Nanotechnology for Drug Delivery and Cancer Therapy

2022 ◽  
pp. 338-362
Author(s):  
Israt Jahan
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Metallic Nanoparticles ◽  
Polymeric Nanoparticles ◽  
System Diagnosis ◽  
Wide Range ◽  
Health Related ◽  
Cancer Diagnosis And Therapy ◽  
Potential Use ◽  
Targeted Drug Delivery System

Nanotechnology facilitates exclusive opportunities for investigating and controlling a wide range of biomedical approaches at nano-scale, which could provide a groundbreaking impact on medicine, biology, and other health-related areas. This latest technology offers certain distinctive benefits in different aspects such as nanocarriers of targeted drug delivery system, diagnosis and treatment of cancer, vaccination and immunotherapy, biosensing and imaging for clinical diagnosis. A wide range of nanomaterials with biomedical prominence have already been exploited for drug delivery and cancer therapy comprising, solid lipid nanoparticles, metallic nanoparticles, polymeric nanoparticles, carbon nanotube, nanogel-based compounds, nanocapsules, magnetic nanoparticles, nanofluids, nanowires, liposomes, etc. Therefore, this chapter reviewed the potential use of different nanomaterials for therapeutic applications, especially for drug delivery and cancer diagnosis and therapy by focusing their suitability and biocompatibility for extensive and safer usages.

scholarly journals Natural Ingredient-Based Polymeric Nanoparticles for Cancer Treatment

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3620 ◽  
Author(s):  
Ka Hong Wong ◽  
Aiping Lu ◽  
Xiaoyu Chen ◽  
Zhijun Yang
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Current Knowledge ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Therapeutic Effects ◽  
Natural Materials ◽  
Wide Range ◽  
Clinical Potential ◽  
Novel Drug

Cancer is a global health challenge. There are drawbacks to conventional chemotherapy such as poor bioavailability, development of drug resistance and severe side effects. Novel drug delivery system may be an alternative to optimize therapeutic effects. When such systems consist of natural materials, they offer important advantages: they are usually highly biocompatible, biodegradable, nontoxic and nonimmunogenic. Furthermore, natural materials can be easily modified for conjugation with a wide range of therapeutic agents and targeting ligands, according to the therapeutic purpose. This article reviews different natural ingredients and their applications in drug delivery systems for cancer therapy. Firstly, an overview of the polysaccharides and protein-based polymers that have been extensively investigated for drug delivery are described. Secondly, recent advances in using various natural ingredient-based polymeric nanoparticles for cancer therapy are reviewed. The characteristics of these delivery systems are summarized, followed by a discussion of future development and clinical potential. This review aims to summarize current knowledge and provide a basis for developing effective tailor-made formulations for cancer therapy in the future.

Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

2019 ◽  
Vol 25 (37) ◽  
pp. 3917-3926
Author(s):  
Sajjad Molavipordanjani ◽  
Seyed Jalal Hosseinimehr
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Medical Imaging ◽  
Cancer Diagnosis ◽  
Carbon Nanoparticles ◽  
Tumor Targeting ◽  
Polymeric Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Active Targeting ◽  
Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

A novel α-enolase-targeted drug delivery system for high efficacy prostate cancer therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (28) ◽  
pp. 13673-13683 ◽  
Author(s):  
Luyao Wang ◽  
Mengke Qu ◽  
Shiqi Huang ◽  
Yu Fu ◽  
Liuqing Yang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
High Efficacy ◽  
Prostate Cancer Therapy ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

The current work has designed a novel α-enolase-targeted drug delivery system for high efficacy prostate cancer therapy using the pHCT74 peptide.

Targeted drug delivery system for oral cancer therapy using sonoporation

2009 ◽  
Vol 38 (7) ◽  
pp. 572-579 ◽  
Author(s):  
Hironobu Maeda ◽  
Kazuhiro Tominaga ◽  
Kenjiro Iwanaga ◽  
Fuminori Nagao ◽  
Manabu Habu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Oral Cancer ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Stimuli-responsive Polymeric nanosystems for therapeutic applications

2021 ◽  
Vol 27 ◽  
Author(s):  
Mayank Handa ◽  
Ajit Singh ◽  
S.J.S. Flora ◽  
Rahul Shukla
Keyword(s):  
Drug Delivery ◽  
Metallic Nanoparticles ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Delivery Systems ◽  
Specific Drug ◽  
Stimuli Responsive

Background: Recent past decades have reported emerging of polymeric nanoparticles as a promising technique for controlled and targeted drug delivery. As nanocarriers, they have high drug loading and delivery to the specific site or targeted cells with an advantage of no drug leakage within en route and unloading of a drug in a sustained fashion at the site. These stimuli-responsive systems are functionalized in dendrimers, metallic nanoparticles, polymeric nanoparticles, liposomal nanoparticles, quantum dots. Purpose of Review: The authors reviewed the potential of smart stimuli-responsive carriers for therapeutic application and their behavior in external or internal stimuli like pH, temperature, redox, light, and magnet. These stimuli-responsive drug delivery systems behave differently in In vitro and In vivo drug release patterns. Stimuli-responsive nanosystems include both hydrophilic and hydrophobic systems. This review highlights the recent development of the physical properties and their application in specific drug delivery. Conclusion: The stimuli (smart, intelligent, programmed) drug delivery systems provide site-specific drug delivery with potential therapy for cancer, neurodegenerative, lifestyle disorders. As development and innovation, the stimuli-responsive based nanocarriers are moving at a fast pace and huge demand for biocompatible and biodegradable responsive polymers for effective and safe delivery.

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