scholarly journals Natural Ingredient-Based Polymeric Nanoparticles for Cancer Treatment

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3620 ◽  
Author(s):  
Ka Hong Wong ◽  
Aiping Lu ◽  
Xiaoyu Chen ◽  
Zhijun Yang
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Current Knowledge ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Therapeutic Effects ◽  
Natural Materials ◽  
Wide Range ◽  
Clinical Potential ◽  
Novel Drug

Cancer is a global health challenge. There are drawbacks to conventional chemotherapy such as poor bioavailability, development of drug resistance and severe side effects. Novel drug delivery system may be an alternative to optimize therapeutic effects. When such systems consist of natural materials, they offer important advantages: they are usually highly biocompatible, biodegradable, nontoxic and nonimmunogenic. Furthermore, natural materials can be easily modified for conjugation with a wide range of therapeutic agents and targeting ligands, according to the therapeutic purpose. This article reviews different natural ingredients and their applications in drug delivery systems for cancer therapy. Firstly, an overview of the polysaccharides and protein-based polymers that have been extensively investigated for drug delivery are described. Secondly, recent advances in using various natural ingredient-based polymeric nanoparticles for cancer therapy are reviewed. The characteristics of these delivery systems are summarized, followed by a discussion of future development and clinical potential. This review aims to summarize current knowledge and provide a basis for developing effective tailor-made formulations for cancer therapy in the future.

scholarly journals Recent development in novel drug delivery systems for delivery of herbal drugs: An updates

2021 ◽  
Vol 8 (2) ◽  
pp. 008-018
Author(s):  
Prajakta N. Dongare ◽  
Anuja S. Motule ◽  
Mahesh R. Dubey ◽  
Manisha P. More ◽  
Prerna A. Patinge ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Herbal Medicines ◽  
Delivery Systems ◽  
Therapeutic Effects ◽  
Herbal Drugs ◽  
Active Components ◽  
Novel Drug ◽  
Herbal Formulations

In the recent years, herbal medicines have gained worldwide attention of peoples and researchers due to their esthetic value, more patient’s compliance and prominent therapeutic effects. Novel drug delivery systems for delivery of herbal drugs possesses several advantages over conventional formulations. It includes enhancement of solubility, bioavailability, and protection from toxicity, etc. The herbal drugs can be used in a more upright course with enhanced efficacy by incorporating them into suitable dosage forms. This can be achieved by designing novel drug delivery systems for such drugs. Such systems are polymeric nanoparticles, nanocapsules, phytosomes, animations, microsphere, etc. The present article highlights the current condition of the development of novel herbal formulations and summarizes their type of active components, biological activity, and applications of novel formulations.

Effect of NDDS on Polyherbal Formulation

2021 ◽  
pp. 106-148
Author(s):  
Sandeep Onkar Waghulde ◽  
Nilofar A. Khan ◽  
Nilesh Gorde
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Plant Materials ◽  
Ancient Times ◽  
Reduced Toxicity ◽  
Novel Drug ◽  
Herbal Formulations

In India, in ancient times, people used plant materials to make drug polyherbal formulations. Herbal drugs have enormous therapeutic potential which can be explored through various beneficial drug delivery systems and novel drug delivery systems. Great advancement has been made in the uses of plant therapeutics on the development of novel herbal formulations like polymeric nanoparticles, nanocapsules, liposomes, phytosomes, nanoemulsions, microsphere, transferosomes, and ethosomes. These formulations have reported having various advantages over the traditional formulations such as improved solubility and bioavailability, reduced toxicity, controlled drug delivery, protections of plant actives from degradation. Also, having the drug targeting properties with improved selectivity, drug delivery, and effectiveness with dose reduction not only increases the safety but also patient compliance.

NANO-CARRIER BASED DRUG DELIVERY SYSTEMS CONTAINING BIOACTIVE FROM CARICA PAPAYA FOR ANTI-DIABETIC ACTIVITY

2021 ◽  
Vol 11 (6) ◽  
pp. 9-15
Author(s):  
Rima Ramesh Patil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Carica Papaya ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Patient Comfort ◽  
Synthetic Drugs ◽  
Therapeutic Benefits ◽  
Alternative Drug ◽  
Novel Drug

Significant progress has been achieved in the creation of novel drug delivery systems based on herbal bioactive in recent years. Herbal formulations for novel drug delivery systems are more efficient and have more benefits than other alternatives. Papaya (Carica papaya Linn) is very popular for its nutritious as well as therapeutic benefits all over the world. Carica papaya is a tropical and subtropical fruit that is used as a vegetable and in herbal medicine to treat a variety of ailments. The rising prevalence of diabetes, along with the harsh side effects of some synthetic drugs, has prompted an increase in the search for natural alternatives. Liposomes, phytosomes, ethosomes microspheres, nano-capsules, transferosomes, polymeric nanoparticles, nano-emulsions, and nano-emulsions have all been developed using bioactive and plant extracts. The primary motivation for the advancement of alternative drug delivery is to improve drug delivery quality and safety while also providing greater patient comfort.

Lipid-Coated Nanosized Drug Delivery Systems For An Effective Cancer Therapy

2020 ◽  
Vol 17 ◽  
Author(s):  
Ozge Esim ◽  
Canan Hascicek
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Delivery Systems ◽  
Inorganic Nanoparticles ◽  
Coated Nanoparticle

: Currently, despite many active compounds have been introduced to the treatment, cancer remains one of the most vital causes of mortality and reduced quality of life. Conventional cancer treatments may have undesirable consequences due to the continuously differentiating, dynamic and heterogeneous nature of cancer. Recent advances in the field of cancer treatment have promoted the development of several novel nanoformulations. Among them, the lipid coated nanosized drug delivery systems have gained an increasing attention by the researchers in this field owing to the attractive properties such as high stability and biocompatibility, prolonged circulation time, high drug loading capacity and superior in vivo efficacy. They possess the advantages of both the liposomes and polymeric nanoparticles which makes them a chosen one in the field of drug delivery and targeting. Core-shell type lipid-coated nanoparticle systems, which provide the most prominent advantages of both liposomes such as biocompatibility and polymeric/inorganic nanoparticles such as mechanic properties, offer a new approach to cancer treatment. This review discusses design and production procedures used to prepare lipid-coated nanoparticle drug delivery systems, their advantages and multifunctional role in cancer therapy and diagnosis, as well as the applications they have been used in.

scholarly journals Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1329 ◽  
Author(s):  
Febrina Sandra ◽  
Nisar Ul Khaliq ◽  
Anwar Sunna ◽  
Andrew Care
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Future Directions ◽  
Cancer Nanomedicine ◽  
Diagnostic Agents ◽  
Poor Understanding ◽  
Potential Alternative ◽  
Clinical Potential

In recent years, it has become apparent that cancer nanomedicine’s reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their “bio–nano” interactions. Protein-based nanoparticles (PNPs) are rapidly emerging as versatile vehicles for the delivery of therapeutic and diagnostic agents, offering a potential alternative to synthetic nanoparticles. PNPs are abundant in nature, genetically and chemically modifiable, monodisperse, biocompatible, and biodegradable. To harness their full clinical potential, it is important for PNPs to be accurately designed and engineered. In this review, we outline the recent advancements and applications of PNPs in cancer nanomedicine. We also discuss the future directions for PNP research and what challenges must be overcome to ensure their translation into the clinic.

scholarly journals Transfersomes: a novel technique for transdermal drug delivery

2019 ◽  
Vol 9 (1) ◽  
pp. 279-285 ◽  
Author(s):  
Priyanka Chaurasiya ◽  
Eisha Ganju ◽  
Neeraj Upmanyu ◽  
Sudhir Kumar Ray ◽  
Prabhat Jain
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Entrapment Efficiency ◽  
Delivery Systems ◽  
Ionic Surfactant ◽  
Wide Range ◽  
Novel Drug

Novel drug delivery systems are now a days is creating a new interest in development of drug deliveries. Vesicular drug delivery system is also a part of these novel drug delivery systems. TDDS is the permeability of the skin, it is permeable to small molecules, lipophilic drug and highly impermeable to the macromolecules and hydrophilic drugs. Recent approaches have resulted in design of two vesicular carriers, ethosomes and ultra flexible lipid based elastic vesicles, transferosomes. Transferosomes have recently been introduced, which are capable of transdermal delivery of low as well as high molecular weight drugs. This offers several potential advantages over conventional routes like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half life drugs, improving physiological and pharmacological response and have been applied to increases the efficiency of the material transfer across the intact skin, by the use of penetration enhancers, iontophoresis, sonophoresis and use of colloidal carriers such as lipid vesicles (liposomes & proliposomes) and non-ionic surfactant vesicles (niosomes & proniosomes). It is suitable for controlled and targeted drug delivery and it can accommodate drug molecules with wide range of solubility. Due to its high deformability it gives better penetration of intact vesicles. They are biocompatible and biodegradable as they are made from natural phospholipids and have high entrapment efficiency. The preparation variables are depending upon the procedure involved for manufacturing of formulation and the preparation procedure was accordingly optimized and validated. Characterization of transferosomes can be done to know the vesicle size, morphology, drug content, entrapment efficiency, penetration ability, occlusion effect, surface charge, in vitro drug release, in vitro skin penetration etc., It increases stability of labile drugs and provides control release. Transferosomes thus differs from such more conventional vesicles primarily by its softer, more deformable, better adjustable artificial membrane. Keywords: Novel Drug Delivery System, Biocompatible, Characterization, Transferosomes.

scholarly journals TRANSFEROSOME: A RECENT APPROACH FOR TRANSDERMAL DRUG DELIVERY

2018 ◽  
Vol 8 (5-s) ◽  
pp. 100-104 ◽  
Author(s):  
Abhay Kumar
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ionic Surfactant ◽  
Drug Molecules ◽  
Wide Range ◽  
Targeted Drug ◽  
Novel Drug

Novel drug delivery systems are now a day is creating a new interest in development of drug deliveries. The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. Transferosomes are capable of transdermal delivery of low as well as high molecular weight drugs. This offers several potential advantages over conventional routes like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half life drugs, improving physiological and pharmacological response and have been applied to increases the efficiency of the material transfer across the intact skin, by the use of penetration enhancers and non-ionic surfactant vesicles. It is suitable for controlled and targeted drug delivery and it can accommodate drug molecules with wide range of solubility. Due to its high deformability it gives better penetration of intact vesicles. Transferosome possess an infrastructure consisting of hydrophobic and hydrophilic moieties together and as a result can accommodate drug molecules with wide range of solubility. They are biocompatible and biodegradable as they are made from natural phospholipids and have high entrapment efficiency. In this review, we have focused on transferosome with discussions on novel drug delivery systems for targeted delivery of therapeutics and important issues and challenges for future clinical applications. Keywords: Novel drug delivery systems, Transferosomes, Transdermal drug delivery, Targeted drug delivery

Engineered polymer nanoplatforms for targeted tumor cells and controlled release cargos to enhance cancer treatment

2021 ◽  
Vol 28 ◽  
Author(s):  
Zhenjie Wang ◽  
Longguang Tang ◽  
Qingchun Mu ◽  
Siyao Che ◽  
Yongbing Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
The Body ◽  
Great Effort ◽  
Imaging Probes ◽  
Effective Diagnosis

: Cancer is composed of a serious of uncontrollably c ells, which finally form tumors to negatively impact the functions of the body and induce other serious diseases, even lead people to death. During the last decades, scientists devote great effort to study cancer, however there are no effective diagnosis and treatments. Nanomaterials have attracted great attention in biomedical field in recent years, which have been widely used as optical imaging probes and delivery systems for cancer therapy. Among the numerous nanomaterials, polymeric nanoparticles occupy a prominent position because of their tunable micro-size, multifunctional surface, prominent biocompatibility and high drug-carrying capacity. These significant advantages endow them over the traditional nanomaterials and become a potential therapy for cancer. In this review, we focus on the applications of polymeric nanoparticles in cancer theranostics, especially as the drug delivery systems for cancer treatment. This review provides an overview of the advancement of synthesis, application of polymeric nanoparticles-based drug delivery systems and highlights the evaluation for cancer therapy.

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