A Simple Linear Discrimination Algorithm for AD Patients and Normal Controls

2012 ◽  
Vol 155-156 ◽  
pp. 18-22
Author(s):  
Yun Yi Yan ◽  
Guo Zhang Hu ◽  
Bao Long Guo ◽  
Yu Jie He
Keyword(s):  
Standard Deviation ◽  
Confidence Intervals ◽  
Sensitivity And Specificity ◽  
Classification Accuracy ◽  
Simple Method ◽  
Linear Discrimination ◽  
Significant Difference ◽  
The Mean ◽  
Normal Controls ◽  
Discrimination Method

One simple but effective discrimination method was presented in this paper to separate AD from normal controls. After detecting the thickness of cortex with highly significant difference, the mean and standard deviation of these vertices are computed to construct confidence intervals. We introduced one relax coefficients to control the width of intervals and by experiments the coefficients was optimized. Experiments results showed that using this simple method, the classification accuracy, sensitivity and specificity of Alzheimer’s disease versus normal controls could be as high as 85%, 88.89% and 93.84% respectively.

A COMPARISON OF TWO METHODS FOR MEASUREMENT OF ALDOSTERONE SECRETION RATE IN MAN

1966 ◽  
Vol 53 (2) ◽  
pp. 177-188 ◽  
Author(s):  
P. Lund-Johansen ◽  
T. Thorsen ◽  
K. F. Støa
Keyword(s):  
Urinary Excretion ◽  
Normal Subjects ◽  
Secretion Rate ◽  
Aldosterone Secretion ◽  
Simple Method ◽  
Mean Values ◽  
Pathological Conditions ◽  
Significant Difference ◽  
Derivative Method ◽  
The Mean

ABSTRACT A comparison has been made between (A), a relatively simple method for the measurement of aldosterone secretion rate, based on paper chromatography and direct densitometry of the aldosterone spot and (B) a more elaborate isotope derivative method. The mean secretion rate in 9 normal subjects was 112 ± 26 μg per 24 hours (method A) and 135 ± 35 μg per 24 hours (method B). The »secretion rate« in one adrenalectomized subject after the intravenous injection of 250 μg of aldosterone was 230 μg per 24 hours (method A) and 294 μg per 24 hours (method B). There was no significant difference in the mean values, and correlation between the two methods was good (r = 0.80). It is concluded that the densitometric method is suitable for clinical purposes as well as research, being more rapid and less expensive than the isotope derivative method. Method A also measures the urinary excretion of the aldosterone 3-oxo-conjugate, which is of interest in many pathological conditions. The densitometric method is obviously the less sensitive and a prerequisite for its use is an aldosterone secretion of 20—30 μg per 24 hours. Lower values are, however, rare in adults.

PENGARUH PENDIDIKAN KESEHATAN REPRODUKSI PADA PEER GROUP (TEMAN SEBAYA) TERHADAP PENGETAHUAN DAN PERSEPSI REMAJA TENTANG PENDEWASAAN USIA PERKAWINAN DI SMA NEGERI 1 KECAMATAN NAMORAMBE KAB. DELI SERDANG 2018

2020 ◽  
Vol 1 (2) ◽  
pp. 56-66
Author(s):  
Irma Linda
Keyword(s):  
Standard Deviation ◽  
Health Education ◽  
Reproductive Health ◽  
Peer Group ◽  
Peer Groups ◽  
A Value ◽  
Significant Difference ◽  
Reproductive Health Education ◽  
The Mean ◽  
Adolescent Perceptions

Background: Early marriages are at high risk of marital failure, poor family quality, young pregnancies at risk of maternal death, and the risk of being mentally ill to foster marriage and be responsible parents. Objective: To determine the effect of reproductive health education on peer groups (peers) on the knowledge and perceptions of adolescents about marriage age maturity. Method: This research uses the Quasi experimental method with One group pre and post test design, conducted from May to September 2018. The statistical analysis used in this study is a paired T test with a confidence level of 95% (α = 0, 05). Results: There is an average difference in the mean value of adolescent knowledge between the first and second measurements is 0.50 with a standard deviation of 1.922. The mean difference in mean scores of adolescent perceptions between the first and second measurements was 4.42 with a standard deviation of 9.611. Conclusion: There is a significant difference between adolescent knowledge on the pretest and posttest measurements with a value of P = 0.002, and there is a significant difference between adolescent perceptions on the pretest and posttest measurements with a value of p = 0.001. Increasing the number of facilities and facilities related to reproductive health education by peer groups (peers) in adolescents is carried out on an ongoing basis at school, in collaboration with local health workers as prevention of risky pregnancy.

Comparative Analysis of the Exposure and Surgical Freedom of the Endoscopic Extended Minipterional Craniotomy and the Transorbital Endoscopic Approach to the Anterior and Middle Cranial Fossae

2018 ◽  
Vol 17 (2) ◽  
pp. 174-181 ◽  
Author(s):  
Raywat Noiphithak ◽  
Juan C Yanez-Siller ◽  
Juan M Revuelta Barbero ◽  
Raymond I Cho ◽  
Bradley A Otto ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Standard Deviation ◽  
Minimally Invasive ◽  
Vertical Axis ◽  
Endoscopic Approach ◽  
Extended Version ◽  
Specific Approach ◽  
Significant Difference ◽  
Surgical Application ◽  
The Mean

AbstractBACKGROUNDNumerous minimally invasive approaches to the skull base have been successively developed. Knowledge of the surgical nuances of a specific approach may facilitate approach selection. This study sought to compare the nuances of an extended version of the minipterional craniotomy (EMPT) with those of the transorbital endoscopic approach (TOEA) to the anterior and middle cranial fossae (ACF and MCF, respectively).OBJECTIVETo quantitatively analyze and compare the area of exposure and surgical freedom between EMPT and TOEA to the ACF and MCF.METHODSEMPT and TOEA were carried out in 5 latex-injected cadaveric heads, bilaterally (10 sides). For each approach, the area of exposure, surgical freedom, and angle of attack were obtained with neuronavigation and statistically compared.RESULTSNo significant difference was found between the mean area of exposure of EMPT and TOEA at the ACF and MCF (P = .709 and .317, respectively). The mean exposure area at the ACF was of 13.4 ± 2.6 cm2 (mean ± standard deviation) and 13.0 ± 1.9 cm2 for EMPT and TOEA, respectively. Except for the crista galli, EMPT afforded a larger area of surgical freedom at all targets. EMPT also achieved significantly greater attack angles in vertical axis except to the crista galli. The horizontal attack angles to all targets were similar between approaches.CONCLUSIONEMPT and TOEA offer a comparable area of exposure at the ACF and MCF in the cadaver; however, the instrument maneuverability afforded by EMPT is superior. Further studies are necessary to better define their precise surgical application.

scholarly journals Assessment of decrease in renal function associated with hypothyroidism

2021 ◽  
Vol 12 (1) ◽  
pp. 275-286
Author(s):  
Ayesha Ammar ◽  
Kahkashan Bashir Mir ◽  
Sadaf Batool ◽  
Noreen Marwat ◽  
Maryam Saeed ◽  
...  
Keyword(s):  
Renal Function ◽  
Confidence Interval ◽  
Creatinine Clearance ◽  
Confidence Intervals ◽  
Standard Error ◽  
Radioactive Iodine ◽  
T Test ◽  
Euthyroid State ◽  
Significant Difference ◽  
The Mean

Objective: Study was aimed to see the effects of hypothyroidism on GFR as a renal function. Material and methods: Total of Fifty-eight patients were included in the study. Out of those forty-eight patients were female and the rest were male. Out of fifty eight patients, fifty three patients were of thyroid cancer in which hypothyroidism was due to discontinuation of thyroxine before the administration of radioactive iodine for Differentiated thyroid cancer.Moreover, remaining five patients were post radioactive iodine treatment (for hyperthyroidism) hypothyroid. All of the patients were above eighteen years of age with TSH value > 30µIU/ml. Pregnant and lactating females were excluded.Renal function tests (urea/creatinine, creatinine clearance) and serum electrolytes followed by Tc-99m-DTPA renal scan for GFR assessment (GATES’ method) were carried out in all subjects twice during the study, One study during hypothyroid state (TSH > 30 µIU/ml) and other during euthyroid state (TSH between 0.4 to 4µ IU/ml). The results of Student’s t-test showed significant difference in renal functions (Urea, creatinine, creatinine clearance, GFR values) in euthyroid state and hypothyroid state (p-value <0.05). RESULTS: In case of creatinine the paired t test reveal the mean 1.014±0.428, with standard error of 0.669 within 95% confidence interval, for creatinine clearance 80.11±14.12 with standard error of 1.94 within 95% confidence intervals, for urea the mean 28±12.13 with standard error of 1.607 within 95% confidence intervals and for GFR for individual kidney is 38.056±8.56 with standard error of 1.3717 within 95% confidence interval. There was no difference in the outcome of the 2 groups. Conclusion: Hypothyroidism impairs renal function to a significant level and hence needs to be prevented and corrected as early as possible.

scholarly journals Using Questions Box in Teaching Simple Past Tense

2016 ◽  
Vol 3 (2) ◽  
pp. 131-140
Author(s):  
Shanty Halim
Keyword(s):  
Standard Deviation ◽  
Experimental Method ◽  
Past Tense ◽  
Significant Difference ◽  
The Mean ◽  
Ujung Pandang ◽  
Research Show

This research is aimed at finding out to find out whether the use of questions box effective in teaching simple past or not. This research used pre-experimental method. Furthermore, this research was conducted at Politeknik Negeri Ujung Pandang.  There were 20 students as sample.  The findings of this research show that using questions box is effective in teaching simple past tense. It was proven by the significant difference between the students’ mean score in pretest and posttest when used SPSS program. There was significant different ability of the students before giving treatment and after giving treatment. In the pretest, the mean score of the students pretest was 2.32 and the mean score of posttest was 7.52. Standard deviation of pretest was 1.42 and the standard deviation of posttest was 0.75. The researcher also found that the students have positive interest toward the use of questions box in teaching simple past tense at Politeknik Negeri Ujung Pandang.

scholarly journals Oral and Skin Lesions Among Yemeni Khat Abusers While Chewing and After Quitting：Crosse-Sectional Survey

2021 ◽  
Author(s):  
Rowida A. Albarmaqi ◽  
Yi-Qun Kuang ◽  
Yu-Ye Li ◽  
Noha Saleh Gholais
Keyword(s):  
Standard Deviation ◽  
Dental Health ◽  
Skin Lesions ◽  
Routine Practice ◽  
Cross Sectional ◽  
Khat Chewing ◽  
Skin Symptoms ◽  
Significant Difference ◽  
The Mean ◽  
Symptoms And Signs

Abstract Background: Khat chewing is a routine practice in Yemen. Associations between Khat chewing and various adverse oral-dental health conditions have been recorded, however, adverse skin health evidence is still lacking. Objective: To investigate the difference between oral and skin symptoms and signs while chewing Khat and after quitting chewing among Yemeni khat abusers. Method: A descriptive cross-sectional study was conducted on a sample of 300 Yemeni Khat ex-chewer participants in china. Khat chewing status data, a range of oral and skin symptoms and signs, and other pertinent variables were collected using self-administered questionnaires by WeChat. The mean differences between oral and skin symptoms and signs while chewing Khat and after quitting chewing were investigated using the Paired Samples t-test. Result: Of the 300 Yemeni who participated in the study, 255(85%) were men and 45(15%) were women. The oral symptoms and signs mean while chewing was 0.26, 0.022 (standard deviation [SD], whereas that after quitting chewing Khat was 0.10 (mean), 0.269 (standard deviation [SD], t (12.00), P=0.00. The skin symptoms and signs mean while chewing was 0.13, 0.28 (standard deviation [SD], whereas that after quitting chewing Khat was M=0.06, 0.21(standard deviation [SD], t (9.407), P=0.00. Conclusions: There is a statistically significant difference between the mean oral and skin symptoms and signs while chewing and after quitting, whereas long-term Khat chewing negatively affects oral and skin health.

15. Quantitative Analysis: Description and Inference

2020 ◽  
pp. 393-421
Author(s):  
Sandra Halperin ◽  
Oliver Heath
Keyword(s):  
Quantitative Analysis ◽  
Standard Deviation ◽  
Confidence Intervals ◽  
Quantitative Research ◽  
Building Blocks ◽  
Descriptive Statistics ◽  
Central Tendency ◽  
Margin Of Error ◽  
Univariate Statistics ◽  
The Mean

This chapter deals with quantitative analysis, and especially description and inference. It introduces the reader to the principles of quantitative research and offers a step-by-step guide on how to use and interpret a range of commonly used techniques. The first part of the chapter considers the building blocks of quantitative analysis, with particular emphasis on different ways of summarizing data, both graphically and with tables, and ways of describing the distribution of one variable using univariate statistics. Two important measures are discussed: the mean and the standard deviation. After elaborating on descriptive statistics, the chapter explores inferential statistics and explains how to make generalizations. It also presents the concept of confidence intervals, more commonly known as the margin of error, and measures of central tendency.

scholarly journals The Comparison of Semen Collection in Electroejaculation, Rectal Massage and Combination of Both Methods in the Critically Endangered Malayan Pangolin, Manis javanica

Animals ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1948
Author(s):  
Reza Tarmizi ◽  
Yap Keng Chee ◽  
Symphorosa Sipangkui ◽  
Zainal Zahari Zainuddin ◽  
Wan-Nor Fitri
Keyword(s):  
Standard Deviation ◽  
Progressive Motility ◽  
Semen Collection ◽  
Significant Difference ◽  
Semen Characteristics ◽  
Manis Javanica ◽  
Consistent Method ◽  
The Mean ◽  
Genetic Pool ◽  
Collection Methods

This article describes the semen characteristics from different collection methods between captive and confiscated Malayan pangolins, Manis javanica. Semen was collected from 15 pangolins; two captive and 13 confiscated individuals at the mean weight of 9.36 ± 1.94 kg. The three semen collection methods employed were electroejaculation, rectal massage and a combination of both techniques. The semen characteristics (mean ± standard deviation) of the Malayan pangolin are volume (73.75 ± 144.57 µL), pH (7.63 ± 0.53), spermatozoa concentration (997.19 ± 728.98 × 106 /mL), total motility (59.60% ± 30.00%), progressive motility (48.95% ± 30.93%), mass motility (3.50 ± 1.50) and live spermatozoa (80.25% ± 13.45%). There was no significant difference in semen characteristics between the three collection methods. The percentages of live spermatozoa were significantly different, suggesting better samples from captive compared to confiscated animals. However, there was no significant difference in spermatozoa kinetics between the captive and confiscated samples, suggesting the potential of utilizing confiscated individuals for gamete recovery to conserve the genetic pool of pangolins. All three methods of semen collection were successfully performed in pangolins and should be considered; however, electroejaculation remains the most consistent method of obtaining semen from the species.

scholarly journals Prostate-Specific Antigen Density: A Measurement to Differentiate Benign Hypertrophy of Prostate from Prostate Carcinoma

2020 ◽  
Vol 12 (01) ◽  
pp. 44-48
Author(s):  
Chandan Kumar Nath ◽  
Bhupen Barman ◽  
Pranjal Phukan ◽  
Stephen L. Sailo ◽  
Biswajit Dey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Sensitivity And Specificity ◽  
Prostate Volume ◽  
Specific Antigen ◽  
Prostate Specific Antigen Density ◽  
Significant Difference ◽  
The Mean ◽  
Set Up ◽  
The Individual

Abstract Background Determination of isolated prostate-specific antigen (PSA) in asymptomatic individuals has not demonstrated sufficient sensitivity and specificity to be useful in the routine evaluation of prostate disease. To enhance the accuracy of serum PSA we have used a proportion of serum PSA and prostate volume, which we refer to as prostate-specific antigen density (PSAD). Prostate volume in this study was calculated using transrectal ultrasonography (TRUS). Materials and Methods A total of 106 patients with prostatic disease clinically confined to the prostate glands were evaluated. Results and Observation The mean PSAD for prostate cancer was 0.15 ± 0.01 while that for benign hypertrophy of the prostate (BPH) was 0.11 ± 0.02 (p < 0.05). Significant difference (p < 0.05) was noted in the prostate volume in these two groups with the mean prostate volume measured by TRUS in the BPH to be 53.85 ± 9.71 mL compared with 58.14 ± 7.48 mL in the carcinoma. PSA density of 0.13 ng/mL can be used as a cutoff for the individual in our set-up who should go for prostate biopsy with sensitivity and specificity of over 90%. Conclusion These results suggest that PSAD may be useful in distinguishing BPH and prostate cancer.

scholarly journals Robust Confidence Intervals for PM2.5 Concentration Measurements in the Ecuadorian Park La Carolina

Sensors ◽  
2020 ◽  
Vol 20 (3) ◽  
pp. 654 ◽  
Author(s):  
Wilmar Hernandez ◽  
Alfredo Mendez ◽  
Rasa Zalakeviciute ◽  
Angela Maria Diaz-Marquez
Keyword(s):  
Air Pollution ◽  
Standard Deviation ◽  
Confidence Intervals ◽  
Quality Index ◽  
Urban Park ◽  
Absolute Deviation ◽  
The Mean ◽  
Concentration Measurements ◽  
Pm2.5 Concentration

In this article, robust confidence intervals for PM2.5 (particles with size less than or equal to 2.5   μ m ) concentration measurements performed in La Carolina Park, Quito, Ecuador, have been built. Different techniques have been applied for the construction of the confidence intervals, and routes around the park and through the middle of it have been used to build the confidence intervals and classify this urban park in accordance with categories established by the Quito air quality index. These intervals have been based on the following estimators: the mean and standard deviation, median and median absolute deviation, median and semi interquartile range, a -trimmed mean and Winsorized standard error of order a , location and scale estimators based on the Andrew’s wave, biweight location and scale estimators, and estimators based on the bootstrap- t method. The results of the classification of the park and its surrounding streets showed that, in terms of air pollution by PM2.5, the park is not at caution levels. The results of the classification of the routes that were followed through the park and its surrounding streets showed that, in terms of air pollution by PM2.5, these routes are at either desirable, acceptable or caution levels. Therefore, this urban park is actually removing or attenuating unwanted PM2.5 concentration measurements.

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