scholarly journals Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway

2020 ◽  
Vol 14 (2) ◽  
pp. 127 ◽  
Author(s):  
Wuttipong Masraksa ◽  
Supita Tanasawet ◽  
Pilaiwanwadee Hutamekalin ◽  
Tulaporn Wongtawatchai ◽  
Wanida Sukketsiri
Keyword(s):  
Lung Cancer ◽  
Tyrosine Kinase ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Focal Adhesion ◽  
Receptor Tyrosine Kinase ◽  
Migration And Invasion ◽  
Tyrosine Kinase Signaling ◽  
Kinase Signaling Pathway

scholarly journals ER-positive breast cancer cells are poised for RET-mediated endocrine resistance

2017 ◽  
Author(s):  
Sachi Horibata ◽  
Edward J. Rice ◽  
Hui Zheng ◽  
Lynne J. Anguish ◽  
Scott A. Coonrod ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Endocrine Resistance ◽  
Breast Cancers ◽  
Kinase Signaling ◽  
Tyrosine Kinase Signaling ◽  
Kinase Signaling Pathway

AbstractThe RET tyrosine kinase signaling pathway is involved in the development of endocrine resistant ER+ breast cancer. However, the expression of the RET receptor itself has not been directly linked to clinical cases of resistance, suggesting that additional factors are involved. We show that both ER+ endocrine resistant and sensitive breast cancers have functional RET tyrosine kinase signaling pathway, but that endocrine sensitive breast cancer cells lack RET ligands that are necessary to drive endocrine resistance. Transcription of one RET ligand, GDNF, is necessary and sufficient to confer resistance in the ER+ MCF-7 cell line. In patients, RET ligand expression predicts responsiveness to endocrine therapies and correlates with survival. Collectively, our findings show that ER+ tumor cells are “poised” for RET mediated endocrine resistance, expressing all components of the RET signaling pathway, but endocrine sensitive cells lack high expression of RET ligands that are necessary to initiate the resistance phenotype.

Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression

Tumor Biology ◽  
2014 ◽  
Vol 35 (12) ◽  
pp. 12139-12149 ◽  
Author(s):  
Hung-Che Huang ◽  
Lo-Lin Tsai ◽  
Jen-Pi Tsai ◽  
Shu-Ching Hsieh ◽  
Shun-Fa Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Lung ◽  
Akt Signaling ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Migration And Invasion ◽  
Akt Signaling Pathway ◽  
Human Lung Cancer Cells

Visna-maedi Virus Induces Interleukin-8 in Sheep Alveolar Macrophages through a Tyrosine-kinase Signaling Pathway

1998 ◽  
Vol 18 (4) ◽  
pp. 532-537 ◽  
Author(s):  
Isabelle Legastelois ◽  
Hélène Levrey ◽  
Timothy Greenland ◽  
Jean-François Mornex ◽  
Geneviève Cordier
Keyword(s):  
Tyrosine Kinase ◽  
Signaling Pathway ◽  
Alveolar Macrophages ◽  
Interleukin 8 ◽  
Kinase Signaling ◽  
Tyrosine Kinase Signaling ◽  
Kinase Signaling Pathway
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