Evaluation of serum c-reactive protein levels in subjects with aggressive and chronic periodontitis in comparison with healthy controls: A clinico-biochemical study

IntroductionImmune alterations are believed to be an important part in etiopathogenesis of affective disorders. However, it is not clear if the altered immune mediators are related to distinct disorders or particular psychopathology.AimsThe aim of our study was to explore the differences in C-reactive protein levels (CRP) between euthymic BD patients and healthy controls, as well as to explore the relationship between CRP and lifetime presented psychopathology within BD.MethodsThe study group consisted of 83 patients diagnosed with BD, compared to the healthy control group (n = 73) and matched according to age, gender, and body mass index (BMI). Lifetime psychopathology has been assessed according to predominant polarity as well as previous history of suicide attempts and psychotic episodes.ResultsThe CRP levels were significantly higher in BD patients when compared to healthy controls. After covarying for confounders, we observed that CRP levels, in euthymic BD patients, were related to number of previous suicide attempts, but not other indicators of lifetime psychopathology.ConclusionsBD patients per se, and particularly those with more suicide attempts, are more likely to present with proinflammatory state, even when in remission. Previous history of suicide attempts could bear specifically vulnerable endophenotype within BD. Systemic, longitudinal monitoring of the course of illness, and potential inflammatory mediators that underlie its systemic nature is warranted.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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SEVERE CHRONIC PERIODONTITIS AND C-REACTIVE PROTEIN LEVELS

Revista de Saúde Coletiva da UEFS ◽

10.13102/rscdauefs.v6i2.1168 ◽

2017 ◽

Vol 6 (2) ◽

pp. 1

Author(s):

Johelle De Santana Passos Soares ◽

Isaac Suzart Gomes-Filho ◽

Julita Maria Freitas Coelho ◽

Simone Seixas da Cruz ◽

Luís Claúdio Lemos Correia ◽

...

Keyword(s):

Chronic Periodontitis ◽

Descriptive Analysis ◽

Cross Sectional Study ◽

Blood Collection ◽

C Reactive Protein ◽

Clinical Attachment Loss ◽

Cross Sectional ◽

Protein Levels ◽

Reactive Protein ◽

Significant Difference

This study aims to analyze the relationship between chronic periodontitis and C-reactive protein (CRP), taking certain associated factors into consideration. A cross-sectional study was conducted on a sample of 75 adults of both sexes. After the participants had been interviewed, they underwent physical and dental examinations and blood collection. CRP levels were evaluated by means of nephelometry. A periodontal clinical examination was conducted by trained examiners and the diagnosis of chronic periodontitis was established when at least 30% of the individual’s teeth presented clinical attachment loss ≥ 5 mm. The analysis procedures consisted of descriptive analysis and linear regression. The results showed that there was no statistically significant difference in CRP levels between the groups with and without periodontitis. The median CRP level in the group with periodontitis was 2.3 mg/l (25-75% interquartile range, IQR = 0.74-5.4) and in the group without periodontitis, 1.8 mg/l (25-75% IQR = 0.79-4.54) (p = 0.417). Log CRP was significantly correlated only with the individual’s body mass index (BMI). The main findings from this study indicate that there is no association between severe chronic periodontitis and CRP, and factors like BMI need to be analyzed carefully in studies on this topic.

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Estimation of C-Reactive Protein Levels in Chronic Periodontitis

Indian Journal of Public Health Research & Development ◽

10.5958/0976-5506.2019.01228.2 ◽

2019 ◽

Vol 10 (6) ◽

pp. 1

Author(s):

N Prashaanthi ◽

Anitha Roy ◽

G Savitha

Keyword(s):

Chronic Periodontitis ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein

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Impact of scaling and root planing on C-reactive protein levels in gingival crevicular fluid and serum in chronic periodontitis patients with or without diabetes mellitus

Journal of Periodontal & Implant Science ◽

10.5051/jpis.2014.44.4.158 ◽

2014 ◽

Vol 44 (4) ◽

pp. 158 ◽

Cited By ~ 6

Author(s):

Mahendra Mohan ◽

Rajesh Jhingran ◽

Vivek Kumar Bains ◽

Vivek Gupta ◽

Rohit Madan ◽

...

Keyword(s):

Diabetes Mellitus ◽

Chronic Periodontitis ◽

Gingival Crevicular Fluid ◽

Scaling And Root Planing ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Root Planing ◽

Crevicular Fluid

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Evaluation of C-reactive Protein Levels in the Saliva of Covid Recovered Patients

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i57a34005 ◽

2021 ◽

pp. 344-351

Author(s):

Soorya Ganesh ◽

Palati Sinduja ◽

. Priyadharshini ◽

V. Meghashree

Keyword(s):

Point Of Care ◽

Complete Recovery ◽

Acute Phase Reactant ◽

Healthy Controls ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Non Invasive ◽

The Difference ◽

Set Up

Introduction: The acute phase reactant synthesized by the liver. CRP is an annular (ring- shaped) metameric protein set up in plasma, whose circulating immersion rise in response to inflammation. The idea of the study is to estimate the C-reactive protein situations in the salivary samples of COVID- 19 recovered cases and healthy controls. Materials and Methods: An experimental study on salivary samples of COVID recovered cases. The study was non-invasive and easy to perform without important vexation to cases. The samples were acquired from cases who came to the clinics of Saveetha Dental College and Hospitals. An aggregate of 20 saliva samples was collected from recruited cases 10 of whom were healthy controls and 10 were collected from cases who had made complete recovery from COVID infection. Results: C-reactive protein (CRP) could be generally used as a biomarker of systemic inflammation, routinely measured in serum blood samples. Still salivary samples offer a non-invasive and simply accessible preference which might upgrade point of care (POC) testing for inflammation. This study illustrates the group of healthy controls and COVID recovered cases. Conclusion: Within the limitations of our study, we were capable to interpret the difference of CRP levels between COVID recovered cases and healthy individualities.

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Is ischemic modified albumin a marker in osteomyelitis patients?

Journal of the Pakistan Medical Association ◽

10.47391/jpma.719 ◽

2020 ◽

pp. 1-13

Author(s):

Cihan Adanas ◽

Sezai Ozkan ◽

Canan Demir

Keyword(s):

Prospective Study ◽

Key Words ◽

Albumin Level ◽

Healthy Controls ◽

C Reactive Protein ◽

Cross Sectional ◽

Ischemia Modified Albumin ◽

Protein Levels ◽

Reactive Protein ◽

The Cross

Abstract Objective: To compare the levels of ischemia modified albumin between osteomyelitis patients and healthy controls. Method: The cross-sectional prospective study was conducted at Van Yüzüncü Y?l University, Van, Turkey, from May 2018 to May 2019, and comprised inpatients diagnosed with osteomyelitis, and healthy controls. Serum IMA concentrations were determined spectrophotometrically at 470nm wavelength. Serum ischemia modified albumin levels were measured and compared between the patients and the controls. Data was analysed using SPSS 20. Results: Of the 77 subjects, 37(48%) were patients and 40(52%) were controls. Serum ischemia modified albumin level in patients was significantly higher than controls (p<0.05). There was a significant correlation between ischemia modified albumin and C-reactive protein levels (p<0.05). Conclusion: Serum ischemia modified albumin level in patients was significantly higher than controls (p<0.05). Key Words: Osteomiyelitis, Ischemia-modified albumin, Receiving operation curve, Biomarker, C-reactive protein. Continuous...

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Association of Cytokines, High Sensitive C-Reactive Protein, VEGF and Beta-Defensin-1 Gene Polymorphisms and Their Protein Expressions with Chronic Periodontitis in the Chinese Population

The International Journal of Biological Markers ◽

10.5301/jbm.5000010 ◽

2013 ◽

Vol 28 (1) ◽

pp. 100-107 ◽

Cited By ~ 10

Author(s):

Ye Tian ◽

Jin-le Li ◽

Liang Hao ◽

Yuan Yue ◽

Min Wang ◽

...

Keyword(s):

Chronic Periodontitis ◽

Chinese Population ◽

Restriction Enzymes ◽

Serum Levels ◽

Interleukin 12 ◽

Healthy Controls ◽

C Reactive Protein ◽

Chi Square ◽

Reactive Protein ◽

Genotype Frequencies

Purposes This study aimed at investigating the association between interleukin-6 (IL-6), interleukin-12 (IL-12), C-reactive protein (CRP), vascular endothelial growth factor (VEGF) and β-defensin-1 polymorphisms and the susceptibility to periodontitis in the Chinese population. Methods DNA was extracted from the blood samples of 532 healthy individuals and 122 chronic periodontitis (CP) patients enrolled in the study. The genes encoding IL-6, IL-12, CRP, VEGF and β-defensin-1 were amplified using PCR and digested with restriction enzymes. The protein expression of the abovementioned genes was determined by ELISA. Differences in the allele/genotype frequencies were assessed with the chi-square test. Results The frequencies of the C/C genotypes of IL-6, IL-12, and VEGF were higher in CP patients than healthy controls (66.3% vs 25.9%; 27.8% vs 19.9%; and 64.8% vs 52.1%, respectively). In the patients' group we also recorded frequencies of the A/A genotypes of CRP and VEGF higher than in healthy controls (63.1% vs 58.1% and 64.8% vs 35.2%, respectively). Protein production evaluated by ELISA demonstrated significant differences between CP patients and healthy controls for IL-6, IL-12, CRP, VEGF and β-defensin-1. Conclusions The genotypes of IL-6, IL-12, VEGF and β-defensin-1 and their protein productions were associated with CP in a Chinese population. Genotypes and serum levels of CRP were associated with CP, but alleles frequency showed no difference between CP patients and healthy controls.

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