Hair Growth Promoting Effects of 650 nm Red Light Stimulation on Human Hair Follicles and Study of Its Mechanisms via RNA Sequencing Transcriptome Analysis

In present investigation was carried out to screening of hair growth promoting potentiality of petroleum ether extract of Abrus precatorius leaf. Preliminary chemical tests and TLC analysis revealed the presence flavonoids and saponins. Hair growth promoting activity of petroleum ether of Abrus precatorius was screened by considering different parameters which included time taken for covering bald patch, length of hair produced, percentage of hair follicles in anagen and telogen phases, time of hair growth initiation and completion and level of minerals in blood. The petroleum ether extract of Abrus precatorius showed a very good hair growth promoting activity at a dose of 300 mg/kg which was comparable to that of 2% minoxidil. After 30 days of treatment with test and standard drugs it was observed that, time taken for covering the bald patch, hair growth initiation and completion time and quantitative hair growth were found to be comparable to that of the standard drug. An increase in percentage of hair follicles turning from telogen phase to anagen phase was noted. The control treated group of animals showed poor hair growth for all the parameters. Keywords: Abrus precatorius Linn, Anagen, Catagen, Telogen, Minoxidil

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Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth

Acta Dermato Venereologica ◽

10.1080/000155500459240 ◽

2000 ◽

Vol 80 (5) ◽

pp. 329-334 ◽

Cited By ~ 36

Author(s):

Nelly Billoni, Bruno Buan, Brigitte Gauti

Keyword(s):

Human Hair ◽

Hair Growth ◽

Hair Follicles ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptors

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Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation

Archives of Dermatological Research ◽

10.1007/s00403-017-1732-5 ◽

2017 ◽

Vol 309 (5) ◽

pp. 381-388 ◽

Cited By ~ 12

Author(s):

Hyunju Woo ◽

Seungjun Lee ◽

Seungbeom Kim ◽

Deokhoon Park ◽

Eunsun Jung

Keyword(s):

Hair Follicle ◽

Human Hair ◽

Hair Growth ◽

Sinapic Acid ◽

Dermal Papilla ◽

Human Hair Follicle ◽

Dermal Papilla Cells ◽

Akt Activation ◽

Growth Promoting

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Extract ofAllium tuberosum Rottler ex SprengPromoted the Hair Growth through Regulating the Expression of IGF-1

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/413538 ◽

2015 ◽

Vol 2015 ◽

pp. 1-11 ◽

Cited By ~ 7

Author(s):

Ki Moon Park ◽

Dong Woo Kim ◽

Seung Ho Lee

Keyword(s):

Growth Factor ◽

Hair Growth ◽

Control Mouse ◽

Ethanol Extract ◽

Insoluble Fraction ◽

Hair Follicles ◽

Gel Chromatography ◽

Skin Area ◽

Dorsal Skin ◽

Growth Promoting

Allium tuberosum Rottler ex Spreng(ATRES) has been used as a traditional medicine for the treatment of abdominal pain, diarrhea, and asthma. In this study, we investigated the hair growth promoting activities of ATRES on telogenic C57BL6/N mice. Hair growth was significantly increased in the dorsal skin of ethanol extract of ATRES treated mouse group compared with the control mouse group. To enrich the hair promoting activity, an ethanol-insoluble fraction was further extracted in sequence withn-hexane, dichloromethane, ethyl acetate,n-butanol, and distilled water. Interestingly, we found that extraction withn-butanol is most efficient in producing the hair promoting activity. In addition, the soluble fraction of then-butanol extract was further separated by silica gel chromatography and thin layer chromatography (TLC) resulting in isolating four single fractions which have hair growth regeneration potential. Furthermore, administration of ATRES extracts to dorsal skin area increased the number of hair follicles compared with control mouse group. Interestingly, administration of ATRES extract stimulated the expression of insulin-like growth factor-1 (IGF-1) but not of keratin growth factor (KGF) or vascular endothelial growth factor (VEGF). Taken together, these results suggest that ATRES possesses strong hair growth promoting potential which controls the expression of IGF-1.

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Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle

Scientific Reports ◽

10.1038/s41598-019-53612-5 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 5

Author(s):

Mira Choi ◽

Soon-Jin Choi ◽

Sunhyae Jang ◽

Hye-In Choi ◽

Bo-Mi Kang ◽

...

Keyword(s):

Growth Factor ◽

Mouse Model ◽

Organ Culture ◽

Human Hair ◽

Hair Growth ◽

Shikimic Acid ◽

Ex Vivo ◽

Hair Follicles ◽

Anagen Hair

AbstractShikimic acid (SA) has recently been found to be a major component of plant stem cells. The exact effects of SA on human hair follicles (HFs) is unknown. The purpose of this study was to examine the effects of SA on hair growth. We investigated the effect of SA on an in vivo C57BL/6 mouse model. We examined the expression of mannose receptor (MR), which is a known receptor of SA, in human HFs and the effect of SA on human dermal papilla cells (hDPCs), outer root sheath cells (hORSCs), and on ex vivo human hair organ culture. SA significantly prolonged anagen hair growth in the in vivo mouse model. We confirmed expression of the MR in human HFs, and that SA increased the proliferation of hDPCs and hORSCs. It was found that SA enhanced hair shaft elongation in an ex vivo human hair organ culture. SA treatment of hDPCs led to increased c-myc, hepatocyte growth factor, keratinocyte growth factor and vascular endothelial growth factor levels and upregulation of p38 MAPK and cAMP response element-binding protein levels. Our results show that SA promotes hair growth and may serve as a new therapeutic agent in the treatment of alopecia.

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Fibroblast Growth Factors Stimulate Hair Growth throughβ-Catenin and Shh Expression in C57BL/6 Mice

BioMed Research International ◽

10.1155/2015/730139 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 10

Author(s):

Wei-hong Lin ◽

Li-Jun Xiang ◽

Hong-Xue Shi ◽

Jian Zhang ◽

Li-ping Jiang ◽

...

Keyword(s):

Growth Factors ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Hair Growth ◽

Hair Follicles ◽

Control Group ◽

Fibroblast Growth ◽

Acidic Fibroblast Growth Factor ◽

Anagen Phase ◽

Growth Promoting

Growth factors are involved in the regulation of hair morphogenesis and cycle hair growth. The present study sought to investigate the hair growth promoting activities of three approved growth factor drugs, fibroblast growth factor 10 (FGF-10), acidic fibroblast growth factor (FGF-1), and basic fibroblast growth factor (FGF-2), and the mechanism of action. We observed that FGFs promoted hair growth by inducing the anagen phase in telogenic C57BL/6 mice. Specifically, the histomorphometric analysis data indicates that topical application of FGFs induced an earlier anagen phase and prolonged the mature anagen phase, in contrast to the control group. Moreover, the immunohistochemical analysis reveals earlier induction ofβ-catenin and Sonic hedgehog (Shh) in hair follicles of the FGFs-treated group. These results suggest that FGFs promote hair growth by inducing the anagen phase in resting hair follicles and might be a potential hair growth-promoting agent.

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