scholarly journals Rationale for using Peltophorum africanum (Fabaceae) extracts in veterinary medicine

2005 ◽  
Vol 76 (2) ◽  
Author(s):  
S.E. Bizimenyera ◽  
G.E. Swan ◽  
H. Chikoto ◽  
J.N. Eloff
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Ethanol Extract ◽  
Well Being ◽  
Acetone Extract ◽  
Deciduous Tree ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Antioxidant Compounds ◽  
Root Bark ◽  
Traditional Use

Peltophorum africanum (Fabaceae) is a deciduous tree widespread in southern Africa. The plant has many ethnomedical and ethnoveterinary uses. Root and bark decoctions are used to treat diarrhoea, dysentery, sore throat, wounds, back and joint pains, HIV-AIDS, venereal diseases and infertility. Pastoralists and rural farmers use the root and bark extracts to treat diarrhoea, dysentery, infertility, and to promote well-being and resistance to diseases in cattle. To evaluate these ethnobotanical leads, dried leaves, stem bark and root bark were extracted with ethanol, acetone, dichloromethane and hexane. Polyphenols in the extract were determined by the Folin-Ciocalteu method with gallic acid as standard. Qualitative antioxidant activity was screened by spraying thin layer chromatograms (TLC) of the extracts with 0.2 % 1, 1-diphenyl-2-picryl hydrazyl (DPPH), and quantified with Trolox equivalent antioxidant capacity (TEAC) assay. Minimum inhibitory concentration (MIC) and total antibacterial activity (TAA) were determined by serial microplate dilution for Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Enterococcus faecalis, with gentamicin as standard and tetrazolium violet as growth indicator. Acetone and ethanol extracted the largest quantity of material. Polyphenols concentration was 49.2% in acetone extract of the root and 3.8 % in dichloromethane extract of the leaf. Antioxidant activity of at least 5 antioxidant compounds as measured by TEAC ranged from 1.34 (ethanol extract of the root) to 0.01 (hexane extract of the leaf). The total antibacterial activity (volume to which active compounds present in 1 g plant material can be diluted and still inhibit bacterial growth) was 1263 mℓ/g for ethanol extract of the root against S. aureus, and 800 mℓ/g for acetone extract of the root against P. aeruginosa. There was substantial activity against both Gram-positive and Gram-negative bacteria, with MIC values of 0.08 mg/mℓ for S. aureus and 0.16 mg/mℓ for P. aeruginosa. There is therefore a rationale for the traditional use of root and bark of P. africanum in treating bacterial infection related diseases.

scholarly journals UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BULBUS BAWANG DAYAK (Eleutherine americana Merr) DENGAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazyl)

PHARMACON ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 451
Author(s):  
Rizkah V. Mokoginta ◽  
Herny E. I. Simbala ◽  
Karlah L.R Mansauda
Keyword(s):  
Antioxidant Activity ◽  
Vitamin C ◽  
Ethanol Extract ◽  
Antioxidant Compounds ◽  
Onion Plant ◽  
Dpph Method ◽  
Ic50 Values ◽  
Experimental Laboratory ◽  
Ethanol Extracts ◽  
Eleutherine Americana

ABSTRACTDayak onion plant (Eleutherine americana Merr.) or commonly called forest onion is a typical plant of Central Kalimantan that has been used by local peoples for cure a various types of diseases. This study aims to determine the activity of antioxidant compounds from Dayak bulb ethanol extracts from Kotamobagu City. This research method is an experimental laboratory. Initially the Dayak bulb sample was extracted maceration with 96% ethanol solvent then evaporated until a thick extract was obtained. As a parameter, the DPPH method (1,1-diphenyl-2-picrylhydrazyl) was used to test the antioxidant activity of the samples at concentrations of 50, 60, 70, 80 and 90 mg / L and as a comparison standard used Vitamin C with concentrations of 2, 4, 6, 8 and 10 mg / L. The results obtained showed antioxidant activity in Dayak bulb ethanol extracts with IC50 values of 41.46 mg / L and on vitamin C IC50 values of 1.04 mg / L. Based on these results it can be concluded that the onion bulb ethanol extract has very strong antioxidant activity. Keywords: Dayak Onion bulbs, Activity, Antioxidant, DPPH  ABSTRAK Tanaman bawang Dayak (Eleutherine americana Merr.) atau biasa disebut bawang hutan merupakan tanaman khas Kalimantan Tengah yang sudah dipergunakan masyarakat lokal sebagai obat berbagai jenis penyakit. Penelitian ini bertujuan untuk mengetahui aktivitas senyawa antioksidan dari ekstrak etanol bulbus bawang Dayak yang berasal dari Kota Kotamobagu. Metode penelitian ini adalah eksperimental laboratorium. Awalnya sampel bulbus bawang Dayak diekstraksi maserasi dengan pelarut etanol 96% kemudian dievaporasi hingga didapatkan ekstrak kental. Sebagai parameter, digunakan metode DPPH (1,1-diphenyl-2-picrylhydrazyl) untuk pengujian aktivitas antioksidan sampel pada konsentrasi 50, 60, 70, 80 dan 90 mg/L dan sebagai standar pembanding digunakan Vitamin C dengan konsentrasi 2, 4, 6, 8 dan 10 mg/L. Hasil penelitian yang didapat menunjukkan aktivitas antioksidan pada ekstrak etanol bulbus bawang Dayak dengan nilai IC50 sebesar 41,46 mg/L dan pada vitamin C nilai IC50 sebesar 1,04 mg/L. Berdasarkan hasil tersebut dapat disimpulkan bahwa ekstrak etanol bulbus bawang Dayak memiliki aktivitas antioksidan yang sangat kuat. Kata kunci: Bulbus Bawang Dayak, Aktivitas, Antioksidan, DPPH

scholarly journals Aktivitas Antioksidan Ekstrak Etanol Daun Ganitri (Elaeocarpus Ganitrus Roxb.) dengan Metode DPPH (2,2 Difenil-1-Pikrilhidazil)

2021 ◽  
Vol 18 (1) ◽  
pp. 60-67
Author(s):  
Naelaz Zukhruf Wakhidatul Kiromah ◽  
Sadam Husein ◽  
Titi Pudji Rahayu
Keyword(s):  
Antioxidant Activity ◽  
Free Radicals ◽  
Leaf Extract ◽  
Ethanol Extract ◽  
Antioxidant Compounds ◽  
Synthetic Antioxidant ◽  
Activity Test ◽  
Impaired Liver ◽  
Ic50 Value ◽  
Dpph Method

Free radicals are one of the cause of various diseases. The use of synthetic antioxidant compounds could prevent the effect of the free radicals, however may cause adverse effects on the human body such as impaired liver, lung, intestinal and poisoning. Therefore antioxidant from natural resources needs to be developed. The purpose of this research was to determine the antioxidant activity and IC50 value of the ethanol extract of ganitri (Elaeocarpus ganitrus Roxbs.) leaves. Ganitri leaf ethanol extract activity test was carried out using DPPH method with vitamin C as a standard. Antioxidant activity was determined as a decreas in the absorbance of DPPH at 517 nm wavelength after an addition of the extract with the concentrations of 20, 40, 80, and 100 ppm. The antioxidant acitivity measurement of the ganitri leaf extract showed that the linier regression equation obtained was y = 0.3669x + 29.546, r = 0.4573 while the IC50 value was 54,12 ppm. Based on the result, it is concluded that the ethanol extract of ganitri (Elaeocarpus ganitrus Roxb.) leaf showed was categorized as strong antioxidant.

scholarly journals Antioxidant Activity of Indian Propolis - An In Vitro Evaluation

2016 ◽  
Vol 5 ◽  
pp. 79-85 ◽  
Author(s):  
Shubharani Ramnath ◽  
Sivaram Venkataramegowda
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Vitamin C ◽  
Tamil Nadu ◽  
Radical Scavenging ◽  
Ethanol Extract ◽  
Activity Level ◽  
In Vitro Assays ◽  
Antioxidant Compounds

Antioxidants from the natural products are essential to prevent the progression of free radical mediated diseases. In the present study, ethanol extract of propolis collected from different geographical origin were evaluated for their free radical scavenging potential by employing different in-vitro assays such as DPPH, ABTS, Nitric oxide and Hydrogen peroxide. All the tested samples contained considerable amount of total phenols and vitamin C content. In the entire assay, the percentage of inhibition increased with the increase in concentration. Among the propolis samples collected, the highest activity was found in Tamil Nadu, Kerala, Karnataka and Haryana. The difference in the antioxidant activity level was obtained from the assay may reflect a relative difference in the ability of antioxidant compounds to scavenge different free radicals in the extract. Phenols and vitamin C are the major contributors to antioxidant activity in propolis. The propolis from these locations may be of considerable interest in preventing the ill effects of excessive free radical generation in the human body.

scholarly journals SANTALUM ALBUM;

2019 ◽  
Vol 26 (05) ◽  
Author(s):  
Sonia Gull ◽  
Asim Mushtaq ◽  
Muhammad Umer ◽  
Sajid Mehmood
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Radical Scavenging ◽  
Antioxidant Compounds ◽  
Phytochemical Analysis ◽  
Santalum Album ◽  
Zone Of Inhibition ◽  
Staph Aureus ◽  
Lemon Grass

Medicinal plants are good alternate of antibiotics against many bacterial as well as other diseases. Santalum album (Sandal) and Cymbopogon (Lemon grass) are two important medicinal plants whose important components were extracted by sequential extraction from non-polar to polar solvents. The study was aimed at finding antibacterial and radical scavenging potential of Santalum album (Sandal) and Cymbopogon (Lemon grass). Study Design: In vitro study. Setting: Department of Biochemistry and Molecular Biology, University of Gujrat, Gujrat. Period: 12 months. Material and Methods: Sequential extracts of Santalum album and Cymbopogon with n-hexane, chloroform, acetone, ethylacetate, ethanol, butanol and water respectively were prepared to evaluate antibacterial activity against Staph aureus (25923), Staph aureus (38541), E.coli (25922), E.coli (35318), Streptococcus pyrogenes (Tc-11-2) and Shigella sonnei (BB-8). 2,2-Diphenyl-1-picrylhydrazyl (DPPH) was used to assess antioxidant activity. Results: Ethanolic and acetone extracts of sandal and lemongrass showed significant inhibtory activity against all seven strains. In case of sandal, acetone extract exhibited highest inhibitory activity against Staph aureus (25923) with 17±2 mm zone of inhibition while ethanolic extract of lemon grass showed highest activity with 16.333 ± 1.154mm zone of inhibition against E.Coli (35318). Other solvents including chloroform, n-hexane, ethyl acetate and butanol also showed considerable antibacterial activity, but water extracts of both plants showed no activity. All polarity based extracts of both plants exhibited antioxidant activity, ethanolic extracts of sandal and lemon grass showed highest radical scavenging activity with 84.366 ±1.504% and 83.766 ±4.272% inhibitions respectively. The minimum antioxidant activity was observed for chloroform extracts of sandal and n-hexane extract of lemongrass. Conclusion: we concluded that some plants have good antibacterial and antioxidant potential. Their phytochemical analysis can be carried out to find potent antibacterial and antioxidant compounds. This will be effective in combating bacterial diseases because mostly microbes are developing resistance against currently available antibiotics.

scholarly journals AKTIVITAS ANTIOKSIDAN DAN ANTIBAKTERI DARI DERIVAT METIL EKSTRAK ETANOL DAUN GAMBIR (Uncaria gambir)

2020 ◽  
Vol 15 (4) ◽  
pp. 145
Author(s):  
IRMA KRESNAWATY ◽  
ACHMAD ZAINUDDIN
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Antibacterial Activities ◽  
Chemistry Laboratory ◽  
Bacteria Growth ◽  
Ft Ir ◽  
Uv Visible ◽  
Chloroform Methanol

<p>ABSTRAK</p><p>Banyak tanaman yang dilaporkan memiliki kandungan senyawabahan aktif antioksidan dan antibakteri. Salah satu tanaman Indonesia yangmemiliki aktivitas ini adalah gambir (Uncaria gambir). Pada penelitian ini,ekstrak etanol daun gambir diubah menjadi derivat metilnya untukmembuatnya lebih larut dalam lemak dan diamati pengaruh derivatisasitersebut terhadap aktivitas antioksidan di laboratorium kimia organik danpengujian aktivitas antibakteri di laboratorium mikrobiologi UniversitasPadjadjaran. Penelitian ini dilaksanakan di laboratorium Kimia OrganikJurusan Kimia dan laboratorium Mikrobiologi Jurusan Biologi UniversitasPadjadjaran dari bulan Desember 2004 - Juli 2005. Ekstrak gambirdimetilasi  menggunakan  dimetil  sulfat  (DMS)  dan  dimurnikanmenggunakan kromatografi kolom dengan pelarut bergradien (kloroform :metanol = 99:1 ; 98:2 ; 95:5 ; 80:20 ; 70:30; dan 50:50 v/v) dan kemudianmenggunakan kloroform : metanol = 99 : 1 v/v. Aktivitas antioksidanmenunjukkan penurunan yang tampak dari peningkatan, yaitu : IC 50  13,41ppm untuk ekstrak etanol menjadi 121,81 ppm untuk hasil metilasi.Aktivitas antibakteri juga menunjukkan penurunan setelah dimetilasikarena adanya penurunan diameter hambat pertumbuhan bakteri. Duaisolat (isolat 1 dan 2) yang diperoleh dari hasil pemurnian dikarakterisasimenggunakan spektrofotometer UV-Visible dan FT-IR. Hasil yangdiperoleh mengindikasikan adanya senyawa fenolik yang ditunjukkan olehregang –OH pada 3445 dan 3448 cm -1 dan regang CH aromatik pada 3010dan 3030 cm -1 . Isolat 1 memiliki aktivitas antioksidan dan antibakteri yanglebih tinggi dibandingkan isolat 2.</p><p>Kata kunci : Uncaria gambir, derivat metil, antibakteri dan aktivitasantioksidan</p><p>ABSTRACT</p><p>The antioxidant and antibacterial activities of ethanolextract of gambir leaves (Uncaria gambir)</p><p>There are many plants in Indonesia reported to contain antioxidantand antibacterial substances. One of them having these activities is gambir(Uncaria gambir). In this research, ethanol extract of gambir leaves waschanged into its methyl derivate in order to make it more soluble in fats.The effect of the derivatization on antioxidant activity was observed atorganic chemistry laboratory and antibacterial activity was observed atmicrobiology laboratory of the Padjadjaran University. This research wascarried out in December 2004 to July 2005. Gambir extract wasmethylized using dimethylsulphate (DMS) and then purified usingcoloumn chromatography with gradient solvents (chloroform : methanol =99:1; 98:2; 50:50; 80:20; 70:30; and 50:50 v/v), and then with chloroform :methanol = 99:1 v/v. The antioxidant activity showed a decrease indicatedby an increase of IC 50 from 13.41 ppm for ethanolic extract to become121.81 ppm for the methylated compounds. The antibacterial activity alsoshowed a decrease after methylization due to the decrease of inhibitiondiameter of bacteria growth. Two isolates (isolate 1 and 2) obtained fromthe  purification  steps  were  characterized  using  UV-Visiblespectrophotometer and FT-IR. The results indicated the existence ofphenolic compunds showed by -OH stretching in 3,445 and 3,448 cm -1 ;and CH aromatic stretching in 3,010 and 3,030 cm -1 . Isolate 1 was higherin antioxidant and antibacterial activities than isolate 2.</p><p>Key words : Uncaria gambir, methyl derivative, antibacterial, antioxidantactivities</p>

scholarly journals UJI AKTIVITAS ANTIOKSIDAN DARI EKSTRAK ETANOL BUNGA KANA MERAH (Canna coccinea Mill) MENGGUNAKAN METODE DPPH

PHARMACON ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 542
Author(s):  
Afrilia Veronika Rumangu ◽  
Adithya Yudistira ◽  
Henki Rotinsulu
Keyword(s):  
Antioxidant Activity ◽  
Radical Scavenging Activity ◽  
Ornamental Plants ◽  
Radical Scavenging ◽  
Ethanol Extract ◽  
Free Radical Scavenging ◽  
Antioxidant Compounds ◽  
Dpph Method ◽  
The Family ◽  
Concentration Test

Cana plants are flower ornamental plants whose genus or margins are the only ones in the family Cannacea. This study aims to determine the activity of antioxidant compounds from ethanol extract of  Canna coccinea  Mill flower. by using the DPPH method. Flowers Canna coccinea  Mill  extracted using maceration with ethanol as a solvent. As a parameter, testing of antioxidant activity was carried out using the DPPH (1,1 – diphenyl-2-pikrilhidrazil) method which was measured using UV-Vis Spectrophotometry at a wavelength of 517nm. The result showed that ethanol of Canna coccinea Mill,flower proven to have antioxidant activity in each concentration test. The highest concentration has an free radical scavenging activity by reaching of 56,00%.Keywords: Flowers Canna coccinea Mill, Antioxidant, Extraction, DPPH ABSTRAKTanaman kana adalah tanaman hias bunga yang genus atau marganya merupakan satu-satunya dalam family Cannaceae. Penelitian ini bertujuan untuk mengetahui aktivitas senyawa antioksidan dari ekstrak etanol bunga Canna coccinea Mill. dengan menggunakan metode DPPH. Bunga Canna coccinea Mill. diekstraksi menggunakan metode maserasi dengan etanol sebagai pelarut. Sebagai parameter, pengujian aktivitas antioksidan dilakukan dengan metode DPPH (1,1-difenil-2-pikrilhidrazil) yang diukur menggunakan Spektrofotometri UV-Vis pada panjang gelombang 517 nm. Hasil penelitian menunjukkan ekstrak etanol bunga Canna coccinea Mill. terbukti memiliki aktivitas antioksidan disetiap konsentrasi pengujian. Konsentrasi tertinggi memiliki aktivitas penangkal radikal bebas dengan mencapai presentase 56,00%.Kata Kunci : Bunga Canna coccinea Mill, Antioksidan, Ekstraksi, DPPH

scholarly journals Pengaruh Salinitas terhadap Pertumbuhan dan Aktivitas Antioksidan Dunaliella salina (Chlorophyceae: Dunaliellaceae)

2020 ◽  
Vol 9 (2) ◽  
pp. 181-185
Author(s):  
Intan Budi Setiasih ◽  
Agus Sabdono ◽  
Rini Pramesti
Keyword(s):  
Antioxidant Activity ◽  
Dunaliella Salina ◽  
Ethanol Extract ◽  
Optimal Growth ◽  
Antioxidant Compounds ◽  
Green Microalgae ◽  
Optimal Salinity ◽  
Dpph Method ◽  
Experimental Laboratory ◽  
Biology Laboratory

ABSTRAK: Dunaliella salina merupakan salah satu jenis mikroalgae hijau yang mengandung berbagai senyawa bioaktif termasuk senyawa antioksidan untuk melawan radikal bebas. Pertumbuhan mikroalgae dipengaruhi oleh lingkungan salah satunya adalah salinitas. Penelitian ini bertujuan mengetahui salinitas optimal untuk pertumbuhan dan aktivitas antioksidan D. salina berdasarkan nilai persen inhibisi. Penelitian ini dilaksanakan di Laboratorium Terpadu dan Laboratorium Biologi Fakultas Perikanan dan Ilmu Kelautan, Universitas Diponegoro, Semarang pada bulan Mei - Juli 2018. Metode penelitian yang digunakan adalah eksperimental laboratoris. D. salina dikultur pada lima salinitas yang berbeda yaitu 20, 25, 30, 35 dan 40 ppt.  Pengamatan dilakukan selama 7x24 jam, dipanen dan diekstrak dengan pelarut etanol yang selanjutnya dianalisis aktivitas antioksidannya dengan metode 1,1-difenil-2-pikrilhidrazil (DPPH). Hasil penelitian menunjukkan pertumbuhan optimal terjadi pada salinitas 30 ppt, dan aktivitas antioksidan tertinggi dicapai pada salinitas 20 ppt (9,88±0,59) yang termasuk dalam kategori lemah.ABSTRACT: D. salina is a type of green microalgae that contains various bioactive compounds including antioxidant compounds to fight free radicals. Microalgal growth is influenced by the environmental conditions such as  salinity. This study aims were to determine the optimal salinity of growth and antioxidant activity in ethanol extract based on percent inhibition values. This research was conducted in the Integrated Laboratory and Biology Laboratory of the Faculty of Fisheries and Marine Sciences, Diponegoro University, Semarang in May - July 2018.The research method used was an experimental laboratory. D. salina was cultivated with five different salinities on 20,  25, 30, 35 and 40 o/oo. Observation was carried out for 7x24 hours, harvested and extracted with ethanol solvent and then analyzed its antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The results showed that optimal growth of D. salina was 30 o/oo  in salinity, and the highest antioxidant activity was 20 o/oo in salinity (9.88 ± 0.59) and included in the weak category.

scholarly journals Antibacterial, Anti-inflammatory and Antioxidant Potential of Ethanol Extract of Ipomoea staphylina Roem. & Schult

2021 ◽  
pp. 97-106
Author(s):  
G. Kokila ◽  
P. Jeevan
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Medicinal Plant ◽  
Ethanol Extract ◽  
Inflammatory Activity ◽  
Diffusion Method ◽  
Drug Candidate ◽  
Dependent Manner ◽  
Human Beings ◽  
Anti Inflammatory

In the present study we evaluate the antibacterial, anti-inflammatory and antioxidant activity of medicinal plant Ipomoea staphylina Roem & Schult. Many bacteria are harmful to human beings and animals. Theses bacteria make diseases the host organisms. Many antibiotics are available in the marker for the treatment of bacterial diseases. However, antibiotics cause unwanted side effect. Thus, the study focused to evaluate ethanol extract of Ipomoea staphylina against bacterial pathogens. Antibacterial activity was evaluated by the method of well diffusion method. Antiinflamatory and antioxidant activity was evaluated by in vitro study method. Ethanol extract of Ipomoea staphylina showed antibacterial activity against different bacteria isolated from chicken at dose depended manner ie., higher dose of plant extract possessed maximum inhibition zone (21.67 ± 1.45 mm) (P<0.05) against selected bacteria. Moreover, plant ethanol extract possessed anti-inflammatory activity and antioxidant activity at dose dependent manner (P<0.05). Higher dose (100 μg/ml) of ethanol extract of Ipomoea staphylina showed maximum anti-inflammatory activity (68.38 %) and antioxidant activity (72%). From this result it is concluded that the medicinal plant Ipomoea staphylina Roem. & Schult. possessed antibacterial, anti-inflammatory and antioxidant activity. Further detailed study will be conducted for the new drug candidate discovery.

scholarly journals Phytochemical Screening and Antibacterial Activity of Stem Bark, Leaf and Root Extract of Sclerocarya birrea (A. Rich.) Hochst

2017 ◽  
Vol 5 (4) ◽  
pp. 127-131
Author(s):  
Lawaly Maman Manzo ◽  
Halima Diallo Bako ◽  
Moussa Idrissa
Keyword(s):  
Antibacterial Activity ◽  
Gastrointestinal Diseases ◽  
Stem Bark ◽  
Root Extract ◽  
Root Bark ◽  
Phytochemical Screening ◽  
Zone Of Inhibition ◽  
Traditional Use ◽  
Plant Parts ◽  
Sclerocarya Birrea

Background: Sclerocarya birrea is widely used in Nigerien communities for medicinal purposes to treat several gastrointestinal diseases including diarrhea. To lend credibility to its traditional use against diarrhea, laboratory studies were conducted. Objective: The aim of this study is to investigate the antibacterial activity and the phytochemical constituents of the crude extracts of root, bark and leaf of S. birrea. Materials and Methods: The collected different plant parts were air dried, powdered and separately extracted with ethanol and methanol. The alkaloid, flavonoid, saponin and tannin contents in all the plant parts were estimated using standard methods. The total and serially diluted fractions of the extracts were tested for antibacterial activity against selected enteropathogens by agar well diffusion and deep-well microdilution method. Results: Phytochemical screening revealed the presence of flavonoid, saponin and tannin in all the plant extracts. The extracts from the different parts showed varied antibacterial activity against the test bacteria. The bark extracts showed superior activity against Escherichia coli (zone of inhibition = 17 mm) and Salmonella typhi (zone of inhibition = 20 mm) at 200 mg/mL. Conclusion: The presence of important phytochemical groups and the antibacterial potential of alcoholic extracts of S. birrea could permit to justify its traditional usage against diarrhea.

scholarly journals Bioprospection of Enggano Macroscopic Fungi as Antibacterial and Antioxidant Agents

2021 ◽  
Vol 20 (2) ◽  
pp. 201-210
Author(s):  
Evana Evana ◽  
Kartika Dyah Palupi ◽  
Listiana Oktavia ◽  
Ahmad Fathoni
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Antioxidant Properties ◽  
Antioxidant Compounds ◽  
Activity Assay ◽  
Tropical Country ◽  
Antioxidant Agents ◽  
Ic50 Values ◽  
Weak Activity ◽  
Antibacterial And Antioxidant Activity

Macrofungi in Indonesia have not been widely studied for their pharmacological activity, especially as a source of antibacterial and antioxidant properties, even though Indonesia as a tropical country has quite a high diversity of macrofungi. This study aims to reveal the potential of macrofungi from the Enggano forest as a source of antibacterial and antioxidant compounds. Four types of macrofungi were collected and their metabolites were extracted using four types of organic solvents. Antibacterial and antioxidant activity assay of the extract was carried out using the TLC Bioautography method. From the sixteen macrofungal extracts, there is one extract that has the strongest antibacterial activity compared to the others, namely n-hexane Coriolopsis polyzona. It showed moderate antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 256–128 μg/mL, respectively. Meanwhile, the antioxidant activity of the macrofungal extracts showed weak activity with IC50 values of 3080–7370 μg/mL (AAI values of 0.033–0.079).

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