scholarly journals A REVIEW OF UNIQUE PANCHAKARMA MODALITY- SARVANGADHARA

2021 ◽  
Vol 9 (10) ◽  
pp. 2481-2485
Author(s):  
Minu Yadav ◽  
Gopesh Mangal
Keyword(s):  
Present Article ◽  
Neurological Diseases ◽  
The Body ◽  
Modern Literature ◽  
Treatment Modalities ◽  
Research Papers ◽  
Chronic Stage ◽  
Degenerative Disorders ◽  
Ayurvedic Treatment ◽  
Published Research

The classical Ayurvedic texts are endowed with unique treatment modalities. Panchakarma procedures form an important backbone in Ayurvedic treatment. One of the Panchakarma therapies is the Sarvangadhara. It is also known as Kayaseka, Pizhichil, Seka and Dhara. It is classified under Sagni Sweda as Parisheka Swedana by Acharya Charaka whereas Acharya Sushruta mentions it under Drava Sweda. It is a special Bahir-Parimarjana therapy where it does both Snehana and Swedana simultaneously. In this procedure medicated liquid (oil/Kwa- tha/Takra) is poured over the body in form of Dhara or stream for a stipulated period. The present study aims to review the procedure of Sarvangadhara through the study of various Ayurvedic and modern literature, published research papers, and textbooks. The procedure induces sweating and relieves stiffness, heaviness and coldness in the body. It is very helpful in Vata-Pradhana diseases like neurological diseases and degenerative disorders. Par- isheka Swedana is mentioned as Samanya-Chikitsa of Vata-Vyadhi. It is widely practised in Ankylosing spondylosis and the chronic stage of osteoarthritis condition. The medicines are changed based on the conditions like Takra- Dhara is adopted in cases of psoriasis and Dhanyamla-Dhara in obesity. In the present article, an attempt has been made to review the procedure and benefits of Sarvangadhara as a Pan- chakarma therapy in the treatment of various diseases. Keywords: Sarvangadhara, Parishek, Pizhichil, Seka, Dhara, Swedana

Ayurvedic Management of Ankylosing Spondylitis - A Case Report

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr. Vibhu Powar ◽  
Dr. Totad Muttappa ◽  
Dr. Vasantha B ◽  
Dr. Girish KJ ◽  
Dr. Rachana MS
Keyword(s):  
Ankylosing Spondylitis ◽  
Upper Limb ◽  
Axial Skeleton ◽  
The Body ◽  
Treatment Modalities ◽  
Low Back ◽  
Female Ratio ◽  
Oral Medications ◽  
Before And After ◽  
Ayurvedic Treatment

Introduction: Ankylosing Spondylitis (AS) is a sero negative chronic inflammatory arthritis of unknown cause that primarily affects the axial skeleton which usually begins in the second or third decade of life with a male to female ratio of 3:1. The prevalence rate of AS in India is 0.03%. It is clinically correlated to Danda Apatanaka in Ayurveda. It is caused due to the vitiated Vata and Kapha Dosha which enters the Dhamani and causes stiffness of the body. Due to its known complications and its tendency to hamper the quality of life, there is a need for an effective Ayurvedic intervention. This report is based on a case of Ankylosing Spondylitis which presented with pricking pain over nape of the neck and low back associated with stiffness and restricted movements, swelling over nape of neck right shoulder and right side of face, associated with restricted movements of right upper limb. Methods: This case was diagnosed as Danda Apatanaka and was treated with Basti Karma, Abhyanga along with oral medications. Assessment was done before and after treatment using relevant scales. Result: After 2 weeks of treatment pain and swelling over the nape of neck, right shoulder and face resolved completely, pain and stiffness of low back reduced, pain in right upper limb reduced and patient was able to perform normal movements. Stiffness of neck still persisted. Conclusion: Ankylosing spondylitis can be effectively managed by Ayurvedic treatment modalities after proper assessment of the involved Dosha and Dhatus.

scholarly journals Efficacy of Uttar Basti in Urethral Stricture – A Review

The Healer ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 32-35
Author(s):  
Pratigya Koju ◽  
Bijendra Shah ◽  
Dr Raj Kishor Shah
Keyword(s):  
Urethral Stricture ◽  
Effective Procedure ◽  
Modern Literature ◽  
Research Papers ◽  
Classical Text ◽  
Highly Effective ◽  
Treatment Procedures ◽  
Collective Information ◽  
Published Research

Introduction: Narrowing of lumen of urethra is known as urethral stricture.70% of uretral stricture is inscidious at bulb. Trauma,infections like( TB,Gonorrhoea), TURP are the main causes of urethral stricture. Symptoms include varying amt of urethral dischargeæ morning dew drop”,difficulty in micturation,dribbling of urine, increased frequency,incomplete voiding of urine etc. According to modern literature, urethroplasty and dilatation of urethra are the treatment procedures followed for urethral stricture. In Ayurveda urethral stricture can be correlated with mutra marga samkocha. According to Sushruta Samhita uttarbasti is one of the effective procedure for mutra marga samkocha. Material and methods: This paper provides a collective information regarding Mutra Marga Samkocha( Urethral Stricture), from Nighantu, Samhita and Modern Medicine.Uttarbasti is performed by the use of oils like Bala taila,Tila taila,Apamarga kshar taila etc. Result and Discussion: Most of the concerned informations are retrieved from published international journals and classical text of Ayurveda. As per published research papers uttarbasti is highly effective in case of urethral stricture. Conclusion:

Biocompatible Nanovesicular Drug Delivery Systems with Targeting Potential for Autoimmune Diseases

2020 ◽  
Vol 26 (42) ◽  
pp. 5488-5502 ◽  
Author(s):  
Yub Raj Neupane ◽  
Asiya Mahtab ◽  
Lubna Siddiqui ◽  
Archu Singh ◽  
Namrata Gautam ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Immunological Tolerance ◽  
Delivery Systems ◽  
The Body ◽  
Autoimmune Response ◽  
Treatment Modalities

Autoimmune diseases are collectively addressed as chronic conditions initiated by the loss of one’s immunological tolerance, where the body treats its own cells as foreigners or self-antigens. These hay-wired antibodies or immunologically capable cells lead to a variety of disorders like rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, multiple sclerosis and recently included neurodegenerative diseases like Alzheimer’s, Parkinsonism and testicular cancer triggered T-cells induced autoimmune response in testes and brain. Conventional treatments for autoimmune diseases possess several downsides due to unfavourable pharmacokinetic behaviour of drug, reflected by low bioavailability, rapid clearance, offsite toxicity, restricted targeting ability and poor therapeutic outcomes. Novel nanovesicular drug delivery systems including liposomes, niosomes, proniosomes, ethosomes, transferosomes, pharmacosomes, ufasomes and biologically originated exosomes have proved to possess alluring prospects in supporting the combat against autoimmune diseases. These nanovesicles have revitalized available treatment modalities as they are biocompatible, biodegradable, less immunogenic and capable of carrying high drug payloads to deliver both hydrophilic as well as lipophilic drugs to specific sites via passive or active targeting. Due to their unique surface chemistry, they can be decorated with physiological or synthetic ligands to target specific receptors overexpressed in different autoimmune diseases and can even cross the blood-brain barrier. This review presents exhaustive yet concise information on the potential of various nanovesicular systems as drug carriers in improving the overall therapeutic efficiency of the dosage regimen for various autoimmune diseases. The role of endogenous exosomes as biomarkers in the diagnosis and prognosis of autoimmune diseases along with monitoring progress of treatment will also be highlighted.

Vitiligo: An Updated Narrative Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Alexander K. C. Leung ◽  
Joseph M. Lam ◽  
Kin Fon Leong ◽  
Kam Lun Hon
Keyword(s):  
Present Article ◽  
English Literature ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Calcineurin Inhibitors ◽  
Ultraviolet B ◽  
Lower Limbs ◽  
Treatment Modalities ◽  
Topical Corticosteroids ◽  
Topical Calcineurin Inhibitors

Background: Vitiligo is a relatively common acquired pigmentation disorder that can cause significant psychological stress and stigmatism. Objective: This article aims to familiarize physicians with the clinical manifestations, evaluation, diagnosis, and management of vitiligo. Methods: A Pubmed search was conducted in Clinical Queries using the key term "vitiligo". The search included metaanalyses, randomized controlled trials, clinical trials, observational studies, and reviews. The search was restricted to the English literature. The information retrieved from the above search was used in the compilation of the present article. The information retrieved from the above search was used in the compilation of the present article. Results: Approximately one quarter of patients with vitiligo have the onset before 10 years of age. Genetic, immunological, neurogenic and environmental factors may have a role to play in the pathogenesis. Vitiligo typically presents as acquired depigmented, well-demarcated macules/patches that appear milk- or chalk-white in color. Lesions tend to increase in number and enlarge centrifugally in size with time. Sites of predilection include the face, followed by the neck, lower limbs, trunk, and upper limbs. The clinical course is generally unpredictable. In children with fair skin, no active treatment is usually necessary other than the use of sunscreens and camouflage cosmetics. If treatment is preferred for cosmesis, topical corticosteroids, topical calcineurin inhibitors, and narrowband ultraviolet B phototherapy are the mainstays of treatment. Conclusion: The therapeutic effect of all the treatment modalities varies considerably from individual to individual. As such, treatment must be individualized. In general, the best treatment response is seen in younger patients, recent disease onset, darker skin types, and head and neck lesions. Topical corticosteroids and calcineurin inhibitors are the treatment of choice for those with localized disease. Topical calcineurin inhibitors are generally preferred for lesions on genitalia, intertriginous areas, face, and neck. Narrowband ultraviolet B phototherapy should be considered in patients who have widespread vitiligo or those with localized vitiligo associated with a significant impact on the quality of life who do not respond to treatment with topical corticosteroids and calcineurin inhibitors.

A Critical Study of Violent Asphyxial Deaths with Ancient Perspective

2017 ◽  
Vol 1 (4) ◽  
Author(s):  
Kalpana Denge ◽  
Rupali Gatfane
Keyword(s):  
Present Article ◽  
Modern Science ◽  
Modern Literature ◽  
Critical Study ◽  
Contemporary Science ◽  
Ancient Literature ◽  
Modern Knowledge ◽  
Ancient Texts

Asphyxia is most commonly appearing as a major cause of unnatural deaths. Scattered references can be reviewed in ancient literature regarding asphyxial death. Description of various signs of asphyxial death is given briefly in ancient texts and it is worthwhile to study them with the help of modern science. In ancient literature these asphyxial deaths are described briefly as Kanthapeedan, Dhoomopahat and Udakahat. In modern literature asphyxial deaths are described as hanging, strangulation, suffocation and drowning which occur in homicidal or suicidal purpose or accidental. Viewing these references, asphyxial deaths are studied comprehensively with the object of highlighting it with the help of modern knowledge. Thus present article deals with exploration of ancient references of asphyxial death with the help of contemporary science.

scholarly journals Chitosan Adsorbent Derivatives for Pharmaceuticals Removal from Effluents: A Review

Macromol ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 130-154
Author(s):  
Efstathios V. Liakos ◽  
Maria Lazaridou ◽  
Georgia Michailidou ◽  
Ioanna Koumentakou ◽  
Dimitra A. Lambropoulou ◽  
...  
Keyword(s):  
Emerging Contaminants ◽  
Low Cost ◽  
Value Added ◽  
Ph Effects ◽  
Hydroxyl Groups ◽  
Research Papers ◽  
Natural Polysaccharide ◽  
Best Fitting ◽  
Isotherm And Kinetic Models ◽  
Published Research

Chitin is mentioned as the second most abundant and important natural biopolymer in worldwide scale. The main sources for the extraction and exploitation of this natural polysaccharide polymer are crabs and shrimps. Chitosan (poly-β-(1 → 4)-2-amino-2-deoxy-d-glucose) is the most important derivative of chitin and can be used in a wide variety of applications including cosmetics, pharmaceutical and biomedical applications, food, etc., giving this substance high value-added applications. Moreover, chitosan has applications in adsorption because it contains amino and hydroxyl groups in its molecules, and can thus contribute to many possible adsorption interactions between chitosan and pollutants (pharmaceuticals/drugs, metals, phenols, pesticides, etc.). However, it must be noted that one of the most important techniques of decontamination is considered to be adsorption because it is simple, low-cost, and fast. This review emphasizes on recently published research papers (2013–2021) and briefly describes the chemical modifications of chitosan (grafting, cross-linking, etc.), for the adsorption of a variety of emerging contaminants from aqueous solutions, and characterization results. Finally, tables are depicted from selected chitosan synthetic routes and the pH effects are discussed, along with the best-fitting isotherm and kinetic models.

scholarly journals Timing of Bisphosphonate Initiation After Fracture: What Does the Data Really Say?

2020 ◽  
Vol 11 ◽  
pp. 215145932098036
Author(s):  
David W. Barton ◽  
C. Taylor Smith ◽  
Amit S. Piple ◽  
Sterling A. Moskal ◽  
Jonathan J. Carmouche
Keyword(s):  
Fracture Healing ◽  
Clinical Studies ◽  
Osteoporosis Treatment ◽  
The Body ◽  
Non Union ◽  
Increased Risk ◽  
Level I ◽  
Timing Of Initiation ◽  
The Impact ◽  
Published Research

Introduction: Osteoporosis is often not clinically recognized until after a fracture occurs. Individuals who have 1 fracture are at increased risk of future fractures. Prompt initiation of osteoporosis treatment following fracture is critical to reducing the rate of future fractures. Antiresorptives are the most widely used class of medications for the prevention and treatment of osteoporosis. Many providers are hesitant to initiate antiresorptives in the acute post-fracture period. Concerns include interference with bone remodeling necessary for successful fracture healing, which would cause increased rates of non-union, malunion, and refracture. While such concerns should not extend to anabolic medications, physicians may also hesitate to initiate anabolic osteoporosis therapies due to high cost and/or lack of familiarity. This article aims to briefly review the available data and present a digestible narrative summary to familiarize practicing orthopaedic surgeons with the essential details of the published research on this topic. Results: The results of 20 clinical studies and key pre-clinical studies related to the effect of anti-resorptive medications for osteoporosis on fracture healing are summarized in the body of this narrative review. Discussion & Conclusions: While few level I studies have examined the impact of timing of initiation of osteoporosis medications in the acute post-fracture period, the few that have been published do not support these concerns. Specifically, data from level I clinical trials indicate that initiating bisphosphonates as early as 2 weeks post-fracture does not increase rates of non-union or malunion. By reviewing the available data, we hope to give clinicians the confidence to initiate osteoporosis treatment promptly post-fracture.

Investigation of solution techniques of unit commitment problems: A review

2021 ◽  
pp. 0309524X2199244
Author(s):  
Vineet Kumar ◽  
Ram Naresh ◽  
Amita Singh
Keyword(s):  
Power Systems ◽  
Planning Process ◽  
Unit Commitment ◽  
Operational Planning ◽  
Recent Past ◽  
Research Papers ◽  
Start Up ◽  
Subsequent Step ◽  
Commitment Problems ◽  
Published Research

The Unit Commitment (UC) is a significant act of optimization in day-to-day operational planning of modern power systems. After load forecasting, UC is the subsequent step in the planning process. The electric utilities decide in advance which units are to start-up, when to connect them to the network, the sequence in which the generating units should be shut down and for how long. In view of the above, this paper attempts on presenting a thorough and precise review of the recent approaches applied in optimizing UC problems, incorporating both stochastic and deterministic loads, based on various peer reviewed published research papers of reputed journals. It emphasizes on non-conventional energy and distributed power generating systems along with deregulated and regulated environment. Along with an overview, a comprehensive analysis of the UC algorithms reported in the recent past since 2015 has been discussed for the assistance of new researchers concerned with this domain.

scholarly journals Consistency of causal claims in observational studies: a review of papers published in a general medical journal

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e043339
Author(s):  
Camila Olarte Parra ◽  
Lorenzo Bertizzolo ◽  
Sara Schroter ◽  
Agnès Dechartres ◽  
Els Goetghebeur
Keyword(s):  
Medical Journal ◽  
Observational Studies ◽  
The Other ◽  
Research Papers ◽  
General Medical Journal ◽  
Outcome Relationship ◽  
Causal Statement ◽  
Data Source ◽  
Published Research ◽  
Causal Language

ObjectiveTo evaluate the consistency of causal statements in observational studies published in The BMJ.DesignReview of observational studies published in a general medical journal.Data sourceCohort and other longitudinal studies describing an exposure-outcome relationship published in The BMJ in 2018. We also had access to the submitted papers and reviewer reports.Main outcome measuresProportion of published research papers with ‘inconsistent’ use of causal language. Papers where language was consistently causal or non-causal were classified as ‘consistently causal’ or ‘consistently not causal’, respectively. For the ‘inconsistent’ papers, we then compared the published and submitted version.ResultsOf 151 published research papers, 60 described eligible studies. Of these 60, we classified the causal language used as ‘consistently causal’ (48%), ‘inconsistent’ (20%) and ‘consistently not causal’(32%). Eleven out of 12 (92%) of the ‘inconsistent’ papers were already inconsistent on submission. The inconsistencies found in both submitted and published versions were mainly due to mismatches between objectives and conclusions. One section might be carefully phrased in terms of association while the other presented causal language. When identifying only an association, some authors jumped to recommending acting on the findings as if motivated by the evidence presented.ConclusionFurther guidance is necessary for authors on what constitutes a causal statement and how to justify or discuss assumptions involved. Based on screening these papers, we provide a list of expressions beyond the obvious ‘cause’ word which may inspire a useful more comprehensive compendium on causal language.

scholarly journals Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases

2021 ◽  
Vol 22 (14) ◽  
pp. 7302
Author(s):  
Bryan Latrell Holloman ◽  
Mitzi Nagarkatti ◽  
Prakash Nagarkatti
Keyword(s):  
Autoimmune Diseases ◽  
Chronic Inflammation ◽  
Cannabinoid Receptors ◽  
T Regulatory Cells ◽  
Neurological Diseases ◽  
Suppressor Cells ◽  
The Body ◽  
New Class ◽  
Wide Range ◽  
Clinical Disorders

Chronic inflammation is considered to be a silent killer because it is the underlying cause of a wide range of clinical disorders, from cardiovascular to neurological diseases, and from cancer to obesity. In addition, there are over 80 different types of debilitating autoimmune diseases for which there are no cure. Currently, the drugs that are available to suppress chronic inflammation are either ineffective or overtly suppress the inflammation, thereby causing increased susceptibility to infections and cancer. Thus, the development of a new class of drugs that can suppress chronic inflammation is imperative. Cannabinoids are a group of compounds produced in the body (endocannabinoids) or found in cannabis (phytocannabinoids) that act through cannabinoid receptors and various other receptors expressed widely in the brain and immune system. In the last decade, cannabinoids have been well established experimentally to mediate anti-inflammatory properties. Research has shown that they suppress inflammation through multiple pathways, including apoptosis and inducing immunosuppressive T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Interestingly, cannabinoids also mediate epigenetic alterations in genes that regulate inflammation. In the current review, we highlight how the epigenetic modulations caused by cannabinoids lead to the suppression of inflammation and help identify novel pathways that can be used to target autoimmune diseases.

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