scholarly journals Comparative study of efficacy of Gunja Beeja lepa and Shunthi Churna lepa in Inflammatory Conditions of Arthritis - A Randomized Controlled Single Blinded Clinical Study

2020 ◽  
Vol 11 (2) ◽  
pp. 200-204 ◽  
Author(s):  
Nilima Wadnerwar ◽  
Prasad K S R ◽  
Meena Deogade ◽  
Amol Kadu

Background: Life style disorders are an emerging problem in India where various types of arthritis are hampering the routine activities of people due to severe pain and inflammation. In such circumstances, everybody wants quick relief with the symptoms. Visha dravya used in Ayurveda are known for their quick action. Gunja (Abrus precatorius Linn) is a visha indicated in various diseases for internal and external use. Objectives: A randomized clinical study was conducted to assess the efficacy of Gunja beeja lepa to manage the local inflammatory conditions of Arthritis in comparison with a standard anti-inflammatory Ayurvedic drug Shunthi (Zingiber officinalis Linn) to provide a potent anti-inflammatory drug for the purpose of clinical practice. Material and methods: Patients suffering from transient mono or bi-arthropathies of knee were applied Gunja beeja lepa in comparison with local application of standard anti-inflammatory Ayurvedic drug Shunthi. Assessment was done with the help of Disease Activity Score (DAS-28-3) including three variables viz; tender joint score (Range 0-28), Swollen Joint Count (Range 0-28) and Erythrocyte sedimentation rate. Statistical comparisons were performed by both paired, unpaired student’s t test by using Sigma stat software (version 3.1) for both the experimental the groups at p<0.05 (level of significance). Result: Intervention with Gunja beeja lepa was statistically significant (p=0.003) in comparison with the intervention with Shunthi churna lepa. Conclusion: Gunja Beeja lepa is effective in comparison with standard anti-inflammatory Ayurvedic drug Shunthi in inflammatory conditions of Arthritis.

2016 ◽  
Vol 14 (2) ◽  
pp. 185-189 ◽  
Author(s):  
Karla Dalliane Batista Leal ◽  
Ramon Weyler Duarte Leopoldino ◽  
Rand Randall Martins ◽  
Lourena Mafra Veríssimo

ABSTRACT Objective To investigate potential intravenous drug incompatibilities and related risk factors in a pediatric unit. Methods A cross-sectional analytical study conducted in the pediatric unit of a university hospital in Brazil. Data on prescriptions given to children aged 0-15 years from June to October 2014 were collected. Prescriptions that did not include intravenous drugs and prescriptions with incomplete dosage regimen or written in poor handwriting were excluded. Associations between variables and the risk of potential incompatibility were investigated using the Student’s t test and ANOVA; the level of significance was set at 5% (p<0.05). Relative risks were calculated for each drug involved in potential incompatibility with 95% confidence interval. Results A total of 222 children participated in the study; 132 (59.5%) children were male and 118 (53.2%) were aged between 0 and 2 years. The mean length of stay was 7.7±2.3 days. Dipyrone, penicillin G and ceftriaxona were the most commonly prescribed drugs. At least one potential incompatibility was detected in about 85% of children (1.2 incompatibility/patient ratio). Most incompatibilities detected fell into the non-tested (93.4%), precipitation (5.5%), turbidity (0.7%) or chemical decomposition (0.4%) categories. The number of drugs and prescription of diazepam, phenytoin, phenobarbital or metronidazole were risk factors for potential incompatibility. Conclusion Most pediatric prescriptions involved potential incompatibilities, with higher prevalence of non-tested incompatibilities. The number of drugs and prescription of diazepam, phenobarbital, phenytoin or metronidazole were risk factors for potential incompatibilities.


Revista CERES ◽  
2017 ◽  
Vol 64 (1) ◽  
pp. 18-24
Author(s):  
Dayvid Vianêis Farias de Lucena ◽  
Fernanda Vieira Henrique ◽  
Amara Gyane Alves de Lima ◽  
Almir Pereira de Souza ◽  
Pedro Isidro da Nóbrega Neto

ABSTRACT The objective of this study was to investigate the effect of the ketoprofen on the preemptive analgesia in female cats submitted to ovariohysterectomy. Sixteen healthy cats were distributed into two groups, with eight animals each, by means of a draw, in a preemptive group (PREG), in which the animal received ketoprofen (1 mg/kg) subcutaneously two hours before the surgery; and postsurgery group (POSG), in which ketoprofen (1 mg/kg) was administered subcutaneously immediately after surgery. In both groups, ketoprofen was given 24, 48 and 72 hours after the first adminstration. Heart and respiratory frequencies and glycemia were measured in all animals during the days first ten postsurgery. Analgesia was measured by assigning scores at zero, two, four, six, 12, 24, 48, 72, 96, 120, 144, 168, 192, 216 and 240 hours after the surgical procedure. Statistical analysis was performed using two-way analysis of variance followed by Tukey's test to compare the moments and Student's t-test for comparison between groups. Pain scores were evaluated using test of U-Mann-Withney or Kruskall-Wallis, all at the 5% level of significance. Pain scores were significantly lower in PREG in M0, M6, M72, M96 and M120. No significant difference was found in the levels of glycemia in comparison to baseline values. Ketoprofen promotes postsurgery analgesia in female cats submitted to ovariohysterectomy and preemptive and postsurgery administration provides an earlier reduction of pain scores when compared to postoperative administration, only.


2009 ◽  
Vol 8 (3) ◽  
pp. 497-502
Author(s):  
Sandra Kalil Bussadori ◽  
Carlos Eduardo Bugano de Oliveira ◽  
Carolina Cardoso Guedes ◽  
Kristianne Porta Fernandes ◽  
Analúcia Ferreira Marangoni ◽  
...  

The aim of the study was to assess cephalometric abnormalities in the tegumentary profile of patients with Class II malocclusion. Twenty patients with average age of seven years and eight months were divided into: Group I - control, Class I, no malocclusions (n=10); Group II – Class II malocclusion (n=10). Standardized radiography was performed for the obtainment of the cephalometric points. Langlade’s classification was employed and the features were used: GN.Sn.Pog, ANL,A´-Gv, Pog´- Gv, Ls-GV, Li-GV, Sls-Gv, Sli-Gv. The Student’s t-test and Pearson’s correlation were used, with the level of significance set at 5%. The results show that the patients with Class II had more convex tegumentary profile, less protruded mid face and upper lip, less depth of the upper lip groove and more retracted lower lip and tegumentary chin, with statistically significant differences between groups (p0.005). The conclusion is that the patients with Class II malocclusion exhibited cephalometric abnormalities in the tegumentary profile.


2005 ◽  
Vol 19 (3) ◽  
pp. 209-215 ◽  
Author(s):  
Rejane Maria Holderbaum ◽  
Elaine Bauer Veeck ◽  
Helena Willhelm Oliveira ◽  
Carmem Lúcia Silva ◽  
Ângela Fernandes

The goal of this study was to evaluate skeletal, dental and chronological development in an HIV-positive group of children, as compared with a control group, during a four-year period. Panoramic radiographs and hand and wrist radiographs of 60 children were taken. The children, of both sexes, aged 5 years and 2 months to 15 years and 5 months, were selected as follows: 30 HIV-positive volunteers who had acquired the disease vertically, and 30 volunteers who did not present the HIV infection or any other systemic disease. All radiographs were technically standardized and analyzed according to criteria established by Nolla (dental age), Greulich and Pyle (bone age), and Eklöf and Ringertz (bone age). The results were submitted to Student's t-test at a 5% level of significance. Based on the comparison between the chronological age and the dental or the skeletal age, significant differences were observed between HIV-positive and HIV-negative children, both in 1999 and in 2003 (p < 0.05). Considering the results obtained with the methodology used, it was concluded that HIV-positive children of both sexes presented delayed bone development despite the administration of antiretroviral drugs, and that HIV-positive female children presented younger dental ages compared with their chronological ages in 1999 and in 2003; and HIV-positive males, in 1999.


Author(s):  
Emmanuel Ifeanyi Obeagu ◽  
Precious Omotunde ◽  
Getrude Uzoma Obeagu ◽  
Richard I. Eze ◽  
Ukamaka Edward ◽  
...  

Background: Obesity is a serious health problem, it increases heart-related diseases and its prevalence continues to increase due to genetic and lifestyle influences. This study aims to evaluate the hematological parameters of obese individuals based on gender in the Omisanjana region of Ado Ekiti, Ekiti state. Nigeria. Materials and Methods: The research is based on a cross-sectional study of obese and non-obese individuals in hospitals. The study was carried out in the Omisanjana area of ​​Ado Ekiti, Ekiti state. Fifty (50) obese individuals and fifty (50) apparently non-obese individuals were recruited as controls and participated in the study. The data are shown in the table and are expressed as mean ± standard deviation, and are analyzed using the Student's t test of the statistical software package for social sciences (SPSS, version 20.0), and the level of significance is established at p≤ 0.05. Results: The results showed no significant difference in PCV (p=0.3783), WBC (p=0.501), LYM (p=0.149), GRAN (p=0.336), MID (p=0.242), ,RBC (p=0.243), HGB (p=0.086), HCT (p=0.323), MCV (p=0.943), MCH p=0.097), MCHC (p=0.922), PLT (p=0.941), when compared between obese individuals and non-obese individuals based on sex respectively. Conclusion: The study showed no statistically significant changes, and it may be because there are no significant changes in the physiological factors and the growth factors of the precursor cells in the bone marrow, so the body mass index (BMI) has no effect on hematological parameters.


Author(s):  
Jagadees R. Pandarikkal ◽  
Annamma Kurien ◽  
Davis Paul

Background: There has been an increase in proportion of workers suffering from occupational diseases compared to past. Only limited studies have been conducted to evaluate the pulmonary functions of carpenters, exposed to wood dust. Hence the present study was undertaken to find out any functional impairment in carpenters due to their occupational environment.Methods: Study was done in 300 subjects who were divided into two groups of 150 each. One group comprised carpenters with minimum 5 years exposure to wood dust. Other group comprised matching healthy subjects who served as controls. Pulmonary function parameters were recorded from all subjects. Parameters recorded were SlowVital Capacity (SVC), Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), and Peak Expiratory flow Rate (PEFR).  ‘Knudson and Collagens’ standard reference values for south Indians were used here for interpretation. Statistical analysis of the data of study subjects and the controls were done by using student’s ‘t’ test. The level of significance was fixed as 5%.Results: A statistically significant reduction in SVC, FVC, FEV1and PEFR was seen in the study group compared to control group. FEV1/FVC was less than 80% of the predicted values in 8% of the study population. Seventeen percentage of the study population had less than 80% of predicted value of both FEV1 and FVC with normal FEV1/FVC.Conclusions: Lung functions of carpenters show statistically significant reduction compared to normal healthy adults. This could be due to their exposure to wood dust.


AYUSHDHARA ◽  
2021 ◽  
pp. 3276-3282
Author(s):  
Nisarga.M.S ◽  
Prakruthi G

Background and Objectives: Timira, one among the Drushtigata netraroga can be compared with many disorders from refractive errors to cataract. In the present study we have compared Timira to Refractive errors which is considered as one among the avoidable blindness. Clinical features of Prathama patalagata timira is similar with the signs and symptoms of refractive errors. Padabhayanga is considered as Chakshushya and we have references in classics stating the utility of the same. With this background we have planned the work by selecting BAMS Students as the participants which will also motivate and inspire them for conducting further research. Objectives: To evaluate the therapeutic effect of Padabhyanga in the management of Timira w.s.r. to Refractive error in BAMS Students. Methods: A Randomised clinical study was taken up to scientifically validate the effects of Padabhyanga wherein 20 patients of Timira were selected. Patients were treated with Padabhyanga for 48 consecutive days. The effect of treatment was statistically analyzed using Paired student’s ‘t’–test. Results: Based on the statistical analysis Padabhyanga had better effect on all parameters thus managing the condition successfully. Interpretation & Conclusion: Padabhyanga is the effective modality of treatment which can be adopted in Timira w.s.r. to Refractive errors as a part of Dinacharya which is cost effective with minimum time duration.


Author(s):  
MICHAEL S. OKPALEKE ◽  
VALENTINE C. IKAMAISE ◽  
KENNETH K. AGWU ◽  
ANTHONY C. UGWU ◽  
MICHAEL P. OGOLODOM

Objective: The objective of the study was to develop a reference luminal diameter (LD) of the abdominal aorta (AA) in Abuja, Nigeria. Methods: The LD of the AA of 422 male and female healthy subjects was measured sonographically using standard protocol. The relationship between age, body mass index (BMI), gender, and the LD of the AA was determined in the subjects. Statistical analysis was performed by the Student’s t-test and Pearson’s correlation coefficient at p < 0.05 level of significance. Results: The values of the LD of the AA in the healthy subjects were 15.16 ± 0.55 mm in males and 15.15 ± 0.55 mm in females. The 5th and 95th percentile normal reference limits of the AA were 14.20–16.10 mm, respectively. There were no significant differences in the LD measurements in male and female subjects. Age correlated strongly positively with LD (ɼ=0.90) of the AA in both genders. BMI showed weak positive correlation with LD (ɼ=0.136) of the AA in female healthy subjects only. Conclusion: The reference LD of the AA in the study population was 15.16 ± 0.55 mm in males and 15.15 ± 0.55 mm in females. The LD of the AA increased proportionately with age.


2021 ◽  
Vol 25 (1) ◽  
pp. 61-66
Author(s):  
Jorge Honorio M. Brito

The author describes the grading system used in the course of oral histology and embriology of the dentistry graduation at Federal University of Rio Grande do Sul, in wich the programmatic content is appraised through five partially cumulative written examinations concerning the five units that integrate the refered content. The results were compared and analyzed statistically by the Student's t test, for a level of significance of 0.01. The conclusion is for the validity of the method, wich provides a relearning, reenforcing the retention of the acquired knowledge in the mentioned discipline.


2002 ◽  
Vol 23 (6) ◽  
pp. 509-514 ◽  
Author(s):  
Lew C. Schon ◽  
Kelly W. Short ◽  
Olga Soupiou ◽  
Kenneth Noll ◽  
John Rheinstein

To evaluate the use of an immediate postoperative prosthesis (IPOP) for transtibial amputees, we compared patient outcomes from a prospective clinical study of 19 patients managed with an IPOP with those of a retrospective review of a matched historic control group of 23 patients managed with standard soft dressings. Data were analyzed with the Student's t-test, and significance was set at P=0.05. The IPOP patients had no surgical revisions, whereas the patients with standard soft dressings had 11. This was a significant difference. IPOP patients also had significantly fewer postoperative complications and shorter times to custom prosthesis than did controls.


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