scholarly journals The Use of Magnetite Nanoparticles in Applied Medicine

2011 ◽  
Vol 694 ◽  
pp. 205-208 ◽  
Author(s):  
Аndrey Nikolaevich Belousov
Keyword(s):  
Magnetic Field ◽  
Magnetite Nanoparticles ◽  
Cell Metabolism ◽  
Intensive Therapy ◽  
Total Activity ◽  
Biological Action ◽  
Surface Proteins ◽  
Magnetite Particle ◽  
High Sorption ◽  
Magnetite Particles

Nowadays nanotechnology as a new direction of science allows to develop therapeutic methods of the endogenous intoxication syndrome and to create a new class of biocompatible sorbents. In Ukraine first preparations of medical nanotechnology were produced and patented in 1998. These are “IKBB” intracorporeal biocorrector, magnet-controlled sorbent (MCS-B), and “Micromage-B”. The preparations are based on colloid magnetite particles (Fe3O4) from 6 to 12 nm. Adsorption layer provides a high sorption activity to magnetite nanoparticles. Total activity of their sorption surface is 800 – 1200 m2/g, magnetic field intensity produced by each particle is 300 - 400 kA/m, ζ – potential is – 19 mV. Each magnetite particle is a subdomain elementary magnetite of a sphere shape. The main biological action of nanotechnology preparations is direct to regulation of cell metabolism. Therapeutic effect of this preparation is based on the influence of adsorption process and of constant magnetic field that surrounds colloid magnetite particle on cellular and subcellular structures. Point of attack is surface proteins of cell membranes. Colloid magnetite particles modify composition of protein molecules thereby effecting transport of substances to a cell. Using magnet-controlled sorbent the method of extracorporal hemocorrection on the whole is rather the method of effective and reliable way to activate natural processes of detoxication of organism, than the method of artificial detoxication. The absence of contra-indication and incidental effects (haematic, haemodynamic, hormone, electrolytic, immune) creates real predisposition for using this method in intensive therapy of intoxication syndrome.

ONE-DIMENSIONAL MAGNETITE CHAINS OF NANOPARTICLES SYNTHESIS BY SELF-ASSEMBLY IN MAGNETIC FIELD

2005 ◽  
Vol 19 (15n17) ◽  
pp. 2757-2762 ◽  
Author(s):  
Y. ZHANG ◽  
R. SHI ◽  
H. Q. XIONG ◽  
Y. ZHAI ◽  
Y. K. SUN
Keyword(s):  
Magnetic Field ◽  
Self Assembly ◽  
Hysteresis Loops ◽  
Chain Structure ◽  
Silicon Substrates ◽  
Vibrating Sample Magnetometer ◽  
Magnetite Particle ◽  
Ferrous Hydroxide ◽  
One Dimensional ◽  
Magnetite Particles

Magnetite chains of spheres with different radii and lengths were prepared by aging ferrous hydroxide gel with 0.2M KNO3 under different external magnetic fields which induced the ultra-fine magnetite particles to combine into chain structure. The magnetite particle size and the chain length could be adjusted by varying the field intensity. The chains could be deposited on silicon substrates to form aligned structure in magnetic field. The hysteresis loops were measured in different directions by a vibrating sample magnetometer (VSM). The structure and magnetic properties were discussed.

scholarly journals Frequency dependence of magnetothermal properties for magnetic fluid and magnetically functionalized implants

2018 ◽  
Vol 185 ◽  
pp. 09003
Author(s):  
R.T. Salakhova ◽  
A. G. Vylegzhanin ◽  
E.A. Kashtanov ◽  
V.I. Zverev ◽  
R. Müller ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Frequency Dependence ◽  
Magnetic Fluid ◽  
Magnetite Nanoparticles ◽  
Polymer Coating ◽  
Experimental Setup ◽  
Ac Magnetic Field ◽  
Magnetic Heating ◽  
Magnetite Particles

Heating of the magnetic nanoparticles in AC magnetic field is the effect promising for application in medicine. The mechanisms of heating in AC-magnetic field implies nontrivial dependence of the power dissipated by magnetic nanoparticles on frequency. With the use of a reconfigurable experimental setup, this frequency-dependent magnetic heating was measured on two characteristic examples: the magnetite nanoparticles conventionally used in medicine and polymer coating with micrometer sized magnetite particles. The saturation of the heating power with frequency is shown that is more pronounced for the second case of microparticles.

Histological Evaluation of a New Biomaterial Releasing Magnetite Nanoparticles inside Bone Metastases for Thermotherapy

2007 ◽  
Vol 361-363 ◽  
pp. 1211-1214
Author(s):  
Patrick Frayssinet ◽  
Marylène Combacau ◽  
Michel Gougeon ◽  
Nicole Rouquet
Keyword(s):  
Magnetic Field ◽  
Bone Metastasis ◽  
Tumor Cells ◽  
Magnetite Nanoparticles ◽  
Histological Evaluation ◽  
Close Proximity ◽  
Rabbit Bone ◽  
Magnetite Particles ◽  
Oscillating Magnetic Field ◽  
Mineral Matrix

Magnetite nanoparticles were used for their ability to be heated when they are put in an oscillating magnetic field. When they are located inside tumors they can eradicate the tumor cells by heating. We have developed a biomaterial constituted by a mineral degradable matrix containing magnetite nanoparticles. This material can be injected into bone metastasis in which it sets and releases magnetite particles uptaked inside the cancer cells. We have implanted this material inside rabbit bone to check by histology the fate of the nanoparticles in bone. The implant matrix was degraded within a few days releasing the nanoparticles. They were found inside monocytes and fibroblasts having ingrown the material. The nanoparticles could form aggregates which then were fragmented in micro/nanoparticles penetrating the surrounding cells. This study showed that the nanoparticles are released from the mineral matrix within a few days and penetrate the cells in their close proximity.

SHEDDING OF SURFACE PROTEINS BY PORCINE THYROID CELLS

1980 ◽  
Vol 85 (2) ◽  
pp. 245-251 ◽  
Author(s):  
A. BRENNAN ◽  
P. M. POVEY ◽  
B. REES SMITH ◽  
R. HALL
Keyword(s):  
Cell Surface ◽  
Sodium Dodecyl Sulphate ◽  
Culture Medium ◽  
Cell Metabolism ◽  
Sodium Dodecyl ◽  
Surface Proteins ◽  
Half Time ◽  
Thyroid Cells ◽  
Peptide Cleavage ◽  
Membrane Bound

Isolated porcine thyroid cells were surface-labelled with 125I using the lactoperoxidase technique. Samples of the cells were then cultured and harvested at various intervals for up to 7 days. The labelled proteins remaining on the cells or shed into the culture medium were analysed by electrophoresis on polyacrylamide gels run in sodium dodecyl sulphate. These studies indicated that the several different surface proteins of the thyroid cells were lost from the cell surface at similar rates (half-time of approximately 28 h) as the result, at least in part, of a process which depended on active cell metabolism. In addition, the gel profiles obtained from analysis of both medium and membrane-bound labelled proteins were similar and this suggested that peptide cleavage was not involved in the shedding of the majority of these proteins.

scholarly journals Prooxidant and antioxidant activity of blood plasma and histology of internal organs of rats after intravenous administration of magnetite nanoparticles

2013 ◽  
Vol 59 (3) ◽  
pp. 330-338 ◽  
Author(s):  
I.V. Milto ◽  
T.K. Klimenteva ◽  
I.V. Suhodolo ◽  
N.A. Krivova
Keyword(s):  
Antioxidant Activity ◽  
Blood Plasma ◽  
Intravenous Administration ◽  
Magnetite Nanoparticles ◽  
The Body ◽  
Antioxidant Systems ◽  
Internal Organs ◽  
Intravenous Injections ◽  
Magnetite Particles ◽  
Dose Dependent

The effect of a single and multiple intravenous injections of a nanosized magnetite suspension on total prooxidant and antioxidant activity of blood plasma has been investigated by the method of luminol-dependent chemoluminescence. Magnetite nanoparticles possess dose-dependent prooxidant properties due to their iron atoms and at the same time their trigger compensatory activation of antioxidant systems in the rat blood plasma. After a single intravenous administration of magnetite the studied parameters of blood plasma returned to the normal level by the end of the experiment as due to removal of nanoparticles from the body. In the case of multiple administration of the magnetite suspension dose-dependent changes in the pro- and antioxidant plasma activity persist during the whole experiment. Accumulation of magnetite particles in the cells of the mononuclear phagocytic system in the rats’ liver, lungs and kidneys is associated with hemodynamic damages, local dystrophic and necrotic changes of parenchyma in these organs. After a single intravenous injection magnetite nanoparticles are identified in the rat organs for 40 days, but their number decreases by the end of the experiment.

scholarly journals Effect of the polymeric coating over Fe3O4 particles used for magnetic separation

2010 ◽  
Vol 8 (5) ◽  
pp. 1041-1046 ◽  
Author(s):  
Raúl Reza ◽  
Carlos Martínez Pérez ◽  
Claudia Rodríguez González ◽  
Humberto Romero ◽  
Perla García Casillas
Keyword(s):  
Particle Size ◽  
Magnetite Nanoparticles ◽  
Average Particle Size ◽  
Spherical Shape ◽  
Polymeric Coating ◽  
Average Particle ◽  
Synthesis Conditions ◽  
Aging Conditions ◽  
Magnetite Particles ◽  
Average Size

AbstractIn this work, the synthesis of magnetite nanoparticles by two variant chemical coprecipitation methods that involve reflux and aging conditions was investigated. The influence of the synthesis conditions on particle size, morphology, magnetic properties and protein adsorption were studied. The synthesized magnetite nanoparticles showed a spherical shape with an average particle size directly influenced by the synthesis technique. Particles of average size 27 nm and 200 nm were obtained. When the coprecipitation method was used without reflux and aging, the smallest particles were obtained. Magnetite nanoparticles obtained from both methods exhibited a superparamagnetic behavior and their saturation magnetization was particle size dependent. Values of 67 and 78 emu g−1 were obtained for the 27 nm and 200 nm magnetite particles, respectively. The nanoparticles were coated with silica, aminosilane, and silica-aminosilane shell. The influence of the coating on protein absorption was studied using Bovine Serum Albumin (BSA) protein.

scholarly journals Effect of Tetramethylammonium Hydroxide on Nucleation, Surface Modification and Growth of Magnetic Nanoparticles

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Ângela L. Andrade ◽  
José D. Fabris ◽  
José D. Ardisson ◽  
Manuel A. Valente ◽  
José M. F. Ferreira
Keyword(s):  
Zeta Potential ◽  
Magnetite Nanoparticles ◽  
Heat Dissipation ◽  
Tetramethylammonium Hydroxide ◽  
Precipitation Method ◽  
Attenuated Total Reflectance ◽  
X Ray Diffraction ◽  
Experimental Conditions ◽  
Transmission Electron ◽  
Magnetite Particles

Nanoparticles of magnetite (Fe3O4) were obtained by reacting ferric chloride with sodium sulphite, through the reduction-precipitation method. The effects of adding tetramethylammonium hydroxide (TMAOH) during or after the precipitation of the iron oxide were studied in an attempt to obtain well-dispersed magnetite nanoparticles. Accordingly, the following experimental conditions were tested: (i) precipitation in absence of TMAOH (sample Mt), (ii) the same as (i) after peptizing with TMAOH (Mt1), (iii) TMAOH added to the reaction mixture during the precipitation of magnetite (Mt2). Analyses with transmission electron microscopy (TEM), X-ray diffraction, Mössbauer spectroscopy, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), zeta potential, and magnetization measurements up to 2.5 T revealed that magnetite was normally formed also in the medium containing TMAOH. The degree of particles agglomeration was monitored with laser diffraction and technique and inspection of TEM images. The relative contributions of Néel and Brownian relaxations on the magnetic heat dissipation were studied by investigating the ability of suspensions of these magnetite nanoparticles to release heat in aqueous and in hydrogel media. Based on ATR-FTIR and zeta potential data, it is suggested that the surfaces of the synthesized magnetite particles treated with TMAOH become coated with (CH3)4N+cations.

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