LTCC-3D Coaxial Flow Focusing Microfluidic Reactor for Micro and Nanoparticle Fabrication and Production Scale-Out

2013 ◽  
Vol 10 (3) ◽  
pp. 102-108 ◽  
Author(s):  
Mario Ricardo Gongora-Rubio ◽  
Juliana de Novais Schianti ◽  
Houari Cobas Gomez ◽  
Andre da Costa Teves
Keyword(s):  
Particle Production ◽  
High Surface ◽  
Thermal Inertia ◽  
Volume Ratio ◽  
Chemical Processes ◽  
Nano Particles ◽  
Batch Reactors ◽  
Thermal Coefficient ◽  
Flow Focusing ◽  
Production Scale

Miniaturization of chemical processes is becoming a must for green chemistry and sustainable industry processes, so technological research in this direction is well received. Continuous microreactor systems hold many potential benefits over batch reactors, in that they allow: high surface-to-volume ratio, fine adjustment of chemical reaction residence times, small thermal inertia, and fast changes in temperature. Advantages of multilayer green ceramics for microprocess applications include: that the LTCC substrate is chemically inert to most solvents, that it has a high contact angle, that it presents low thermal coefficient of expansion, and that it can withstand high operational temperatures and high internal pressures. For these reasons, LTCC-based microsystem technologies allow the implementation of different unitary operations for chemical processes, making it an enabling technology for the miniaturization of chemical processes. In fact, recently, LTCC microfluidic reactors have been used to produce microparticles and nanoparticles with excellent control of size distribution and morphology. The present work provides a report on the performance of a 3D LTCC coaxial flow focusing micro-fluidic reactor designed to fabricate microparticles and nano-particles using nanoprecipitation through an antisolvent; with electric potential size tuning. We also implement an approach to particle production scale-out.

LTCC-3D FLOW FOCUSING FLUIDIC MICROREACTOR FOR NANOPARTICLE FABRICATION AND PRODUCTION SCALE-OUT

2013 ◽  
Vol 2013 (CICMT) ◽  
pp. 000110-000117
Author(s):  
Mario Ricardo Gongora-Rubio ◽  
Juliana de Novais Schianti ◽  
Houari Cobas Gomez ◽  
Andre da Costa Teves
Keyword(s):  
High Surface ◽  
Thermal Inertia ◽  
Volume Ratio ◽  
Chemical Processes ◽  
Batch Reactors ◽  
Thermal Coefficient ◽  
Flow Focusing ◽  
Production Scale ◽  
Excellent Control ◽  
Internal Pressures

Miniaturization of chemical processes is becoming a must for green chemistry and sustainable industry processes, so technological research in this direction is well received. Continuous microreactor systems hold many potential benefits over batch reactors allowing: high surface-to-volume ratio, fine adjustment of chemical reaction residence times, small thermal inertia and fast changes in temperature. Advantages of multilayer green ceramics for microprocess applications include: LTCC substrate is chemically inert to most solvents, it has a high contact angle, presents low thermal coefficient of expansion, can withstand high operational temperatures and high internal pressures. For these reasons, LTCC-based microsystem technologies allow the implementation of different unitary operations for chemical process, making it an enabling technology for the miniaturization of chemical processes. In fact, recently LTCC microfluidic reactors have been used to produce micro and nanoparticles with excellent control of size distribution and morphology. The present work provides a report on the performance of a 3D LTCC flow focusing Microfluidic reactor designed to fabricate Nanoparticles using nano precipitation through an anti-solvent, with electric potential size tuning. We also implement an approach to nanoparticle production scale-out.

scholarly journals Nanotechnology and Its Applications to Medicine: an over view

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H Ibrahim
Keyword(s):  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Electrospinning Process ◽  
Nano Particles ◽  
High Production Rate ◽  
Nano Fiber ◽  
Nano Medicine ◽  
Bio Compatibility

Abstract Nowadays there are more interesting with nanotechnology and its applications in several sectors specially in medicine for diagnoses, therapeutic and research biomedical tools. It can be defined as any process or technique used to produce material in nano-scale structure with particle size ranged from 1-100 nm. The utilization of nanotechnology in human health benefits known as nano medicine. So that nanotechnology has firmly entered the drug delivery realm to maximize drug therapeutic activity and minimize its undesirable side effects. Herein we deal with both nanoparticles and nano-fibers and their applications in medical field. Nano-particles have unique properties from its small size with high surface area therefore it provides larger than particle numbers from that prepared with convention methods. In addition, nanoparticles can be used to improve various drug bio-availability from its biodegradability and bio-compatibility. Nano-fibers have huge surface area to volume ratio which increase its performance in several applications. Nano-fiber produced via electrospinning process (simple and have high production rate). It can be used in many applications such as water filtration, tissue engineering scaffold, wounds, fiber composites, drug release and protective clothes.

Advantages and Limitations of Using Nano Sized Powders for Powder Injection Molding Process: A Review

2012 ◽  
Vol 59 (2) ◽  
Author(s):  
Javad Rajabi ◽  
Norhamidi Muhamad ◽  
Abu Bakar Sulong ◽  
Abdolali Fayyaz ◽  
Azizah Wahi
Keyword(s):  
Injection Molding ◽  
Large Scale ◽  
Sintering Temperature ◽  
High Surface ◽  
Volume Ratio ◽  
Powder Injection Molding ◽  
Nano Particles ◽  
Powder Injection ◽  
Injection Molding Process ◽  
Molding Process

Powder injection molding (PIM) is among the most known forming techniques that use material powders. This technique has been widely evaluated for the production of large scale and small components using metal and ceramic powders. Nano particles have larger surface-to-volume ratio compared with large-sized particles, thus they display high surface area. Some merits in the application of nano-sized particles in the PIM process includes increasing its comparative density at a low sintering temperature, decreasing sintering temperature, decreasing grain size of sintered bodies, increasing hardness value, and improving surface properties. However, it also has several disadvantages, which include increasing the viscosity behaviour of feedstock, oxidation, and agglomeration. This article reviews current studies on the effects of nano-sized particles on the PIM process and finding solutions to address its disadvantages.

scholarly journals Enzymatic microreactors in biocatalysis: history, features, and future perspectives

Biocatalysis ◽  
2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Enzo Laurenti ◽  
Ardson dos Santos Vianna Jr.
Keyword(s):  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Immobilized Enzymes ◽  
Reaction Rates ◽  
Chemical Processes ◽  
Biochemical Processes ◽  
Enzymatic Microreactors ◽  
Materials Used ◽  
Broad Overview

AbstractMicrofluidic reaction devices are a very promising technology for chemical and biochemical processes. In microreactors, the micro dimensions, coupled with a high surface area/volume ratio, permit rapid heat exchange and mass transfer, resulting in higher reaction yields and reaction rates than in conventional reactors. Moreover, the lower energy consumption and easier separation of products permit these systems to have a lower environmental impact compared to macroscale, conventional reactors. Due to these benefits, the use of microreactors is increasing in the biocatalysis field, both by using enzymes in solution and their immobilized counterparts. Following an introduction to the most common applications of microreactors in chemical processes, a broad overview will be given of the latest applications in biocatalytic processes performed in microreactors with free or immobilized enzymes. In particular, attention is given to the nature of the materials used as a support for the enzymes and the strategies employed for their immobilization. Mathematical and engineering aspects concerning fluid dynamics in microreactors were also taken into account as fundamental factors for the optimization of these systems.

scholarly journals Effects of Nanoparticles on properties of Self Compacting Concrete (SCC) and Self Compacting Mortar (SCM)

2019 ◽  
Vol 8 (3) ◽  
pp. 2977-2979
Keyword(s):  
Construction Industry ◽  
Surface Effect ◽  
High Surface ◽  
Volume Ratio ◽  
Recent Time ◽  
Nano Particles ◽  
Gel Formation ◽  
Self Compacting Concrete ◽  
Research Areas ◽  
Insight Into

Nanotechnology is the most attractive research areas because of its useful applications that have gradually recognized itself in the recent time. Nanoparticles are potential materials in construction industry. Nanoparticles have excellent properties and high surface-to-volume ratio, are known to improve the microstructure of concrete, accelerate the CSH gel formation, and improve the properties of concrete. This study aims to understand the properties of self-compacting concrete (SCC) containing nanoparticles such as nano SiO2, TiO2, ZrO2, CuO. Influence of nano particles to SCC and SCM has received extensive interest from both researchers and construction industry due to their interface improving effect, surface effect and smaller size. This study significantly reviews recent research carried out on the influence of Nano particles on properties of both SCC and SCM. Detailed review on the fresh, strength, microstructural and durability properties of Self Compacting Concrete containing Nano particles are presented. This paper also aims to provide a widespread knowledge insight into possible application of Nanopartices on SCC and SCM in the construction industry. Keywords: Nanotechnology, nanoparticles, CSH gel formati

scholarly journals Nano Wonders in Concrete Technology: Mini Review

2020 ◽  
Vol 1 (1) ◽  
pp. 25-28
Author(s):  
Anwar Khitab
Keyword(s):  
Chemical Reactivity ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Weather Conditions ◽  
Nano Particles ◽  
Self Healing ◽  
Active Ingredients ◽  
Concrete Technology ◽  
The Matrix

Concrete is one of the most significant materials, man has produced. Conventionally, it is a mixture of cement, sand, coarse aggregates and water. It is versatile, and gains strength in a few weeks after its casting. It can withstand extreme weather conditions. However, traditional concrete also has some drawbacks. It has low tensile strength and develops cracks, which limit its usefulness. The performance of concrete can be enhanced by carefully selecting its ingredients and employing appropriate modern techniques. One such technique is the use of nano particles. Nano particles, due to their small size, possess very high surface area to volume ratio. They can be used as inert filler as well as chemically active ingredients in cementitious composites. Being filler, they can fill up very small voids in the matrix. As active ingredients, they can result in higher chemical reactivity. This work focuses on the wonders, nano particles have brought in concrete technology. The topics include self-healing, de-pollutant, de-icing and energy-saving concrete materials.

Electron holography of catalysts

1995 ◽  
Vol 53 ◽  
pp. 416-417
Author(s):  
A. K. Datye ◽  
D. S. Kalakkad ◽  
L. F. Allard ◽  
E. Völkl
Keyword(s):  
Heterogeneous Catalysts ◽  
High Surface ◽  
High Surface Area ◽  
Atomic Scale ◽  
Nano Particles ◽  
Phase Image ◽  
Electron Holography ◽  
Specimen Thickness ◽  
Phase Information ◽  
Particle Structure

The active phase in heterogeneous catalysts consists of nanometer-sized metal or oxide particles dispersed within the tortuous pore structure of a high surface area matrix. Such catalysts are extensively used for controlling emissions from automobile exhausts or in industrial processes such as the refining of crude oil to produce gasoline. The morphology of these nano-particles is of great interest to catalytic chemists since it affects the activity and selectivity for a class of reactions known as structure-sensitive reactions. In this paper, we describe some of the challenges in the study of heterogeneous catalysts, and provide examples of how electron holography can help in extracting details of particle structure and morphology on an atomic scale.Conventional high-resolution TEM imaging methods permit the image intensity to be recorded, but the phase information in the complex image wave is lost. However, it is the phase information which is sensitive at the atomic scale to changes in specimen thickness and composition, and thus analysis of the phase image can yield important information on morphological details at the nanometer level.

scholarly journals Geometric correction for thermographic images of asteroid 162173 Ryugu by TIR (thermal infrared imager) onboard Hayabusa2

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Takehiko Arai ◽  
Tatsuaki Okada ◽  
Satoshi Tanaka ◽  
Tetsuya Fukuhara ◽  
Hirohide Demura ◽  
...  
Keyword(s):  
Surface Roughness ◽  
High Surface ◽  
Thermal Inertia ◽  
Thermal Infrared ◽  
Shape Model ◽  
Infrared Imager ◽  
Least Squares Fit ◽  
Temperature Maps ◽  
Pixel Scale ◽  
Thermal Infrared Imager

AbstractThe thermal infrared imager (TIR) onboard the Hayabusa2 spacecraft performed thermographic observations of the asteroid 162173 Ryugu (1999 JU$$_3$$ 3 ) from June 2018 to November 2019. Our previous reports revealed that the surface of Ryugu was globally filled with porous materials and had high surface roughness. These results were derived from making the observed temperature maps of TIR using a projection method onto the shape model of Ryugu as geometric corrections. The pointing directions of TIR were calculated using an interpolation of data from the SPICE kernels (NASA/NAIF) during the periods when the optical navigation camera (ONC) and the light detection and ranging (LIDAR) observations were performed. However, the mapping accuracy of the observed TIR images was degraded when the ONC and LIDAR were not performed with TIR. Also, the orbital and attitudinal fluctuations of Hayabusa2 increased the error of the temperature maps. In this paper, to solve the temperature image mapping problems, we improved the correction method by fitting all of the observed TIR images with the surface coordinate addressed on the high-definition shape model of Ryugu (SFM 800k v20180804). This correction adjusted the pointing direction of TIR by rotating the TIR frame relative to the Hayabusa2 frame using a least squares fit. As a result, the temperature maps spatially spreading areas were converged within high-resolved $$0.5^\circ$$ 0 . 5 ∘ by $$0.5^\circ$$ 0 . 5 ∘ maps. The estimated thermal inertia, for instance, was approximately 300$$\sim$$ ∼ 350 Jm$$^{-2}$$ - 2 s$$^{-0.5}$$ - 0.5 K$$^{-1}$$ - 1 at the hot area of the Ejima Saxum. This estimation was succeeded in case that the surface topographic features were larger than the pixel scale of TIR. However, the thermal inertia estimation of smooth terrains, such as the Urashima crater, was difficult because of surface roughness effects, where roughness was probably much smaller than the pixel scale of TIR.

scholarly journals Electrospun Nanofibers for Sensing and Biosensing Applications—A Review

2021 ◽  
Vol 22 (12) ◽  
pp. 6357
Author(s):  
Kinga Halicka ◽  
Joanna Cabaj
Keyword(s):  
High Surface ◽  
High Surface Area ◽  
Toxic Metal ◽  
Volume Ratio ◽  
Electrospun Nanofibers ◽  
Clinical Diagnostics ◽  
Loading Capacity ◽  
Electrospun Nanofiber ◽  
Sensing Platforms ◽  
Different Types

Sensors and biosensors have found applications in many areas, e.g., in medicine and clinical diagnostics, or in environmental monitoring. To expand this field, nanotechnology has been employed in the construction of sensing platforms. Because of their properties, such as high surface area to volume ratio, nanofibers (NFs) have been studied and used to develop sensors with higher loading capacity, better sensitivity, and faster response time. They also allow to miniaturize designed platforms. One of the most commonly used techniques of the fabrication of NFs is electrospinning. Electrospun NFs can be used in different types of sensors and biosensors. This review presents recent studies concerning electrospun nanofiber-based electrochemical and optical sensing platforms for the detection of various medically and environmentally relevant compounds, including glucose, drugs, microorganisms, and toxic metal ions.

scholarly journals Study of the geometry of open channels in a layer-bed-type microfluidic immobilized enzyme reactor

2021 ◽  
Author(s):  
Cynthia Nagy ◽  
Robert Huszank ◽  
Attila Gaspar
Keyword(s):  
Immobilized Enzyme ◽  
High Surface ◽  
Volume Ratio ◽  
Volumetric Flow Rate ◽  
Enzyme Reactor ◽  
Channel Pattern ◽  
Immobilized Enzyme Reactor ◽  
Split Flow ◽  
Parallel Streams ◽  
Enzymatic Microreactors

AbstractThis paper aims at studying open channel geometries in a layer-bed-type immobilized enzyme reactor with computer-aided simulations. The main properties of these reactors are their simple channel pattern, simple immobilization procedure, regenerability, and disposability; all these features make these devices one of the simplest yet efficient enzymatic microreactors. The high surface-to-volume ratio of the reactor was achieved using narrow (25–75 μm wide) channels. The simulation demonstrated that curves support the mixing of solutions in the channel even in strong laminar flow conditions; thus, it is worth including several curves in the channel system. In the three different designs of microreactor proposed, the lengths of the channels were identical, but in two reactors, the liquid flow was split to 8 or 32 parallel streams at the inlet of the reactor. Despite their overall higher volumetric flow rate, the split-flow structures are advantageous due to the increased contact time. Saliva samples were used to test the efficiencies of the digestions in the microreactors. Graphical abstract

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