scholarly journals AYURVEDIC CONCEPT OF KNOWING UNKNOWN DISEASE (ANUKTA VYADHI) W.S.R. TO THALASSEMIA

2020 ◽  
Vol 8 (10) ◽  
pp. 4876-4880
Author(s):  
Kalpana Ladvikar

Thalassemia is the most common genetic disorder resulting from abnormality of Globin chain. It is the worldwide problem of today’s era and until no answer to any medical science. It is the challenging disorder for the scientist. The nature of the disease is genetic regarding this so many literatures available in the modern science but in Ayurveda has no answer for this disease. To add the new concept of disease Thalassemia (Anukta Vyadhi In Ayurveda), aim of study is to understand the unknown disease, the concept of Beeja, Beejabhaga and Beejabhagavayava should be clear because of its genetic nature of thalassemia. Charaka mentioned Aptopadesha method of examination, we can acquire knowledge as described by wise men, or Apta, use to understand a disease:

Author(s):  
Shivanand F Kawane

As we know Shukra dhatu is a most essential end product of the rest of all 6 dhatus of sharira. So, an analytical comparative research study has been made on infertility(bandhatva) patients. In this study, we explain tenets of shukra dhatu and different types of shukra doshas according to Acharya Charaka and Sushruta. According to doshas 8 types of Shukra doshas explaind by acharya and 9 types of semen abnormality by modern science. An attempt has been made to correlate these shukra doshas with an abnormality of semen according to modern medical science, on the basis of clinical features, physical appearance, and laboratory examination of semen. For the study 20 patient suffering from any kind of infertility has been selected from O.P.D. of Shalya Tantra department of Arogyashala rugnalaya, Nashik. On observation, the result showed out of 20 patients , 10 patients suffering from vatapittaj, 6 from shukra kshaya, 2 from vataj and 2 from pittaj shukra dosha according to ayurvedic point of view. Simultaneously we correlate it with different clinical conditions of semen and we found Out of 20 patients, 8 suffering from Oligoasthenospermia, 6 from Oligospermia, 2 from Asthenozoospermia, 2 from Tetratazospermia, 2 from Infective semen.  


2021 ◽  
Vol 17 (2) ◽  
pp. 118-124
Author(s):  
Amirmehdi Sarvestani ◽  
Mohammad Almasian ◽  
Amirhossein Nafari

Background: The prevalence of fungal infections has been increasing in recent years. Cystic fibrosis (CF) is a genetic disorder that affects organs such as the intestines, liver, pancreas, and especially the lungs. Introduction: Fungal pathogens are becoming a challenge in CF. Advanced medical science is associated with longer life expectancy in some patient groups. Method: A review was conducted on studies found on online databases, including Google Scholar, PubMed, and Scopus. Internet-based searches were performed on these databases for cystic fibrosis, respiratory infections, and fungal infection profiling to identify all relevant studies published between 2010 and 2020. Result: Fungal pathogens most frequently isolated from the respiratory tract include the Aspergillus genus, the Candida genus, Scedosporium apiospermum, and the Rasamsonia genus. In cystic fibrosis, these organisms usually colonize the respiratory and intestinal tracts and cause hypersensitivity responses and invasive diseases. Conclusion: Fungus-patient interactions are complicated and depend on various factors. Moreover, the emergence of drug-resistant species is a serious health issue, and the development of new treatments is crucial.


Blood ◽  
2005 ◽  
Vol 105 (8) ◽  
pp. 3353-3355 ◽  
Author(s):  
Emanuela Tolosano ◽  
Sharmila Fagoonee ◽  
Cinzia Garuti ◽  
Linda Valli ◽  
Nancy C. Andrews ◽  
...  

Abstract Classic hereditary hemochromatosis (HH) is a common genetic disorder of iron metabolism caused by a mutation in the HFE gene. Whereas the prevalence of the mutation is very high, the clinical penetrance of the disease is low, suggesting that the HFE mutation is a necessary but not sufficient cause of clinical HH. Several candidate modifier genes have been proposed in mice and humans, including haptoglobin. Haptoglobin is the plasma protein with the highest binding affinity for hemoglobin. It delivers free plasma hemoglobin to the reticuloendothelial system, thus reducing loss of hemoglobin through the glomeruli and allowing heme-iron recycling. To gain insight into the role of haptoglobin as a modifier gene in HH, we used Hfe and haptoglobin double-null mice. Here, we show that Hfe and haptoglobin compound mutant mice accumulate significantly less hepatic iron than Hfe-null mice, thus demonstrating that haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in HH. (Blood. 2005;105:3353-3355)


Author(s):  
Isabel Periquito ◽  
Catarina Carrusca ◽  
Joana Morgado ◽  
Brígida Robalo ◽  
Carla Pereira ◽  
...  

AbstractTurner syndrome is a common genetic disorder with an incidence of 1 in 2500 live births. Spontaneous fertility is rare in such patients and is most likely in women with mosaicism or very distal Xp deletions. The authors report an unusual case of familial Turner syndrome in a woman with mosaicism 45,X/46,Xdel(Xp) karyotype with three documented spontaneous pregnancies, which resulted in two daughters with 46,Xdel(X)(p11.4)mat karyotype and a healthy son. The mother was first diagnosed by the age of 11 and did not receive contraceptive medication, due to information that she would be infertile. Both daughters were referred to an endocrinology unit and are now under growth hormone treatment, and have been growing in the 3rd percentile. This family illustrates the complexity and difficulties in counseling, follow-up and treatment in Turner syndrome, namely referring to a tertiary center, fertility and treatment such as growth hormone and hormonal replacement, due to the heterogeneity of the clinical spectrum.


2021 ◽  
Vol 9 (6) ◽  
pp. 1299-1302
Author(s):  
Sejalgamit Sejalgamit

Hair is crowning glory and mark of identity of human being. Indralupata in modern science correlate with alopecia aereata. It is characterized by localised areas of non-scarring hair loss which can be co-related with indralupta. Due to side effects and limitation of contemporary science, some harmless and effective medicines are expected from alternative medical science. indralupta disease is described under heading of kshudraroga by sushruta, vagbhata etc.in modern science its main treatment is corticosteroids which is having harmful side effects and not advisable for long term use.so it is necessary to find better remedies .it can be easily fulfilled by Ayurveda. Here, a case of female patient suffering from indralupta was successfully treated with jaluaka and haridra and nimbalepa. Keywords: kshudraroga, indralupta, jaluaka, haridra and nimbalepa


2021 ◽  
Vol 21 (1) ◽  
pp. 134-140
Author(s):  
Rosidah Omar ◽  
Norizan Ahmad ◽  
Ngee Wen Sze

Thalassaemia and abnormal haemoglobins are the most common genetic disorder worldwide. School-based screening thalassaemia program for form four students was introduced with the objective to screen for the thalassaemia status. There is paucity in the data in Kedah on distribution of thalassaemia carrier and the associated factors. Hence this study aims to identify the factors associated with being a thalassaemia carrier and to describe the laboratory cost for the thalassaemia screening. This study used secondary data from the school-based thalassaemia screening in 2018 obtained from Kedah State Health Department. Results showed the prevalence of thalassaemia carrier among form four students in Kedah was 10.91%. Multivariate logistic regression showed that students from Baling, Padang Terap and Yan were 1.40, 1.34 and 1.23 times more likely to be a thalassaemia carrier respectively compared to Kota Setar (aOR Baling 1.40;95% CI 1.21,1.64; aOR Padang Terap 1.34;95% CI 1.11,1.61 and aOR Yan 1.23;95% CI 1.03,1.47). Malay and Siamese students were five times more likely be thalassaemia carriers compared to Indian (aOR Malay 5.16;95%CI 3.42,7.79, aOR Siamese 5.63;95%CI 3.19,9.97). Meanwhile, Chinese students had 2.61 higher odds to be a thalassaemia carrier compared to Indian (aOR Chinese 2.61;95%CI 1.65,4.12). The laboratory cost for the thalassaemia screening ranged from RM2.14 to RM142.14 per participant. As for conclusion, this study reported high prevalence (10.91%) of thalassaemia carriers in Kedah. Our study also confirmed that the district and the ethnicity significantly influenced the thalassaemia carrier status. The identified factors should inform future thalassaemia campaign to prevent higher prevalence of thalassaemia patients.


2018 ◽  
Vol 90 (3) ◽  
pp. 107-112
Author(s):  
N B Voloshina ◽  
M F Osipenko ◽  
N V Litvinova ◽  
A N Voloshin

The iron overload syndrome can be associated with various acquired states and hereditary factors. Hereditary hemochromatosis is the most common genetic disorder. Without therapeutic intervention the disease can lead to the development of life-threatening complications such as cirrhosis, hepatocellular carcinoma. The article presents data on pathogenesis, diagnosis and treatment of hereditary hemochromatosis. Own clinical observation is given.


2020 ◽  
Vol 23 (2) ◽  
pp. 103-106
Author(s):  
VL Spasova ◽  
LI Koleva ◽  
DI Toncheva ◽  
VI Karamisheva

Abstract The aim of this case report was to show the consequences of pregnancy in a cystic fibrosis (CF) patient with a rare mutation. We present a case of a patient with CF, pregnant for the second time, who gave birth to a healthy child. Her mutation status revealed the presence of relatively rare mutation c.3718-2477C>T that is associated with a milder phenotype of the disease. During pregnancy, her vital signs were within normal limits. She had no exacerbations after the third gestational month. Cystic fibrosis is the most common genetic disorder among Caucasians. Over the last few decades, the survival rate and the lifespan of patients with CF have increased progressively. This is why more affected women are choosing to become pregnant. Predictive factors for the pregnancy outcome are basal pulmonary function [measured by forced expiratory volume/1 second (FEV1)], nutritional status [measured by body mass index (BMI)], diabetes and bacterial colonization. The report of our case emphasizes the need for establishing the exact mutations in CF patients who plan to become pregnant in order to predict the possible outcomes of this specific period of life. Moreover, genetic counseling is strongly recommended for the right understanding of the pregnancy risks in such cases.


2017 ◽  
Vol 14 (3) ◽  
pp. 2453
Author(s):  
Sırrı Tiryaki

The first inventions made by the first humans on earth to survive started the beginning of first scientific activities. The first instruments made of bone and stone are a product of this philosophy. The fact that human beings begin to lead a life based on settled life means the world science develops rapidly. Because the settled life enabled the establishment of villages and cities for world civilization and the commencement of trade. Along with all these things, concepts such as writing, books, literature, library, astronomy, mathematics, chemistry and physics began to enter into human life. The discovery of mining revealed the facts like armed soldiers, armies and states. Along with the concept of the state, scientific activities have become more systematic and more widespread. Because it is known that states supported scientific activities within their borders. For example, the creation of the writing by the Sumerian civilization, the preparation of textbooks, the development of the calendar, the development of medical science in Egypt, the invention of the compass by the Chinese civilization, the opening of the museum in Alexandria in the Hellenistic Age and the starting of the studies about anatomy in this museum, the opening of a three different educational institutions in Rome, were all happening as a result of the encouragement and support of the respective states. In this study, we tried to put forth that all the scientific activities in the Old Era the basis of the modern science as well.Extended English abstract is in the end of PDF (TURKISH) file. ÖzetYeryüzündeki ilk insanların hayata kalabilmek için yaptıkları ilk icatlar aynı zamanda ilk bilimsel faaliyetleri başlamaktadır. Kemik ve taştan yapılan ilk aletler bu felsefenin bir ürünüdür. İnsanoğlunun yerleşik yaşama dayalı bir hayat sürdürmeye başlaması ise dünya biliminin hızla gelişmesi anlamına gelmektedir. Çünkü yerleşik yaşam dünya uygarlığı için köylerin ve kentlerin kurulması ve ticaretin başlaması demekti. Bütün bunların yanı sıra yerleşik yaşamla birlikte yazı, kitap, edebiyat, kütüphane, astronomi, matematik, kimya ve fizik gibi kavramlar insan hayatına girmeye başladı. Madenciliğin keşfi ise silahlı askerler, ordular ve devletler gibi olguları ortaya çıkardı. Devlet kavramıyla birlikte bilimsel faaliyetler daha sistematik hâle geldi ve daha da yaygınlaştı. Çünkü devletlerin kendi sınırları içerisinde bilimsel aktiviteleri teşvikleri söz konusuydu. Örneğin yazının Sümer uygarlığı tarafından icat edilmesi, ders kitaplarının hazırlanması, takvimin geliştirilmesi, Mısır’da tıp biliminin oldukça gelişmesi, pusulanın Çin uygarlığı tarafından icat edilmesi, Helenistik Çağ’da İskenderiye kentinde müzenin açılması ve bu müzede anatomi alanında çalışmaların başlatılması ile Roma’da üç farklı eğitim kurumunun açılması gibi konuların tamamı dönemin söz konusu devletlerinin teşvik ve destekleri sonucunda gerçekleşen olgulardı. Çalışmamızda Eski Çağdaki bütün bu bilimsel faaliyetlerin aynı zamanda modern bilimin temelini oluşturduğunu ortaya koymaya çalıştık.


2021 ◽  
Vol 45 (5) ◽  
pp. 629-640
Author(s):  
Seung-Hwan Lee ◽  
Kun-Ho Yoon

The year 2021 marks the 100th anniversary of the discovery of insulin, which has greatly changed the lives of people with diabetes and become a cornerstone of advances in medical science. A rapid bench-to-bedside application of the lifesaving pancreatic extract and its immediate commercialization was the result of a promising idea, positive drive, perseverance, and collaboration of Banting and colleagues. As one of the very few proteins isolated in a pure form at that time, insulin also played a key role in the development of important methodologies and in the beginning of various fields of modern science. Since its discovery, insulin has evolved continuously to optimize the care of people with diabetes. Since the 1980s, recombinant DNA technology has been employed to engineer insulin analogs by modifying their amino acid sequence, which has resulted in the production of insulins with various profiles that are currently used. However, unmet needs in insulin treatment still exist, and several forms of future insulins are under development. In this review, we discuss the past, present, and future of insulin, including a history of ceaseless innovations and collective intelligence. We believe that this story will be a solid foundation and an unerring guide for the future.


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