Vitamin C-Induced Oxalate Nephropathy

Although a multitude of syndromes have been thoroughly described as a result of vitamin deficiencies, over consumption of such substances may also be quite dangerous. Intratubular crystallization of calcium oxalate as a result of hyperoxaluria can cause acute renal failure. This type of renal failure is known as oxalate nephropathy. Hyperoxaluria occurs as a result of inherited enzymatic deficiencies known as primary hyperoxaluria or from exogenous sources known as secondary hyperoxaluria. Extensive literature has reported and explained the mechanism of increased absorption of oxalate in malabsorptive syndromes leading to renal injury. However, other causes of secondary hyperoxaluria may also take place either via direct dietary consumption of oxalate rich products or via other substances which may metabolize into oxalate within the body. Vitamin C is metabolized to oxalate. Oral or parenteral administration of this vitamin has been used in multiple settings such as an alternative treatment of malignancy or as an immune booster. This article presents a clinical case in which ingestion of high amounts of vitamin C lead to oxalate nephropathy. This article further reviews other previously published cases in order to illustrate and highlight the potential renal harm this vitamin poses if consumed in excessive amounts.

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Knowledge and awareness on natural dietary immunoboosters to combat Covid 19-A survey

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.2830 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 609-617

Author(s):

Aldrin Joshua A ◽

Gayatri Devi R ◽

Gifrina Jayaraj

Keyword(s):

Vitamin C ◽

The Body ◽

Phagocytic Index ◽

Small Scale ◽

Immunomodulatory Activity ◽

Upper Respiratory Tract ◽

Scale Population ◽

Spss Software ◽

Immune Booster ◽

Tract Infections

A natural immune booster is an additional immunizing agent which helps to increase and sustain the immune response of the body. Circumin is an active compound in turmeric which is a natural antioxidant which is used as an immune booster, antimicrobial, antipathogen and as a detoxifying agent. Pepper contains piperine that has antioxidant potential which will decrease the level of lipid peroxidase and has immunomodulatory activity, it increases macrophage migration index and phagocytic index. The vitamin C is a powerful antioxidant that reduces the duration and severity of upper respiratory tract infections. Along with natural immune boosters, healthy practices like yoga and meditation will regulate and maintain organ functions, thereby improving our immunity. The main aim of the study is to create an awareness on natural dietary immunoboosters to combat COVID 19. A self structured questionnaire comprising of about 15 questions was prepared and circulated through online based i.e. Google forms. The results were obtained and statistically analyzed through SPSS software. The survey was done on a small scale population comprising 110 participants in which 62 male (56.4%) and 48 female (43.6%) participated. About 95.5% of the population are aware that taking citrus fruits that have vitamin C will boost their immunity but only 4.5% of them are not aware. 80% of the population are aware that green tea is a powerful antioxidant which will help in building immunity but 9.1% were not aware and 10.9% was not sure of the fact. 82.7% of the population are well aware that spinach and other green vegetables have to be cooked as little as possible to retain nutrients present in them but only 10.9% of them were not sure and 6.4% of them were not aware.

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Cashew-Induced Oxalate Nephropathy: A Rare Cause of Acute Renal Failure

Military Medicine ◽

10.1093/milmed/usab453 ◽

2021 ◽

Author(s):

Oliver Lee ◽

Katherine Park ◽

Kelly Sun ◽

John-Paul O’Shea ◽

Sarah Gordon

Keyword(s):

Renal Failure ◽

Acute Renal Failure ◽

Inflammatory Diseases ◽

Primary Hyperoxaluria ◽

Kidney Injury ◽

Genetic Mutation ◽

Primary Care Visit ◽

Dietary History ◽

History Of ◽

Oxalate Nephropathy

ABSTRACT We present a rare case of cashew-induced oxalate nephropathy in a 69 year old veteran male with history of type 2 diabetes mellitus, nephrolithiasis, and undiagnosed chronic kidney disease (CKD). Oxalate nephropathy is a rare cause of acute renal failure with poor prognosis. The various causes of oxalate nephropathy are categorized as primary or secondary hyperoxaluria. Primary hyperoxaluria is caused by genetic mutation in genes involved in the metabolism of glyoxylate. Secondary hyperoxaluria is caused by mal-absorptive state, excessive intake of oxalate-rich diet, inflammatory diseases, and medications such as orlistat and antibiotics. Diet-induced oxalate nephropathy is often identified after unexplained acute kidney injury in patients with underlying CKD. Definitive diagnosis requires renal biopsy as laboratory tests are non-specific. A simple dietary history in CKD patients during routine primary care visit may lead to early diagnosis and lead to prevention of acute renal failure and progression of renal disease.

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PENGARUH STIMULASI PEMBERIAN TABLET HISAP VITAMIN CTERHADAP PENINGKATAN SEKRESI SALIVA PADA PASIEN GAGALGINJAL KRONIK YANGMENJALANI TERAPI HEMODIALISADI RS PKU MUHAMMADIYAH GOMBONG

Jurnal Ilmiah Kesehatan Keperawatan ◽

10.26753/jikk.v12i1.135 ◽

2016 ◽

Vol 12 (1) ◽

Author(s):

Bambang Utoyo ◽

Podo Yuwono ◽

Wening Tri Kusumawati

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Vitamin C ◽

Intervention Group ◽

Sampling Technique ◽

Salivary Secretion ◽

T Test ◽

The Body ◽

Saliva Secretion ◽

Paired T Test

Chronic renal failure is a progressive deterioration in kidney function and irreversible, in where the body is unable to maintain fluid balance and electrolyte metabolism. Inpractice, patients must limit fluid diet to prevent complications. However, such action may affect some aspect of the human body, that is dry mouth or xerostomiadue to decrease saliva production. To reduce patient complaint, actions which can be done is to stimulate gland salivary with chemical stimulation using lozenges sour taste vitamin C. The aim of this study is to the determine the stimulation effect of the vitamin C lozenges provision to increase salivary secretion in patients with chronic renal failure undergoing hemodialysis therapy in PKU Muhammadiyah Gombong Hospital.This study used a quasi experimental design with pretest — postest design. Samples amounts 42 respondents, consisting of 21 respondents control and 21 respondents intervention by using Purposive Sampling technique. Data analysis technique using Paired t Test to determine whether there were significant differences in salivary secretion in the pretest and postest.Based on a statistical test Paired t Test found a significant increase in the salivary secretion between pretest saliva and postest one intervention group with a value of p=0,003. In conclusion, stimulation of vitamin C lozenges giving has affect to increase saliva secretion in patients with chronic renal failure undergoing hemodialysis therapy in PKU Muhammadiyah Gombong Hospital. Keywords: stimulation, secretion of saliva, chronic renal failure

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Biochemical Investigation to Determine the Factors Involved in Renal Failure Formation for Dialysis Patients

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.01085 ◽

2021 ◽

pp. 6275-6280

Author(s):

Marwan Talib Joudah ◽

Shaker M. Saleh ◽

Wisam Talib Joudah ◽

Mohammed Talib Joudah

Keyword(s):

Renal Failure ◽

Kidney Diseases ◽

The Body ◽

Dialysis Patients ◽

Waste Products ◽

Dialysis Unit ◽

Medical Facilities ◽

High Hba1c ◽

Other Substances ◽

Positive Results

Renal failure is on the top list of kidney diseases as being frequently reported in many medical facilities around the globe. Human kidneys play an important role in excreting, reabsorbing, secreting and filtrating substances in the body. Healthy kidney must excrete the waste products of the body in urine and preserve albumin, and other useful substances in the body. The current study aims to figure out the expected factors of renal failure formation in dialysis patients. Likewise, it is designed to search for any correlation between the imbalanced levels of electrolytes and kidney deterioration. The current study was conducted in Ramadi city-Iraq with the assistance of Al-Ramadi Educational Hospital (REH). The (14th) samples of renal failure patients were collected from dialysis unit at (REH). (2-3 mL) of blood was taken from a patient’s vein. The serum was separated from plasma with the use of a centrifuge. All samples were undergone centrifuging for (4-7 min) at (550 rpm). Afterward, samples were subjected to biochemical examinations to determine the levels and quantities of some biochemical elements and other substances in the selected cases. It was found that some patients had been recorded with a decrease in glomerular filtration rate (GFR), high HbA1c level (˃ 6.5 mg/dL) (21.5%), anemia (˂ 12.0 mg/dL) (%100) in women and (˂ 13.5 mg/dL) in men (%100), Uremia (˃ 45mg/dL) (%100), hypercalcemia (˃10.5 mg/dL) (%7.14), hyperkalemia (˃ 5.1 mg/dL) (%92.8), and Hypernatremia (˃145 mg/dL) (%28.5). Some results obtained, imbalanced levels of the mentioned substances, are either progressed with kidney deterioration, or they are the causes of renal failure. Changes in the levels of some blood substances were observed, and positive results were obtained regarding the aim of the study. Levels or quantities of some blood substances play an important role in preserving kidneys good performance. For instance, when the level of glucose in blood raises, a severe damage to the blood vessels of the kidney takes place and results in poor kidney's performance. While, an increment in the K serum level causes a sudden cardiac death. Changing in some levels and quantities of blood substances could be a core cause of renal failure formation, however, some of them develops when kidney deteriorates.

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A hidden cause of oxalate nephropathy: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-021-02732-6 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Tala Mahmoud ◽

Elias C. Ghandour ◽

Bernard G. Jaar

Keyword(s):

Kidney Disease ◽

Interstitial Fibrosis ◽

Primary Hyperoxaluria ◽

Kidney Injury ◽

Imaging Study ◽

Nutritional Deficiencies ◽

Tubular Atrophy ◽

Dietary Consumption ◽

Hereditary Disorders ◽

Oxalate Nephropathy

Abstract Background Oxalate nephropathy is a rare disorder that can result in acute kidney injury (AKI) and progresses to end-stage kidney disease (ESKD). The causes can be either primary or secondary. Primary hyperoxaluria includes a group of hereditary disorders with enzymatic defects in the glyoxylate pathway, resulting in decreased oxalate metabolism. Secondary hyperoxaluria, often overlooked can result from increased intestinal absorption, nutritional deficiencies, decreased fluid intake, impaired excretion, and increased dietary consumption of oxalate. Case presentation We present a Caucasian case of acute oxalate induced nephropathy associated with consumption of large quantities of green vegetables in a patient with chronic kidney disease (CKD). Imaging study showed no evidence of kidney stone, but a kidney biopsy revealed acute tubular injury, tubular atrophy, interstitial fibrosis, and dense tubular deposition of calcium oxalate crystals. Upon further questioning the patient, we learned that in the months prior to presentation, he had very significantly increased his consumption of green vegetables. Because of no clinical improvement, the patient was initiated and maintained on hemodialysis. Conclusion This report illustrates a case of acute oxalate nephropathy in the setting of very high dietary consumption of oxalate-rich foods in a patient with advanced CKD. Special attention should be given to the secondary causes of hyperoxaluria in patients with predisposing conditions such as CKD.

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COMPARISON OF ANTIHYPERTENSIVE EFFECT OF MOXONIDINE VERSUS CLONIDINE IN RENAL FAILURE PATIENTS.

Journal of Drug Discovery and Therapeutics ◽

10.32553/jddt.v6i9.440 ◽

2018 ◽

Vol 6 (9) ◽

Author(s):

DR.MATHEW GEORGE ◽

DR.LINCY JOSEPH ◽

MRS.DEEPTHI MATHEW ◽

ALISHA MARIA SHAJI ◽

BIJI JOSEPH ◽

...

Keyword(s):

Blood Pressure ◽

Renal Failure ◽

Blood Flow ◽

Blood Vessel ◽

Blood Vessels ◽

High Blood Pressure ◽

Antihypertensive Effect ◽

The Body ◽

Ability To Work ◽

Blood Flows

Blood pressure is the force of blood pushing against blood vessel walls as the heart pumps out blood, and high blood pressure, also called hypertension, is an increase in the amount of force that blood places on blood vessels as it moves through the body. Factors that can increase this force include higher blood volume due to extra fluid in the blood and blood vessels that are narrow, stiff, or clogged(1). High blood pressure can damage blood vessels in the kidneys, reducing their ability to work properly. When the force of blood flow is high, blood vessels stretch so blood flows more easily. Eventually, this stretching scars and weakens blood vessels throughout the body, including those in the kidneys.

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Perbandingan Efek Suplementasi Tablet Tambah Darah Dengan Dan Tanpa Vitamin C Terhadap Kadar Hemoglobin Pada Ibu Hamil Dengan Usiakehamilan 16-32 Minggu Di Desa Keniten Kecamatan Mojo Kabupaten Kediri

Jurnal Ilmu Kesehatan ◽

10.32831/jik.v3i1.49 ◽

2017 ◽

Vol 3 (1) ◽

pp. 76

Author(s):

Siti Asiyah ◽

Dwi Estuning Rahayu ◽

Wiranti Dwi Novita Isnaeni

Keyword(s):

Treatment Group ◽

Vitamin C ◽

Gestational Age ◽

Group Treatment ◽

Sampling Technique ◽

Hemoglobin Level ◽

The Body ◽

Control Group ◽

Fetal Organ ◽

And Control

The needed of Iron Tablet in pregnancy was increase than mother who not pregnant. That cause of high metabolism at the pregnancy for formed of fetal organ and energy. One of effort for prevent anemia in mother pregnant with giving the Iron tablet and vitamin c. The reason of this research in 4 June – 11 July 2014 is for compare the effect of iron tablet suplementation with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks In Desa Keniten Kecamatan Mojo Kabupaten Kediri. This research method using comparative analytical. Research design type of Quasy Eksperiment that have treatment group and control group. Treatment group will giving by Iron tablet and 100 mg vitamin C, and control group just giving by iron tablet during 21 days. Population in this research are all of mother pregnant with Gestational Age Of 16-32 Weeks with Sampling technique is cluster random sampling is 29 mother pregnant. Comparison analysis of iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks, data analysis using Mann Whitney U-test and the calculated U value (44,5) less than U-table (51). So there was difference of iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks Therefore, the addition of vitamin C on iron intake is needed to increase the uptake of iron tablets. When the amount of iron uptake increases, the reserves of iron in the body will also increase, so as to prevent anemia in pregnant women; Keywords : Iron Tablet (Fe), Vitamin C, Hemoglobin level, Mother Pregnant

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Investigating Benzene and Metabolite Mediated Alterations in Nrf2 Signaling in Murine Fetal Liver Cells

Inquiry@Queen's Undergraduate Research Conference Proceedings ◽

10.24908/iqurcp.9801 ◽

2018 ◽

Author(s):

Enoch Lam

Keyword(s):

Free Radicals ◽

Cell Cultures ◽

Childhood Leukemia ◽

Fetal Liver ◽

White Blood Cells ◽

Chemical Exposure ◽

The Body ◽

Chain Reactions ◽

Additional Cell ◽

Other Substances

Leukemia is a cancer of the blood, where the body produces an overabundance of immature white blood cells. It is the most common childhood cancer and possibly originates from chemical exposure during fetal development. Understanding the molecular mechanism and causes of childhood leukemia will help the development of therapeutic and preventative strategies to reduce and treat occurrences of this cancer. Benzene is a non-polar aromatic ring that has been confirmed to cause leukemia in adults. Benzene metabolites can generate free radicals that could potentially be involved in the development of childhood leukemia through in utero exposures. It is found in tobacco smoke, gasoline, industrial solvents and many other substances. Pregnant mothers can be chronically exposed to these substances through daily activities. In order to help determine the mechanism of benzene toxicity, a study was performed to determine the presence of free radicals in the livers of fetal mice at gestation day 14. Fetal liver cell cultures were exposed to varying concentrations of benzene and additional cell cultures were exposed to various concentrations of a benzene metabolite mixture, composed of hydroquinone and benzoquinone. RNA was extracted from these cells and converted into complementary DNA. cDNA was then used in quantitative polymerase chain reactions to analyze a set of genes that are regulated by an antioxidant pathway. This pathway can be activated in response to oxidative stress, and a change in gene expression would indicate the presence of benzene or benzene metabolite toxicity in the liver at gestation day 14.

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