Problems associated with currently used hypertension treatment and their potential improvements of excessive blood pressure, blood glucose ns body weight by the individualized optimal dose of each medication plus addition of optimal dose of Vitamin D3 using its unique 7 beneficial effects

2018 ◽  
Vol 06 ◽  
Author(s):  
Yoshiaki Omura
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Blood Glucose ◽  
Vitamin D3 ◽  
Optimal Dose ◽  
Hypertension Treatment ◽  
Beneficial Effects

scholarly journals Glycaemic Control, Lipid Profile, Blood Pressure and Body Weight Status Among Diabetics in Rural Malaysia

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Hazizi AS ◽  
Zaitun Y ◽  
Kandiah M ◽  
Chan SP
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Blood Glucose ◽  
Glycaemic Control ◽  
Lipid Profile ◽  
Weight Status ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Body Weight Status

Introduction: Diabetes is associated with a high risk of cardiovascular disease. The management of blood glucose, dyslipidaemia and other modifiable risk factor, is a key element in the multifactorial approach to prevent complications of type 2 diabetes. Materials and Methods: A cross sectional study was conducted to determine the level of glycaemic control, lipid profile, blood pressure and body weight status among type 2 diabetics in rural Malaysia. A total of 237 diabetic subjects participated in this study. Physical examination was carried out, including measurements of height, weight, waist and hip circumferences, and systolic and diastolic blood pressure. Fasting venous blood samples were collected to determine the glucose level and lipid profile. Results: About 70% of the subjects had a high body mass index (BMI), equal to or above 25 kg/ m2. More than 60% of the subjects had systolic blood pressure ≥ 140 mmHg and/or diastolic ≥ 90 mmHg. Mean fasting blood glucose was 9.84±4.54 mmol/L. Mean total cholesterol was 5.18±1.35 mmol/L. High density lipoprotein cholesterol (HDLC) and triglyceride (TG) and glucose levels were higher in male than in female, but not statistically significant (p>0.05). However, low density lipoprotein cholesterol (LDLC) was higher in females than males (p<0.05). Mean HDLC was below 1.0 mmol/L in all subjects. Conclusion: Glycaemic control, lipid profile, blood pressure and body weight status were not satisfactory and may increase the risk of microvascular and macrovascular complications among these subjects. Appropriate intervention programs should be implemented for better diabetes control among rural subjects.

scholarly journals Usage of Fruit-Infused Water for Prevention of Dehydration Due to Endurance Exercise

2018 ◽  
Vol 13 (3) ◽  
pp. 417-422
Author(s):  
Mohammad Arif Ali ◽  
Setya Rahayu ◽  
Nanang Indardi ◽  
Gustiana Mega Anggita ◽  
Fatona Soraya ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Experimental Research ◽  
Endurance Exercise ◽  
Previous Investigation ◽  
Fluid Intake ◽  
Post Exercise ◽  
Beneficial Effects ◽  
Urine Color ◽  
Before And After

This study aimed to extend previous investigation regarding its beneficial effects on changes of blood glucose. This experimental research was conducted from 06:00-12:00. Twenty-four young men (age 19-20 y.o.) were divided into three groups, Fasting-Exercise-Only (FEO), Fasting-Exercise-Water (FEW), and Fasting-Exercise with Fruit-Infused Water (FEF). Subjects underwent fasting for 12 h before the experimental day. The data of body weight (Kg) and macroscopic urine color were collected before and after exercise. Body weight in all experimental groups were decreased by 1% during endurance exercise. There were no differences in decrease of body weight between FEF and FEW groups compared to FEO group (p>.05). The change in urine color was significantly different between pre-exercise and post-exercise data (p<.05). The darkest urine color was observed in FEO group (4.75), followed by FEW group (4.25), while FEF group (3.63) did not reach dehydration level. In conclusion, fruit-infused water is suggested to be drink as a choice for fluid intake during exercise.

Diet enriched with fresh coconut decreases blood glucose levels and body weight in normal adults

2018 ◽  
Vol 15 (3) ◽  
Author(s):  
Venugopal Vijayakumar ◽  
Nagashree R. Shankar ◽  
Ramesh Mavathur ◽  
A. Mooventhan ◽  
Sood Anju ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Fatty Acid ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Fiber Intake ◽  
Groundnut Oil ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Fresh Coconut

Abstract Background There exist controversies about the health effects of coconut. Fresh coconut consumption on human health has not been studied substantially. Fresh coconut consumption is a regular part of the diet for many people in tropical countries like India, and thus there is an increasing need to understand the effects of fresh coconut on various aspects of health. Aim To compare the effects of increased saturated fatty acid (SFA) and fiber intake, provided by fresh coconut, versus monounsaturated fatty acid (MUFA) and fiber intake, provided by a combination of groundnut oil and groundnuts, on anthropometry, serum insulin, glucose levels and blood pressure in healthy adults. Materials Eighty healthy volunteers, randomized into two groups, were provided with a standardized diet along with either 100 g fresh coconut or an equivalent amount of groundnuts and groundnut oil for a period of 90 days. Assessments such as anthropometric measurements, blood pressure, blood sugar and insulin levels were performed before and after the supplementation period. Results Results of this study showed a significant reduction in fasting blood sugar (FBS) in both the groups. However, a significant reduction in body weight was observed in the coconut group, while a significant increase in diastolic pressure was observed in the groundnut group. Conclusions Results of this study suggest that fresh coconut-added diet helps reduce blood glucose levels and body weight in normal healthy individuals.

scholarly journals LIGHT-ROASTED GREEN COFFEE EXTRACT IMPROVED ADIPONECTIN, INSULIN RESISTANCE, AND METABOLIC PROFILE OF METABOLIC SYNDROME RAT MODEL

2017 ◽  
Vol 10 (9) ◽  
pp. 279 ◽  
Author(s):  
Mifetika Lukitasari ◽  
Dwi Adi Nugroho ◽  
Mohammad Saifur Rohman ◽  
Nur Ida Panca Nugrahini ◽  
Teguh Wahyu Sardjono
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Blood Glucose ◽  
Metabolic Profile ◽  
Adiponectin Level ◽  
Fasting Blood Glucose ◽  
Enzyme Linked Immunosorbent Assay ◽  
Green Coffee

  Objective: The objective of this study is to investigate the effect of light-roasted green coffee bean extract (GCE) administration for 7 weeks on the improvement of metabolic profile, adiponectin level, homeostatic model assessment insulin resistance (HOMA-IR) index in metabolic syndrome (MS) rat model.Methods: Adult male Sprague-Dawley rats were induced by a combination of high sucrose and high-fat diet for 8 weeks and streptozotocin injection in the 2nd week. The MS was confirmed by NCEP-ATP III criteria. They were divided into six weight-matched groups (n=5), normal control, MS, metformin and simvastatin-treated group (DMS), 100 and 200/body weight (bw) GCE (GCE 100 and GCE 200, respectively). The extracts were given through oral gavage daily for 7 weeks. The effect of GCE on body weight, serum glucose, triglyceride, (TG) and high-density lipoprotein (HDL) level was analyzed by colorimetric method. HOMA-IR index and adiponectin were analyzed by enzyme-linked immunosorbent assay methods.Result: Fasting blood glucose, TG, and systolic blood pressure decreased significantly (p<0.05) in both GCE groups. Moreover, after 7 weeks, those parameters were significantly lower (p<0.05) compared to that of MS group. Only GCE 100 group that showed a significant decrease in HDL level. GCE 100 mg/bw and 200 mg/bw group showed significantly higher adiponectin level compared to that of MS and DMS group. Furthermore, GCE 100, GCE 200, and DMS group showed a significant lower HOMA-IR index compared to that of MS group.Conclusion: 7 weeks GCE administration could decrease fasting blood glucose, profile lipid, blood pressure, and improved adiponectin level and HOMA-IR index.

Acupuncture and related techniques for obesity and cardiovascular risk factors: a systematic review and meta-regression analysis

2020 ◽  
Vol 38 (4) ◽  
pp. 227-234
Author(s):  
Jianrong Chen ◽  
Dongping Chen ◽  
Qing Ren ◽  
Weifeng Zhu ◽  
Sheng Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Weight ◽  
Cardiovascular Risk ◽  
Blood Glucose ◽  
Cardiovascular Risk Factors ◽  
Density Lipoprotein ◽  
Moderate Quality ◽  
Meta Regression ◽  
Quality Evidence

Objective: To assess how acupuncture and related techniques affect weight-related indicators and cardiovascular risk factors compared with non-acupuncture interventions in overweight and obese patients. Methods: We searched PubMed, Embase and CENTRAL up to 19 April 2018 and included relevant randomised controlled trials (RCTs). Weighted mean differences (WMDs) and 95% confidence intervals (CI) were pooled using the inverse variance method with random-effects model. Prespecified hypotheses were tested in meta-regression to investigate the source of heterogeneity. Statistical software packages used were RevMan 5.3.5 and Stata 14.0. Results: Thirty-three RCTs were included (n=2503 patients). Compared with non-acupuncture interventions, acupuncture produced a greater reduction in body weight (WMD −1.76 kg, 95% CI −2.22 to −1.30, I2=77%; moderate quality), body mass index (WMD −1.13 kg/m2, 95% CI −1.38 to −0.88, I2=85%; low quality) and waist circumference (WMD −2.42 cm, 95% CI −3.22 to −1.62, I2=75%; moderate quality). Acupuncture plus lifestyle intervention resulted in a greater reduction in body weight than acupuncture alone (MD −1.94 kg, 95% CI −3.17 to −0.70). Acupuncture also led to a greater reduction in total cholesterol (WMD −12.87 mg/dL, 95% CI −22.17 to −3.57, I2=87%; very low quality) and low-density lipoprotein cholesterol (WMD −13.52 mg/dL, 95% CI −21.47 to −5.58, I2=74%; low quality). The differences were not statistically significant for blood glucose or blood pressure. Conclusion: In the short term, acupuncture and related techniques may produce a small but statistically significant degree of weight loss based on moderate- to low-quality evidence, and improve serum lipid parameters based on low- to very-low-quality evidence. Their effects on blood glucose and blood pressure remain uncertain.

scholarly journals Alpha-ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling

2020 ◽  
Author(s):  
Gang Shu ◽  
Yexian Yuan ◽  
Jia Sun ◽  
Canjun Zhu ◽  
Jinlong Feng ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Mouse Model ◽  
Resistance Exercise ◽  
Glucose Homeostasis ◽  
Metabolic Function ◽  
Inhibitory Effects ◽  
Hepatic Gluconeogenesis ◽  
Beneficial Effects

Abstract While resistance exercise effectively improves overall health in diabetic patients, the underlying biological mechanism by which resistance exercise improves metabolic function and glucose homeostasis remain mostly unknown. Previously, we identified a myometabolite-mediated metabolic pathway that is essential for the beneficial effects of resistance exercise on metabolic function. We found that resistance exercise-induced α-ketoglutaric acid (AKG) stimulates muscle hypertrophy and fat loss through 2-oxoglutarate receptor 1 (OXGR1)-dependent adrenal activation. Here, we provided evidence for the beneficial effects of AKG on glucose homeostasis in a diet-induced obesity (DIO) mouse model, which are independent of OXGR1. We showed that circulating AKG levels are negatively correlated with the fraction of blood glycated hemoglobin (HbA1c) in both humans and mice and significantly decreased in DIO mice. Consistently, pharmacological elevation of AKG effectively decreased body weight, blood glucose, and hepatic gluconeogenesis without changing insulin sensitivity and glucose tolerance in DIO mice. Notably, OXGR1KO blocked the inhibitory effects of AKG on body weight but failed to affect AKG’s suppression on blood glucose and hepatic gluconeogenesis, indicating distinct mechanisms for AKG’s regulation on energy balance and glucose homeostasis. In supporting this view, we showed that serpina1e, a member of protease inhibitor serpins superfamily, mediates the direct inhibitory effects of AKG on gluconeogenesis in both in vitro hepatocytes and liver slice. By using a liver-specific serpina1e deletion mouse model, we further demonstrated that liver serpina1e is required for the inhibitory effects of AKG on hepatic gluconeogenesis and hyperglycemia in DIO mice. Finally, we provided in vitro evidence to support a model in which AKG decreases hepatic gluconeogenesis by targeting trimethylation of lysine 27 on histone 3 (H3K27me3) in seprina1e promoter region. Our studies established an important role of AKG in glucose homeostasis, and identified the AKG-serpina1e pathway as potential therapeutic targets to attenuate hyperglycemia.

scholarly journals Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight

2017 ◽  
Vol 25 (5) ◽  
pp. 1091-1102.e4 ◽  
Author(s):  
Yalin Zhang ◽  
Judith M. Reichel ◽  
Cheng Han ◽  
Juan Pablo Zuniga-Hertz ◽  
Dongsheng Cai
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Blood Glucose ◽  
Central Control ◽  
Astrocytic Process

Chia seed (Salvia hispanica L.) supplementation to the diet of adults with type 2 diabetes improved systolic blood pressure: A randomized controlled trial

2021 ◽  
pp. 026010602098181
Author(s):  
Eman Zaid Marzouq Alwosais ◽  
Ebaa Al-Ozairi ◽  
Tasleem A Zafar ◽  
Sharifa Alkandari
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Body Weight ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Inflammatory Marker ◽  
Control Group ◽  
Food Ingredients ◽  
Chia Seed

Background: Functional food ingredients, such as dietary fiber, long-chain polyunsaturated fatty acids, and high-quality protein, have been shown to help control blood glucose concentration and lower high blood pressure (BP), as well as improving other cardiovascular disease risk factors. However, little research has assessed the impacts of consuming chia seeds, which are rich in these nutrients, on metabolic and physiological outcomes, and results are conflicting. Aim: The study aimed to investigate the possible effects of chia seeds on fasting blood glucose, insulin, glycated hemoglobin, BP, lipid profile, body weight, and the inflammatory marker – high-sensitivity C-reactive protein – in people with type 2 diabetes (T2DM). Methods: Adults with T2DM ( n = 42) were randomly assigned equally to the chia seed group, which consumed 40 g/day chia seeds for 12 weeks, or a control group, which did not consume any supplement. Blood samples were collected at baseline and after a 12-week intervention period to assess the study outcomes, such as glycemic control, BP, cardiovascular risk parameters including lipid profile, inflammatory marker, and body weight. Results: Adjusted for gender and baseline values, the chia seed group had systolic BP (SBP) significantly reduced compared to control [ t (1) = 2.867, p = 0.007, η 2 p = 0.174]. No differences were observed in any other parameter tested in the chia seed or control group. Conclusions: People with T2DM and hypertension, maintaining usual dietary consumption, physical activity pattern, and medications, had significantly reduced SBP compared to the control group when having consumed 40 g/d of chia seeds for 12 weeks.

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