scholarly journals Cause and Effect Relationship of Body Weight and Knee Osteoarthritis: Experience from a Tertiary Institution in South-Eastern Nigeria

2019 ◽  
Vol 2 (1) ◽  
pp. 9-13
Author(s):  
C G Oguzie ◽  
O A Lasebikan ◽  
C J Onyempka ◽  
D C Chukwumam ◽  
V C Asodike ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
Body Mass ◽  
Strong Support ◽  
The Elderly ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Tertiary Institution ◽  
Increased Risk ◽  
The Mean

It is well established that obesity is related to osteoarthritis of the knees. The aim of this study was to investigate the risk of knee osteoarthritis in relation to body mass index (BMI) and specifically, to assess the risk of knee osteoarthritis (OA) attributable to obesity. We also aimed to determine if there is a higher risk with an increase in BMI. This is an observational case-referent study of patients with knee pain. Patients were recruited from the orthopaedics clinic. The cases were patients that presented with radiologically diagnosed knee osteoarthritis, while the referents were other patients that also attended the orthopedic clinic at the same time. The referents were randomly selected. Body Mass Index was calculated and classified based on the WHO international classification. Data were analyzed using SPSS version 21. A total of 152 patients were included in the study and 67.1% were females while 32.9% were males giving a ratio of 2:1. The mean age was 57.72+/-12.5 years, the mean weight was 79.47+/- 13.41kg (95% CI 77.32 – 81.62) and the mean BMI was 27.80+/-6.2kg/m2. 56.6% had knee osteoarthritis. 8.6% (n = 13) were bilateral, 18.4% (n = 28) in the left knee and 29.6% (n = 45) in the right knee. The relationship between obesity and the presence of knee osteoarthritis was statistically significant (p 0.047). A Chi-squared test for trend also did not show an increased risk for knee osteoarthritis with increasing BMI (p 0.105). In conclusion, knee osteoarthritis is a degenerative joint disease that mostly affects the elderly. Our findings give strong support to the already existing knowledge of the positive relationship between obesity and knee osteoarthritis; however, increasing BMI did not increase the risk of knee OA.

scholarly journals Relationship between Body Mass Index (BMI) and Knee Osteoarthritis at the UKI General Hospital, Jakarta in 2017

2021 ◽  
Vol 11 (10) ◽  
pp. 365-377
Author(s):  
Ronald Vinantius Munthe ◽  
Wendy Hendrika ◽  
Natasya Yoreskitha Gurusinga
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
General Hospital ◽  
Body Mass ◽  
Joint Space Narrowing ◽  
Joint Space ◽  
Joint Disease ◽  
Key Words Knee ◽  
Cross Sectional ◽  
The Mean

Knee osteoarthritis is a degenerative joint disease usually suffered by elderly patients, contributing to the high risk of disability. The risk factors that affect the severity of knee osteoarthritis are obesity, age, sex, occupation, patient's history of the disease, trauma and other factors. Excessive body weight is a factor that exacerbates the disease of Osteoarthritis. Generally, this research is aimed to examine the correlation between Body Mass Index (BMI) and knee osteoarthritis at UKI General Hospital in 2017. The researcher used a descriptive-analytic study with a cross-sectional approach. In this study, the researcher used 30 samples. The results showed that there was a relationship between BMI and the incidence of knee osteoarthritis. This study indicates that BMI values above average (more than 24.9) can affect the occurrence of joint space narrowing in patients. Patients with abnormal BMI have a risk of 6,429 times the risk of joint space narrowing compared to patients with normal BMI. The mean BMI value of patients with knee osteoarthritis at UKI General Hospital is 25.6. Therefore, the researcher concluded that there is a correlation between BMI and knee osteoarthritis, in which a high BMI value (>24.9) may affect the occurrence of joint space narrowing among the patients. The mean BMI value among the osteoarthritis patients at UKI General Hospital is 25.6, indicating that most osteoarthritis patients are pre-obese/overweight. Key words: Knee osteoarthritis, Body Mass Index (BMI), joint space narrowing

Cognitive Decline, Body Mass Index, and Waist Circumference in Community-Dwelling Elderly Participants

2017 ◽  
Vol 30 (2) ◽  
pp. 67-76 ◽  
Author(s):  
Jorge Mario Rodríguez-Fernández ◽  
Emily Danies ◽  
José Martínez-Ortega ◽  
William C. Chen
Keyword(s):  
Body Mass Index ◽  
Waist Circumference ◽  
Cognitive Decline ◽  
Body Mass ◽  
Lean Mass ◽  
The Elderly ◽  
Community Dwelling ◽  
Increased Risk ◽  
Nationally Representative ◽  
Reduced Risk

Objective: The aim of this study was to explore the association of body mass index (BMI), waist circumference (WC), and BMI and WC changes over time with cognitive decline in a nationally representative sample. Methods: A total of 5239 participants (≥65 years) were followed for 3 years as part of the National Health and Aging Trends Study. Cox proportional hazard regression was applied to model the risk of cognitive decline. Results: BMI, after adjusting for WC and main confounders, was associated with reduced risk of cognitive decline (hazard ratio [HR] 0.97 for each unit BMI increase, 0.95-0.99). After stratifying by gender and age, this effect remained significant among females and young elders ≤80 years. A BMI decrease and WC increase >10% over the study period were associated with increased risk of cognitive decline (HR 1.98, 1.16-3.38; HR 1.30, 1.04-1.62, respectively). Conclusion: In the elderly individuals, lean mass, as measured by BMI adjusted for WC, was associated with reduced risk of cognitive decline. Loss of lean mass and gain of fat mass, as measured by WC adjusted for BMI, were associated with elevated risk of cognitive decline.

scholarly journals Serum Metabolites as Potential Biomarkers for Diagnosis of Knee Osteoarthritis

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Qingmeng Zhang ◽  
Heng Li ◽  
Zhendong Zhang ◽  
Fan Yang ◽  
Jiying Chen
Keyword(s):  
Knee Osteoarthritis ◽  
Metabolic Profile ◽  
Elderly Population ◽  
The Elderly ◽  
Ultra Performance Liquid Chromatography ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Healthy Controls ◽  
Knee Oa ◽  
Potential Biomarkers

Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic profiles of 40 patients with knee OA and 20 healthy controls (HC) were analyzed by ultra-performance liquid chromatography coupled to mass spectrometry. An OA-specific metabolic profile was established that can clearly discriminate patients with OA from HCs. Fourteen metabolites that are involved in the metabolism of amino acids, purine, energy, glycolysis, fatty acids, and lipids were significantly altered in patients with OA compared to HCs. These metabolites could be potentially used as biomarkers for the diagnosis of knee OA.

scholarly journals The correlation between body mass index and the risk of osteoporosis in Acehnese adult females in Zainoel Abidin General Hospital

2021 ◽  
Vol 5 (1) ◽  
pp. 113
Author(s):  
Nadia Safhira Putri Ananda ◽  
Husnah Husnah ◽  
Safrizal Rahman
Keyword(s):  
Body Mass Index ◽  
General Hospital ◽  
Body Mass ◽  
Sampling Technique ◽  
The Elderly ◽  
The Body ◽  
P Value ◽  
Cross Sectional ◽  
Adult Females ◽  
Increased Risk

Background: Osteoporosis is a condition in which bone become weak and brittle characterized with lower bone density and quality causing increased risk of fracture. The elderly is the most common group to be affected and female is more prone compared to male. One of modifiable risk factors of osteoporosis is low body mass index or underweight. This study aimed to investigate the correlation between body mass index and the risk of osteoporosis on Acehnese adult females in RSUDZA.Methods: This was an analytic observational-cross sectional study which was completed at the Internal Medicine and Orthopedic Policlinic at Zainoel Abidin General Hospital Banda Aceh from August 27th to September 13th 2019. The sampling method used was nonprobability sampling with accidental sampling technique. The body mass index was obtained by measuring respondents’ height and weight while the risk of osteoporosis was assessed by measuring OSTA Score.Results: Results showed that most of respondents was aged between 40-45 years old (55.4%) and there are 62 respondents (74.7%) with abnormal body mass index consisted of 9 underweight respondents (10.8%), 11 overweight respondents (13.3%), and 42 obese respondents (50.6%). The risk of osteoporosis was dominantly mild (69.9%). There were 7 underweight respondents (77.8) had moderate risk of osteoporosis while 2 underweight respondents had severe risk (22.2%). Meanwhile, 41 obese respondents had mild risk of osteoporosis (97.6%). Correlation test using Spearman showed p value 0.000 (p < 0.05) and rs = -0,731 which means that there is a strong correlation between body mass index and the risk of osteoporosis.Conclusions: Lower body mass index is directly proportional with higher risk of osteoporosis.

Underweight as a risk factor for esophageal squamous cellcarcinoma: A nationwide population-based study.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 14-14
Author(s):  
Yoon Jin Choi ◽  
Dong Ho Lee
Keyword(s):  
Body Mass Index ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Body Mass ◽  
Normal Weight ◽  
Heavy Alcohol ◽  
Increased Risk ◽  
Heavy Alcohol Use ◽  
The Mean

14 Background: Obesity is a well-known risk factor for the development of esophageal cancer (EC). However, the impact of underweight on esophageal squamous cell carcinoma (ESCC) has not been fully recognized to date. Therefore, we herein sought to determine the risk of EC in subjects with underweight. Methods: We analyzed the clinical data from a total of 264,084 individuals with the age of 40 years or older, who received healthcare checkups arranged by the national insurance program, between 2003 and 2008. Newly diagnosed EC was identified using the claims data during a median follow-up duration of 7.9 years. Results: The mean body mass index (BMI) of patients was 23.80 ± 3.05kg/m2, and 6,784 individuals (2.6%) were classified as being underweight (BMI < 18.5 kg/m2). During the study period, 278 individuals (0.1%) developed EC. It was determined that underweight and obesity—compared with normal weight—were significantly associated with 73% increased risk and 30% decreased risk of EC, respectively. Excess risk of EC in the underweight group was independent of age, gender, smoking, and alcohol consumption. Heavy alcohol use had a synergistically increasing effect for developing EC among those in the underweight group. Conclusions: The mean body mass index (BMI) of patients was 23.80 ± 3.05kg/m2, and 6,784 individuals (2.6%) were classified as being underweight (BMI < 18.5 kg/m2). During the study period, 278 individuals (0.1%) developed EC. It was determined that underweight and obesity—compared with normal weight—were significantly associated with 73% increased risk and 30% decreased risk of EC, respectively. Excess risk of EC in the underweight group was independent of age, gender, smoking, and alcohol consumption. Heavy alcohol use had a synergistically increasing effect for developing EC among those in the underweight group.

Body mass index and white matter lesions in elderly women. An 18-year longitudinal study

2004 ◽  
Vol 16 (3) ◽  
pp. 327-336 ◽  
Author(s):  
D. R. Gustafson ◽  
B. Steen ◽  
I. Skoog
Keyword(s):  
Body Mass Index ◽  
White Matter ◽  
Body Mass ◽  
Elderly Women ◽  
White Matter Lesions ◽  
Vascular Risk Factor ◽  
The Elderly ◽  
Overweight And Obesity ◽  
Increased Risk ◽  
Blood Pressures

Background: We investigated the longitudinal relationship between body mass index (BMI), a major vascular risk factor, and white matter lesions (WMLs) in older women.Methods: Twenty-seven Swedish women were followed from age 70 to 88. Measurements of BMI, and systolic and diastolic blood pressures were conducted at 70, 75, 79, 85, and 88 years. WMLs were measured using computerized tomography at age 85 and 88 (85/88).Results: Women with any WMLs at age 85/88 had higher BMI at age 70 (p=0.003) and 75 (p=0.006), compared to women without WMLs. Increasing severity of WMLs was related to BMI at age 70 (p<0.001), 75 (p<0.001), 79 (p=0.017), and 85 (p=0.025). After consideration of other vascular factors, BMI at age 70, 75, and 79 was most significantly related to WML at 85/88. Every 1.0 kg/m2 increase in BMI at age 70 increased risk of WMLs twofold.Conclusions: Overweight and obesity may be important contributors to the presence of WMLs in the elderly.

Body Mass Index of 23 or More is a Risk Factor for Hypertension and Hyperlipidemia in Japanese Workers

2007 ◽  
Vol 104 (3) ◽  
pp. 733-738 ◽  
Author(s):  
Tomoyuki Kawada ◽  
Maki Morihashi ◽  
Harumi Ueda ◽  
Takako Sirato
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Weight Control ◽  
Cross Sectional ◽  
Japanese Workers ◽  
Increased Risk ◽  
The Mean ◽  
Cross Sectional Design ◽  
Prevention Of Hypertension ◽  
The Relationship

In comparison with western populations, body mass index (BMI) of the Japanese population is typically lower. In this study, the relationship between BMI and other metabolic risk factors was examined in 1,130 male manufacturing workers surveyed from 2000 to 2003. The association between the BMI and the relative risk of hypertension was evaluated in a cross-sectional design using logistic regression analysis. The mean BMI in the subjects was 23.6 ( SD = 3.2). Of the total number of subjects, 26.6% and 3.3% were classified as pre-obese and obese, respectively. Multivariate analysis indicated that BMI of 23 or greater was significantly associated with an increased risk of hypertension and/or hyperlipidemia. Health education of weight control of borderline obesity of workers is important for the primary prevention of hypertension and hyperlipidemia in Japan.

scholarly journals Undiagnosed Hypertension among Youth (18-24 years) Referred to the Nutrition Clinic in Ardabil City, North West of Iran, from 2016 to 2018

2019 ◽  
Author(s):  
Fatemeh Ghannadiasl
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Stage I ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Undiagnosed Hypertension ◽  
Increased Risk ◽  
The Mean ◽  
Apparently Healthy

Introduction: Blood pressure among youth is associated with increased risk of future cardiovascular disease occurrence. The studies done on hypertension prevalence among young population are still insufficient. The purpose of this study was to determine undiagnosed hypertension, based on the Seventh Report of the Joint National Committee (JNC7) on Prevention, Detection, Evaluation and Treatment of High Blood Pressure updated guidelines among the apparently healthy young group of Iranian population. Methods: In this cross-sectional study, 901 volunteers, without previous hypertension history, in the age group of 18-24 years old (body mass index< 40 kg/m2) were assessed in Ardabil city from September 2016 to March 2008.They were apparently healthy youth and reported that their body weight had been stable for at least the last 3 months. Blood pressure was measured by standardized protocols based on American Heart Association guidelines, and the final value was obtained using the mean of the two careful readings of office blood pressure monitoring. Data were analyzed using Statistical Package for Social Sciences version 21.0. One-way analysis of variance was applied to determine the differences among hypertension groups, and p values <0.05 were considered statistically significant. Results: The mean of age, weight and body mass index was 19.48±1.64 (years), 60.54±11.45 (kg) and 21.39±3.17 (kg/m2), respectively. According to the JNC7 updated guidelines (2017), 17.4% subjects fell into elevated blood pressure whereas 2.1% and 1.7% into stage I and II hypertension category, respectively. Males were significantly more likely to have elevated blood pressure and stage I and stage II hypertension than females (p<0.001). Conclusion: According to the JNC7 updated guidelines, there is a significant prevalence of undiagnosed elevated blood pressure and hypertension (21.1%) among Iranian youth population. These results emphasize the need for careful monitoring of the blood pressure even among apparently healthy young adults.

scholarly journals Association between body mass index and the risk of atrial fibrillation and ischemic stroke according to age: a nationwide population-based cohort study

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
H J Ahn ◽  
S R Lee ◽  
E K Choi ◽  
K D Han ◽  
S I Kwon ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Body Mass Index ◽  
Cohort Study ◽  
Ischemic Stroke ◽  
Body Mass ◽  
Age Groups ◽  
The Elderly ◽  
Population Based ◽  
Age Group ◽  
Increased Risk

Abstract Background Atrial fibrillation (AF) and ischemic stroke (IS) are two significant cardiovascular diseases that confer an enormous healthcare burden. A limited study comprehensively evaluated the association between full ranges of body mass index (BMI), including underweight, and AF or IS risks, especially in the different age subgroups. Purpose We investigated the association between BMI and AF and IS incidence according to the Korean population's age groups. Methods This was a nationwide population-based cohort study using data from the Korea National Health Insurance Service, including 9 194 477 healthy adults who underwent a medical examination in 2009. We stratified the study population into three age subgroups: age 20–39 (young, 33.1%), age 40–64 (middle-aged, 56.3%), and age over 65 years (elderly, 10.6%). In each age group, the individuals were categorized based on BMI (kg/m2) into underweight (&lt;18.5), normal (18.5 to &lt;23), overweight (23 to &lt;25), obese I (25 to &lt;30), and obese II (≥30). The first occurrences of AF and IS were followed up until December 31, 2018. According to BMI in each age group, the risks of AF and IS were analyzed by Cox proportional hazards regression with 95% confidence intervals (CI) by adjusting age, sex, lifestyle behaviors, and comorbidities. Results Overall, both underweight and higher BMI were associated with an increased risk of AF and stroke across all age groups. The increased risk of AF for patients with obese II was slightly accentuated compared to patients with normal BMI in the young population than elderly population (hazard ratio [HR] 1.78, 95% CI 1.63–1.94 for age 20–39 years; HR 1.55, 95% CI 1.48–1.61 for age ≥65 years, respectively). For underweight individuals, however, the increased risk of AF became more prominent in the elderly: HR and 95% CI was 1.12 (1.07–1.17) in the age over 65 years old, and 1.05 (0.94–1.16) in the age 20–39. Regarding IS, the young group presented a considerable increment in the magnitude of HRs in both underweight and higher BMI groups. However, the association between the BMI and stroke risk became attenuated in the elderly: HRs and 95% CI in underweight and obese II individuals were 1.10 (0.93–1.30) and 2.223 (1.99–2.49) in the age 20–39 group, whereas 0.97 (0.93–1.01) and 1.03 (0.98–1.08) in the age over 65 years old. Conclusions Underweight as well as obesity was associated with increased risks of AF and IS in the general population. In both AF and IS, the gradient of risks according to BMI was apparent at young ages; thus, maintaining normal body weight should be warranted in early life. An interplay of several factors other than BMI may contribute to ischemic stroke in the old ages, requiring integrated risk management in older patients. FUNDunding Acknowledgement Type of funding sources: None.

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