Cytomorphological features of papillary thyroid carcinomas with the development of radioiodine-resistance

Background. The problem of diagnosis and treatment of papillary thyroid cancer (PTC) are radioiodine resistant metastases (RIRM). An urgent issue is the possibility of their early prediction and diagnosis based on the detection of cytomorphological features of the PTC and its metastases, which correlate with the development of radioiodine (RI) resistance. Purpose – detection of cytomorphological features of primary PTC and its metastases in patients who subsequently showed resistance to 131I therapy, compared with the control group of patients who achieved a positive effect of 131I therapy. Materials and Methods. A comparative analysis of morphological features in histological conclusions and the study of cytological characteristics in the fine-needle aspiration (FNA) smears of primary PTC and their primary metastases, as well RIRM оf experimental and control groups of patients were conducted. The experimental group consisted of 152 patients who showed resistance to RI therapy, the control group – 161 patients who achieved a positive effect of RI therapy. Statistical processing was done in Statistica 12. Results and discussion. It is shown that the frequency of follicular structures in the material of primary PTC of patients with a positive effect of 131I therapy is significantly higher, and the frequency of necrotic changes is significantly lower than in patients with the development of RIRM (p <0.05 by criterion χ2). The frequency of follicular structures in the histological material and FNA smears of primary metastases of patients with a positive effect of 131I therapy is significantly higher, and oxyphilic changes are significantly lower than in patients with the development of RIRM (p <0.05 by criterion χ2). Oxyphilic changes were observed significantly more often in the RIRM compared with primary metastases of the control group (p = 0.03). It was proved that cystic changes are significantly more common in FNA smears and histological material of RIRM in comparison with primary metastases of experimental and control groups of patients (p <0.05). Conclusions. TThe use of the presence of oxyphilic and cystic changes in the FNA smears and histological material of metastases of the PTC as prognostic factors of RI resistance is proposed. The presence of follicular structures in the materials of primary PTC and metastases can be a prognostic factor of effective RI therapy.

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PENGARUH METODE PRAKTIKUM BERBANTUAN FLASH TERHADAP HASIL BELAJAR SISWA PADA MATERI HIDROKARBON DI KELAS XI IPA SMA MUHAMMADIYAH PONTIANAK

AR-RAZI Jurnal Ilmiah ◽

10.29406/arz.v4i2.684 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Salmauwati Salmauwati ◽

Muhamad Agus Wibowo ◽

Dedeh Kurniasih

Keyword(s):

Learning Outcomes ◽

Practical Method ◽

Control Group ◽

Control Groups ◽

Lecture Method ◽

Post Test ◽

Quasi Experimental ◽

Teaching Learning ◽

And Control ◽

Positive Effect

ABSTRACTThis study was initiated by the students’ low learning outcomes on Chemistry subject and the teachers’ preference in using lecture method in teaching learning process.This study aimed at 1) finding out the differences of students’ learning outcomes between the use of flash media-assisted practical method and lecture method on hydrocarbon class at grade XI MIA of SMA Muhammadiyah I Pontianak. Using quasi experimental design and Control Group Posttes Design, this study employed the students of grade XI MIA 2 as the samples of experiment group, andthe students of grade XI MIA 2 as the samples of control group. The data collection techniques used were measurement and observation. While the instruments employed were observation sheet and essay. TheU-Mann Whitneytest revealed that the post test score of 0,0140< 0,05 Ho was rejected, while the Ha one was accepted. It means that there was correlation of students’ learning outcomes between the experiment and the control groups. In addition, the effect size result was 1,086 > 0,8 and considered high which indicated the positive effect of flash media-assisted practical method in enhancing students’ learning achievement.Keywords: flash, learning outcomes, hydrocarbon, practical method

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To Tweet or Not to Tweet, That is the Question: A Randomized Trial of Twitter Effects on Article Engagement in Medical Education

10.1101/642769 ◽

2019 ◽

Author(s):

Lauren A. Maggio ◽

Todd C. Leroux ◽

Anthony R. Artino

Keyword(s):

Medical Education ◽

Randomized Trial ◽

Preliminary Evidence ◽

Control Group ◽

Control Groups ◽

Significant Difference ◽

Incident Rate ◽

And Control ◽

Positive Effect ◽

Small Positive Effect

AbstractMany medical education journals use Twitter to garner attention for their articles. The purpose of this study was to test the effects of tweeting on article page views and downloads.The authors conducted a randomized trial usingAcademic Medicinearticles published in 2015. Beginning in February through May 2018, one article per day was randomly assigned to a Twitter (case) or control group. Daily, an individual tweet was generated for each article in the Twitter group that included the title, #MedEd, and a link to the article. The link delivered users to the article’s landing page, which included immediate access to the HTML full text and a PDF link. The authors extracted HTML page views and PDF downloads from the publisher. To assess differences in page views and downloads between cases and controls, a time-centered approach was used, with outcomes measured at 1, 7, and 30 days.In total, 189 articles (94 cases, 95 controls) were analyzed. After days 1 and 7, there were no statistically significant differences between cases and controls on any metric. On day 30, HTML page views exhibited a 63% increase for cases (M=14.72, SD=63.68) when compared to controls (M=9.01, SD=14.34; incident rate ratio=1.63, p=0.01). There were no differences between cases and controls for PDF downloads on day 30.Contrary to the authors’ hypothesis, only one statistically significant difference in page views between the Twitter and control groups was found. These findings provide preliminary evidence that after 30 days a tweet can have a small positive effect on article page views.

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Breast Microecology Improvement Using Probiotics Following Needle Aspiration in Patients With Lactational Breast Abscess: a Multi-center Randomized Double-blind Controlled Trial

10.21203/rs.3.rs-280421/v1 ◽

2021 ◽

Author(s):

Yi Zhang ◽

Yajun Gao ◽

Jing Qin ◽

Xiaoting Li ◽

Fei Jiang ◽

...

Keyword(s):

Controlled Trial ◽

Reaction Rates ◽

Needle Aspiration ◽

Healing Time ◽

Control Group ◽

Cure Rate ◽

Control Groups ◽

Clinical Trial Registry ◽

Double Blind ◽

And Control

Abstract Background: Studies show that oral probiotics can improve the breast microecology and thus alleviate the inflammatory response; however, there is a lack of experimental data corresponding to cases with existing abscesses. We aimed to investigate the effect of Lactobacillus fermentum CECT5716 during needle aspiration in patients with lactational breast abscesses.Methods: Patients (aged 20–41 years) with lactational single-cavity breast abscesses (diameter 3–6 cm) from 12 hospitals were randomly assigned to the experimental (n=51) and control groups (n=50). Outcome measures included the abscess cure rate on day-5 of treatment, delactation rate, relieving pain rate, and the number of needle aspirations until day-28.Results: The experimental group’s 5-day cure rate (43.1%, 22/51) was significantly higher (p<0.05). The breastfeeding continuation on day-5 did not differ significantly (experimental group: 88.2%, 45/51; control group: 96.0%, 48/50; p=0.269). In the experimental and control groups, 19.6% and 14.0% of patients experienced moderate to severe pain on day-5, respectively, with no statistically significant differences (p=0.451). The median number of needle aspirations up to day-28 was two in the experimental (1–3 times) and control (1–4 times) groups, with no statistically significant differences (Mann–Whitney U test, p=0.322). Four patients in each group developed diarrhea, with adverse reaction rates of 7.84% (4/51) and 8.0% (4/50), respectively. No adverse reactions were reported in the infants.Conclusion: L. fermentum can shorten the healing time in patients with lactational breast abscesses.Trial registration: This study was registered in the Chinese Clinical Trial Registry (http://www.chictr.org.cn), registration number: ChiCTR2000032682, registration date: May 6, 2020.

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The Effectiveness of the Implementation of the Flipped Classroom Learning Strategy on Motivation, Discipline and Learning Results

10.31227/osf.io/7av6d ◽

2019 ◽

Author(s):

Darmansyah

Keyword(s):

Flipped Classroom ◽

Learning Strategy ◽

Control Group ◽

Research Subject ◽

Classroom Learning ◽

Control Groups ◽

And Control ◽

Positive Effect ◽

Experimental Group ◽

Better Than

This study examined the effectiveness of the flipped classroom learning strategy on student’s motivation, discipline and learning results on the classroom action research subject. The research subject consists of 66 students grouped into experimental and control groups which were taught separately by using the flipped classroom learning strategy and a conventional discussion strategy. Flipped classroom learning strategy with technology has a significant positive effect on student’s motivation, discipline and learning results. It can be concluded that the experimental group of students taught by flipped classroom strategy is better than the control group in all three domains.

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Susceptibility to injury during a fall among blind children

Advances in Rehabilitation ◽

10.2478/rehab-2013-0039 ◽

2012 ◽

Vol 26 (2) ◽

pp. 63-70 ◽

Cited By ~ 1

Author(s):

Dariusz Boguszewski ◽

Martyna Zabłocka ◽

Jakub Adamczyk

Keyword(s):

Physical Activity ◽

Research Group ◽

Risk Groups ◽

Control Group ◽

Blind People ◽

Control Groups ◽

Blind Children ◽

And Control ◽

The Relationship ◽

Positive Effect

Abstract Introduction: The aim of this study was examine the relationship between ability of safe falls and occurrence injuries from the effect of falls, among blind children. Material and methods: More than one hundred children (10-16 years old) was in research and control groups. In the research group was 51 blind people, in control group 66 sighted in a proper manner. Test of Susceptibility to Injury During the Falls (TSIDF) by Kalina and interview directed to determine the number and frequency of falls and their consequences (number and type of injuries) and selected lifestyle factors were used as a research tools. Results: Blind children made more mistakes in test (TSIDF) than their non-disabled peers (although they are trained to safe falls). This may prove that a high susceptibility to injury of the children from the research group. However blind people had more injuries after the falls. Study confirmed positive effect of physical activity on the level of safe falls skills. Conclusion: Physical fitness, physical activity and especially exercises of safe falls skills can be important element of prevention of falls. This concern to high-risk groups, such as blind people.

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Effect of Preoperative Intravitreal Bevacizumab on the Surgical Outcome of Neovascular Glaucoma at Different Stages

Journal of Ophthalmology ◽

10.1155/2017/7672485 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Junki Kwon ◽

Kyung Rim Sung

Keyword(s):

Success Rate ◽

Surgical Outcome ◽

Intravitreal Bevacizumab ◽

Neovascular Glaucoma ◽

Control Group ◽

Ahmed Glaucoma Valve ◽

Control Groups ◽

And Control ◽

Positive Effect

Purpose. To evaluate the effect of preoperative intravitreal bevacizumab (IVB) injection on the surgical outcome of Ahmed glaucoma valve (AGV) implantation according to the angle status in neovascular glaucoma (NVG) eyes. Materials and Methods. This retrospective study included 70 NVG patients who underwent AGV implantation and were followed up for at least 12 months. An IVB injection before AGV implantation was administered to 45 eyes (IVB group), while it was not administered to 25 eyes (control group). Subgroup analyses were done at different stages in terms of the extent of peripheral anterior synechiae (PAS). Results. Mean follow-up period after AGV implantation was 27 ± 15 months. The IVB group showed higher prevalence of the eyes with less than 50% of PAS than that of the control group (78% versus 44%). The overall success rate 1 year postoperatively was 80% and 64% for the IVB and control groups, respectively (P=0.142). When PAS extent was less than 50%, preoperative IVB had a marginally positive effect on surgical outcome (HR = 0.39, P=0.064, per 1-time IVB injection). Conclusions. Preoperative IVB may enhance the success rate of AGV implantation in NVG eyes, before PAS has extensively formed. Further prospective randomized studies controlling the extent of PAS are warranted.

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Effects of Additive Feeding with Pollen and Water on Some Characteristics of Honeybee Colonies and Pine Honey Production

Turkish Journal of Agriculture - Food Science and Technology ◽

10.24925/turjaf.v3i12.948-951.576 ◽

2015 ◽

Vol 3 (12) ◽

pp. 948 ◽

Cited By ~ 3

Author(s):

Halil Yeninar ◽

Ethem Akyol ◽

Alaeddin Yörük

Keyword(s):

Control Group ◽

Not Given ◽

Control Groups ◽

Honey Production ◽

Adult Worker ◽

And Control ◽

Positive Effect ◽

Better Than ◽

Honey Yield

This study was carried out to determine the effects of additive feeding with pollen and water on honey yield, colony population, winter loses and wintering ability of colonies in pine honey production season in Muğla province of Turkey. Total twenty honeybee colonies had similar physiological pattern (queen age, genotype, amount of adult worker bees (number of frames covered with adult worker bees), sealed brood areas (cm2) and food stocks) were used and randomly divided into four groups. Three of them were fed extra with pollen+water, pollen and water. The control colonies were not given additive foods. Honey yield in pollen+water, pollen, water and control groups were found to be 24.2±1.1, 17.3±0.8, 16.3±1.0 and 12.0±0.6 kg/colony respectively. Group means were statistically significant. From September 25 to February 15 (wintering), losses of the adult worker bees in pollen+water, pollen, water and control groups were 50%, 69%, 68% and 82%, decrease of sealed brood areas in the groups were 48%, 66%, 68% and 85%, respectively. Wintering ability of pollen+water, pollen, water and control groups were found to be 92.1±3.2, 70.4±17.8, 67.1±16.7 and 51.0±21.2% respectively. The results showed that additive feeding in pine honey production season, especially feeding with both pollen+water provided nearly 100% more honey production and 80% better wintering ability than the control group. In addition, feeding with only pollen or water had similar positive effect (approximately 40%) better than control group

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The Effect of Using Cell Phone Dictionary on Improving Male and Female Iranian EFL Learners’ Spelling

International Journal of English Linguistics ◽

10.5539/ijel.v6n6p175 ◽

2016 ◽

Vol 6 (6) ◽

pp. 175

Author(s):

Amir Reza Nemat Tabrizi ◽

Mohammad Bagheri Fard

Keyword(s):

Cell Phone ◽

Control Group ◽

Control Groups ◽

Class Session ◽

Male And Female ◽

Efl Learners ◽

The Mean ◽

And Control ◽

Positive Effect ◽

Experimental Group

<p>This paper attempts to investigate the effect of using cell phone dictionaries on improving male and female Iranian high school EFL learners’ spelling. To this end, ninety participants were randomly selected from Dinodanesh and Etrat high schools in Lordegan city, and they were given a spelling pretest based on their course book. Then sixty subjects whose scores were within the range of one standard deviation above and below the mean were selected as homogeneous and divided into experimental and control groups. Using cell phone dictionaries was conducted in eight class session, during which experimental group received training with cell phone dictionaries while the control group only received training without any cell phone dictionaries. The data were collected via a pretest and a posttest. The analysis of the test scores using t-test revealed that the experimental group did statistically better in the test. The results revealed that using cell phone dictionary had positive effect on improving EFL learners’ spelling. At the end, a two-way ANOVA was run to compare the two groups plus the effect of gender on such performance. The results indicated that treatment have an effect on the improving of both male and female EFL learners’ spelling.</p>

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THE EFFECT OF REAL MODEL IN ENHANCING METACOGNITION OF ABSTRACT PHYSICS TOPIC

International Journal of Research -GRANTHAALAYAH ◽

10.29121/granthaalayah.v6.i6.2018.1383 ◽

2018 ◽

Vol 6 (6) ◽

pp. 389-395

Author(s):

I Wayan Distrik ◽

Chandra Ertikanto ◽

Agus Suyatna ◽

Wayan Suana

Keyword(s):

Control Group ◽

Control Groups ◽

Real Model ◽

Group Data ◽

Post Test ◽

Quasi Experimental ◽

And Control ◽

Positive Effect ◽

Metacognitive Ability ◽

Looking Back

This paper outlines the effect of REAL model in enhancing students' metacognitive abilities on abstract physics topics, such as electricity and magnetism. The study employed a pre-test and post-test quasi-experimental design with a control group. The experiment group (n = 30) was taught using the REAL model while control group (n = 30) was taught using the traditional method. REAL model includes recognizing the concept of targets through analogies, explaining concepts with multiple representations, applying concepts to sample solutions, and looking back at self-weakness through reflection self. Pre-test and post-tests were given at the beginning and at the end of the treatment for each group. Data were analyzed by descriptive and inferential methods. The results showed that REAL model has a positive effect in increasing students’ metacognitive ability shown by significant n-gain difference between experiment and control groups. During the study, students also felt motivated and more confident in solving physics problems shown by more than 80% of them responded positively to the learning model.

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Determination of the role of polymorphic variants of the interferon-gamma gene (IFNG) in the development of tuberculosis in the Yakut population

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2020-98-12-27-32 ◽

2021 ◽

Vol 98 (12) ◽

pp. 27-32

Author(s):

L. I. Mordovskaya ◽

M. V. Egorova ◽

T. M. Klimova ◽

S. D. Аlekseeva

Keyword(s):

Venous Blood ◽

Statistical Processing ◽

Control Group ◽

Case Group ◽

Control Groups ◽

Significant Difference ◽

Hardy Weinberg Equilibrium ◽

Polymorphic Variants ◽

And Control

The objective of the study: to determine the role of polymorphic variants T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the development of tuberculosis in the population of Yakut nationality.Subjects and methods. The case-control study was conducted. The subject for the study was DNA samples from 172 tuberculosis patients (the case group) and 367 people with an excluded diagnosis of tuberculosis (the control group). All participants of the study belonged to Yakut nationality. For genotyping, DNA was isolated from venous blood. The genotyping was performed by real-time polymerase chain reaction. For statistical processing, Pearson's χ2 test and odds ratio with 95% confidence intervals were used.The results of the study showed that the distribution of genotypes of polymorphisms T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the case and control groups corresponded to the Hardy – Weinberg equilibrium. There was no statistically significant difference in frequencies of alleles and genotypes of polymorphisms T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the patients from the case and control groups.Conclusions. The results of the study did not reveal the association of alleles and genotypes of the rs2430561 and rs2069718 polymorphic variants of the IFNG gene with the risk of developing tuberculosis for people of Yakut nationality.

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