CONCENTRATIONS DE LA PROGESTERONE, DES OESTROGENES ET DU CORTISOL DANS LE PLASMA DES VACHES AYANT DONNE NAISSANCE A DES JUMEAUX OU AYANT EU DES RETENTIONS PLACENTAIRES

1979 ◽  
Vol 59 (3) ◽  
pp. 481-490 ◽  
Author(s):  
P. MATTON ◽  
V. ADELAKOUN ◽  
J. J. DUFOUR
Keyword(s):  
Plasma Concentration ◽  
Postpartum Period ◽  
Multiple Births ◽  
Control Group ◽  
Plasma Progesterone ◽  
Retained Placenta ◽  
Different Types ◽  
Foetal Membranes ◽  
Plasma Steroids ◽  
Peripartum Period

Plasma steroids (cortisol, progesterone, estrone and estradiol) were studied during the peripartum period in cows with three different types of parturition: unifoetal normal (VUN), unifoetal with retained placenta (VRP), multifoetal with or without retained placenta (VG). In the control group, cortisol rose gradually from 8 ng/ml on day −7 to 11 ng/ml on the day of parturition and thereafter came back to the level of day −7. In the VRP group, cortisol was slightly lower than in the control on day −7 and it did not vary significantly before or after parturition. In the group of cows with multiple births, where retained placenta was encountered in 3/4 cases, cortisol was much higher than in control animals. Plasma progesterone decreased gradually from 5.5 ng/ml to less than 1 ng/ml on the day of parturition in the control group. In the group VRP and VG, it was significantly higher than in the control on the 2 days before and on the day of parturition. The patterns of estrone and estradiol were similar in the groups VUN and VRP until the first day following parturition, but much higher in the cows giving birth to twins. During the postpartum period, the drop in estrogens was much slower in the VRP and VG groups than in the VUN control group. These results suggest that retention of the placenta is not linked with the plasma concentration of cortisol but rather associated with an increased level of progesterone on the day of parturition and that the slower decrease in estrogen levels after parturition would be the result of the persisting attachment of the foetal membranes.

A Common Thrombomodulin Amino Acid Dimorphism Is Associated with Myocardial Infarction

1997 ◽  
Vol 77 (02) ◽  
pp. 248-251 ◽  
Author(s):  
Lena Norlund ◽  
Johan Holm ◽  
Bengt Zöller ◽  
Ann-Kristin Öhlin
Keyword(s):  
Myocardial Infarction ◽  
Amino Acid ◽  
Plasma Concentration ◽  
Acute Coronary Syndromes ◽  
Protein C ◽  
Integral Membrane Protein ◽  
Control Group ◽  
Healthy Controls ◽  
Coronary Syndromes ◽  
Premature Myocardial Infarction

SummaryEndothelial dysfunction and haemostatic imbalance are believed to be important aetiological factors in the development of acute coronary syndromes. Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C anticoagulant pathway. We have investigated the importance of a common C/T dimorphism in the TM gene (nucleotide 1418) for development of premature myocardial infarction (MI). The C/T dimorphism predicts an Ala455 to Val replacement in the sixth EGF-like domain of TM. The dimorphism was investigated in 97 MI survivors and 159 healthy controls. The C allele was significantly more frequent among patients than controls (p = 0.035). The allele frequency for the C allele was 0.82 in the patients and 0.72 in the control group. The plasma concentration of TM was investigated among healthy controls but was not related to the C/T dimorphism. In conclusion, the association of the C allele with premature MI, suggests that the TM gene and the C/T dimorphism may be aetiological factors involved in the pathogenesis of MI. Possibly, the Ala455 to Val replacement may affect the function of the TM molecule and the activation of the protein C anticoagulant pathway.

Clinical Impact of Co-medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study

2020 ◽  
Vol 21 (2) ◽  
pp. 126-131
Author(s):  
Bhuvanachandra Pasupuleti ◽  
Vamshikrishna Gone ◽  
Ravali Baddam ◽  
Raj Kumar Venisetty ◽  
Om Prakash Prasad
Keyword(s):  
Plasma Concentration ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Plasma Concentrations ◽  
Control Group ◽  
Drug Concentrations ◽  
Significant Difference ◽  
Post Hoc ◽  
Hydrolysis Of ◽  
Cytochrome P 450

Background: Clobazam (CLBZ) metabolized primarily by Cytochrome P-450 isoenzyme CYP3A4 than with CYP2C19, Whereas Levetiracetam (LEV) is metabolized by hydrolysis of the acetamide group. Few CYP enzymes are inhibited by Proton Pump Inhibitors (PPIs) Pantoprazole, Esomeprazole, and Rabeprazole in different extents that could affect drug concentrations in blood. The aim of the present study was to evaluate the effect of these PPIs on the plasma concentrations of LEV and CLBZ. Methods: Blood samples from 542 patients were included out of which 343 were male and 199 were female patients and were categorized as control and test. Plasma samples analyzed using an HPLC-UV method. Plasma concentrations were measured and compared to those treated and those not treated with PPIs. One way ANOVA and games Howell post hoc test used by SPSS 20 software. Results: CLBZ concentrations were significantly 10 folds higher in patients treated with Pantoprazole (P=0.000) and 07 folds higher in patients treated with Esmoprazole and Rabeprazole (P=0.00). Whereas plasma concentration of LEV control group has no statistical and significant difference when compared to pantoprazole (P=0.546) and with rabeprazole and esomeprazole was P=0.999. Conclusion: The effect of comedication with PPIs on the plasma concentration of clobazam is more pronounced for pantoprazole to a greater extent when compared to esomeprazole and rabeprazole. When pantoprazole is used in combination with clobazam, dose reduction of clobazam should be considered, or significance of PPIs is seen to avoid adverse effects.

scholarly journals The Effect of Different Types of Internal Curing Liquid on the Properties of Alkali-Activated Slag (AAS) Mortar

2021 ◽  
Vol 13 (4) ◽  
pp. 2407
Author(s):  
Guang-Zhu Zhang ◽  
Xiao-Yong Wang ◽  
Tae-Wan Kim ◽  
Jong-Yeon Lim ◽  
Yi Han
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Deionized Water ◽  
Internal Curing ◽  
Control Group ◽  
Alkali Activated Slag ◽  
Different Types ◽  
Naoh Solution ◽  
Activated Slag ◽  
Alkali Activated

This study shows the effect of different types of internal curing liquid on the properties of alkali-activated slag (AAS) mortar. NaOH solution and deionized water were used as the liquid internal curing agents and zeolite sand was the internal curing agent that replaced the standard sand at 15% and 30%, respectively. Experiments on the mechanical properties, hydration kinetics, autogenous shrinkage (AS), internal temperature, internal relative humidity, surface electrical resistivity, ultrasonic pulse velocity (UPV), and setting time were performed. The conclusions are as follows: (1) the setting times of AAS mortars with internal curing by water were longer than those of internal curing by NaOH solution. (2) NaOH solution more effectively reduces the AS of AAS mortars than water when used as an internal curing liquid. (3) The cumulative heat of the AAS mortar when using water for internal curing is substantially reduced compared to the control group. (4) For the AAS mortars with NaOH solution as an internal curing liquid, compared with the control specimen, the compressive strength results are increased. However, a decrease in compressive strength values occurs when water is used as an internal curing liquid in the AAS mortar. (5) The UPV decreases as the content of zeolite sand that replaces the standard sand increases. (6) When internal curing is carried out with water as the internal curing liquid, the surface resistivity values of the AAS mortar are higher than when the alkali solution is used as the internal curing liquid. To sum up, both NaOH and deionized water are effective as internal curing liquids, but the NaOH solution shows a better performance in terms of reducing shrinkage and improving mechanical properties than deionized water.

scholarly journals Evaluation of Galectin-3 Plasma Concentration in Adolescents with Ventricular Arrhythmia

2021 ◽  
Vol 18 (5) ◽  
pp. 2410
Author(s):  
Radosław Pietrzak ◽  
Tomasz M. Książczyk ◽  
Elżbieta Górska ◽  
Łukasz A. Małek ◽  
Bożena Werner
Keyword(s):  
Plasma Concentration ◽  
Ventricular Arrhythmia ◽  
Linear Regression Analysis ◽  
Holter Monitoring ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Control Group ◽  
Healthy Children ◽  
Ventricular Ejection Fraction ◽  
Galectin 3

Galectin-3 (G3) is a biomarker known as an inflammatory state exponent. The aim of this paper was to analyze the G3 in adolescents with ventricular arrhythmia (VES) in order to evaluate its impact on myocardial tissue preservation. The study group (SG) consisted of 25 VES adolescents. The control group (CG) was 21 healthy children. G3 was assessed in the SG and CG. In the SG electrocardiography, Holter monitoring, echocardiography and CMR were performed. The G3 in SG was 13.45 ± 11.4 ng/mL and in CG 7.2 ± 2.0 ng/mL, p < 0.001. Moderate positive correlation between the G3 and z-score of the left ventricular diameter (r = 0.47, p = 0.041) and moderate negative correlation between the G3 and the left ventricular ejection fraction in cardiac magnetic resonance (CMR EF) (−0.49, p = 0.032) were found. According to the multiple linear regression analysis, CMR EF and VES were independent predictors for G3 elevation. Conclusion: Galectin-3 plasma concentration is elevated and correlates with the chosen left ventricular dysfunction parameters in adolescents suffering from ventricular arrhythmia. Further investigation is necessary to establish if elevated G3 is a useful biomarker for screening young individuals with ventricular arrhythmia who are at risk of structural cardiovascular pathology.

P1-303: Low levels of sRAGE plasma concentration in different types of dementia

2006 ◽  
Vol 2 ◽  
pp. S185-S185
Author(s):  
Livia Bernardi ◽  
Raffaele Maletta ◽  
Carmine Tomaino ◽  
Enzo Emanuele ◽  
Angela D'Angelo ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Different Types ◽  
Low Levels

Passively immunizing ewes against inhibin during the luteal phase of the oestrous cycle raises the plasma concentration of FSH

1989 ◽  
Vol 123 (3) ◽  
pp. 383-391 ◽  
Author(s):  
G. E. Mann ◽  
B. K. Campbell ◽  
A. S. McNeilly ◽  
D. T. Baird
Keyword(s):  
Plasma Concentration ◽  
Luteal Phase ◽  
Passive Immunization ◽  
Oestrous Cycle ◽  
Ovulation Rate ◽  
Control Group ◽  
Pituitary Cells ◽  
Marked Rise ◽  
Peripheral Plasma

ABSTRACT Passive immunization was used to investigate the importance of inhibin in the negative feedback loop regulating the production of FSH in sheep. An antiserum raised to the 1–26 peptide fragment of the N-terminus of the α-chain of porcine inhibin was first shown to neutralize the suppressive effects of inhibin on the production of FSH by dispersed ovine pituitary cells in vitro. Groups of five mature Scottish Blackface ewes on day 8 of the luteal phase of the oestrous cycle were then injected with either 10 ml plasma from normal ewes (control) or 10 ml ovine inhibin antiserum. On day 10, luteal regression was induced by an i.m. injection of cloprostenol (100 μg), and ovulation rate determined 6 days later by laparoscopy. Peripheral plasma samples were collected throughout the experimental period. Following treatment, there was no change in the peripheral plasma concentration of LH in either group. Following injection of the inhibin antiserum, the concentration of FSH rose significantly (P<0·001) compared with the control group. The concentration of FSH rose from 1·42 ± 0·06 to a maximum of 2·58 ± 0·23 (s.e.m.) μg/l by 5·6 ±0·9 h, this maximum lasting 9·0±1·1 h. By 32·8 ±6·9 h, the concentration of FSH had returned to pretreatment levels, while the titre of free antibody in the plasma of treated ewes was still high. In the treated ewes, there were one single and four double ovulations compared with three single and two double ovulations in the control group, indicating that the inhibin immunization may have resulted in an increase in ovulation rate. We conclude that the marked rise in the plasma concentration of FSH following injection of inhibin antiserum provides strong evidence that inhibin is an important factor in the regulation of FSH production by the pituitary gland at this time. Journal of Endocrinology (1989) 123, 383–391

scholarly journals Free contraception and behavioural nudges in the postpartum period: evidence from a randomised control trial in Nairobi, Kenya

2018 ◽  
Vol 3 (5) ◽  
pp. e000888 ◽  
Author(s):  
Margaret McConnell ◽  
Claire Watt Rothschild ◽  
Allison Ettenger ◽  
Faith Muigai ◽  
Jessica Cohen
Keyword(s):  
Postpartum Period ◽  
Randomised Control Trial ◽  
Control Group ◽  
Modern Contraceptive ◽  
Contraceptive Methods ◽  
Birth Intervals ◽  
Financial Barriers ◽  
Maternity Hospitals ◽  
Sms Reminder ◽  
The Impact

BackgroundShort birth intervals are a major risk factor for poor maternal and newborn outcomes. Utilisation of modern contraceptive methods during the postpartum period can reduce risky birth intervals but contraceptive coverage during this critical period remains low.MethodsWe conducted a randomised controlled experiment to test whether vouchers for free contraception, provided with and without behavioural ‘nudges’, could increase modern contraceptive use in the postpartum period. 686 pregnant women attending antenatal care in two private maternity hospitals in Nairobi, Kenya, were enrolled in the study. The primary outcomes were the use of modern contraceptive methods at nearly 3 months and 6 months after expected delivery date (EDD). We tested the impact of a standard voucher that could be redeemed for free modern contraception, a deadline voucher that expired 2 months after delivery and both types of vouchers with and without a short message service (SMS) reminder, relative to a control group that received no voucher and no SMS reminder.ResultsBy nearly 6 months after EDD, we find that the combination of the standard voucher with an SMS reminder increased the probability of reporting utilisation of a modern contraceptive method by 25 percentage points (pp) (95% CI 6 pp to 44 pp) compared with the control group. Estimated impacts in other treatment arms were not statistically significantly different from the control group.ConclusionsReducing financial barriers to postpartum contraception alone may not be enough to encourage take-up. Programmes targeting the postpartum period should consider addressing behavioural barriers to take-up.

scholarly journals Peculiarities of pregnansy and childbirth in patients with a burdened gynecological anamnesis

2020 ◽  
Vol 5 ◽  
pp. 5-10
Author(s):  
T. P. Andriichuk ◽  
A. Ya. Senchuk ◽  
V. I. Chermak
Keyword(s):  
Retrospective Study ◽  
High Risk ◽  
Pregnant Women ◽  
Postpartum Period ◽  
Control Group ◽  
Careful Monitoring ◽  
Pregnancy And Childbirth ◽  
History Of ◽  
High Level ◽  
Adaptive Reactions

The objective: to study the features of pregnancy, childbirth, postpartum period, fetal status and newborns in patients with a history of chronic salpingo-оophoritis.Materials and methods. Conducted a retrospective study of 150 birth histories and neonatal development maps. All patients were divided into two groups. The main group includes 100 patients with chronic salpingo-оophoritis, for which they received anti-inflammatory treatment from 1 to 3 times before pregnancy. The control group included 50 pregnant women who did not suffer from chronic salpingo-оophoritis.Results. Our analysis of pregnancy, childbirth, fetal and neonatal status in women with chronic salpingo-оophoritis indicates that such patients have a complicated obstetric and gynecological and somatic history, which forms an unfavorable basic condition of organs and systems, imperfect adaptation to pregnancy, high risk of failure of adaptive reactions. The result is a violation of the formation and development of the mother-placenta-fetus system and, as a consequence, a high level of complications during pregnancy, childbirth and perinatal pathology.Conclusion. Patients suffering from chronic salpingo-oophoritis should be considered at high risk of possible complications during pregnancy and childbirth. This category of women needs quality preconception training and careful monitoring during pregnancy.

scholarly journals Effect of inorganic and organic zinc supplementation on coccidial infections in goat kids

2011 ◽  
Vol 80 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Petra Strnadová ◽  
Vlasta Svobodová ◽  
Leoš Pavlata ◽  
Ľubica Mišurová ◽  
Rudolf Dvořák
Keyword(s):  
Zinc Oxide ◽  
Plasma Concentration ◽  
Blood Plasma ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Control Group ◽  
Organic Zinc ◽  
Highest Weight ◽  
Weight Gains ◽  
Zinc Concentrations

The aim of this study was to identify the effect of zinc-enriched diet fed to goats and their kids on the number of Coccidia oocysts shed by kids, on clinical signs of coccidiosis, weight gains, and kids’ blood plasma concentration of zinc. A total of 22 goat kids were divided into 4 groups of 5 or 6 animals. Goats and kids from the control group did not receive any additional zinc, the second group was supplemented with inorganic zinc (zinc oxide), the third group was given zinc lactate, and the fourth group received chelated zinc. Samples of kids’ faeces were taken weekly from 3 to 9 weeks of their age (a total of 7 samples were taken). Samples of faeces were examined by a quantitative method to detect the number of oocysts. Kids were weighed weekly and their blood was taken in order to determine zinc concentrations in blood plasma. Animals from the group supplemented with zinc chelate and zinc lactate shed a significantly (p ≤ 0.05) lower number of oocysts (13.4% and 11.9%, respectively) compared to the number of oocyst shed by control and zinc oxide supplemented groups (25% and 49.7%, respectively). Shedding of oocysts was not accompanied by clinical symptoms of coccidiosis in any of the groups. Kids supplemented with zinc chelate showed significantly highest weight gains and blood plasma concentration of zinc (p ≤ 0.05) as compared to control and inorganic zinc supplemented groups. Organic zinc is to be recommended to be used as a prophylaxis against coccidiosis in goat kids.

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