confirmation that the key factor in the growth of the heat transfer intensity at the boiling of nanofluids is indeed a change in the nature and microrelief of the heating surface. Bibl. 20, Fig. 9, Tab. 2.

scholarly journals How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1510
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska
Keyword(s):  
Silk Fibroin ◽  
Biomedical Applications ◽  
Magnetic Particles ◽  
Chemical Properties ◽  
Ternary Mixtures ◽  
Cross Linking ◽  
Advantages And Disadvantages ◽  
Physico Chemical ◽  
Binary And Ternary Mixtures ◽  
To Receive

This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

scholarly journals Heat Transmission Reinforcers Induced by MHD Hybrid Nanoparticles for Water/Water-EG Flowing over a Cylinder

Coatings ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 623
Author(s):  
Firas A. Alwawi ◽  
Mohammed Z. Swalmeh ◽  
Amjad S. Qazaq ◽  
Ruwaidiah Idris
Keyword(s):  
Heat Transfer ◽  
Heat Transfer Rate ◽  
Transfer Rate ◽  
Volume Fraction ◽  
Liquid Velocity ◽  
Flow Characteristics ◽  
Hybrid Nanoparticles ◽  
Critical Parameters ◽  
Heat Transmission ◽  
Constant Wall Temperature

The assumptions that form our focus in this study are water or water-ethylene glycol flowing around a horizontal cylinder, containing hybrid nanoparticles, affected by a magnetic force, and under a constant wall temperature, in addition to considering free convection. The Tiwari–Das model is employed to highlight the influence of the nanoparticles volume fraction on the flow characteristics. A numerical approximate technique called the Keller box method is implemented to obtain a solution to the physical model. The effects of some critical parameters related to heat transmission are also graphically examined and analyzed. The increase in the nanoparticle volume fraction increases the heat transfer rate and liquid velocity; the strength of the magnetic field has an adverse effect on liquid velocity, heat transfer, and skin friction. We find that cobalt nanoparticles provide more efficient support for the heat transfer rate of aluminum oxide than aluminum nanoparticles.

scholarly journals Templated quasicrystalline ordering of single elements and molecules

2014 ◽  
Vol 70 (a1) ◽  
pp. C81-C81
Author(s):  
H. R. Sharma ◽  
J. A. Smerdon ◽  
K. Nozawa ◽  
K. M. Young ◽  
T. P. Yadav ◽  
...  
Keyword(s):  
Substrate Surface ◽  
Chemical Properties ◽  
Scanning Tunneling ◽  
Three Dimension ◽  
Tunneling Microscopy ◽  
Quantum Size ◽  
Adsorption Energies ◽  
Molecular Layers ◽  
Physical And Chemical ◽  
The Impact

We have used quasicrystals as templates for the exploration of new epitaxial phenomena. Several interesting results have been observed in the growth on surfaces of the common Al-based quasicrystals [1]. These include pseudomorphic monolayers, quasiperiodically modulated multilayer structures, and fivefold-twinned islands with magic heights influenced by quantum size effects [1]. Here we present our recent works on the growth of various elements and molecules on a new substrate, icosahedral (i) Ag-In-Yb quasicrystal, which have resulted in various epitaxial phenomena not observed previously. The growth of Pb on the five-fold surface of i-Ag-In-Yb yields a film which possesses quasicrystalline ordering in three-dimension [2]. Using scanning tunneling microscopy (STM) and DFT calculations of adsorption energies, we find that lead atoms occupy the positions of atoms in the rhombic triacontahedral (RTH) cluster, the building block of the substrate, and thus grow in layers with different heights and adsorption energies. The adlayer–adlayer interaction is crucial for stabilizing the epitaxial quasicrystalline structure. We will also present the first example of quasicrystalline molecular layers. Pentacene adsorbs at tenfold-symmetric sites of Yb atoms around surface-bisected RTH clusters, yielding quasicrystalline order [3]. Similarly, C-60 growth on the five-fold surface of i-Al-Cu-Fe at elevated temperature produces quasicrystalline layer, where the growth is mediated by Fe atoms on the substrate surface [3]. The finding of quasicrystalline thin films of single elements and molecules opens an avenue for further investigation of the impact of the aperiodic atomic order over periodic order on the physical and chemical properties of materials.

Highly Subcooled Flow Boiling: A Model for Estimating Heat Transfer Behind Sliding Bubbles in a Narrow Channel

2012 ◽  
Author(s):  
Arif B. Ozer ◽  
Donald K. Hollingsworth ◽  
Larry. C. Witte
Keyword(s):  
Heat Transfer ◽  
Flow Field ◽  
Heat Generation ◽  
Wall Temperature ◽  
Flow Boiling ◽  
Narrow Channel ◽  
Heated Wall ◽  
Uniform Heat ◽  
Proposed Model ◽  
Sliding Bubbles

A quenching/diffusion analytical model has been developed for predicting the wall temperature and wall heat flux behind bubbles sliding in a confined narrow channel. The model is based on the concept of a well-mixed liquid region that enhances the heat transfer near the heated wall behind the bubble. Heat transfer in the liquid is treated as a one-dimensional transient conduction process until the flow field recovers back to its undisturbed level prior to bubble passage. The model is compared to experimental heat transfer results obtained in a high-aspect-ratio (1.2×23mm) rectangular, horizontal channel with one wide wall forming a uniform-heat-generation boundary and the other designed for optical access to the flow field. The working fluid was Novec™ 649. A thermochromic liquid crystal coating was applied to the outside of the uniform-heat-generation boundary, so that wall temperature variations could be obtained and heat transfer coefficients and Nusselt numbers could be obtained. The experiments were focused on high inlet subcooling, typically 15–50°C. The model is able to capture the elevated heat transfer rates measured in the channel without the need to consider nucleate boiling from the surface or microlayer evaporation from the sliding bubbles. Surface temperatures and wall heat fluxes were estimated for 17 different experimental conditions using the proposed model. Results agreed with the measured values within ±15% accuracy. The insight gathered from comparing the results of the proposed model to experimental results provides the basis for a better understanding of the physics of subcooled bubbly flow in narrow channels.

scholarly journals Dual Targeting of Cancer Cells and MMPs with Self-Assembly Hybrid Nanoparticles for Combination Therapy in Combating Cancer

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1990
Author(s):  
Kai Zhang ◽  
Jingjing Li ◽  
Xiaofei Xin ◽  
Xiaoqing Du ◽  
Di Zhao ◽  
...  
Keyword(s):  
T Cells ◽  
Cancer Cells ◽  
Self Assembly ◽  
Chemotherapeutic Agents ◽  
Hybrid Nanoparticles ◽  
Control Group ◽  
Hyperthermia Treatment ◽  
Immune Modulators ◽  
Dual Targeting

The co-delivery of chemotherapeutic agents and immune modulators to their targets remains to be a great challenge for nanocarriers. Here, we developed a hybrid thermosensitive nanoparticle (TMNP) which could co-deliver paclitaxel-loaded transferrin (PTX@TF) and marimastat-loaded thermosensitive liposomes (MMST/LTSLs) for the dual targeting of cancer cells and the microenvironment. TMNPs could rapidly release the two payloads triggered by the hyperthermia treatment at the site of tumor. The released PTX@TF entered cancer cells via transferrin-receptor-mediated endocytosis and inhibited the survival of tumor cells. MMST was intelligently employed as an immunomodulator to improve immunotherapy by inhibiting matrix metalloproteinases to reduce chemokine degradation and recruit T cells. The TMNPs promoted the tumor infiltration of CD3+ T cells by 2-fold, including memory/effector CD8+ T cells (4.2-fold) and CD4+ (1.7-fold), but not regulatory T cells. Our in vivo anti-tumor experiment suggested that TMNPs possessed the highest tumor growth inhibitory rate (80.86%) compared with the control group. We demonstrated that the nanoplatform could effectively inhibit the growth of tumors and enhance T cell recruitment through the co-delivery of paclitaxel and marimastat, which could be a promising strategy for the combination of chemotherapy and immunotherapy for cancer treatment.

scholarly journals Experimental Investigation of Thermo-Physical Properties of Tri-Hybrid Nanoparticles in Water-Ethylene Glycol Mixture

2021 ◽  
Vol 18 (8) ◽  
Author(s):  
Anwar Ilmar RAMADHAN ◽  
Wan Hamzah AZMI ◽  
Rizalman MAMAT
Keyword(s):  
Heat Transfer ◽  
Thermal Conductivity ◽  
Ethylene Glycol ◽  
Physical Properties ◽  
Dynamic Viscosity ◽  
Volume Concentration ◽  
Hybrid Nanoparticles ◽  
Maximum Enhancement ◽  
Hybrid Nanofluids ◽  
Thermo Physical Properties

In recent years, research has focused on enhancing the thermo-physical properties of a single component nanofluid. Therefore, hybrid or composite nanofluids have been developed to improve heat transfer performance. The thermo-physical properties of the Al2O3-TiO2-SiO2 nanoparticles suspended in a base of water (W) and ethylene glycol (EG) at constant volume ratio of 60:40 and different volume concentrations were investigated. The experiment was conducted for the volume concentrations of 0.05, 0.1, 0.2, and 0.3% of Al2O3-TiO2-SiO2 nanofluids at different temperatures of 30, 40, 50, 60, and 70 °C. Thermal conductivity and dynamic viscosity measurements were carried out at temperatures ranging from 30 to 70 °C by using KD2 Pro Thermal Properties Analyzer and Brookfield LVDV III Ultra Rheometer, respectively. The highest thermal conductivity for tri-hybrid nanofluids was obtained at 0.3% volume concentration, and the maximum enhancement was increased up to 9% higher than the base fluid (EG/W). Tri-hybrid nanofluids with a volume concentration of 0.05% gave the lowest effective thermal conductivity of 4.8 % at 70 °C temperature. Meanwhile, the dynamic viscosity of the tri-hybrid nanofluids was influenced by volume concentration and temperature. Furthermore, tri-hybrid nanofluids behaved as a Newtonian fluid for volume concentrations from 0.05 to 3.0%. The properties enhancement ratio (PER) estimated that the tri-hybrid nanofluids will aid in heat transfer for all samples in the present. The new correlations for thermal conductivity and dynamic viscosity of tri-hybrid nanofluids were developed with minimum deviation. As a conclusion, the combination of the enhancement in thermal conductivity and dynamic viscosity for tri-hybrid at 0.3% volume concentration was found the optimum condition with more advantage for heat transfer than other concentrations.

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