scholarly journals Drinking Water Toxicity of Sodium Fluoride in Steroid Producing Glands and Antioxidant Ascorbate Defense System in Albino Rats (Rattus norvegicus)

2012 ◽  
Vol 02 (02) ◽  
Author(s):  
Priyanka Mehta ◽  
Kunwar Bahadur Singh
Keyword(s):  
Drinking Water ◽  
Sodium Fluoride ◽  
Rattus Norvegicus ◽  
Albino Rats ◽  
Defense System ◽  
Water Toxicity

scholarly journals Original Article. Toxic effect of sodium fluoride on hydroxyproline level and expression of collagen-1 gene in rat bone and its amelioration by Tamrindus indica L. fruit pulp extract

2016 ◽  
Vol 9 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Amit Raj Gupta ◽  
Sahadeb Dey ◽  
Mohini Saini ◽  
Devendra Swarup
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Toxic Effect ◽  
Sodium Fluoride ◽  
Albino Rats ◽  
Continuous Exposure ◽  
Collagen Gene ◽  
Fruit Pulp ◽  
Rat Bone

Abstract Excessive fluoride intoxication plays an important role in the development of dental, skeletal and non-skeletal fluorosis. The aim of this study was to ascertain the toxic effect of excessive fluoride ingestion on the level of hydroxyproline and expression of type 1 collagen gene in rat bone and its amelioration by supplementation with Tamarindus indica fruit pulp extract. Forty albino rats were randomly assigned to four groups. The first group served as control and received only tap water. The second group received sodium fluoride (200 ppm) through drinking water. The third group received T. indica fruit pulp extract (200 mg/kg body weight) alone and the fourth group received the T. indica fruit pulp extract (200 mg/kg body weight) along with fluorinated drinking water (200 ppm) daily by gavage for a period of 90 days. The level of hydroxyproline and expression of type 1 collagen gene using quantitative real time PCR in the tibia bone decreased significantly with continuous exposure to sodium fluoride. Co-administration of T. indica fruit pulp extract during exposure to fluoride through drinking water restored the level of calcium, phosphorus and alkaline phosphatase in serum and the concentration of hydroxyproline in urine. It increased the level of hydroxyproline and expression of type 1 collagen gene in the tibia as compared to untreated fluoride-exposed rats. It is concluded that T. indica fruit pulp extract has an ameliorative potential to protect the bone from fluoride induced collagen damage.

scholarly journals Mitigative effect of Momordica cymbalaria fruit extract against sodium fluoride induced hepatotoxicity in Wistar male albino rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Raghavendra Mitta ◽  
Sushmitha Duddu ◽  
Raghuveer Yadav Pulala ◽  
Pradeepkumar Bhupalam ◽  
Venkatakirankumar Mandlem ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Blood Serum ◽  
Sodium Fluoride ◽  
Total Protein ◽  
Reduced Glutathione ◽  
Serum Biomarkers ◽  
Albino Rats ◽  
Serum Total Protein ◽  
Treatment Groups ◽  
Group I

AbstractObjectivesThe main objective of the present study is to evaluate the mitigative effect of hydroalcoholic extract of Momordica cymbalaria fruits against sodium fluoride (NaF) induced hepatotoxicity.MethodsIn this study, Wistar male albino rats were randomly divided into five groups of six rats each. Group I and II served as normal and toxic controls. Group III as plant control received extract at a dose of 400 mg/kg b. wt, p.o and Groups IV and V as treatment groups received extract at a dose 200 and 400 mg/kg b. wt, p.o for 30 days. All groups except Groups I and III received 100 ppm of NaF through drinking water. After completion of the study, blood collected for the estimation of liver blood serum biomarkers such as aspartate aminotransferases (AST), alanine aminotransferases (ALT), alkaline Phosphatase (ALP), direct and total bilirubin, total protein and albumin. The liver tissue homogenate was for estimation of lipid peroxidation, catalase, and reduced glutathione levels.ResultsThe results showed that NaF intoxication caused elevation of liver blood serum levels and lipid peroxidation; decreased levels of serum total protein, albumin and liver reduced glutathione, and catalase observed. The treatment groups showed decreased elevated serum biomarkers (ALT, AST, and ALP), liver lipid peroxidation and increased serum total protein and albumin, liver reduced glutathione and catalase levels in a dose-dependent manner. Histopathological studies also further strongly supported for mitigative effects of the plant.ConclusionsIn conclusion, our findings of the study indicated that M. cymbalaria fruits were a potential drug candidate in the treatment of NaF induced hepatotoxicity.

scholarly journals Pneumocystis carinii: its incidence in rodents and enhancement of the infection by corticosteroids

1973 ◽  
Vol 71 (1-2) ◽  
pp. 87-93 ◽  
Author(s):  
Helly A. Lage ◽  
Suelena A. Lage
Keyword(s):  
Rattus Norvegicus ◽  
Guinea Pigs ◽  
Pneumocystis Carinii ◽  
Albino Rats ◽  
The Past ◽  
Albino Mice

A survey was made on the incidence of Pneumocystis carinii in 361 rodents including sewer rats, albino rats, albino mice, guinea-pigs and rabbits. P. carinii was found in 4 of the 215 Rattus norvegicus examined (1,8%). These results accord with recent observations but disagree with investigations made by the researchers who first studied this parasite in the past when high indexes of infection were found. However, in 20 albino rats treated with corticosteroids (betamethazone) we found 8 positive (40%) and in 20 albino mice treated by the same way, 9 were positive for P. carinii (45%). These results confirm the opportunistic character of P. carinii in rodents already well demonstrated in man.

scholarly journals Profil Lipid Tikus Putih Setelah Pemberian Teh Kombucha Kadar 50% Waktu Fermentasi 6, 9 Dan 12 Hari

2017 ◽  
Vol 2 (1) ◽  
pp. 80
Author(s):  
Sri Isdadiyanto
Keyword(s):  
Drinking Water ◽  
Rattus Norvegicus ◽  
Per Oral

Tujuan penelitian ini untuk mengetahui pengaruh pemberian teh kombucha kadar 50% sebagai drinking water dengan variasi waktu fermentasi. Penelitian ini menggunakan Tikus putih (Rattus norvegicus) jantan  sebanyak 16 ekor umur 2 bulan, dengan perlakuan Teh kombucha yang difermentasi selama 6, 9 dan 12 hari pada suhu 25oC per oral. Penelitian ini menggunakan Rancangan Acak Lengkap dengan 4 perlakuan (selama 28 hari) dan 4 ulangan, yaitu : P0 = kontrol, tanpa tambahan teh kombucha, P1 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 6 hari, P2 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 9 hari, P3 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 12 hari. Variabel yang diukur adalah kadar kolesterol, HDL dan LDL. Data yang diperoleh dianalisis menggunakan ANOVA yang dilanjutkan dengan Uji Duncan dengan taraf kepercayaan 95% dengan menggunakan perangkat lunak SPSS 10,0. Hasil penelitian menunjukkan bahwa pemberian teh kombucha dapat menaikkan kadar HDL, menurunkan kadar kolesterol dan LDL serum darah tikus putih (Rattus norvegicus). Kata kunci : Rattus norvegicus, teh kombucha kadar 50%, kolesterol, HDL, LDL

scholarly journals Antinociceptive effect of Pleurotus ostreatus (Oyster Mushroom) Aqueous Extracts in Rattus norvegicus (Albino Rats)

1970 ◽  
Vol 20 (2) ◽  
pp. 483-487
Author(s):  
LF Zitte ◽  
RS Konya
Keyword(s):  
Aqueous Extract ◽  
Rattus Norvegicus ◽  
Pleurotus Ostreatus ◽  
Hot Water ◽  
Oyster Mushroom ◽  
Albino Rats ◽  
Thermal Stimulus ◽  
Aqueous Extracts ◽  
Standard Drug ◽  
Nociceptive Responses

Antinociceptive is reducing sensitivity to painful stimuli for the individual. The objective of this study was to evaluate the antinociceptive potentials of graded doses of Pleurotus ostreatus (Oyster Mushroom) aqueous extract in Rattus norvegicus (Albino Rats) and its chemical pattern by comparing it with a standard drug and a control using the hot water based flick tail test. Thirty five adult rats of both sexes were used for the experiment which, were divided into five groups of seven rats per group. Group one was used as the control (with 1ml normal saline), while groups two, three and four were treated with 100, 200 and 400 mg/kg of Pleurotus ostreatus aqueous extracts and group five treated with 15 mg/kg Aspirin (a standard drug) as positive control. Hot water at 550C was used to determine the nociceptive responses of the animals to detect anti-nociceptive effects of Pleurotus ostreatus extracts as compared to the control in hot water inflicted pain. The results suggested that Pleurotus ostreatus aqueous extract exhibits antinociceptive properties against thermal stimulus at 550C. The diversity of individual animals’ pain tolerance threshold when immersed in hot water was also observed during the experiment. However, the extract indicated a high degree of anti-nociceptive effect at 30, 60, 90 and 120 minutes post treatment period, with a progressively longer threshold time for pain sensitivity. It was also found that at 90 minute period, the control portrayed a relatively short response time.KEY WORDS: Anti-nociceptive, threshold pain, Pleurotus ostreatus, hot water test flick tail.

Wild-Albino Hybrids and Albino Rats: Thyroid Weight but Not Muricide Differences

1982 ◽  
Vol 50 (2) ◽  
pp. 421-422 ◽  
Author(s):  
M. A. Persinger ◽  
Jane Lundgren
Keyword(s):  
Rattus Norvegicus ◽  
Albino Rats ◽  
Wild Male ◽  
Body Weights

Offspring of 6 wild, male (brown-coated) dump rats ( Rattus norvegicus) and laboratory albino females were compared with the offspring of albino rats on several tissue and muricide measures. At weaning, the 48 hybrid pups (all brown-coated), both vocalized and bit the experimenters' gloves; these behaviors were not apparent in the 40 albino pups. Adult hybrid rats did not kill significantly more mice than albino controls. Although hybrid rats had significantly lighter (ω2 = 55%) wet thyroid weights than albinos, they did not differ in spleen, thymus, adrenal, or body weights.

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