Feasibility of Large Scale Implementation of Personalized Medicine in the Current Scenario

2016 ◽  
Vol 7 (2) ◽  
pp. 30-49 ◽  
Author(s):  
Subhas C. Misra ◽  
Sandip Bisui
Keyword(s):  
Personalized Medicine ◽  
Healthcare System ◽  
Large Scale ◽  
Vital Role ◽  
Healthcare Management ◽  
Medical Doctors ◽  
Common People ◽  
Record System ◽  
Medical Practitioners ◽  
Proper Training

Personalized Medicine (PM) is an emerging concept in the modern healthcare system and can play a vital role in modern healthcare management. If this concept can be adopted and implemented in a proper manner, the entire healthcare system will attain an elevated dimension. However, there exist many difficulties in adopting personalized healthcare system. An attempt has been made in this paper to present the data obtained through survey that has been conducted amongst a group of medical practitioners and a group of patients. The data collected have then been analysed by resorting to statistical techniques. The study shows that despite many personalized medicines have been discovered for use, it is difficult to adopt the personalized medicare system due to lack of adequate infrastructures, healthcare record system, communication among the medical doctors and genomic researchers, awareness and encouragement of common people, proper training of medical doctors, and confidentiality of the patients.

IOT-Based Smart Healthcare System: A Review on Constituent Technologies

2021 ◽  
pp. 2130008
Author(s):  
Manju Lata Sahu ◽  
Mithilesh Atulkar ◽  
Mitul Kumar Ahirwal
Keyword(s):  
Healthcare System ◽  
Service Providers ◽  
Data Communication ◽  
Healthcare Services ◽  
Vital Role ◽  
Medical Practitioners ◽  
Smart Healthcare ◽  
Rural And Remote Areas ◽  
Medical Infrastructure ◽  
Physiological Sensing

The revolution in the Internet of Things (IoT) is redesigning and reshaping the healthcare system technologically, economically and socially. The emerging and rapidly growing IoT-based Smart Healthcare System (SHCS) is seen as a sustainable solution to reduce the burden on the existing healthcare system due to increasing diseases and limited medical infrastructure. IoT-based SHCS plays a vital role in delivery of healthcare services in rural and remote areas where the essential medical amenities, necessary infrastructures and qualified medical practitioners are not available. Therefore, in this paper, a comprehensive investigation of futuristic IoT-based SHCS and its constituents is presented. This paper provides exhaustive review on different techniques and technologies dealing with smart healthcare framework, physiological sensing, signal processing, data communication, cloud computing and data analytics used in IoT-based SHCS. A comparative analysis of existing literature has been carried out to identify the recent trends and advancements in this very dynamic field of global importance. In addition to this, it highlights different issues and challenges, along with the recommendation for further research in the field. The prime objective of this paper is to deliver the state-of-the-art understanding and update about IoT-based SHCS and its constituents by providing a good source of information to the researchers, service providers, technologists, medical practitioners and the general population.

Identifying Critical Changes in Adoption of Personalized Medicine (PM) in Healthcare Management

2016 ◽  
Vol 7 (3) ◽  
pp. 1-15 ◽  
Author(s):  
Subhas C. Misra ◽  
Sandip Bisui ◽  
Kamel Fantazy
Keyword(s):  
Health Care ◽  
Personalized Medicine ◽  
Health Care System ◽  
Electronic Medical Record System ◽  
Healthcare Management ◽  
It Infrastructure ◽  
Record System ◽  
Secure Information ◽  
Medical Record System ◽  
Care System

Among the emerging areas in health-care system, the implementation of Electronic Medical Record system and the discovery of Personalized Medicine are occupying top positions. While some of the personalized drugs have already been discovered, implementing this new medicare system requires a lot of changes in the traditional health-care system. This paper aims at identifying these critical changes required in the adoption of the Personalized Medicine system. A systemic attempt has been made to prepare a list of possible changes required for the adoption based on available literature. This research study shows that changes from reactive to efficient medical care, from trial and error to right treatment for right person at right time, from narrow mind-set to open mindedness, from open information of patients to secure information, from less emphasis on IT infrastructure to more emphasis on IT infrastructure are some of the significant changes that are necessary for implementing the revolutionary medicare system of personalized Medicine.

Critical Challenges for Adopting Personalized Medicine System in Healthcare Management

2014 ◽  
Vol 5 (2) ◽  
pp. 70-89 ◽  
Author(s):  
Subhas Chandra Misra ◽  
Sandip Bisui
Keyword(s):  
Personalized Medicine ◽  
Genomic Analysis ◽  
Healthcare Management ◽  
Board Members ◽  
Medical Doctors ◽  
Response Data ◽  
Academic Paper ◽  
Pharmaceutical Industries ◽  
Statistical Results ◽  
Made In

Personalized Medicine is an emerging approach in today's healthcare management. It bears a very strong potential to consolidate modern e-health systems fundamentally. Scientists have already discovered some of the personalized drugs that can shift the whole medicare process into a new dimension. However, bringing the change in healthcare management is an easy task. There are several critical challenges in the implementation of Personalized Medicine systems. This paper aims at identifying some of these critical challenges through a survey with medical doctors and patients. Challenges involved in implementing Personalized Medicine are listed. A questionnaire was distributed amongst a set of medical doctors, medical researchers, practitioners in pharmaceutical industries, regulatory board members, and a larger section of patients. The response data collected thereby were analysed statistically by using t-test. Summary of the descriptive statistical results of the responses received from medical doctors and patients are presented in tabular form. Based upon the statistical analysis, an attempt has been made in the paper to make a ranking of the challenges. A comparison of the perspectives of the doctors and patients has been made by using bar diagrams. The observations have been discussed in detail and some specific conclusions have been made. To the best of the author's knowledge and belief, this is the first academic paper in which an attempt has been made to suggest the crucial challenges for the implementation of Personalized Medicine. The study shows that both the medical doctors and patients perceive that genomic analysis of all the individuals is the most critical challenge.

An Internet-based health gateway device for interactive communication and automatic data uploading: Clinical efficacy for type 2 diabetes in a multi-centre trial

2016 ◽  
Vol 23 (6) ◽  
pp. 595-604 ◽  
Author(s):  
Jae Hyoung Cho ◽  
Hun-Sung Kim ◽  
Seung Hyun Yoo ◽  
Chang Hee Jung ◽  
Woo Je Lee ◽  
...  
Keyword(s):  
Adverse Events ◽  
Healthcare System ◽  
Glucose Control ◽  
Large Scale ◽  
Diabetes Management ◽  
Intervention Group ◽  
Diabetes Control ◽  
Control Group ◽  
Anthropometric Parameters ◽  
Automatic Data

Introduction The aim of this study was to improve the quality of diabetes control and evaluate the efficacy of an Internet-based integrated healthcare system for diabetes management and safety. Methods We conducted a large-scale, multi-centre, randomized clinical trial involving 484 patients. Patients in the intervention group ( n = 244) were treated with the Internet-based system for six months, while the control group ( n = 240) received the usual outpatient management over the same period. HbA1c, blood chemistries, anthropometric parameters, and adverse events were assessed at the beginning of the study, after three months, and the end of the study. Results There were no initial significant differences between the groups with respect to demographics and clinical parameters. Upon six-month follow-up, HbA1c levels were significantly decreased from 7.86 ± 0.69% to 7.55 ± 0.86% within the intervention group ( p < 0.001) compared to 7.81 ± 0.66% to 7.70 ± 0.88% within the control group. Postprandial glucose reduction was predominant. A subgroup with baseline HbA1c higher than 8% and good compliance achieved a reduction of HbA1c by 0.8 ± 1.05%. Glucose control and waist circumference reduction were more effective in females and subjects older than 40 years of age. There were no adverse events associated with the intervention. Discussion This e-healthcare system was effective for glucose control and body composition improvement without associated adverse events in a multi-centre trial. This system may be effective in improving diabetes control in the general population.

scholarly journals MedShard: Electronic Health Record Sharing Using Blockchain Sharding

2021 ◽  
Vol 13 (11) ◽  
pp. 5889
Author(s):  
Faiza Hashim ◽  
Khaled Shuaib ◽  
Farag Sallabi
Keyword(s):  
Healthcare System ◽  
Small Groups ◽  
Network Performance ◽  
Communication Overhead ◽  
Privacy And Security ◽  
Health Records ◽  
Medical Practitioners ◽  
Blockchain Technology ◽  
Simulation Results ◽  
Electronic Health

Electronic health records (EHRs) are important assets of the healthcare system and should be shared among medical practitioners to improve the accuracy and efficiency of diagnosis. Blockchain technology has been investigated and adopted in healthcare as a solution for EHR sharing while preserving privacy and security. Blockchain can revolutionize the healthcare system by providing a decentralized, distributed, immutable, and secure architecture. However, scalability has always been a bottleneck in blockchain networks due to the consensus mechanism and ledger replication to all network participants. Sharding helps address this issue by artificially partitioning the network into small groups termed shards and processing transactions parallelly while running consensus within each shard with a subset of blockchain nodes. Although this technique helps resolve issues related to scalability, cross-shard communication overhead can degrade network performance. This study proposes a transaction-based sharding technique wherein shards are formed on the basis of a patient’s previously visited health entities. Simulation results show that the proposed technique outperforms standard-based healthcare blockchain techniques in terms of the number of appointments processed, consensus latency, and throughput. The proposed technique eliminates cross-shard communication by forming complete shards based on “the need to participate” nodes per patient.

scholarly journals A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Tao Yue ◽  
Da Zhao ◽  
Duc T. T. Phan ◽  
Xiaolin Wang ◽  
Joshua Jonghyun Park ◽  
...  
Keyword(s):  
Large Scale ◽  
Circulatory System ◽  
Vertical Direction ◽  
Microfluidic System ◽  
Vital Role ◽  
Microvascular Networks ◽  
Biological Studies ◽  
Wide Range ◽  
High Flexibility

AbstractThe vascular network of the circulatory system plays a vital role in maintaining homeostasis in the human body. In this paper, a novel modular microfluidic system with a vertical two-layered configuration is developed to generate large-scale perfused microvascular networks in vitro. The two-layer polydimethylsiloxane (PDMS) configuration allows the tissue chambers and medium channels not only to be designed and fabricated independently but also to be aligned and bonded accordingly. This method can produce a modular microfluidic system that has high flexibility and scalability to design an integrated platform with multiple perfused vascularized tissues with high densities. The medium channel was designed with a rhombic shape and fabricated to be semiclosed to form a capillary burst valve in the vertical direction, serving as the interface between the medium channels and tissue chambers. Angiogenesis and anastomosis at the vertical interface were successfully achieved by using different combinations of tissue chambers and medium channels. Various large-scale microvascular networks were generated and quantified in terms of vessel length and density. Minimal leakage of the perfused 70-kDa FITC-dextran confirmed the lumenization of the microvascular networks and the formation of tight vertical interconnections between the microvascular networks and medium channels in different structural layers. This platform enables the culturing of interconnected, large-scale perfused vascularized tissue networks with high density and scalability for a wide range of multiorgan-on-a-chip applications, including basic biological studies and drug screening.

scholarly journals On the relation between mini-halos and AGN feedback in clusters of galaxies

2020 ◽  
Vol 499 (2) ◽  
pp. 2934-2958
Author(s):  
A Richard-Laferrière ◽  
J Hlavacek-Larrondo ◽  
R S Nemmen ◽  
C L Rhea ◽  
G B Taylor ◽  
...  
Keyword(s):  
Large Scale ◽  
State Of The Art ◽  
Vital Role ◽  
Clusters Of Galaxies ◽  
Relativistic Jets ◽  
X Ray ◽  
Core Cluster ◽  
Central Galaxy ◽  
Central Regions ◽  
Radio Power

ABSTRACT A variety of large-scale diffuse radio structures have been identified in many clusters with the advent of new state-of-the-art facilities in radio astronomy. Among these diffuse radio structures, radio mini-halos are found in the central regions of cool core clusters. Their origin is still unknown and they are challenging to discover; less than 30 have been published to date. Based on new VLA observations, we confirmed the mini-halo in the massive strong cool core cluster PKS 0745−191 (z = 0.1028) and discovered one in the massive cool core cluster MACS J1447.4+0827 (z = 0.3755). Furthermore, using a detailed analysis of all known mini-halos, we explore the relation between mini-halos and active galactic nucleus (AGN) feedback processes from the central galaxy. We find evidence of strong, previously unknown correlations between mini-halo radio power and X-ray cavity power, and between mini-halo and the central galaxy radio power related to the relativistic jets when spectrally decomposing the AGN radio emission into a component for past outbursts and one for ongoing accretion. Overall, our study indicates that mini-halos are directly connected to the central AGN in clusters, following previous suppositions. We hypothesize that AGN feedback may be one of the dominant mechanisms giving rise to mini-halos by injecting energy into the intra-cluster medium and reaccelerating an old population of particles, while sloshing motion may drive the overall shape of mini-halos inside cold fronts. AGN feedback may therefore not only play a vital role in offsetting cooling in cool core clusters, but may also play a fundamental role in re-energizing non-thermal particles in clusters.

scholarly journals The Sense of Smell and Aging: What We Have Learned From Population Studies

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 810-811
Author(s):  
Jayant Pinto
Keyword(s):  
Mental Health ◽  
Older Adults ◽  
Social Life ◽  
Large Scale ◽  
Population Studies ◽  
Vital Role ◽  
Sensory Function ◽  
Physical And Mental Health ◽  
Sense Of Smell ◽  
Health Aging

Abstract Decline of the sense of smell with age causes a marked impact on older adults, markedly reducing quality of life. Olfactory dysfunction impairs nutrition, decreases the ability to experience pleasure, and results in depression, among other burdens. Large-scale population studies have identified impaired olfaction as a key heath indicator that predicts the development of decreased physical and mental health, reduced physical activity, weight loss, mild cognitive impairment and dementia, and mortality itself. These data have been generated via analyses of data from several aging cohorts, including the National Social Life, Health, and Aging Project (NSHAP); the Beaver Dam cohort; the Atherosclerosis Risk in Communities project; the Rush Memory and Aging Project; the Health, Aging, and Body Composition project; the Washington Heights/Inwood Columbia Aging Project; among others. In this presentation, we will review the close connection between olfaction, health, aging, including discussion of insights from these studies. We will also discuss emerging data from NSHAP on the effects of sensory function on cognition, mental health, and social interaction, which demonstrate that sensory function plays a vital role in the lives of older adults. Part of a symposium sponsored by Sensory Health Interest Group.

scholarly journals Personalized medicine for reconstruction of critical-size bone defects – a translational approach with customizable vascularized bone tissue

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Annika Kengelbach-Weigand ◽  
Carolina Thielen ◽  
Tobias Bäuerle ◽  
Rebekka Götzl ◽  
Thomas Gerber ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Large Scale ◽  
Critical Size ◽  
Therapeutic Option ◽  
Living Organism ◽  
Bone Defects ◽  
Sheep Model ◽  
Simple Alternative ◽  
Translational Approach ◽  
Near Future

AbstractTissue engineering principles allow the generation of functional tissues for biomedical applications. Reconstruction of large-scale bone defects with tissue-engineered bone has still not entered the clinical routine. In the present study, a bone substitute in combination with mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC) with or without growth factors BMP-2 and VEGF-A was prevascularized by an arteriovenous (AV) loop and transplanted into a critical-size tibia defect in the sheep model. With 3D imaging and immunohistochemistry, we could show that this approach is a feasible and simple alternative to the current clinical therapeutic option. This study serves as proof of concept for using large-scale transplantable, vascularized, and customizable bone, generated in a living organism for the reconstruction of load-bearing bone defects, individually tailored to the patient’s needs. With this approach in personalized medicine for the reconstruction of critical-size bone defects, regeneration of parts of the human body will become possible in the near future.

scholarly journals Limits of data anonymity: lack of public awareness risks trust in health system activities

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Felix Gille ◽  
Caroline Brall
Keyword(s):  
Large Scale ◽  
Public Awareness ◽  
Personal Data ◽  
Public Trust ◽  
Online News ◽  
Healthcare Management ◽  
Contact Tracing ◽  
Common Denominator ◽  
The Public ◽  
Privacy And Anonymity

AbstractPublic trust is paramount for the well functioning of data driven healthcare activities such as digital health interventions, contact tracing or the build-up of electronic health records. As the use of personal data is the common denominator for these healthcare activities, healthcare actors have an interest to ensure privacy and anonymity of the personal data they depend on. Maintaining privacy and anonymity of personal data contribute to the trustworthiness of these healthcare activities and are associated with the public willingness to trust these activities with their personal data. An analysis of online news readership comments about the failed care.data programme in England revealed that parts of the public have a false understanding of anonymity in the context of privacy protection of personal data as used for healthcare management and medical research. Some of those commenting demanded complete anonymity of their data to be willing to trust the process of data collection and analysis. As this demand is impossible to fulfil and trust is built on a false understanding of anonymity, the inability to meet this demand risks undermining public trust. Since public concerns about anonymity and privacy of personal data appear to be increasing, a large-scale information campaign about the limits and possibilities of anonymity with respect to the various uses of personal health data is urgently needed to help the public to make better informed choices about providing personal data.

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