Distribution of ABO blood groups in the patients with intracranial aneurysm and association of different risk factors with particular blood type

Approximately 300 different types of blood groups are identified so far, the ABO and Rh antigens are still the clinically most significant and genetically most polymorphic of all human blood group systems to date. A total of 200 unrelated individuals from Uttar Pradesh were studied for the phenotype and allele frequency distribution of ABO and Rh (D) blood groups. In total 200 samples analyzed, phenotype B blood type has the highest frequency 36.5% (n=73), followed by O (34.5%; n=69), A (20.5%; n=41) and AB (8.5%; n=17). The O, A and B frequencies were 0.5849, 0.1571 and 0.2580 respectively. The overall phenotypic frequencies of ABO blood groups were B>O>A>AB. The variation in phenotypic frequencies between male and female might be due to small sample size of male sample. The allelic frequency of Rh-negative was 0.2.

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Prevalence of ABO blood groups in patients with haematological malignancies: a retrospective study

Hematology & Transfusion International Journal ◽

10.15406/htij.2020.08.00215 ◽

2020 ◽

Vol 8 (1) ◽

pp. 13-17

Author(s):

Ashwin Mathew ◽

Kirana Pailoor, ◽

Konchady Deepthi ◽

Suresh Shenoy

Keyword(s):

Sex Ratio ◽

Blood Group ◽

Haematological Malignancy ◽

Geographical Location ◽

Blood Groups ◽

Blood Type ◽

Haematological Malignancies ◽

Abo Blood Groups ◽

College Hospital ◽

And Gender

Background: The pattern and distribution of Haematological malignancies vary depending on age, sex and geographical location. Studies on the association between Haematological cancers and ABO blood types have been largely conflicting. The objective of our study was to determine the distribution of ABO blood groups among patients with Haematological malignancies and to correlate with age and gender. Materials and Methods: This was a chart based observational descriptive study involving the review of records of 85 patients with various Haematological malignancies in Father Muller Medical College Hospital for a period of two years from July 2017- June 2019. Age, gender, malignant condition, ABO and Rh blood group were collected for each case. Data was analyzed statistically by frequency and percentage. Results: The peak age incidence for various Haematological malignancies was in the fifth and sixth decades of life with a mean age of 47.The male to female sex ratio was almost 1:1. Majority of the patients were of the O blood group and an association of O blood group with various hematological malignancies with male preponderance was noted. Altogether, Leukemias were the most common Haematological malignancy observed in this study. Conclusion: The distribution, age and sex ratio of Haematological malignancies in our study was comparable to those reported by other authors with Acute Myeloid Leukemia (AML) being the most common Haematological malignancy in our environment. There was no significant association between Haematological cancers and ABO blood type of the patients, but probably individuals with O Rh positive blood group are more prone to

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Association of ABO blood groups with risk factors of intracranial cerebral aneurysm formation

International Journal of Students� Research ◽

10.4103/2230-7095.149764 ◽

2014 ◽

Vol 4 (2) ◽

pp. 36

Author(s):

Anil Nanda ◽

ShyamalC Bir ◽

Piyush Kalakoti ◽

Sudheer Ambekar ◽

Papireddy Bollam

Keyword(s):

Risk Factors ◽

Cerebral Aneurysm ◽

Blood Groups ◽

Abo Blood Groups ◽

Aneurysm Formation

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Modelling of time-to-events in an ambispective study: illustration with the analysis of ABO blood groups on venous thrombosis recurrence

10.1101/2021.11.20.21266583 ◽

2021 ◽

Author(s):

Gaëlle Munsch ◽

Louisa Goumidi ◽

Astrid van Hylckama Vlieg ◽

Manal Ibrahim-Kosta ◽

Maria Bruzelius ◽

...

Keyword(s):

Risk Factors ◽

Statistical Power ◽

Association Studies ◽

Blood Groups ◽

Genome Wide Association Studies ◽

Abo Blood Groups ◽

Genome Wide ◽

Increased Risk ◽

Independent Risk Factors ◽

Analyse Time

In studies of time-to-events, it is common to collect information about events that occurred before the inclusion in a prospective cohort. In an ambispective design, when the risk factors studied are independent of time, including both pre- and post-inclusion events in the analyses increases the statistical power but may lead to a selection bias. To avoid such a bias, we propose a survival analysis weighted by the inverse of the survival probability at the time of data collection about the events. This method is applied to the study of the association of ABO blood groups with the risk of venous thromboembolism (VT) recurrence in the MARTHA and MEGA cohorts. The former relying on an ambispective design and the latter on a standard prospective one. In the combined sample totalling 2,752 patients including 993 recurrences, compared with the O1 group, A1 has an increased risk (Hazard Ratio (HR) of 1.18, p=4.2x10-3), homogeneously in MARTHA and in MEGA. The same trend (HR=1.19, p=0.06) was observed for the less frequent A2 group. In conclusion, this work clarified the association of ABO blood groups with the risk of VT recurrence. Besides, the methodology proposed here to analyse time-independent risk factors of events in an ambispective design has an immediate field of application in the context of genome wide association studies.

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Relationship between ABO blood group and breast cancer at AL-Nassyria city / Iraq

10.32792/thi/sc/vol.1.is.1.04 ◽

2008 ◽

pp. 26-29

Keyword(s):

Breast Cancer ◽

Risk Factor ◽

Cancer Patients ◽

Blood Group ◽

High Frequency ◽

Blood Groups ◽

Blood Type ◽

Abo Blood Group ◽

Abo Blood Groups ◽

Control Samples

The current study included 200 patients with breast cancer that resemble to patient samples were collected from AL-Nassyria hospital also 279 samples as control which was collected from blood bank at ALNassiryia province . The study attempted to correlate ABO blood group with incidence to breast cancer .The results shown that type A of ABO blood group high frequency then followed by type O with in AL-Nassyria region also the results reported that A, B, O and AB blood groups frequencies of patient samples percentage were 60%, 20%, 10% and 10% respectively as well as the ABO blood groups frequencies of control samples percentage were 26%, 28%,38% and 8% respectively. The results observed there is high significant differences between ABO blood group frequencies of cancer patients and ABO blood group frequencies of control samples .The results indicated that the blood type should be considered one of risk factor as well as regarded as preclinical marker.

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Human ABO Blood Groups and Their Associations with Different Diseases

BioMed Research International ◽

10.1155/2021/6629060 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Silamlak Birhanu Abegaz

Keyword(s):

Cognitive Impairment ◽

Cardiovascular Diseases ◽

Blood Group ◽

Blood Groups ◽

Blood Type ◽

Abo Blood Groups ◽

E Coli ◽

Salmonella Infections ◽

Increased Risk ◽

Abo Blood Type

Introduction. Human ABO blood type antigens exhibit alternative phenotypes and genetically derived glycoconjugate structures that are located on the red cell surface which play an active role in the cells’ physiology and pathology. Associations between the blood type and disease have been studied since the early 1900s when researchers determined that antibodies and antigens are inherited. However, due to lack of antigens of some blood groups, there have been some contentious issues with the association between the ABO blood group and vulnerability to certain infectious and noninfectious diseases. Objective. To review different literatures that show the association between ABO blood groups and different diseases. Method. Original, adequate, and recent articles on the same field were researched, and the researcher conducted a comprehensive review on this topic. Thus, taking out critical discussions, not only a descriptive summary of the topic but also contradictory ideas were fully retrieved and presented in a clear impression. In addition, some relevant scientific papers published in previous years were included. The article search was performed by matching the terms blood types/groups with a group of terms related to different diseases. The articles were screened and selected based on the title and abstract presented. Results. The susceptibility to various diseases, such as cancer, cardiovascular diseases, infections and hematologic disorders, cognitive disorders, circulatory diseases, metabolic diseases, and malaria, has been linked with ABO blood groups. Moreover, blood group AB individuals were found to be susceptible to an increased risk of cognitive impairment which was independent of geographic region, age, race, and gender. Disorders such as hypertension, obesity, dyslipidemia, cardiovascular disease (CVD), and diabetes were also more prevalent in individuals with cognitive impairment. Early etiological studies indicated that blood type O has a connection with increased incidence of cholera, plague, tuberculosis infections, and mumps, whereas blood type A is linked with increased incidence of smallpox and Pseudomonas aeruginosa infection; blood type B is also associated with increased incidence of gonorrhea, tuberculosis, and Streptococcus pneumoniae, E. coli, and salmonella infections; and blood type AB is associated with increased incidence of smallpox and E. coli and salmonella infections. Diabetes mellitus, hypercholesterolemia, arterial hypertension, and family history for ischemic heart disease are the most common risk factors for cardiovascular diseases and can be genetically transmitted to offspring. Higher incidence of cancers in the stomach, ovaries, salivary glands, cervix, uterus, and colon/rectum was common in blood type A people than in O type people. The link between the ABO blood type and thromboembolic diseases and bleeding risk are intervened by the glycosyltransferase activity and plasma levels and biologic activity of vWF (Von Willebrand factor), a carrier protein for coagulation factor VIII which is low in O type. Conclusion. Several studies related to the ABO phenotype show that genetically determined human ABO blood groups were correspondingly linked with an increased risk of various infectious and noninfectious diseases. However, further investigations are needed particularly on the molecular level of ABO blood groups and their association with various diseases.

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Allelic Variants Within the ABO Blood Group Phenotype Confer Protection Against Critical COVID-19 Hospital Presentation

Frontiers in Medicine ◽

10.3389/fmed.2021.759648 ◽

2022 ◽

Vol 8 ◽

Author(s):

Herbert F. Jelinek ◽

Mira Mousa ◽

Nawal Alkaabi ◽

Eman Alefishat ◽

Gihan Daw Elbait ◽

...

Keyword(s):

Candidate Gene ◽

Blood Group ◽

Population Sample ◽

Blood Groups ◽

Blood Type ◽

Candidate Gene Approach ◽

Abo Blood Group ◽

Abo Blood Groups ◽

Allelic Variants ◽

A Genome

Introduction: Coronavirus disease 2019 (COVID-19) disease severity differs widely due to numerous factors including ABO gene-derived susceptibility or resistance. The objective of this study was to investigate the association of the ABO blood group and genetic variations of the ABO gene with COVID-19 severity in a heterogeneous hospital population sample from the United Arab Emirates, with the use of an epidemiological and candidate gene approach from a genome-wide association study (GWAS).Methods: In this cross-sectional study, a total of 646 participants who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recruited from multiple hospitals and population-based (quarantine camps) recruitment sites from March 2020 to February 2021. The participants were divided into two groups based on the severity of COVID-19: noncritical (n = 453) and critical [intensive care unit (ICU) patients] (n = 193), as per the COVID-19 Reporting and Data System (CO-RADS) classification. The multivariate logistic regression analysis demonstrated the association of ABO blood type as well as circulating anti-A antibodies and anti-B antibodies as well as A and B antigens, in association with critical COVID-19 hospital presentation. A candidate gene analysis approach was conducted from a GWAS where we examined 240 single nucleotide polymorphisms (SNPs) (position in chr9: 136125788-136150617) in the ABO gene, in association with critical COVID-19 hospital presentation.Results: Patients with blood group O [odds ratio (OR): 0.51 (0.33, 0.79); p = 0.003] were less likely to develop critical COVID-19 symptoms. Eight alleles have been identified to be associated with a protective effect of blood group O in ABO 3'untranslated region (UTR): rs199969472 (p = 0.0052), rs34266669 (p = 0.0052), rs76700116 (p = 0.0052), rs7849280 (p = 0.0052), rs34039247 (p = 0.0104), rs10901251 (p = 0.0165), rs9411475 (p = 0.0377), and rs13291798 (p = 0.0377).Conclusion: Our findings suggest that there are novel allelic variants that link genetic variants of the ABO gene and ABO blood groups contributing to the reduced risk of critical COVID-19 disease. This study is the first study to combine genetic and serological evidence of the involvement of the ABO blood groups and the ABO gene allelic associations with COVID-19 severity within the Middle Eastern population.

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ABO Blood Groups and the Risk of Venous Thromboembolism (VTE) Among Saudi Patients at a Tertiary Care Hospital in Riyadh

Blood ◽

10.1182/blood-2019-128050 ◽

2019 ◽

Vol 134 (Supplement_1) ◽

pp. 4926-4926

Author(s):

Ghaydaa Juma Kullab ◽

Abdul Rehman Z. Zaidi ◽

Sultan Albaqmi ◽

Haya Alajlan ◽

Mohammed Abdullah Alsheef

Keyword(s):

Venous Thromboembolism ◽

Blood Group ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Blood Groups ◽

Blood Type ◽

Care Hospital ◽

Abo Blood Groups ◽

Blood Types ◽

Obesity Status

Background: ABO blood types are scientifically proved to be associated with the risk of venous thromboembolism (VTE), but data is lacking in the Saudi population. Aims: We aimed to investigate the association between ABO blood types and VTE, to explore potential interactions between ABO blood type with sex and obesity status. Methods: This was a retrospective study with a total of 998 patients, who were admitted with venous thromboembolism at our tertiary care hospital, between January 2010 and January 2018. Demographic and clinical data were collected. We used chi-square tests to assess the association between ABO blood group and the development of VTE. It was decided that the test will be considered significant if the p-value is <0.05. Results: Out of 998 VTE patients, 506 of patients were excluded, because their ABO blood group was not tested. Therefore, 492 patients were qualified as study subjects, of whom 66% of patients had DVT, 23% of patients had pulmonary embolism. Most of them had provoked VTE. Female patients constituted the majority of the study subjects (82.5%). Sample distribution appeared that O blood group was present in 34.1% of all VTE patients, while non-O-blood groups were present in 66% of them. Overall, there was a non-significant difference between VTE in patients with non-O blood type compared to O blood type (p=0.268). Conclusions: Non-O-blood groups (A, B, AB) are the most common blood types in Saudi patients with VTE. There is no statistically significant association between ABO blood groups, gender, and obesity status. Disclosures No relevant conflicts of interest to declare.

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ABO Blood Group and RhD status Are Not Associated with Mortality and Morbidity in Critically Ill Patients; a Multicentre Observational Study of 29 512 Patients

10.21203/rs.3.rs-944620/v2 ◽

2022 ◽

Author(s):

Thomas Kander ◽

Martin F. Bjurström ◽

Attila Frigyesi ◽

Magnus Jöud ◽

Caroline U. Nilsson

Keyword(s):

Critically Ill ◽

Blood Group ◽

Critically Ill Patients ◽

Blood Groups ◽

Blood Type ◽

Circulatory Support ◽

Critically Ill Patient ◽

Abo Blood Groups ◽

Number Of Patients ◽

Transfusion Requirements

Abstract Background. Previous studies have demonstrated an association between ABO blood groups and many types of disease. The present study primarily aimed to identify associations between ABO blood groups, RhD groups and mortality/morbidity outcomes in critically ill patients both in a main cohort and in six pre-defined subgroups. The secondary aim was to investigate any differences in transfusion requirement between the different ABO blood groups and RhD status.Methods. Adult patients admitted to any of the five intensive care units (ICUs) in Skåne, Sweden, between February 2007 and April 2021 were eligible for inclusion. The outcomes were mortality analysed at 28– and 90–days as well as at the end of observation and morbidity measured using days alive and free of (DAF) invasive ventilation (DAF ventilation) and DAF circulatory support, including vasopressors or inotropes (DAF circulation), maximum Sequential Organ Failure Assessment score (SOFAmax) the first 28 days after admission and length of stay. All outcomes were analysed in separate multivariable regression models (adjusted for age and sex), generating odds or hazard ratios for each blood group and RhD status using blood group O and RhD negative as reference. Transfusion requirements were also investigated.Results. In total, 29 512 unique patients were included in the analyses. There were no significant differences for any of the outcomes between non-O blood groups and blood group O, or between RhD groups. In five pre-defined subgroups (sepsis, septic shock, acute respiratory distress syndrome, cardiac arrest and trauma) there were no differences in mortality between non-O blood groups and blood group O or between the RhD groups. The Covid-19 cohort was not investigated given the low number of patients. Furthermore, we could not demonstrate any differences in the number of transfused patients between the ABO blood groups or between the RhD groups.Conclusions. ABO blood type and RhD status do not appear to influence mortality or morbidity in a general critically ill patient population. There were no differences in the number of transfused patients between the ABO blood groups or between the RhD status groups.

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Prevalence of Plasmodium Falciparum among Medical Students with different ABO Groups and Electrophoretic Patterns in a Tertiary Institution in Nnewi, Nigeria

Sokoto Journal of Medical Laboratory Science ◽

10.4314/sokjmls.v6i3.12 ◽

2021 ◽

Vol 6 (3) ◽

pp. 89-95

Author(s):

Nancy Chiatogu Ibeh ◽

Kelechi Theresa Obinna ◽

Onochie Manafa Patrick

Keyword(s):

Plasmodium Falciparum ◽

Medical Students ◽

Blood Group ◽

Parasite Density ◽

Blood Groups ◽

Blood Type ◽

Abo Blood Groups ◽

Tertiary Institution ◽

Electrophoretic Patterns ◽

Malaria Episodes

There is evidence that Plasmodium falciparum (Pf) malaria is influenced by ABO blood type but the extent of association is not fully established. Some investigators opinioned that haemoglobin electrophoretic patterns are a factor in susceptibility to Pf infection but there is no consensus on possible association between it and ABO blood group and Hb genotypes. This study was designed to determine the prevalence of Pf among different ABO blood groups and Hb electrophoretic patterns of medical students of a tertiary institution in Nnewi, Nigeria. A total of 80 subjects (41 males and 39 females) aged 18-30 years who reported to the Medical Centre of the institution on account of febrile illness were recruited for the study. Information on age, previous malaria episodes and recent use of prophylaxis were sought. Three milliliters (3ml) of blood were collected into EDTA container for ABO grouping, Hb electrophoresis and blood films for P. falciparum detection and quantification by microscopy. Pf prevalence among the subjects was 47.5% (38/80). Thirty-one (38.75%) of the subjects were of blood group O, 27 (33.75%) group A, 19 (23.75%) blood group B and 3(3.75%) blood group AB. Fifty-two (65%) of the subjects were Hb AA and 28 (35%) AS. No significance difference was seen between malaria episodes and ABO blood groups; Hb electrophoretic patterns; gender and parasite density (p>0.05) respectively. A negative correlation was observed between parasite density and age (r= -0.180, p = 0.109). Pf infection, frequency of infection and parasite load is not influenced by blood group and Hb electrophoretic patterns in our study population.

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