Biochemical Investigation to Determine the Factors Involved in Renal Failure Formation for Dialysis Patients

2021 ◽  
pp. 6275-6280
Author(s):  
Marwan Talib Joudah ◽  
Shaker M. Saleh ◽  
Wisam Talib Joudah ◽  
Mohammed Talib Joudah
Keyword(s):  
Renal Failure ◽  
Kidney Diseases ◽  
The Body ◽  
Dialysis Patients ◽  
Waste Products ◽  
Dialysis Unit ◽  
Medical Facilities ◽  
High Hba1c ◽  
Other Substances ◽  
Positive Results

Renal failure is on the top list of kidney diseases as being frequently reported in many medical facilities around the globe. Human kidneys play an important role in excreting, reabsorbing, secreting and filtrating substances in the body. Healthy kidney must excrete the waste products of the body in urine and preserve albumin, and other useful substances in the body. The current study aims to figure out the expected factors of renal failure formation in dialysis patients. Likewise, it is designed to search for any correlation between the imbalanced levels of electrolytes and kidney deterioration. The current study was conducted in Ramadi city-Iraq with the assistance of Al-Ramadi Educational Hospital (REH). The (14th) samples of renal failure patients were collected from dialysis unit at (REH). (2-3 mL) of blood was taken from a patient’s vein. The serum was separated from plasma with the use of a centrifuge. All samples were undergone centrifuging for (4-7 min) at (550 rpm). Afterward, samples were subjected to biochemical examinations to determine the levels and quantities of some biochemical elements and other substances in the selected cases. It was found that some patients had been recorded with a decrease in glomerular filtration rate (GFR), high HbA1c level (˃ 6.5 mg/dL) (21.5%), anemia (˂ 12.0 mg/dL) (%100) in women and (˂ 13.5 mg/dL) in men (%100), Uremia (˃ 45mg/dL) (%100), hypercalcemia (˃10.5 mg/dL) (%7.14), hyperkalemia (˃ 5.1 mg/dL) (%92.8), and Hypernatremia (˃145 mg/dL) (%28.5). Some results obtained, imbalanced levels of the mentioned substances, are either progressed with kidney deterioration, or they are the causes of renal failure. Changes in the levels of some blood substances were observed, and positive results were obtained regarding the aim of the study. Levels or quantities of some blood substances play an important role in preserving kidneys good performance. For instance, when the level of glucose in blood raises, a severe damage to the blood vessels of the kidney takes place and results in poor kidney's performance. While, an increment in the K serum level causes a sudden cardiac death. Changing in some levels and quantities of blood substances could be a core cause of renal failure formation, however, some of them develops when kidney deteriorates.

scholarly journals CHRONIC KIDNEY DISEASE

2018 ◽  
Vol 25 (06) ◽  
pp. 887-891
Author(s):  
Tanveer Fatima ◽  
Aurangzeb Afzal ◽  
Sania Ashraf
Keyword(s):  
Renal Failure ◽  
The Body ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Waste Products ◽  
Dialysis Unit ◽  
Complex Procedure ◽  
Back Ache ◽  
Life Threatening ◽  
Stage Renal Disease

Introduction: Hemodialysis is a process of removal of waste products andtoxic substances from the body using an extracorporeal system. During the procedure, lotsof hemodynamic and metabolic changes occur in the body as a result of which patientsundergoing hemodialysis may suffer from complications both acutely during or just after dialysisas well as in long term. Objective: To determine the frequencies of various acute intradialyticcomplications in our hemodialysis patients. Study Design: Cross sectional survey. Setting:Lahore General Hospital, Lahore. Period: 3 months from May 2017 to July 2017. Method:End stage renal disease patients on regular hemodialysis in the dialysis unit of a tertiary carehospital. A total of 81 patients were included in the study. Patients with acute renal failure andacute on chronic renal failure were excluded from the survey. Results: Common complicationsobserved in our studied population included muscle cramps (70.7%), post dialysis fatigue(57.3%), back ache (56.1%), intradialytic shivering (57.3%), hypoglycemia (21.4%), hypotension(37.8%), hypertension (8.5%), headache (13.4%), vomiting (13.4%) and anaphylaxis in 2.4%.Conclusion: Hemodialysis is a complex procedure and can cause many complications mostof which are not life threatening. With proper monitoring and immediate treatment thesecomplications can be overcome without causing interruption in hemodialysis.

scholarly journals Intercorrências Clínicas em Hemodiálise Ambulatorial: Intervenções do Enfermeiro

2021 ◽  
Vol 24 (5-esp.) ◽  
pp. 611-618
Author(s):  
Vânia Aparecida dos Santos ◽  
Haroldo Ferreira Araújo ◽  
Marcio Luiz Dos Santos
Keyword(s):  
Kidney Disease ◽  
Kidney Diseases ◽  
The Body ◽  
Waste Products ◽  
Clinical Complications ◽  
Renal Replacement Therapies ◽  
Urinary Infections ◽  
Toxic Agents ◽  
Volume Of Fluids ◽  
Do So

Os rins têm função vital, pois são responsáveis pela eliminação de toxinas, regulação do volume de líquidos e pela filtragem do sangue (filtram, por minuto, em média 20% do volume sanguíneo bombeado pelo coração). Dessa forma, a função renal é avaliada com base na filtração glomerular (FG) e sua redução é observada na doença renal crônica (DRC), quando ocorre a perda das funções reguladora, excretora e endócrina dos rins. Desequilíbrios esses que podem ser de consequência vascular, por comorbidade secundária, por doença renal secundária a drogas ou agentes tóxicos, infecções urinárias de repetição, doença de próstata, doenças policísticas renal, entre outras. Nas terapias renais substitutivas, a diálise é empregada para remover líquidos e produtos residuais urêmicos do organismo, quando o corpo não consegue mais fazê-lo. Tendo em vista que o procedimento hemodialítico tem complicações potenciais, considera-se vital  que o enfermeiro deva estar apto para intervir em tais intercorrências, portanto, ficando evidente a importância deste estudo. Objetiva-se, portanto, descrever as intervenções do enfermeiro em intercorrências clínicas durante a hemodiálise ambulatorial, bem como descrever as principais intercorrências durante as sessões de hemodiálise ambulatorial e se há protocolos específicos de intervenções do enfermeiro em intercorrências com o paciente dialítico. Trata-se de uma pesquisa de revisão integrativa da literatura, pois esta metodologia de revisão tem por propósito realizar uma dada síntese rigorosa de todas as pesquisas encontradas relacionadas a uma questão específica.   Palavras-chave: Enfermagem. Hemodiálise. Intercorrências   Abstract The kidneys have a vital function, as they are responsible for eliminating toxins, regulating the volume of fluids and filtering the blood (they filter, on average, 20% of the blood volume pumped by the heart per minute). Thus, renal function is assessed based on glomerular filtration (FG) and its reduction is seen in chronic kidney disease (CKD), when the loss of the kidneys regulatory, excretory and endocrine functions occurs. These imbalances can be of vascular consequence, secondary comorbidity, kidney disease secondary to drugs or toxic agents, recurrent urinary infections, prostate disease, polycystic kidney diseases, among others. In renal replacement therapies, dialysis is used to remove uremic fluids and waste products from the body when the body is unable to do so. Bearing in mind that the hemodialysis procedure has potential complications, it is considered nodal that the nurse must be able to intervene in such complications, therefore, the importance of this study is evident. Therefore, the objective is to describe the nurse's interventions in clinical complications during the outpatient hemodialysis, as well as to describe the main complications during the outpatient hemodialysis sessions and if there are specific protocols for the nurse interventions in complications with dialysis patients. It is an integrative literature review research, since this review methodology aims to perform a given rigorous synthesis of all the studies found related to a specific issue.   Keywords: Nursing. Hemodialysis. Complications

scholarly journals Vitamin C-Induced Oxalate Nephropathy

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Jorge Lamarche ◽  
Reji Nair ◽  
Alfredo Peguero ◽  
Craig Courville
Keyword(s):  
Renal Failure ◽  
Vitamin C ◽  
Primary Hyperoxaluria ◽  
The Body ◽  
Extensive Literature ◽  
Vitamin Deficiencies ◽  
Dietary Consumption ◽  
Other Substances ◽  
Immune Booster ◽  
Oxalate Nephropathy

Although a multitude of syndromes have been thoroughly described as a result of vitamin deficiencies, over consumption of such substances may also be quite dangerous. Intratubular crystallization of calcium oxalate as a result of hyperoxaluria can cause acute renal failure. This type of renal failure is known as oxalate nephropathy. Hyperoxaluria occurs as a result of inherited enzymatic deficiencies known as primary hyperoxaluria or from exogenous sources known as secondary hyperoxaluria. Extensive literature has reported and explained the mechanism of increased absorption of oxalate in malabsorptive syndromes leading to renal injury. However, other causes of secondary hyperoxaluria may also take place either via direct dietary consumption of oxalate rich products or via other substances which may metabolize into oxalate within the body. Vitamin C is metabolized to oxalate. Oral or parenteral administration of this vitamin has been used in multiple settings such as an alternative treatment of malignancy or as an immune booster. This article presents a clinical case in which ingestion of high amounts of vitamin C lead to oxalate nephropathy. This article further reviews other previously published cases in order to illustrate and highlight the potential renal harm this vitamin poses if consumed in excessive amounts.

scholarly journals TO IDENTIFY THE COMPONENT PRESENT IN ASS URINE FOR TREATMENT OF EPILEPSY

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Anuj Mishra
Keyword(s):  
Carbon Dioxide ◽  
Fluid Intake ◽  
Environmental Temperature ◽  
Emotional State ◽  
Time Of Day ◽  
Tubular Secretion ◽  
Tubular Reabsorption ◽  
The Body ◽  
Waste Products ◽  
Other Substances

Approximately 150 L of plasma are purified each day by glomerular filtration, tubular secretion, and tubular reabsorption to produce 0.6 to 2.5 L of urine. The amount of urine produced is influenced by environmental temperature, fluid intake, time of day, emotional state, and many other factors.1 The composition of urine reveals much about body function. Metabolic waste products such as carbon dioxide, urea, uric acid, creatinine, sodium chloride, and ammonia are normally present and have no particular pathological significance. The presence of albumin (a protein), glucose, ketones, and various other substances, however, may indicate malfunction of the kidneys or some other organ of the body.1 Biological importance of Ass urine: (Sanskrit :khara; Latin : Asinusequidae) The urine of Ass has been mentioned useful as destroyer of epilepsy (apasmara), intensity (unmada) and in seizures. The mode of its use has been mentioned as internal as drink. Apart from the above mentioned diseases, the urine of Ass has also been prescribed to cure diabetes and various diseases caused by worms.2,3

scholarly journals Hematological and biochemical studies on hemodylitic patients at the Government General Hospital, Wadi Al-Dawaser

2020 ◽  
Vol 6 (2) ◽  
pp. 31
Author(s):  
Somia A. Nassar ◽  
Zeinb A. Yehia ◽  
Alaa A. Alnami ◽  
Alanood N. Aldosari ◽  
Sara M. Abdullah ◽  
...  
Keyword(s):  
Renal Failure ◽  
General Hospital ◽  
Biochemical Parameters ◽  
Serum Glucose ◽  
The Body ◽  
Dialysis Unit ◽  
Hematological Indices ◽  
Hospital Patients ◽  
Serum Biochemical ◽  
The Government

<p class="abstract"><strong>Background:</strong> Renal failure is a slowly progressive disease of kidney, characterized by low glomerular filtration. One of the most important replacement therapy of renal failure is hemodialysis which helping in the removal of toxic fluids and metabolic end products from the body.</p><p class="abstract"><strong>Methods:</strong> This study was carried out on 43 patients with renal failure in the dialysis unit of Wadi Al-Dawaser General Hospital. Patients were 25 males and 18 females, randomly selected for the study between September and November 2018. Blood samples were obtained from all patients pre and post dialysis for serum biochemical analysis including kidney function test, liver function, lipid profile, glucose, electrolytes, while blood sample with anticoagulants collected pre dialysis for complete blood picture.  </p><p class="abstract"><strong>Results:</strong> The hemogram parameters recorded significant decrease while leuckogram insignificantly increase specially eosinophils, in pre-dialysis patients. Serum biochemical parameters were significantly high pre-dialysis recorded 83.7%, 97.7%, 21% for urea, creatinine and uric acid respectively, while significantly decrease post dialysis. In contrast serum glucose and magnesium levels were significantly high pre and post dialysis. As result of decrease of the erythropoietin production in chronic renal failure patients lower hematological indices, increase the risk of anemia are main results.</p><p class="abstract"><strong>Conclusions:</strong> Dialysis improve the biochemical parameters of serum especially creatinine and urea while glucose and magnesium not improved.</p><p class="abstract"> </p>

scholarly journals Potassium  Electrolyte Serum - Urine , and Creatinine  in Chronic Kidney Diseases

2021 ◽  
Author(s):  
dr. Indranila KS Kustarini samsuria ◽  
Peni K Samsuria Mutalib ◽  
Arindra Adirahardja Adirahardja
Keyword(s):  
Linear Regression ◽  
Kidney Diseases ◽  
Multivariate Linear Regression ◽  
The Body ◽  
Electrolyte Imbalance ◽  
Other Substances ◽  
Negative Effect ◽  
Urine Potassium ◽  
The Relationship ◽  
Serum And Urine

Abstract Background: The kidneys are important organs in the human body that have many functions. Kidney function is divided into several processes, namely filtration, reabsorption and secretion of substances in the body. Nephron which is the smallest kidney functional unit that is responsible for accommodating all functions in the kidney. One of the functions of the kidneys is secretion, the secretions in the kidneys work by removing electrolytes and other substances that are no longer needed by the body through urine. When the function of the kidney nephrons is disturbed, it can result in an electrolyte imbalance (K), a buildup of waste from substances that are not needed by the body (creatinine). The objective of this research was to examine the relationship between electrolytes (K) serum, urine and creatinine in patients with CKD.Methods: The research was conducted by observational, anamnesis, and sampling of CKD patients at Dr. Kariadi Semarang during the period March-May 2020.Results: The results of the multivariate linear regression test showed that creatinine had a moderate significant positive effect at p = 0.024 and r = 0.412 on serum K. Meanwhile, from multivariate linear regression, it was found that creatinine had a moderate negative effect at p = 0.027 and r = -0.456 on urine K.Conclusions and suggestions: The findings proved the relationship between creatinine levels and serum and urine potassium levels in patients with CKD. Serum and urine electrolytes can be used as an parameter for CKD management.

Determining Some Factors Affecting the Longevity of Hemodialysis Patients. Using Survival Analysis

2019 ◽  
Author(s):  
Shideh Rafati ◽  
Laleh Hassani ◽  
Mohamad Tamaddondar ◽  
Abdolnabi Sabili
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Survival Time ◽  
Proportional Hazards Model ◽  
Cox Model ◽  
The Body ◽  
Dialysis Session ◽  
Dialysis Unit ◽  
Risk Of Death ◽  
Risk Of Mortality

Abstract Background Dialysis is a method for removing excess fluid and uremic waste from the body of chronic renal-failure patients. In patients with CRF, blood dialysis stops death. Hemodialysis prevents the death of patients with chronic renal failure. Various factors can affect the survival of patients undergoing dialysis treatment. The current study aimed to determine such factors.Methods This descriptive-analytic study examined 252 patients undergoing dialysis from 2010 to 2016 in all of hospitals in Bandar Abbas- Iran, whose data had been recorded in the dialysis unit or it was possible to get their files. The study used Lasso Regression in Cox's proportional hazards model in case with multi variables, background diseases, Body Mass Index,…… The collected data was analyzed using SPSS software and through installing glmnet and survival packages in R software.Results In this study, 35 (13.9%) death events and 217 (86.1%) censored events were observed. The mean survival time of 252 patients was equal to 10.93 ± 7.82 years and the median survival time of these patients was calculated to be ten years. Based on the results of the Cox model under the penalized method of Lasso, The risk of mortality for patients with diploma degree was by 49% lower than that of the illiterate group (HR = 0.51). The risk of death for unemployed patients and farmers was equal to 0.66 (HR = 1.66) and 0.29 (HR = 1.29), respectively, higher than that of employees. Another significant factor in this study is the duration of each dialysis session. The risk of mortality has been reduced by 0.34 (HR = 0.66) for a single increase during dialysis.Conclusions Apart from congenital and underlying diseases which early diagnosis will prevent kidney failure, the risk of mortality will be reduced by training behavioral issues in patients undergoing dialysis such as dialysis at predetermined hours and times and appropriate nutritional behaviors.

The Neonatal Liver Part III: Pathophysiology of Liver Dysfunction

2003 ◽  
Vol 22 (3) ◽  
pp. 5-15 ◽  
Author(s):  
Debbie Fraser Askin ◽  
William Diehl-Jones
Keyword(s):  
Liver Dysfunction ◽  
Plasma Proteins ◽  
The Body ◽  
Clotting Factors ◽  
Waste Products ◽  
Hypoxic Injury ◽  
Metabolic Functions ◽  
Elevated Liver Enzymes ◽  
Other Substances ◽  
Neonatal Liver

The liver, the largest organ in the body, is critical to a number of key metabolic functions. It also plays an important role in removing the waste products of metabolism (particularly ammonia) and in detoxifying drugs and other substances such as endogenous hormones and steroid compounds. In addition, the liver plays a major role in the production of clotting factors, plasma proteins, bile salts, and bilirubin.Many neonates display signs of hepatic dysfunction such as hyperbilirubinemia, hepatomegaly, or elevated liver enzymes. These often occur secondary to systemic illness, such as sepsis or hypoxic injury, or following the use of drugs or parenteral nutrition to treat other problems. Although rare, primary liver disease does occur in neonates and must be recognized promptly, with treatment initiated in a timely manner to prevent unnecessary sequelae. This article, the third in a series on the liver, examines causes of liver dysfunction in neonates, beginning with an overview of jaundice and hepatomegaly and moving to a discussion of specific diseases.

COMPARISON OF ANTIHYPERTENSIVE EFFECT OF MOXONIDINE VERSUS CLONIDINE IN RENAL FAILURE PATIENTS.

2018 ◽  
Vol 6 (9) ◽  
Author(s):  
DR.MATHEW GEORGE ◽  
DR.LINCY JOSEPH ◽  
MRS.DEEPTHI MATHEW ◽  
ALISHA MARIA SHAJI ◽  
BIJI JOSEPH ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Blood Flow ◽  
Blood Vessel ◽  
Blood Vessels ◽  
High Blood Pressure ◽  
Antihypertensive Effect ◽  
The Body ◽  
Ability To Work ◽  
Blood Flows

Blood pressure is the force of blood pushing against blood vessel walls as the heart pumps out blood, and high blood pressure, also called hypertension, is an increase in the amount of force that blood places on blood vessels as it moves through the body. Factors that can increase this force include higher blood volume due to extra fluid in the blood and blood vessels that are narrow, stiff, or clogged(1). High blood pressure can damage blood vessels in the kidneys, reducing their ability to work properly. When the force of blood flow is high, blood vessels stretch so blood flows more easily. Eventually, this stretching scars and weakens blood vessels throughout the body, including those in the kidneys.

METABOLIC SYNDROME IN DIALYSIS PATIENTS

2016 ◽  
pp. 7-11
Author(s):  
Vinh Phu Hoang ◽  
Tam Vo ◽  
Van Tien Le ◽  
Thi Hoai Huong Vo
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Artificial Kidney ◽  
Dialysis Patients ◽  
Cross Sectional ◽  
Average Value ◽  
The Metabolic Syndrome ◽  
End Stage

Objective: To review disorders elements of the metabolic syndrome in patients with end-stage chronic renal failure on dialysis cycle. Materials and methods: A cross sectional descriptive study of 85 patients including end-stage chronic renal failure in dialysis cycle from 5/2015 - 9/2016 at the Department of Artificial Kidney, Hue Central Hospital. Results: The prevalence of metabolic syndrome in dialysis patients was 37.65%. The prevalence of abdominal obesity was 30.6%; The prevalence of hypertension was 72.9%, the average value systolic blood pressure and diastolic blood pressure were 142.24 ± 27.53, 80.35 ± 12.48 mmHg; The prevalence of hyperglycemia was 28%, the average value blood glucose was 4.9 ± 1.19 mmol/l; The prevalence of triglyceride increase was 34.1%, the average value triglyceride was 1.59 ± 0.84 mmol/l. The prevalence of HDL-C increase was 47.1%, the average value HDL-C was 1.24 ± 0.33 mmol/l. Conclusion: The prevalence of metabolic syndrome in dialysis patients is very high, in which hypertension and HDL disturbances are the highest. Key words: chronic renal failure, dialysis, metabolic syndrome

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