Can Time of Implant Placement influence Bone Remodeling?

2016 ◽  
Vol 17 (4) ◽  
pp. 270-274
Author(s):  
Caroline Freitas Rafael ◽  
Bernardo Passoni ◽  
Carlos Araújo ◽  
Maria A de Araújo ◽  
César Benfatti ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Remodeling ◽  
Healing Process ◽  
Bone Architecture ◽  
Implant Placement ◽  
Equal Rate ◽  
Average Analysis ◽  
Immediate Implants ◽  
Group 2 ◽  
Group 1

ABSTRACT Since the alveolar process is tissue “dental dependent,” after the extraction of the dental element, this process suffers some degree of atrophy during the healing process, which can be reduced with the installation of immediate implants, aiming to maintain the original bone architecture. The aim of this study was to investigate the influence of the time of implant placement on bone formation around them. Seven dogs were selected and randomly divided into two groups: Group 1, where implants were placed immediately after extraction of two lower premolars without flap elevation, and group 2, where implants were delayed by 4 months after extractions. Each group received 14 implants, and 4 months after the second surgery, the samples were processed and analyzed histomorphometrically. A mean average analysis and the Kruskal–Wallis test (p < 0.05) were performed. The buccal bone–implant contact (BIC) mean average was found larger in immediate implants (42.61%) compared with delayed implants (37.69%). Group 1 had statistically higher outcomes in bone formation and BIC on the buccal bone wall. It was concluded that performing immediate implants with the palatal approach technique and leaving a buccal GAP enables a higher or at least equal rate to BIC and bone area around them, when compared with delayed implants. Actually, the patients and dentists want to do a shorter treatment with satisfactory results, but it is necessary to understand whether different times of implant placement can influence the results and longevity of the treatment. How to cite this article Rafael CF, Passoni B, Araújo C, de Araújo MA, Benfatti C, Volpato C. Can Time of Implant Placement influence Bone Remodeling? J Contemp Dent Pract 2016;17(4):270-274.

scholarly journals Contribution of the PDL to Osteotomy Repair and Implant Osseointegration

2017 ◽  
Vol 96 (8) ◽  
pp. 909-916 ◽  
Author(s):  
X. Pei ◽  
L. Wang ◽  
C. Chen ◽  
X. Yuan ◽  
Q. Wan ◽  
...  
Keyword(s):  
Bone Formation ◽  
Titanium Implants ◽  
Multiple Time ◽  
New Bone Formation ◽  
Extraction Socket ◽  
Minimally Invasive Surgical ◽  
Implant Placement ◽  
Extraction Site ◽  
Immediate Implants ◽  
Immediate Implant

Our objective was to clarify the fate of the periodontal ligament (PDL) retained in the socket after tooth extraction, then determine if this tissue contributed to the osseointegration of “immediate” implants placed in these fresh extraction sockets. Mice underwent maxillary first molar extraction, the residual PDL was removed by an osteotomy, and titanium implants were placed. The osteotomy was created in such a way that the palatal surface was devoid of PDL remnants while the buccal, mesial, and distal surfaces retained PDL fibers. At multiple time points after surgery, tissues were analyzed using a battery of molecular, cellular, and histomorphometrical assays. We found that PDL remnants mineralized and directly contributed to new bone formation in the extraction site. Compared with regions of an extraction site where the PDL was removed by osteotomy, regions that retained PDL fibers had produced significantly more new bone. Around immediate implants, the retained PDL remnants directly contributed to new bone formation and osseointegration. Thus, we conclude that PDL remnants are inherently osteogenic, and if the tissue is healthy, it is reasonable to conclude that curetting out an extraction socket prior to immediate implant placement should be avoided. This recommendation aligns with contemporary trends toward minimally invasive surgical manipulations of the extraction socket prior to immediate implant placement.

Development of a Segmental Long-bone Defect Model in Sheep

1998 ◽  
Vol 11 (01) ◽  
pp. 01-07 ◽  
Author(s):  
P. Frayssinet ◽  
E. Asimus ◽  
G. Chanoit ◽  
P. Collard ◽  
A. Autefage ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Healing ◽  
Healing Process ◽  
Biological Properties ◽  
Long Bone ◽  
Defect Model ◽  
Metatarsal Bones ◽  
Group 2 ◽  
Long Bone Defect ◽  
Group 1

SummaryA 10 mm-long (Group #1) or 20 mmlong (Group #2) segmental osteoperiosteal defect was performed on the metatarsus of ten adult ewes (5+5). The goal of the study was to search for a critical size defect model leading to nonunion. The bone gap was maintained for three months with an internal fixation device involving two plates set in orthogonal planes. Radiological and histological examinations were performed on harvested metatarsal bones. Three months after surgery Group #1 animals showed obvious signs of bone healing without achieving complete union in all cases. Evidence of a healing process was not observed in Group #2 animals, and histological examination confirmed the complete failure of bone repair in the 20 mm gaps. These results are comparable to those of other authors who have concluded that a bone gap corresponding to 1.4 times the diaphyseal diameter overshoots physiological bone healing capacities. This long bone defect model showed good biological properties allowing callus settlement with minimal impairment in Group #1 and permitted weightbearing and unrestricted motion in the animals. Such a sheep model would be useful for testing hard tissue biomaterials, bone healing enhancement or further developed as an experimental nonunion model.Metatarsal diaphyseal defects (length: 10 or 20 mm) maintained with plates were performed in sheep in search of nonunion after a three-month period. Radiological and histological examinations showed that 10 mm gaps healed spontaneously while 20 mm gaps did not. These results are comparable to those of other authors who concluded that a diaphyseal defect whose length exceeds 1.4 times its diameter is unable to repair. The good biological properties exhibited by this defect model seem to be convenient for testing bone substitutes or bone healing enhancement techniques.

scholarly journals Bone Formation and Adaptive Morphology of the Anterior Tibial Muscle in 3-mm Daily Lengthening Using High-Fractional Automated Distraction and Osteosynthesis with the Ilizarov Apparatus Combined with Intramedullary Hydroxyapatite-Coated Wire

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
A. V. Popkov ◽  
N. A. Kononovich ◽  
G. N. Filimonova ◽  
E. N. Gorbach ◽  
D. A. Popkov
Keyword(s):  
Bone Formation ◽  
Structural Adaptation ◽  
Anterior Tibial Muscle ◽  
Time Points ◽  
Ilizarov Frame ◽  
Anterior Tibial ◽  
Ilizarov Apparatus ◽  
Titanium Wire ◽  
Group 2 ◽  
Group 1

Purpose. We studied osteogenesis and morphofunctional features of the anterior tibial muscle using 3-mm high-frequency automated lengthening with the Ilizarov apparatus alone and in combination with intramedullary nailing. Material and Methods. Tibia was lengthened with a round-the-clock automated distractor at a 3-mm daily rate for 10 days in 16 mongrel dogs. In group 1 (n = 8), a 1.8-mm intramedullary titanium wire coated with hydroxyapatite was introduced into the tibial canal followed by Ilizarov frame mounting and transverse osteotomy of the diaphysis. Distraction mode was 0.025 mm x 120 increments a day. In group 2 (n = 8), distraction mode was the same but nailing was not used. Bone formation and the anterior tibial muscle were studied at two time points: (1) upon distraction completion; (2) three months after the apparatus removal. Bone formation was studied radiographically. Muscle preparations were examined histologically and stereomicroscopically. Results. There was a threefold reduction in the distraction time in both groups. Consolidation took 13.83±4.02 days in group 1 and 33.7±2.4 days in group 2. Muscle macropreparations of the experimental limb in group 1 at study time points did not show significant differences from intact tissues. Muscle histostructure in both groups was characterized by activation of angiogenesis and myohistogenesis, but the volumetric density of microvessels in the lengthening phase was three times higher in group 1. Conclusion. Combined technology significantly reduces the total lengthening procedure and does not compromise limb functions. Intramedullary HA-coated wires promote faster bone formation. The muscle was able to exhibit structural adaptation and plasticity of a restitution type.

Comparison of power-free-chop and phaco-chop techniques for moderate nucleus

2020 ◽  
Author(s):  
Haiqing Bai ◽  
Lin Yao
Keyword(s):  
Healing Process ◽  
Corneal Thickness ◽  
Dissipated Energy ◽  
Thickness Variation ◽  
Negative Effects ◽  
Chi Square ◽  
The Mean ◽  
Group 2 ◽  
Mean Time ◽  
Group 1

Abstract Background: To compare intraoperative and postoperative effects of power-free-chop and phaco-chop techniques for moderate nucleus in phacoemulsification sugery. Methods: Sixty patients were evaluated in 2 groups prospectively. The power-free-chop technique was performed in Group 1 (30 eyes) and the phaco-chop technique in Group 2 (30 eyes). There were no significant differerces between these 2 groups. The cumulative dissipated energy (CDE), time to achieve maximum vision, corneal thickness variation, and time to return to the preoperative values were collected. All parameters were statistically compared in these 2 groups by using the chi-square test and the independent-sample t test. Results: The CDE was 5.53±1.92J in Group 1 and 7.02±1.77J in Group 2. After the operation, the mean time to recover to the maximum vision was 2.80±1.42 days in Group 1 and 3.80±1.92 days in Group 2 respectively. The mean postoperative corneal thickness increased 36.9±14.74μm in Group1 and 46.20±20.67μm in Group 2. And the mean time to return to preoperative pachymetry values were 3.73±1.70 days and 4.83±2.11 days, in Group 1 and Group 2 respectively. There were significant differences in these parameters between both groups. Conclusions: The power-free-chop technique had fewer negative effects on the corneal endothelium as less ultrasound power was used for moderate nucleus cases. This can accelerate the functional healing process and the return to preoperative physiologic values.

scholarly journals Tyrosine-derived polycarbonate membrane in treating mandibular bone defects. An experimental study

2006 ◽  
Vol 3 (10) ◽  
pp. 629-635 ◽  
Author(s):  
Antti J Asikainen ◽  
Jukka Noponen ◽  
Christian Lindqvist ◽  
Mika Pelto ◽  
Minna Kellomäki ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Growth ◽  
Bone Defects ◽  
Membrane Thickness ◽  
New Bone Formation ◽  
Polycarbonate Membrane ◽  
Good Biocompatibility ◽  
The Difference ◽  
Group 2 ◽  
Group 1

This study was designed to evaluate the suitability of a novel bioabsorbable material in treating bone defects. A poly(desaminotyrosyl-tyrosine-ethyl ester carbonate) (PDTE carbonate) membrane (thickness 0.2–0.3 mm) was implanted into the mandibular angle of 20 New Zealand White rabbits to cover a through-and-through defect (12×6 mm). In group 1, the defects were left unfilled but covered with membrane and in group 2 the defects were filled with bioactive glass mesh and covered with membrane, too. Controls were left uncovered and unfilled. The animals were followed for 6, 12, 24 and 52 weeks, respectively. The material was evaluated by qualitative analysis of histological reactions and newly formed bone. We found that PDTE carbonate elicited a modest foreign body reaction in the tissues, which was uniform throughout the study. New bone formation was seen in all samples after six weeks. Group 1 had more new bone formation until 24 weeks and after this the difference settled. Based on findings of this study it was concluded that PDTE carbonate membranes have good biocompatibility and are sufficient to enhance bone growth without additional supportive matrix.

scholarly journals Comparison of power-free-chop and phaco-chop techniques for moderate nuclei

2020 ◽  
Author(s):  
Lin Yao ◽  
Haiqing Bai
Keyword(s):  
Healing Process ◽  
Corneal Thickness ◽  
Dissipated Energy ◽  
Thickness Variation ◽  
Negative Effects ◽  
Chi Square ◽  
The Mean ◽  
Group 2 ◽  
Mean Time ◽  
Group 1

Abstract Background: To compare the intraoperative and postoperative effects of power-free-chop and phaco-chop techniques for moderate nuclei in phacoemulsification surgery. Methods: Sixty patients were evaluated in 2 groups prospectively. The power-free-chop technique was performed in Group 1 (30 eyes), and the phaco-chop technique was performed in Group 2 (30 eyes). There were no significant differences between these 2 groups. The cumulative dissipated energy (CDE), time to achieve maximum vision, corneal thickness variation, and time to return to the preoperative values were collected. All parameters were statistically compared in these 2 groups by using the chi-square test and the independent-sample t -test. Results: The CDE was 5.53±1.92 J in Group 1 and 7.02±1.77 J in Group 2. After the operation, the mean time to recover to the maximum vision was 2.80±1.42 days in Group 1 and 3.80±1.92 days in Group 2. The mean postoperative corneal thickness increased 36.9±14.74 μm in Group 1 and 46.20±20.67 μm in Group 2. The mean time to return to preoperative pachymetry values was 3.73±1.70 days and 4.83±2.11 days in Group 1 and Group 2, respectively. There were significant differences in these parameters between the groups. Conclusions: The power-free-chop technique had fewer negative effects on the corneal endothelium, as less ultrasound power was used for moderate nucleus cases. This can accelerate the functional healing process and the return to preoperative physiologic values.

scholarly journals THE EFFECT OF PHOTODYNAMIC THERAPY AND PLATELET-ENRICHED PLASMA ON THE HEALING OF SKIN RADIATION ULCERS INFECTED BY STAPHYLOCOCCUS AUREUS

2020 ◽  
Vol 25 ◽  
pp. 338-352
Author(s):  
M. Krasnoselsky ◽  
◽  
O. Pushkar ◽  
L. Simonova ◽  
M. Myroshnychenko ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Radiation Ulcer ◽  
Group 3 ◽  
Group 2 ◽  
Radiation Ulcers ◽  
Infected Skin ◽  
Group 1

Objective. To determine in experiment the quality of healing of skin radiation ulcers infected with Staphylococcus aureus (S. aureus) under the photodynamic therapy (PDT) administration and the use of platelet-rich plasma (PRP). Materials and methods. The experiment was performed on 95 male WAG rats of 6 months of age, which were divided into three groups. Group 1 included animals in whom a skin radiation ulcers in the thigh area was simulated, followed by application of a 0.2 ml suspension of reference strain of S. aureus to its surface on the 7th day after irradiation. Group 2 included animals with S. aureus-infected skin radiation ulcers, in whom the PET was administered a day after infection contamination. Group 3 included animals with S. aureus-infected skin radiation ulcers, in whom the PDT was administered a day after infection in the morning, and the PRP was manifold injected in periwound area in the afternoon. The skin with underlying soft tissues from the area of radiation damage were the material for morphological examination. The hematoxylin and eosin, picrofuxin according to van Gizon, Mallory staining were applied to micropreparations. A morphometric study was conducted. Results. In animals with skin radiation ulcers, in whom the PDT was administered upon infection with S. aureus (group 2), compared with animals with simulated infected skin radiation ulcers without treatment (group 1), The activation (i.e. accelerating) of the healing occurred for the period from the 14th to the 52nd day of experiment due to the active processes of wound cleansing from necrotized tissues, less pronounced inflammatory changes in the lesion, and active of appearance and maturation of granulation tissue, less pronounced hemodynamic, ischemic and alternative disorders in the dermis, hypodermis, muscle tissue surrounding the wound cavity, activation of proliferative processes in epithelial layer localized in the marginal parts of the wound. Formation of pathological (hypertrophic or keloid) scar of the skin was the result of healing of skin radiation ulcer infected with S. aureus. In animals with radiation ulcers infected with S. aureus, in the case of PDT and PRP (group 3) the regenerative process was directed not only at accelerating the rate of healing, but also on restoration of original structure of the lost parts of the skin compared with only PDT administration (group 2). Acceleration of the healing of the infected skin radiation ulcer in animals of groups 2 and 3 was due to similar processes. Conclusions. Photodynamic therapy activates and accelerates the healing process of skin radiation ulcers infected with S. aureus and leads to formation of a pathological scar (hypertrophic or keloid). Healing of the infected S. aureus radiation ulcers occurs more actively upon the photodynamic therapy administration in combination with multiple periwound injections of the platelet-enriched plasma, compared with only photodynamic therapy administration, and finishes with an organotypic regeneration and almost complete skin recovery. Key words: photodynamic therapy, platelet-rich plasma, radiation skin ulcer, Staphylococcus aureus, morphology.

scholarly journals Factors Associated with Pain Intensity in Patients Undergoing Orthodontic Treatment Based on Mini-Implants

2021 ◽  
Vol 6 (2) ◽  
pp. 74-81
Author(s):  
Eugen Bud ◽  
Alexandru Vlasa ◽  
Manuela Chibelean ◽  
Krisztina Martha ◽  
Mariana Păcurar ◽  
...  
Keyword(s):  
Pain Intensity ◽  
Orthodontic Treatment ◽  
Bone Pain ◽  
Pain Perception ◽  
Implant Removal ◽  
Age Group ◽  
Factors Associated ◽  
Implant Placement ◽  
Group 2 ◽  
Group 1

Abstract Introduction: Pain is currently reported as the most common side effect associated with orthodontic treatment. The aim of this study was to evaluate the factors associated with the intensity of pain perception during orthodontic procedures consisting in anesthesia, orthodontic mini-implant placement and removal, as well as during the postoperative period following these procedures. Material and Methods: The study included 50 young adults with a permanent dentition in need of orthodontic treatment. The pain assessment was based on visual analogue scale (VAS), using self-report questions from approved questionnaires. Pain severity was analyzed in relation to: anesthesia, implant placement, implant removal, implant movement, elastic traction and gingiva/bone pain around the implant. The study lot was divided into Group 1 – patients experiencing a pain degree of 1 or 2, and Group 2 – patients experiencing a pain degree of 3 or 4 during implant placement. Results: The maximum pain intensity (PI) was recorded during implant placement, which has been associated with a PI of 2.4 ± 0.8 (95% CI: 2.17–2.63), followed by implant removal (PI = 2.36 ± 0.66, 95% CI: 2.17–2.54), gingiva/bone pain around the implant (PI = 2.32 ± 2.58, 95% CI: 2.15–2.48), and elastic traction (PI = 2.26 ± 0.63, 95% CI: 2.08–2.44). Male gender was present in a significantly higher extent in the group of patients presenting a high intensity pain during implant placement (86.3% in Group 2 vs. 3.5% in Group 1, p <0.0001). The age group most sensitive to pain was 18 to 21 years. Conclusions: In our study, pain perception was significantly higher in males and in the 18–21 years age group. The most painful procedure during surgery was the initial moment of implant placement, followed by the moment of implant removal, gingival/bone pain around the implant, and the elastic tractions placed on the implant during anchorage.

scholarly journals Accuracy of dental implant placement with computer-guided surgery: a retrospective cohort study

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Jeong-Kui Ku ◽  
Junggon Lee ◽  
Hyo-Jung Lee ◽  
Pil-Young Yun ◽  
Young-Kyun Kim
Keyword(s):  
Dental Implant ◽  
Drop Out ◽  
Cone Beam ◽  
Virtual Planning ◽  
Guided Surgery ◽  
Implant Placement ◽  
Group 2 ◽  
Implant Treatment ◽  
Approach Group ◽  
Group 1

Abstract Background The aim of this study was to assess the accuracy of virtual planning of computer-guided surgery based on the actual outcomes of clinical dental implant placement. Methods This retrospective study enrolled patients among whom implant treatment was planned using computer-guided surgery with cone beam computed tomography (CBCT). The patients who received implant according to the guide with the flapless and flapped approach were classified as group 1 and 2, respectively, and the others who could not be placed according to the guide were allocated to the drop-out group. The accuracy of implant placement was evaluated with the superimposition of CBCT. Results We analyzed differences in the deviated distance of the entrance point and deviated angulation of the insertion of implant fixtures. With regard to the surgical approach, group 2 exhibited greater accuracy compared to group 1 in deviation distance (2.22 ± 0.88 and 3.18 ± 0.89 mm, respectively, P < 0.001) and angulation (4.27 ± 2.30 and 6.82 ± 2.71°, respectively, P = 0.001). The limitations of guided surgery were discussed while considering the findings from the drop-out group. Conclusions Computer-guided surgery demonstrates greater accuracy in implant placement with the flapless approach. Further research should be conducted to enhance the availability of guides for cases with unfavorable residual bone conditions.

scholarly journals Histopathological effect of platelet-rich plasma on cranial dura mater defects

2021 ◽  
Vol 38 (4) ◽  
pp. 525-528
Author(s):  
Kemal PAKSOY ◽  
Kerameddin AYDIN
Keyword(s):  
Dura Mater ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Female Rats ◽  
Wound Healing Process ◽  
Surface Areas ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

There are many new studies in the selection of materials used in dura material repair. Platelet has important function in hemostasis and coagulation. Also, activated platelets initiate the wound healing process. They provide regeneration of tissue with the appropriate type of tissue. In this experimental study, we used platelet-rich plasma (PRP) on dura mater defect due to these properties. Materials and method: Our study started after we got the approval of Ondokuz Mayıs University Animal Experiments Local Ethics Committee. Thirty Wistar Albino female rats were used. The rats were divided into three groups, each one includes ten. Results: No significant difference was observed in the thickness and surface areas of dura mater in group 1 and group 2. Significant increase was observed in the thickness and surface areas of dura mater in the PRP applied group (Group 3) compared to other groups. New bone areas and new vasculature were observed more frequently in the PRP rooms group (Group 3). Statistical analysis of the data was done by using SPSS 21.0 for Mac (IBM Corporation) statistical package program and based on 0.05 significance level. A significant difference was observed between Group 1 and Group 3 (p> 0.05), a significant difference was observed between both Group 1 and Group 3 and between Group 2 and Group 3 (p <0.05). Conclusion: Providing the regeneration of dura mater in defect situations will contribute to the protection of the barrier feature. In line with this idea, it is thought that PRP can be beneficial for us to reach this goal.

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