The Research of Production Process Statistical Steady-State Based on the Hypothesis Test

2011 ◽  
Vol 314-316 ◽  
pp. 2433-2438
Author(s):  
Wei Zhi Wang
Keyword(s):  
Quality Control ◽  
Steady State ◽  
Production Process ◽  
Quantitative Method ◽  
Large Scale ◽  
Hypothesis Test ◽  
Influence Factors ◽  
Normal Operation ◽  
Scale Production ◽  
Large Scale Production

By only applying a after the event exam in the quality control of the batch production is not enough to meet the needs of modern large-scale production. To a certain extent, modern quality control is a dynamic process of the steady-state judge and adjustment. A simple and reliable steady-state judge rule and method is the premise to guarantee the normal operation. This paper provides a quantitative method to evaluate production process steady-state by analyzing influence factors based on mathematical statistics. The method is both suitable for simple production process and complex production process with sub-processes.

scholarly journals Foaming of rhamnolipids fermentation: impact factors and fermentation strategies

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhijin Gong ◽  
Ge Yang ◽  
Chengchuan Che ◽  
Jinfeng Liu ◽  
Meiru Si ◽  
...  
Keyword(s):  
Production Process ◽  
Large Scale ◽  
Commercial Production ◽  
Impact Factors ◽  
Scale Production ◽  
Large Scale Production ◽  
Foaming Behavior ◽  
Production Strategies ◽  
Potential Applications ◽  
And Control

AbstractRhamnolipids have recently attracted considerable attentions because of their excellent biosurfactant performance and potential applications in agriculture, environment, biomedicine, etc., but severe foaming causes the high cost of production, restraining their commercial production and applications. To reduce or eliminate the foaming, numerous explorations have been focused on foaming factors and fermentation strategies, but a systematic summary and discussion are still lacking. Additionally, although these studies have not broken through the bottleneck of foaming, they are conducive to understanding the foaming mechanism and developing more effective rhamnolipids production strategies. Therefore, this review focuses on the effects of fermentation components and control conditions on foaming behavior and fermentation strategies responded to the severe foaming in rhamnolipids fermentation and systematically summarizes 6 impact factors and 9 fermentation strategies. Furthermore, the potentialities of 9 fermentation strategies for large-scale production are discussed and some further strategies are suggested. We hope this review can further facilitate the understanding of foaming factors and fermentation strategies as well as conducive to developing the more effective large-scale production strategies to accelerate the commercial production process of rhamnolipids.

Liposomes

2017 ◽  
pp. 52-87
Author(s):  
Mangal Shailesh Nagarsenker ◽  
Megha Sunil Marwah
Keyword(s):  
Quality Control ◽  
Large Scale ◽  
Clinical Success ◽  
Scale Production ◽  
Large Scale Production ◽  
Diagnostic Applications ◽  
Set Up ◽  
Insight Into ◽  
Characterisation Techniques

The science of liposomes has expanded in ambit from bench to clinic through industrial production in thirty years since the naissance of the concept. This chapter makes an attempt to bring to light the impregnable contributions of great researchers in the field of liposomology that has witnessed clinical success in the recent times. The journey which began in 1965 with the observations of Bangham and further advances made en route (targeting/stealthing of liposomes) along with alternative and potential liposome forming amphiphiles has been highlighted in this chapter. The authors have also summarised the conventional and novel industrially feasible methods used to formulate liposomes in addition to characterisation techniques which have been used to set up quality control standards for large scale production. Besides, the authors have provided with an overview of primary therapeutic and diagnostic applications and a brief insight into the in vivo behaviour of liposomes.

Microwave Curing and Drying of Cellular Concrete

1992 ◽  
Vol 269 ◽  
Author(s):  
Walter M. van Loock
Keyword(s):  
Production Process ◽  
Feasibility Study ◽  
Building Material ◽  
Large Scale ◽  
Scale Production ◽  
Volumetric Heating ◽  
Microwave Curing ◽  
Thermal Insulator ◽  
Large Scale Production ◽  
Cellular Concrete

ABSTRACTTraditionally the heating and curing of cellular concrete takes place in an autoclave. This building material is a thermal insulator so the curing and drying processes are energy and time consuming. Volumetric heating is an attractive method for improving the throughputs.A feasibility study leads to the conclusion that microwave processing is not likely to be applied in a large scale production process.

Raman spectroscopy in pharmaceutical research and industry

2018 ◽  
Vol 3 (8) ◽  
Author(s):  
Nathalie Jung ◽  
Maike Windbergs
Keyword(s):  
Drug Delivery ◽  
Raman Spectroscopy ◽  
Quality Control ◽  
Drug Delivery Systems ◽  
Large Scale ◽  
Pharmaceutical Research ◽  
Delivery Systems ◽  
Scale Production ◽  
Non Invasive ◽  
Large Scale Production

Abstract In the fast-developing fields of pharmaceutical research and industry, the implementation of Raman spectroscopy and related technologies has been very well received due to the combination of chemical selectivity and the option for non-invasive analysis of samples. This chapter explores established and potential applications of Raman spectroscopy, confocal Raman microscopy and related techniques from the early stages of drug development research up to the implementation of these techniques in process analytical technology (PAT) concepts for large-scale production in the pharmaceutical industry. Within this chapter, the implementation of Raman spectroscopy in the process of selection and optimisation of active pharmaceutical ingredients (APIs) and investigation of the interaction with excipients is described. Going beyond the scope of early drug development, the reader is introduced to the use of Raman techniques for the characterization of complex drug delivery systems, highlighting the technical requirements and describing the analysis of qualitative and quantitative composition as well as spatial component distribution within these pharmaceutical systems. Further, the reader is introduced to the application of Raman techniques for performance testing of drug delivery systems addressing drug release kinetics and interactions with biological systems ranging from single cells up to complex tissues. In the last part of this chapter, the advantages and recent developments of integrating Raman technologies into PAT processes for solid drug delivery systems and biologically derived pharmaceutics are discussed, demonstrating the impact of the technique on current quality control standards in industrial production and providing good prospects for future developments in the field of quality control at the terminal part of the supply chain and various other fields like individualized medicine. On the way from the active drug molecule (API) in the research laboratory to the marketed medicine in the pharmacy, therapeutic efficacy of the active molecule and safety of the final medicine for the patient are of utmost importance. For each step, strict regulatory requirements apply which demand for suitable analytical techniques to acquire robust data to understand and control design, manufacturing and industrial large-scale production of medicines. In this context, Raman spectroscopy has come to the fore due to the combination of chemical selectivity and the option for non-invasive analysis of samples. Following the technical advancements in Raman equipment and analysis software, Raman spectroscopy and microscopy proofed to be valuable methods with versatile applications in pharmaceutical research and industry, starting from the analysis of single drug molecules as well as complex multi-component formulations up to automatized quality control during industrial production.

scholarly journals A Proposal for Six Sigma Integration for Large-Scale Production of Penicillin G and Subsequent Conversion to 6-APA

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Anirban Nandi ◽  
Sharadwata Pan ◽  
Ravichandra Potumarthi ◽  
Michael K. Danquah ◽  
Indira P. Sarethy
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Six Sigma ◽  
Mass Production ◽  
Large Scale ◽  
Penicillin G ◽  
Scale Production ◽  
Large Scale Production ◽  
Subsequent Conversion ◽  
Six Sigma Methodology

Six Sigma methodology has been successfully applied to daily operations by several leading global private firms including GE and Motorola, to leverage their net profits. Comparatively, limited studies have been conducted to find out whether this highly successful methodology can be applied to research and development (R&D). In the current study, we have reviewed and proposed a process for a probable integration of Six Sigma methodology to large-scale production of Penicillin G and its subsequent conversion to 6-aminopenicillanic acid (6-APA). It is anticipated that the important aspects of quality control and quality assurance will highly benefit from the integration of Six Sigma methodology in mass production of Penicillin G and/or its conversion to 6-APA.

Kinetic Models of Hydrogen Production Process by Batch Anaerobic Fermentation from Contained Sugar Wastewater

2013 ◽  
Vol 634-638 ◽  
pp. 981-986
Author(s):  
Dong Gou Sun ◽  
Bing Huang ◽  
Wen Gang Zuo ◽  
Huai Yuan Zhao ◽  
Wen Wei ◽  
...  
Keyword(s):  
Hydrogen Production ◽  
Production Process ◽  
Kinetic Models ◽  
Large Scale ◽  
Anaerobic Fermentation ◽  
Scale Production ◽  
Hydrogen Yield ◽  
Large Scale Production ◽  
The Relationship ◽  
Kinetics Of

The processes of biomass growth, hydrogen production and sucrose degradation were systemically investigated about batch anaerobic fermentation which is based on activated sludge for a basic strain and the simulating sucrose wastewater for a substrate. The kinetics of microbial growth, hydrogen production and sucrose degradation were proposed according to the Compertz equation and the Luedeking-Piret equation. The relationship between the biomass, hydrogen and substrate were also evaluated. The results shown that the hydrogen is a main produce of the formation process which is a growth-associated, a high biomass is favorable to increasing the hydrogen yield and shortening lag time. The three kinetic models equation have a good coincidence with the experimental data, and can really reflect the hydrogen production process from wastewater contained sucrose. The results will provide helpful reference for the large-scale production and theory study of hydrogen production.

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