scholarly journals Blood indices, in-hospital outcome and short-term prognosis in patients with COVID-19 pneumonia

2021 ◽  
Author(s):  
Karrar Al-Buthabhak ◽  
Hussein Nafakhi ◽  
Mohammed H. Shukur ◽  
Ahmed Nafakhi ◽  
Mohammed Alareedh ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Lung Injury ◽  
Hospital Death ◽  
Newly Diagnosed ◽  
Short Term ◽  
Blood Indices ◽  
Hospital Outcome ◽  
Icu Stay ◽  
Increased Risk ◽  
Recovery Status

The predictive role of blood indices in coronavirus disease 2019 (COVID-19) related in-hospital adverse outcomes and post-recovery status is not fully defined. The main aim was to assess the association of complete blood indices measured at baseline with COVID-19 related in-hospital clinical outcomes, including length of hospital and intensive care unit (ICU) stay, receiving mechanical ventilation, degree of lung injury and in-hospital death, and post-recovery status. This retrospective study included patients with newly diagnosed COVID-19 infection from August 20, to September 25, 2020. The initial study cohort included 127 patients with newly diagnosed COVID-19. Of whom 26 patients were excluded, leaving 101 patients for final analysis. low lymphocytes % [Odds ratio and confidence intervals = OR (CI)] [0.2(0.0-0.2, p=0.03] increased the odds of ICU stay length while high platelet mean volume (PMV) [0.9 (1.1-5, p<0.00], high platelet distribution width (PDW) [0.3(0.4-1.9), p<0.00], and low lymphocytes % [0.2 (0.0-0.2), p=0.02] increased the odds of length of hospital stay. Decreased lymphocytes % showed significant independent association with increased risk for mechanical ventilation use [0.9 (0.9-1), p=0.04], extensive degree of lung injury [0.2 (0.1-0.7), p<0.00], and in-hospital death [0.5 (0.3-0.8), p=0.01]. High lymphocytes %[0.9 (0.9-1), p<0.00] and high PMV [0.3 (0.3-0.8), p=0.02] were significantly associated with complete recovery while increased neutrophil % [1 (1-1.1), p=0.04] was associated with increased risk for post recovery fatigue. In conclusion, low lymphocytes % and high neutrophil % are useful markers for predicting adverse in-hospital outcome and post-recovery persistent fatigue, respectively. High PMV and lymphocyte % showed significant association with favorable short-term prognosis.

scholarly journals Chronic Hemodialysis Patients Hospitalized with COVID-19: Short-term Outcomes in the Bronx, New York

Kidney360 ◽  
2020 ◽  
Vol 1 (8) ◽  
pp. 755-762 ◽  
Author(s):  
Molly Fisher ◽  
Milagros Yunes ◽  
Michele H. Mokrzycki ◽  
Ladan Golestaneh ◽  
Emad Alahiri ◽  
...  
Keyword(s):  
New York ◽  
Mechanical Ventilation ◽  
Clinical Characteristics ◽  
Laboratory Data ◽  
Nursing Home Residents ◽  
Chronic Hemodialysis ◽  
Adverse Outcomes ◽  
Hospital Death ◽  
Short Term ◽  
Increased Risk

BackgroundPatients with ESKD who are on chronic hemodialysis have a high burden of comorbidities that may place them at increased risk for adverse outcomes when hospitalized with COVID-19. However, data in this unique patient population are limited. The aim of our study is to describe the clinical characteristics and short-term outcomes in patients on chronic hemodialysis who require hospitalization for COVID-19.MethodsWe performed a retrospective study of 114 patients on chronic hemodialysis who were hospitalized with COVID-19 at two major hospitals in the Bronx from March 9 to April 8, 2020 during the surge of SARS-CoV-2 infections in New York City. Patients were followed during their hospitalization through April 22, 2020. Comparisons in clinical characteristics and laboratory data were made between those who survived and those who experienced in-hospital death; short-term outcomes were reported.ResultsMedian age was 64.5 years, 61% were men, and 89% were black or Hispanic. A total of 102 (90%) patients had hypertension, 76 (67%) had diabetes mellitus, 63 (55%) had cardiovascular disease, and 30% were nursing-home residents. Intensive care unit (ICU) admission was required in 13% of patients, and 17% required mechanical ventilation. In-hospital death occurred in 28% of the cohort, 87% of those requiring ICU, and nearly 100% of those requiring mechanical ventilation. A large number of in-hospital cardiac arrests were observed. Initial procalcitonin, ferritin, lactate dehydrogenase, C-reactive protein, and lymphocyte percentage were associated with in-hospital death.ConclusionsShort-term mortality in patients on chronic hemodialysis who were hospitalized with COVID-19 was high. Outcomes in those requiring ICU and mechanical ventilation were poor, underscoring the importance of end-of-life discussions in patients with ESKD who are hospitalized with severe COVID-19 and the need for heightened awareness of acute cardiac events in the setting of COVID-19. Elevated inflammatory markers were associated with in-hospital death in patients with ESKD who were hospitalized with COVID-19.

scholarly journals Therapeutic Interventions are Important Risk Factors for Delirium in the ICU Setting ： A Multicenter Observational Study

2021 ◽  
Author(s):  
Ying Liu ◽  
Zhiyong Yuan ◽  
Shixia Cai ◽  
Xiaoning Han ◽  
Kai Song ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Enteral Nutrition ◽  
Observational Study ◽  
Univariate Analysis ◽  
Therapeutic Interventions ◽  
Physical Restraints ◽  
Icu Patients ◽  
Icu Stay ◽  
Increased Risk

Abstract Background Delirium is an important independent predictor of negative clinical outcomes in intensive care unit (ICU) patients. The purpose of this study was to investigate the territorial incidence of ICU delirium, its related risk factors, and short-term outcomes in Shandong Province, China, to provide precise information for territorial patient management. Methods A multicenter prospective observational study was conducted. Patients with delirium were defined as any patient with at least one positive CAM-ICU or ICDSC assessment. Demographics, admission clinical data, daily interventions provided to patients and environmental factors were collected. Results From May 1, 2018 to Jan 31, 2020, 536 noncomatose patients were ultimately eligible for the study. One hundred eighteen patients (22%) experienced delirium at least once. In the univariate analysis, age (p = 0.009), SOFA score (p = 0.006), a history of cerebrovascular disease (p = 0.044) and impaired renal function (p = 0.003) were risk factors for delirium. Most therapeutic interventions were linked to delirium in the univariate analysis, including enteral nutrition (p = 0.000), artificial airway (p = 0.021), nasogastric tube (p = 0.001), use of restraint straps (p = 0.000), and use of sedative medications, including midazolam (p = 0.003), propofol (p = 0.032) and butorphanol (p = 0.028). Among the patient’s vital signs and laboratory examinations performed on the day of assessment, body temperature, BUN levels and CRP levels were risk factors for delirium. Midazolam use, chronic renal insufficiency, physical restraints, nosogastric tube, enteral nutrition, and CRP and BUN levels were factors associated with an increased risk of delirium in the multivariate analysis. The durations of mechanical ventilation and ICU stay in patients with delirium was significantly higher than those in patients without delirium [8 (IQR: 4–14) vs 5 (IQR: 3–10) and 9 (IQR: 4–17) vs 6 (IQR: 4–12), p < 0.05]. Conclusions Delirium was associated with prolonged mechanical ventilation and a prolonged ICU stay. Based on the findings from this study, we should not only reduce the use of sedatives and analgesics but also minimize invasive operations, including the placement of nasogastric tubes, to recover eternal nutrition for ICU patients and avoid physical restraints as much as possible to prevent delirium. Trial registration: This study was registered in the Chinese Clinical Trial Registry (ChiCTR1900021360).

scholarly journals 891. Epidemiology and Outcomes of Sepsis in Previously Healthy Patients

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S22-S23
Author(s):  
Mohammad Alrawashdeh ◽  
Michael Klompas ◽  
Steven Q Simpson ◽  
Sameer S Kadri ◽  
Russell Poland ◽  
...  
Keyword(s):  
Healthy People ◽  
Hospital Death ◽  
Short Term ◽  
Electronic Health Record Data ◽  
High Profile ◽  
Increased Risk ◽  
Record Data ◽  
Short Term Mortality ◽  
Sepsis Detection ◽  
Community Onset

Abstract Background Devastating cases of sepsis in previously healthy patients have received widespread attention and helped catalyze state and national mandates to improve sepsis detection and care. It is unclear, however, what proportion of sepsis cases occur in previously healthy people and how their outcomes compare to patients with comorbidities. Methods We conducted a retrospective study of adults admitted from 2009 to 2015 to 373 US hospitals from 3 cohorts using detailed electronic health record data. We identified patients with community-onset sepsis using CDC Adult Sepsis Event criteria and reviewed patients’ ICD-9-CM codes to identify major and minor comorbidities. Generalized linear mixed models were used to identify the association between healthy vs. comorbid status and short-term mortality (in-hospital death or discharge to hospice) among sepsis patients, controlling for demographics and clinical characteristics. Results The cohort included 6,715,286 adult hospitalizations, of which 337,983 (5%) met community-onset sepsis criteria. Most (329,052; 97.4%) sepsis patients had at least one comorbidity (96.1% major, 1.2% minor, 0.1% pregnant) whereas the minority (8,931; 2.6%) were previously healthy. Hospitalized patients without sepsis, by contrast, tended to be healthier (6.2%, Figure 1). Compared with sepsis patients with comorbidities, previously healthy sepsis patients were younger (mean 48.3 + 20 vs. 66.9 + 16.5 years, P < 0.001) and less likely to require ICU care on admission (30.9% vs. 50.5%, P < 0.001). Previously healthy patients were more likely to be discharged home vs. subacute facilities compared with sepsis patients with comorbidities but had higher short-term mortality rates (22.7% vs. 20.8%, P < 0.001) (Figure 2). The increased risk of short-term death in healthy patients persisted on multivariate analysis (adjusted odds ratios 1.36–1.79, P < 0.001). Conclusion The vast majority of patients who develop community-onset sepsis have pre-existing conditions. However, previously healthy patients may be at higher risk for death due to sepsis compared with patients with comorbidities. These findings provide context for high-profile reports about sepsis deaths in previously healthy people and underscore the importance of early sepsis recognition and treatment for all patients. Disclosures All Authors: No reported Disclosures.

scholarly journals Evaluation of N/LP Ratio as a Predictor of Disease Progression and Mortality in COVID-19 Patients Admitted to the Intensive Care Unit

2021 ◽  
Author(s):  
Başak Çakır Güney ◽  
Mert Hayıroğlu ◽  
Didar Şenocak ◽  
Vedat Çiçek ◽  
Tufan Çınar ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Multivariable Analysis ◽  
Hospital Death ◽  
Survival Status ◽  
Inflammatory Index ◽  
Icu Stay

Objective: This research aimed to evaluate whether the neutrophil to lymphocyte and platelet (N/LP) ratio may be used to predict the risk of admission to the intensive care unit (ICU), the need for mechanical ventilation and in-hospital mortality in Coronavirus disease 2019 (COVID-19) cases. Methods: The study was conducted retrospectively on the data of 134 COVID-19 patients who were admitted to the ICU. The N/LP ratio was calculated as follows: neutrophil count x 100 / (lymphocyte count x platelet count). Each member of the research cohort was categorised into 1 of 2 groups based on their survival status (survivor and non-survivor groups). Results: In total, 82 (61%) patients died during the ICU stay. Patients who required mechanical ventilation and died in the ICU stay had significantly higher N/LP ratio than those who did not require it and survived [10 (IQR=4.94-19.38) vs 2.51 (IQR=1.67-5.49), p<0.001] and [11.27 (IQR=4.53-30.02) vs 1.65 (IQR=1-3.24), p<0.001], respectively. The N/LP ratio was linked with the requirement of mechanical ventilation and in-hospital death according to multivariable analysis. In receiver operating characteristic curve analysis, we found that N/LP in predicting admission to the ICU was >4.18 with 61% sensitivity and 62% specificity, it was >5.07 with 74% sensitivity and 73% specificity for the need for mechanical ventilation, and >3.69 with 81% sensitivity and 81% specificity to predict in-hospital death. Conclusion: To our knowledge, this is the first study showing that the N/LP ratio, which is a novel and widely applicable inflammatory index, may be used to predict the risk of ICU admission, mechanical ventilation and in-hospital death in patients with COVID-19 disease.

Association of post-traumatic acute respiratory distress syndrome on poor prognosis: a single-center study

2020 ◽  
pp. 1-16
Author(s):  
Li Luo ◽  
Hao Tang ◽  
Qi Huang ◽  
Junyu Zhu ◽  
Dongpo Jiang ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Hospital Stay ◽  
Poor Prognosis ◽  
Distress Syndrome ◽  
Icu Stay ◽  
Increased Risk ◽  
Post Traumatic

Abstract Objective: To determine the association of post-traumatic acute respiratory distress syndrome (ARDS) on poor prognosis, and provide a theoretical basis for the treatment of patients with post-traumatic ARDS in clinical practice. Methods: This was a retrospective study including trauma victims in the intensive care unit (ICU) of Daping Hospital. The patients were classified as having ARDS or non-ARDS, according to the Berlin definition. Subsequently, these patients were divided into subgroups, according to age, gender and injury site. The relationship between ARDS and prognosis was analyzed, including mechanical ventilation days, length of ICU stay, length of hospital stay, infection, sepsis, multiple organ dysfunction syndrome (MODS) and death. Results: There were 507 trauma patients, out of which 287 cases were with ARDS (56.61%). The duration of mechanical ventilation, ICU stay and hospital stay in the ARDS group was significantly longer than that in the non-ARDS group (5 days vs 3 days, 10 days vs 4 days, 30 days vs 27 days, respectively). In addition, ARDS was associated with an increased risk of infection (P<0.05; OR=4.17; 95%CI=2.72–6.41), sepsis (P<0.05; OR=3.45; 95%CI=2.28–5.22), and MODS (P<0.05; OR=2.82; 95%CI=1.67–4.72), but had no significant association with death (P>0.05). Similar results were found in the subgroup analyses. Conclusions: In conclusion, the prognosis of the patients with post-traumatic ARDS was worse; however, ARDS had little effect on death. Keywords: Trauma; ARDS; Poor Prognosis Continuous...

Perioperative use of renin-angiotensin system inhibitors and short-term outcomes in patients undergoing cardiac surgery

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R.M Vieira De Melo ◽  
D.C Azevedo ◽  
L.N Danziato ◽  
M.T.C.F Fernandes ◽  
L.F.C Alcantara ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Multivariate Regression ◽  
Enzyme Inhibitor ◽  
Kidney Injury ◽  
Adverse Outcomes ◽  
Icu Mortality ◽  
Short Term ◽  
Icu Stay

Abstract Background Controversy exists about whether preoperative angiotensin-converting enzyme inhibitor (ACEi) or an angiotensin receptor blocker (ARB) therapy is associated with adverse outcomes after cardiac surgery. Current guidelines stated that it is uncertain about the safety of the preoperative administration of this medications because of the potential deleterious consequences of perioperative hypotension Purpose To determine the effect of preoperative therapy with ACEi or ARB on short-term outcome after cardiac surgery. Methods Single-center prospective cohort between January 2018 and December 2019. Patients were eligible if they were submitted to elective on-pump cardiac surgery and aged ≥18 years. Patients were divided into two groups according to previous use of ACEi or ARB. All preoperative demographic, clinical, and intraoperative surgical variables were collected prospectively. Outcomes of interests were intensive care unit (ICU) mortality, incidence and duration (hours) of postoperative shock (defined as the need for intravenous vasopressors or inopressors), postoperative acute kidney injury (AKI), defined as a doubling of serum creatinine, duration of mechanical ventilation (hours) and length of stay in the ICU (days). A multivariate regression was performed for categorical outcomes and Kruskal-Wallis test for non-parametric continuous variables. Results 353 patients were evaluated in the period, 182 (51.6%) of male sex, with a mean age of 54.5 (±14.7) and STS mortality and EURO scores of 1.93 (±1.81) and 1.89 (±1.9), respectively. Coronary artery bypass grafting was the common procedure, 168 (47.6%). After multivariate regression, use of ACEi or ARB preoperatively was associated with postoperative shock: RR: 2.03, CI 1.25–3.30, p=0.004; incidence of AKI: RR: 2.84, CI 1.01–7.98, increased length of ICU stay: 4 (3–6) vs 3 (2–5), p=0.03; and increased duration of shock: 10 (0–39) vs 0 (0–24), p&lt;0.01. There was no association with the duration of mechanical ventilation: 10.5 (6–20) vs 11.0 (5–18), p=0.31 or ICU mortality: 14 (7.3%) vs 16 (10.0%), p=0,44. Conclusions The use of preoperative ACEi or ARBs was associated with increased incidence and duration of postoperative shock, incidence of acute kidney injury, and durations of mechanical ventilation and ICU stay. Funding Acknowledgement Type of funding source: None

scholarly journals Gender differences in ECG markers of increased risk for malignant arrhythmias, peripheral blood parameters, and adverse outcomes in patients with COVID-19 pneumonia

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Samet Kasim ◽  
Mohammed Alareedh ◽  
Hussein Nafakhi ◽  
Karrar Al-Buthabhak ◽  
Ahmed Nafakhi
Keyword(s):  
Gender Differences ◽  
Lung Injury ◽  
Peripheral Blood ◽  
Blood Parameters ◽  
Adverse Outcomes ◽  
Qtc Interval ◽  
Hospital Outcome ◽  
Dispersion Of Repolarization ◽  
Increased Risk ◽  
Malignant Arrhythmias

Background: The available data on gender differences in a) markers of cardiac involvement, b) peripheral blood parameters, and c) clinical adverse outcomes related to COVID-19 pneumonia severity are limited in the literature.: Objectives: To investigate gender differences in ECG markers of increased risk for malignant arrhythmias. This includes T from peak to end (Tp-e) interval, corrected QT (QTc), transmural dispersion of repolarization (TDR)(Tp-e/QTc), and index of cardiac electrophysiological balance (iCEB)(QTc/QRS), peripheral blood parameters, and in-hospital adverse outcomes in patients with COVID-19 pneumonia. Methods: A cross sectional study enrolled patients with COVID-19 pneumonia admitted to hospital from August 20th, to September 30th, 2020. Results: A total of 197 patients were included. Ninety-six (47%) were men and 101 women. There were no significant gender related differences concerning comorbidities. Men had higher QRS values, Tp-e interval and TDR, and lower values of iCEB. No significant gender differences were observed in the distribution of QTc interval. Men stayed longer in the hospital and had more extensive lung injury than women. In men, prolonged QTc interval, low lymphocytes %, high platelet distribution width (PDW), and low hemoglobin (Hb) were the main predictors of adverse in-hospital outcome, while prolonged QTc interval, high PDW, and low platelet count were the main predictors of adverse in-hospital outcome for women. Conclusions: Men had higher TDR values, lower iCEB, stayed longer in the hospital, and had more extensive lung injury than women, suggesting that, despite that there was no significant difference in mortality incidents between the two genders, the difference in surrogate markers may indicate that men are at a higher risk for adverse outcomes.

scholarly journals Lung injury induced by short-term mechanical ventilation with hyperoxia and its mitigation by deferoxamine in rats

2020 ◽  
Author(s):  
Xiao-Xia Wang ◽  
Xiao-Lan Sha ◽  
Yulan Li ◽  
Chun-Lan Li ◽  
Su-Heng Chen ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Lung Injury ◽  
Weight Ratio ◽  
Dry Weight ◽  
Lavage Fluid ◽  
Tissue Homogenate ◽  
Short Term ◽  
Artery Cannulation ◽  
Short Period ◽  
The Right

Abstract Background: Long-term mechanical ventilation with hyperoxia can induce lung injury. General anesthesia is associated with a very high incidence of hyperoxaemia, despite it usually lasts for a relatively short period of time. It remains unclear whether short-term mechanical ventilation with hyperoxia has an adverse impact on or cause injury to the lungs. The present study aimed to assess whether short-term mechanical ventilation with hyperoxia may cause lung injury in rats and whether deferoxamine (DFO), a ferrous ion chelator, could mitigate such injury to the lungs and explore the possible mechanism. Methods: Twenty-four SD rats were randomly divided into 3 groups (n=8/group): mechanical ventilated with normoxia group (MV group, FiO2=21%), with hyperoxia group (HMV group, FiO2=90%), or with hyperoxia + DFO group (HMV+DFO group, FiO2=90%). Mechanical ventilation under different oxygen concentrations was given for 4 hours.The HMV+DFO group received continuous intravenous infusion of DFO at 200mg•kg-1•d-1, while the MV and HMV groups received an equal volume of normal saline. Carotid artery cannulation was carried out to monitor the blood gas parameters under mechanical ventilation for 2 hours and 4 hours, respectively, and the PaO2/FiO2 ratio was calculated. After 4 hours ventilation, the right anterior lobe of the lung and BALF from the right lung was sampled for pathological and biochemical assays. Results: PaO2 in the HMV and HMV+DFO groups were significantly higher, but the PaO2/FiO2 ratio were significantly lower than those of the MV group (all p<0.01). The lung pathological scores and the wet-to-dry weight ratio (W/D) in the HMV and HMV+DFO groups were significantly higher than those of the MV group, but score and the W/D ratio were reduced by DFO (p<0.05). Biochemically, HMV resulted in significant reductions in SP-C, SP-D, and GR levels and elevation of XOD in both the Bronchoalveolar lavage fluid and the lung tissue homogenate, and all these changes were prevented or significantly reverted by DFO. Conclusions: Mechanical ventilation with hyperoxia for 4 hours induced oxidative injury of the lungs, accompanied by a dramatic reduction in the concentrations of SP-C and SP-D. DFO could mitigate such injury by lowering XOD activity and elevating GR activity.

scholarly journals Characteristics and Factors Associated with COVID-19 Infection, Hospitalization, and Mortality Across Race and Ethnicity

2020 ◽  
Author(s):  
Chengzhen L. Dai ◽  
Sergey A. Kornilov ◽  
Ryan T. Roper ◽  
Hannah Cohen-Cline ◽  
Kathleen Jade ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Hospital Mortality ◽  
Health System ◽  
Alaska Native ◽  
Clinical Characteristics ◽  
Hospital Death ◽  
Increased Risk ◽  
Hispanic Patients ◽  
Race Ethnicity ◽  
Racial Ethnic

BackgroundData on the characteristics of COVID-19 patients disaggregated by race/ethnicity remain limited. We evaluated the sociodemographic and clinical characteristics of patients across the major racial/ethnic groups and assessed their associations with COVID-19 outcomes.MethodsThis retrospective cohort study analyzed patients who were tested for SARS-CoV-2 in a large, integrated health system spanning California, Oregon, and Washington between March 1 and August 30, 2020. Sociodemographic and clinical characteristics were obtained from electronic health records. Odds of SARS-CoV-2 infection, COVID-19 hospitalization, and in-hospital death were assessed with multivariate logistic regression.Findings289,294 patients with known race/ethnicity were tested for SARS-CoV-2 by PCR, of whom 27.5% were non-White minorities. 15,605 persons tested positive, with minorities representing 58.0%. Disparities were widest among Hispanics, who represented 40.5% of infections but 12.8% of those tested. Hispanics were generally younger and had fewer comorbidities except diabetes than White patients. Of the 3,197 patients hospitalized, 58.9% were non-White. 459 patients died, of whom 49.8% were minorities. Racial/ethnic distributions of outcomes across the health system tracked with state-level statistics. Increase odds of testing positive and hospitalization were associated with all minority races/ethnicities except American Indian/Alaska Native. Highest odds of testing SARS-CoV-2 positive was for Hispanic patients (OR [95% CI]: 3.68 [3.52-3.84]) and highest odds of COVID-19 hospitalization was for Native Hawaiian/Pacific Islander patients (2.13 [1.48 - 3.06]). Hispanic patients also exhibited increased morbidity including need for mechanical ventilation. In multivariate modeling, Hispanic race/ethnicity was associated with increased odds of hospital mortality (1.75 [1.15-2.67]) among patients over age 70, but hospital mortality was not increased for any race/ethnicity sub-population in the multivariate model.InterpretationMajor healthcare disparities were evident, especially among Hispanics who tested positive at a higher rate, and despite younger in age, required excess hospitalization and need for mechanical ventilation compared to their expected demographic proportions. As characteristics of patients varying between race/ethnicity, targeted, culturally-responsive interventions are needed to address the increased risk of poor outcomes among minority populations with COVID-19.FundingBiomedical Advanced Research and Development Authority; National Center for Advancing Translational Sciences

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