Synthesis and Characterization of a Novel SCPC-CO3Ap Cement for Pulp Capping Application in Dentistry

2017 ◽  
Vol 758 ◽  
pp. 29-33 ◽  
Author(s):  
Arief Cahyanto ◽  
Andri Rezano ◽  
Myrna Nurlatifah Zakaria ◽  
Ahmed El-Ghannam
Keyword(s):  
Mechanical Strength ◽  
Antibacterial Properties ◽  
Tissue Response ◽  
Carbonate Apatite ◽  
Pulp Tissue ◽  
Dental Tissue ◽  
Compact Structure ◽  
Pulp Capping ◽  
Ft Ir ◽  
Dentin Regeneration

Silica-calcium phosphate composite (SCPC) and carbonate apatite (CO3Ap) have several superior properties as they are bioactive, bioresorbable and elicit excellent tissue response. The CO3Ap surface layer and hydrated silica developed on the surface of the SCPC may be a key factor for achieving dentin regeneration. On the other hand, calcium hydroxide [Ca(OH)2] have antibacterial properties and biocompatible to dental tissue. Therefore, the combination of CO3Ap, SCPC, and Ca(OH)2 in a bone cement may be favorable as a pulp capping agent that enhances pulp tissue formation and dentin regeneration. The aim of the present study is to synthesize and characterize a novel SCPC-CO3Ap cement for pulp capping application in dentistry. The cement is composed of dicalcium phosphate anhydrous (DCPA), vaterite, Ca(OH)2 and SCPC. The set cement was further characterized by Fourier transform infrared (FT-IR). The microstructure of set cement was examined by scanning electron microscopy (SEM) and the mechanical strength was evaluated by diametral tensile strength (DTS). The FT-IR analyses revealed that the additional bands of carbonate were detected in each sample. The SEM samples of set cement showing more compact surface microstructure of group II compared to other groups. Furthermore, the combination of 5% SCPC and 5% Ca(OH)2 in the cement facilitated a compact structure with superior mechanical strength. The novel SCPC-CO3Ap cement has great potential to be used for pulp capping to facilitate dentin regeneration.

Compressive Strength Evaluation and Phase Analysis of Pulp Capping Materials Based on Carbonate Apatite-SCPC Using Different Concentration of SCPC and Calcium Hydroxide

2018 ◽  
Vol 782 ◽  
pp. 15-20 ◽  
Author(s):  
Arief Cahyanto ◽  
Muga Restunaesha ◽  
Myrna Nurlatifah Zakaria ◽  
Andri Rezano ◽  
Ahmed El-Ghannam
Keyword(s):  
Compressive Strength ◽  
Mechanical Strength ◽  
Calcium Hydroxide ◽  
Phase Analysis ◽  
Xrd Analysis ◽  
Apatite Crystal ◽  
Apatite Formation ◽  
Carbonate Apatite ◽  
Pulp Capping ◽  
Significant Difference

The mechanical strength of pulp capping material based on carbonate apatite and silica calcium-phosphate composite (CO3Ap-SCPC) is one of the key factors for the success of the material in protecting the vitality of the pulp during the formation of apatite and dentin reparative. Modifying the material in the powder phase was known to increase the mechanical strength. The purpose of this study was to determine whether the addition of SCPC and calcium hydroxide in pulp capping materials based on CO3Ap-SCPC would affect the compressive strength of this pulp capping material. In this study, three cement groups were used, each group consisted of dicalcium phosphate anhydrous and vaterite which added by SCPC concentration 0%, 5% and 10% and calcium hydroxide concentration 0%, 5% and 10%, respectively. All groups were tested by a compressive strength test and X-Ray diffraction (XRD) for phase analysis. The mean value of compressive strength with addition of 0% SCPC and 10% Ca(OH)2 was 16.54 ± 1.35 MPa, addition of 5% SCPC and 5% Ca(OH)2 of 18.55 ± 2.81 MPa, addition of 10% SCPC and 0% Ca(OH)2 was 9.22 ± 1.21 MPa. The addition of SCPC and Ca(OH)2 show statistically significant difference in compressive strength (p<0.05). The XRD analysis of the highest compressive strength revealed that the apatite crystal was successfully formed. It can be concluded that incorporated specific amount of SCPC and Ca(OH)2 could improve the mechanical strength and the apatite formation of the CO3Ap-SCPC pulp capping material.

Pulp Tissue Response to Platelets Rich Plasma, Platelets Rich Fibrin and Mineral Trioxide Aggregate as Pulp Capping Materials

2021 ◽  
Vol 8 (4) ◽  
pp. 561-570
Author(s):  
Sarah D. Shaheen ◽  
Maha A. Niazy ◽  
Wael E. Jamil ◽  
Ashraf M. Abu-Seida
Keyword(s):  
Mineral Trioxide Aggregate ◽  
Tissue Response ◽  
Pulp Tissue ◽  
Pulp Capping

Basic Properties of Novel Bioactive Cement Based on Silica-Calcium Phosphate Composite and Carbonate Apatite

2016 ◽  
Vol 720 ◽  
pp. 147-152 ◽  
Author(s):  
Myrna Nurlatifah Zakaria ◽  
Arief Cahyanto ◽  
Ahmed El-Ghannam
Keyword(s):  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Bone Structure ◽  
Control Group ◽  
Apatite Formation ◽  
Carbonate Apatite ◽  
The Novel ◽  
Pulp Tissue ◽  
Group 3 ◽  
Group 2

Silica-calcium phosphate composite (SCPC) and carbonate apatite (CO3Ap) are resorbable bioactive materials with the ability to adapt to bone structure and to induce bone regeneration. Considering the similarity between bone and dental structure, where both are mainly composed of calcium deficient carbonate containing hydroxyapatite, we hypothesize that a SCPC-CO3Ap bone cement might also be favorable for the regeneration of dentin and pulp tissue. Therefore, in the present study we report on the effect of composition and structure of SCPC-CO3Ap cement on the morphology, setting and mechanical properties of the material. The novel bioceramics cement composed of vaterite, dicalcium phosphate anhydrous (DCPA) and SCPC. The powder cement ratio divided into 5 groups: group 1 (60% DCPA : 40% vaterite : 0% SCPC) as a control, group 2 (60% DCPA : 10% vaterite : 30% SCPC), group 3 (60% DCPA : 20% vaterite : 20% SCPC), group 4 (60% DCPA : 30% vaterite : 10% SCPC), and group 5 (60% DCPA : 0% vaterite : 40% SCPC). Each group was mixed by 1M Na2HPO4 aqueous solution at liquid to powder ratio of 0.5 and hardened at 37°C and 100 % of relative humidity for 72 hours. Set cement was examined by X-Ray diffraction (XRD), scanning electron microscopy (SEM) and the mechanical strength was evaluated by diametral tensile strength. XRD patterns revealed that the apatite formation was formed after 72 hours, however the intensity of apatite varied based on the SCPC content. The DTS evaluation indicated that group 3 has the highest mechanical strength compared to others. This was supported by SEM analysis of set cement showing more compact surface microstructure of group 2 and 3 compared to other different ratio and control group. The novel bioceramics cement was successfully made using vaterite, DCPA and SCPC. This new cement is currently being investigated for dental application to induce dentinogenesis.

scholarly journals Evaluation of human pulp tissue response following direct pulp capping with a self-etching adhesive system containing MDPB

2021 ◽  
Author(s):  
Nevin COBANOGLU ◽  
Tuncay ALPTEKİN ◽  
Haruaki KITAGAWA ◽  
Markus B BLATZ ◽  
Satoshi IMAZATO ◽  
...  
Keyword(s):  
Adhesive System ◽  
Tissue Response ◽  
Direct Pulp Capping ◽  
Pulp Tissue ◽  
Pulp Capping

scholarly journals The thickness of odontoblast-like cell layer after induced by propolis extract and calcium hydroxide

2016 ◽  
Vol 49 (1) ◽  
pp. 17
Author(s):  
Irfan Dwiandhono ◽  
Ruslan Effendy ◽  
Sri Kunarti
Keyword(s):  
Calcium Hydroxide ◽  
Cell Layer ◽  
Tissue Response ◽  
Histological Evaluation ◽  
Bacterial Invasion ◽  
Direct Pulp Capping ◽  
Pulp Tissue ◽  
Propolis Extract ◽  
Pulp Capping ◽  
Pulp Inflammation

Background: Propolis is a substance made from resin collected by bees (Apis mellifera) from variety of plants, mixed with its saliva and various enzymes to build a nest. Propolis has potential antimicrobial and antiinflammatory agents with some advantages over calcium hydroxide (Ca(OH)2). Ca(OH)2 has been considered as the “gold standard” of direct pulp-capping materials, but there are still some weakness of its application. First, it can induce pulp inflammation which last up to 3 months. Second, the tissue response to Ca(OH)2 is not always predictable. Third, the tunnel defect can probably formed in dentinal bridge with possible bacterial invasion in that gap. Purpose: This study was aimed to determine and compare the thickness of odontoblast-like cells layer after induced by propolis extract and Ca(OH)2 in rat’s pulp tissue. Method: Class 1 preparation was done in maxillary first molar tooth of wistar mice until the pulp opened. The Ca(OH)2 and propolis extract was applied to induce the formation of odontoblast-like cells, the cavity was filled with RMGIC. The teeth were extracted (after 14 and 28 days of induction). The samples were then processed for histological evaluation. Result: There were significant differences between the thickness of odontoblast-like cells after induced by propolis extract and Ca(OH)2. Conclusion: The propolis extract as the direct pulp capping agent produces thicker odontoblast-like cell layer compared to Ca(OH)2.

scholarly journals Biosealer versus Biodentine for direct pulp capping in dog’s teeth: A histopathological evaluation

2019 ◽  
Author(s):  
Inas M. Al-Sherbiny ◽  
Mona H. Farid ◽  
Ashraf M. Abu-Seida ◽  
Inas Motawea ◽  
Hagar A. Bastawy
Keyword(s):  
Blood Vessels ◽  
Tissue Response ◽  
Control Group ◽  
Image Analyzer ◽  
Pulp Tissue ◽  
Bridge Formation ◽  
Pulp Capping ◽  
Exposure Site ◽  
Reparative Dentin ◽  
Pulp Exposure

Abstract BackgroundThis study compared the effect of Biodentine (BD) and Tech Biosealer Capping (BS) on the pulpal tissue response after pulp capping in dogs, teeth.MethodsThree mongrel dogs were enrolled in this study. Class V cavities with pulp exposure were performed on the buccal surface of 30 teeth (2 experimental groups) and left without pulp exposure in 15 teeth (control group). The cavities of experimental groups were capped with either Biodentine (BD Group, N= 15 teeth) or Tech-Biosealer Capping (BS Group, N= 15 teeth). All cavities (experimental and control groups) were restored with resin-modified glass ionomer. Dentine bridge formation, architechecture of the odontoblastic layers and signs of inflammation were assessed after 1, 2 and 3 months using the computer image analyzer (Leica Qwin 500).ResultsBD group showed a thick newly formed reparative dentin bridge completely closing the exposure site with cell inclusions and mineralization, variable amount of odontoblast-like cells, preserved pulp tissue, marked numerous collagen fibers and blood vessels. While BS group showed an incomplete newly formed reparative dentin bridge with tunnel defect, vacuolated odontoblasts, complete pulp degeneration with multiple edematous spaces, hyperemic blood vessels, extravasated RBCs, multiple calcified structures scattered just beneath the dentin bridge and through the pulp tissue, and newly ill-defined odontoblasts.ConclusionFor pulp capping, Biodentine has better dentine bridge formation and pulp preservation than Tech Biosealer Capping.

Physical properties of different Pulp Capping Materials and Histological Analysis of their effect on Dogs’Dental Pulp Tissue Healing

2018 ◽  
Vol 64 (3) ◽  
pp. 2657-2667
Author(s):  
Mai Hamdy ◽  
Dalia Fayyad ◽  
Mohamed Eldaharawy ◽  
Enas Hegazy
Keyword(s):  
Physical Properties ◽  
Histological Analysis ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Tissue Healing

scholarly journals A New Supported Manganese-Based Coordination Complex as a Nano-Catalyst for the Synthesis of Indazolophthalazinetriones and Investigation of Its Antibacterial Activity

Chemistry ◽  
2021 ◽  
Vol 3 (3) ◽  
pp. 783-799
Author(s):  
Maryam Ariannezhad ◽  
Davood Habibi ◽  
Somayyeh Heydari ◽  
Vahideh Khorramabadi
Keyword(s):  
Antibacterial Activity ◽  
Simple Procedure ◽  
Condensation Reaction ◽  
Antibacterial Properties ◽  
Coordination Complex ◽  
Bacterial Strains ◽  
One Pot ◽  
Nano Catalyst ◽  
Ft Ir ◽  
The One

A new magnetic supported manganese-based coordination complex (Fe3O4@SiO2@CPTMS@MBOL@ Mn) was prepared in consecutive stages and characterized via various techniques (VSM, SEM, TEM, XRD, FT-IR, EDX, TG-DTA, and ICP). To evaluate its application, it was used for synthesis of divers Indazolophthalazinetriones in a simple procedure via the one-pot three-component condensation reaction of aldehydes, dimedone, and phthalhydrazide in ethanol under reflux conditions. The Mn catalyst can be recycled without any noticeable loss in catalytic activity. Additionally, the antibacterial properties of the nano-catalyst were studied against some bacterial strains.

scholarly journals The Effect of Glycidyl Azide Polymer Grafted Tetrafunctional Isocyanate on Polytriazole Polyethylene Oxide-Tetrahydrofuran Elastomer and its Propellant Properties

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 278 ◽  
Author(s):  
Jinghui Hu ◽  
Weiqiang Tang ◽  
Yonghui Li ◽  
Jiyu He ◽  
Xiaoyan Guo ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Polyethylene Oxide ◽  
Mechanical Test ◽  
Glycidyl Azide Polymer ◽  
Interface Interaction ◽  
Ft Ir ◽  
Glycidyl Azide

A new energetic curing reagent, Glycidyl azide polymer grafted tetrafunctional isocyanate (N100-g-GAP) was synthesized and characterized by FT-IR and GPC approaches. Polytriazole polyethylene oxide-tetrahydrofuran (PTPET) elastomer was prepared by N100-g-GAP and alkynyl terminated polyethylene oxide-tetrahydrofuran (ATPET). The resulting PTPET elastomer was fully characterized by TGA, DMA, FTIR and mechanical test. The above analysis indicates that PTPET elastomers using N100-g-GAP as curing reagent have the potential for use in propellants. The overall formulation test of the composite propellants shows that this curing system can effectively enhance mechanical strength and bring a significant improvement in the interface interaction between the RDX & AP particles and binder matrix.

scholarly journals Green Synthesis, Characterization, and Antibacterial Properties of Silver Nanoparticles Obtained by Using Diverse Varieties of Cannabis sativa Leaf Extracts

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4041
Author(s):  
Adriana Cecilia Csakvari ◽  
Cristian Moisa ◽  
Dana G. Radu ◽  
Leonard M. Olariu ◽  
Andreea I. Lupitu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Green Synthesis ◽  
Antioxidant Capacity ◽  
Cannabis Sativa ◽  
Antibacterial Properties ◽  
Green Building ◽  
Human Pathogens ◽  
Leaf Extracts ◽  
Vis Spectroscopy ◽  
Ft Ir

Cannabis sativa L. (hemp) is a plant used in the textile industry and green building material industry, as well as for the phytoremediation of soil, medical treatments, and supplementary food products. The synergistic effect of terpenes, flavonoids, and cannabinoids in hemp extracts may mediate the biogenic synthesis of metal nanoparticles. In this study, the chemical composition of aqueous leaf extracts of three varieties of Romanian hemp (two monoecious, and one dioecious) have been determined by Fourier-Transformed Infrared spectroscopy (FT-IR), high-performance liquid chromatography, and mass spectrometry (UHPLC-DAD-MS). Then, their capability to mediate the green synthesis of silver nanoparticles (AgNPs) and their pottential antibacterial applications were evaluated. The average antioxidant capacity of the extracts had 18.4 ± 3.9% inhibition determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and 78.2 ± 4.1% determined by 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS™) assays. The total polyphenolic content of the extracts was 1642 ± 32 mg gallic acid equivalent (GAE) L−1. After this, these extracts were reacted with an aqueous solution of AgNO3 resulting in AgNPs, which were characterized by UV−VIS spectroscopy, FT-IR, scanning electron microscopy (SEM-EDX), and dynamic light scattering (DLS). The results demonstrated obtaining spherical, stable AgNPs with a diameter of less than 69 nm and an absorbance peak at 435 nm. The mixture of extracts and AgNPs showed a superior antioxidant capacity of 2.3 ± 0.4% inhibition determined by the DPPH• assay, 88.5 ± 0.9% inhibition as determined by the ABTS•+ assay, and a good antibacterial activity against several human pathogens: Escherichia coli, Klebsiella pneumoniae, Pseudomonas fluorescens, and Staphylococcus aureus.

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