Further Thoughts on a New Quota Formula, and Statistical Appendices I and II

Policy Papers ◽  
2006 ◽  
Vol 2006 (64) ◽  
Author(s):  
Keyword(s):  
World Economy ◽  
Ad Hoc ◽  
Extensive Discussion ◽  
Board Of Governors ◽  
Selection Of Variables ◽  
Starting Point ◽  
Functional Forms ◽  
Key Issues ◽  
New Formula ◽  
Selection Of

The Board of Governors in a Resolution adopted on September 18 requested that the Executive Board reach agreement on a new quota formula, starting discussions soon after the Annual Meetings in Singapore. According to the Resolution, this work should be completed by the Annual Meetings in 2007, and no later than the IMFC Meeting in the Spring of 2008. The Resolution states that the new formula should provide a simpler and more transparent means of capturing members’ relative positions in the world economy. This new formula would provide the basis for a second round of ad hoc quota increases, as part of the program of quota and voice reform to be completed by the Annual Meetings in 2007, and no later than by the Annual Meetings of 2008. This paper explores key issues related to a new quota formula as background for an informal Board seminar. This seminar is the first opportunity for the Board to discuss the new formula since the adoption of the Resolution. The paper first reviews the broad considerations and principles that should guide the design of a new quota formula, taking as a starting point the roles of quotas in the Fund. The paper also considers more specific issues in that light, such as the selection of variables and possible functional forms for the new formula. In examining these issues, the paper draws on the extensive discussion of the quota formulas in recent years, taking up questions raised both within the Board and in other fora.

scholarly journals State of the art in selection of variables and functional forms in multivariable analysis—outstanding issues

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Willi Sauerbrei ◽  
◽  
Aris Perperoglou ◽  
Matthias Schmid ◽  
Michal Abrahamowicz ◽  
...  
Keyword(s):  
State Of The Art ◽  
Multivariable Analysis ◽  
Selection Of Variables ◽  
Functional Forms ◽  
Selection Of

Quota and Voice Reform - Stocktaking and Further Considerations, Statistical Appendices I and II, Statement by the Managing Director, and Summing Up of the Board Meeting

Policy Papers ◽  
2007 ◽  
Vol 2007 (47) ◽  
Author(s):  
Keyword(s):  
Low Income ◽  
Global Economy ◽  
World Economy ◽  
Emerging Market ◽  
Low Income Countries ◽  
Board Meeting ◽  
Executive Board ◽  
Board Of Governors ◽  
New Formula ◽  
The Voice

At its Spring Meeting, the IMFC reiterated the importance of implementing the program of quota and voice reforms in line with the timetable set out by the Board of Governors in Singapore. The Committee welcomed the initial informal Board discussions on a new quota formula and stressed the importance of agreeing on a new formula, which should be simple and transparent and should capture members’ relative positions in the world economy. It noted that this reform would result in higher shares for dynamic economies, many of which are emerging market economies, whose weight and role in the global economy have increased. The Committee also stressed the importance of enhancing the voice and participation of low-income countries, a key issue for which is an increase in basic votes, at a minimum preserving the voting share of low-income countries. The Committee called on the Executive Board to continue its work on the reform package as a matter of priority.

Using an Experimental Framework to Support Variables Selection: An Exploratory Study

2021 ◽  
Vol 31 (05) ◽  
pp. 677-692
Author(s):  
Lilian Passos Scatalon ◽  
Rogério Eduardo Garcia ◽  
Ellen Francine Barbosa
Keyword(s):  
Exploratory Study ◽  
Ad Hoc ◽  
Theoretical Foundation ◽  
Support Mechanism ◽  
Threats To Validity ◽  
Selection Of Variables ◽  
Variables Selection ◽  
Preliminary Study ◽  
Selection Of ◽  
Do So

The selection of variables in a given experiment is crucial, since it is the theoretical foundation that guides how data should be collected and analyzed. However, selecting variables is an intricate activity, especially considering areas such as Software Engineering and Education, whose studies should also consider human-related variables in the design. In this scenario, we aim to investigate how a support mechanism helps in the variables selection activity of the experiment process. To do so, we conducted a preliminary study on the use of an experimental framework composed of a catalog of variables. We explored the domain of the integration of software testing into programming education. Participants were divided into two groups (ad hoc and framework support) and asked to select variables for a given experiment goal. We analyzed the results by identifying threats to validity in their experimental design drafts. Results show a significant number of threats of type inadequate explication of constructs for both groups. Nonetheless, the framework helped to increase the clarity of concepts selected as variables. The cause of most raised threats, even with the framework support, was an inaccuracy in selecting the values of such variables (i.e. treatments and fixed values).

Tobacco’s Appeal to the Senses and the Early Modern Smoker’s Still Life

2020 ◽  
pp. 123-150
Author(s):  
Julia Saviello
Keyword(s):  
Still Life ◽  
Sense Data ◽  
Complex Image ◽  
Starting Point ◽  
Depth Analysis ◽  
Tobacco Pipes ◽  
Five Senses ◽  
The Senses ◽  
Cut Tobacco ◽  
Selection Of

Smell and taste – of the five senses these are the two most strongly stimulated by smoking tobacco. The article presents an in-depth analysis of the reflection of both these forms of sensory perception in textual and visual sources concerning the early consumption of the herb. In a first step, tobacco’s changing reception, first as medicine and then as stimulant, is traced through the years of its increasing distribution in Europe, starting in the middle of the 16th century. As this overview reveals, at that time the still little known substance gave rise to new forms of sense perception. Following recent studies on smell and gustation, which have stressed the need to take into account the interactions between these senses, the article probes the manifold stimulation of the senses by tobacco with reference to allegorical representations and genre scenes addressing the five senses. The smoking of tobacco was thematized in both of these art forms as a means of visualizing either smell or taste. Yet, these depictions show no indication of any deliberate engagement with the exchange of sense data between mouth and nose. The question posed at the end of this paper is whether this holds true also for early smoker’s still lifes. In the so-called toebakjes or rookertjes, a subgenre of stilllife painting that, like tobacco, was still a novelty at the beginning of the 17th century, various smoking paraphernalia – such as rolled or cut tobacco, pipes and tins – are arrayed with various kinds of foods and drinks. Finally, the article addresses a selection of such smoker’s still lifes, using the toebakje by Pieter Claesz., probably the first of its kind, as a starting point and the work by Georg Flegel as a comparative example. Through their selection of objects, both offer a complex image of how tobacco engages different senses.

Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana

2020 ◽  
Vol 16 (6) ◽  
pp. 784-795
Author(s):  
Krisnna M.A. Alves ◽  
Fábio José Bonfim Cardoso ◽  
Kathia M. Honorio ◽  
Fábio A. de Molfetta
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Binding Site ◽  
Point Of View ◽  
New Drugs ◽  
Leishmania Mexicana ◽  
Receptor Complexes ◽  
Starting Point ◽  
Dynamics Simulations ◽  
Selection Of

Background:: Leishmaniosis is a neglected tropical disease and glyceraldehyde 3- phosphate dehydrogenase (GAPDH) is a key enzyme in the design of new drugs to fight this disease. Objective:: The present study aimed to evaluate potential inhibitors of GAPDH enzyme found in Leishmania mexicana (L. mexicana). Methods: A search for novel antileishmanial molecules was carried out based on similarities from the pharmacophoric point of view related to the binding site of the crystallographic enzyme using the ZINCPharmer server. The molecules selected in this screening were subjected to molecular docking and molecular dynamics simulations. Results:: Consensual analysis of the docking energy values was performed, resulting in the selection of ten compounds. These ligand-receptor complexes were visually inspected in order to analyze the main interactions and subjected to toxicophoric evaluation, culminating in the selection of three compounds, which were subsequently submitted to molecular dynamics simulations. The docking results showed that the selected compounds interacted with GAPDH from L. mexicana, especially by hydrogen bonds with Cys166, Arg249, His194, Thr167, and Thr226. From the results obtained from molecular dynamics, it was observed that one of the loop regions, corresponding to the residues 195-222, can be related to the fitting of the substrate at the binding site, assisting in the positioning and the molecular recognition via residues responsible for the catalytic activity. Conclusion:: he use of molecular modeling techniques enabled the identification of promising compounds as inhibitors of the GAPDH enzyme from L. mexicana, and the results obtained here can serve as a starting point to design new and more effective compounds than those currently available.

scholarly journals Biomarkers of Angiogenesis and Neuroplasticity as Promising Clinical Tools for Stroke Recovery Evaluation

2021 ◽  
Vol 22 (8) ◽  
pp. 3949
Author(s):  
Lidia Wlodarczyk ◽  
Rafal Szelenberger ◽  
Natalia Cichon ◽  
Joanna Saluk-Bijak ◽  
Michal Bijak ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Stroke Recovery ◽  
Clinical Scales ◽  
Recovery Processes ◽  
Recovery Potential ◽  
Current State ◽  
Standard Procedures ◽  
Key Issues ◽  
Clinical Tools ◽  
Selection Of

Several key issues impact the clinical practice of stroke rehabilitation including a patient’s medical history, stroke experience, the potential for recovery, and the selection of the most effective type of therapy. Until clinicians have answers to these concerns, the treatment and rehabilitation are rather intuitive, with standard procedures carried out based on subjective estimations using clinical scales. Therefore, there is a need to find biomarkers that could predict brain recovery potential in stroke patients. This review aims to present the current state-of-the-art stroke recovery biomarkers that could be used in clinical practice. The revision of biochemical biomarkers has been developed based on stroke recovery processes: angiogenesis and neuroplasticity. This paper provides an overview of the biomarkers that are considered to be ready-to-use in clinical practice and others, considered as future tools. Furthermore, this review shows the utility of biomarkers in the development of the concept of personalized medicine. Enhancing brain neuroplasticity and rehabilitation facilitation are crucial concerns not only after stroke, but in all central nervous system diseases.

Reflections on the theme issue outcomes

2016 ◽  
Vol 8 (4) ◽  
pp. 504-510
Author(s):  
Gunjan M. Sanjeev ◽  
Richard Teare
Keyword(s):  
Customer Service ◽  
Hospitality Industry ◽  
Theme Issue ◽  
Policy Makers ◽  
Content Type ◽  
Starting Point ◽  
Cost Competitiveness ◽  
Hotel Sector ◽  
Practical Implications ◽  
Selection Of

Purpose The paper aims to profile the theme issue of Worldwide Hospitality and Tourism Themes titled “How is the need for innovation being addressed by the Indian hospitality industry?” with reference to the experiences of the theme editor, contributors from the industry and academia and the theme issue outcomes. Design/methodology/approach The paper uses structured questions to enable the theme editor to reflect on the rationale for their theme issue question, the starting-point, the selection of the writing team and material and the editorial process. Findings It highlights recent innovations that have taken place in the Indian hospitality industry especially in the areas of customer service, cost competitiveness, culinary management, revenue management and technology. Practical implications As hotel sector investment in India intensifies, this theme issue will be of interest to hoteliers, policy makers, analysts and others interested in the role that innovation can play in helping to facilitate differentiation between competing hotel products and services. Originality/value There is limited literature available on industry innovations in the Indian context. All the papers in this theme issue were written after several cycles of interaction between academics and practitioners and so they incorporate real–time, relevant and contemporary data.

scholarly journals Revisiting the CompCars Dataset for Hierarchical Car Classification: New Annotations, Experiments, and Results

Sensors ◽  
2021 ◽  
Vol 21 (2) ◽  
pp. 596
Author(s):  
Marco Buzzelli ◽  
Luca Segantin
Keyword(s):  
Real World ◽  
High Performance ◽  
Ad Hoc ◽  
Future Research ◽  
Levels Of Detail ◽  
Excellent Starting Point ◽  
Starting Point ◽  
Hierarchical Nature ◽  
Multiple Levels ◽  
Entire Dataset

We address the task of classifying car images at multiple levels of detail, ranging from the top-level car type, down to the specific car make, model, and year. We analyze existing datasets for car classification, and identify the CompCars as an excellent starting point for our task. We show that convolutional neural networks achieve an accuracy above 90% on the finest-level classification task. This high performance, however, is scarcely representative of real-world situations, as it is evaluated on a biased training/test split. In this work, we revisit the CompCars dataset by first defining a new training/test split, which better represents real-world scenarios by setting a more realistic baseline at 61% accuracy on the new test set. We also propagate the existing (but limited) type-level annotation to the entire dataset, and we finally provide a car-tight bounding box for each image, automatically defined through an ad hoc car detector. To evaluate this revisited dataset, we design and implement three different approaches to car classification, two of which exploit the hierarchical nature of car annotations. Our experiments show that higher-level classification in terms of car type positively impacts classification at a finer grain, now reaching 70% accuracy. The achieved performance constitutes a baseline benchmark for future research, and our enriched set of annotations is made available for public download.

Informed Evaluation of Pathology Residency Programs

2000 ◽  
Vol 124 (6) ◽  
pp. 853-858
Author(s):  
Rebecca F. Yorke
Keyword(s):  
Web Sites ◽  
Recent Literature ◽  
Training Programs ◽  
Data Extraction ◽  
Clinical Pathology ◽  
Study Selection ◽  
Starting Point ◽  
Key Issues ◽  
Pathology Training ◽  
Pathology Education

Abstract Objectives.—To identify resources and summarize important issues in anatomic and clinical pathology training and to assist the pathology resident candidate in evaluating potential training programs. Data Sources.—Published guides for medical residency applicants, recent literature discussing pathology education, and World Wide Web sites. Study Selection.—Resources perceived by the author as valuable for the pathology resident candidate. Data Extraction.—Key issues in pathology education are identified. Data Synthesis.—Issues are discussed from the perspective of a pathology resident candidate, and resources for further information are provided. Conclusions.—The pathology residency candidate faces unique challenges in the residency search process because of the breadth of pathology training and the limited exposure to the practice of pathology in medical school. General guides for residency applicants include little discussion of pathology-specific issues. Recent literature discussing pathology education is fragmented but provides invaluable insights for resident candidates. This review seeks to identify a wide variety of issues and resources as a starting point for evaluating potential training programs.

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