The Ins and Outs of a ‘Cancer Village’

2020 ◽  
Author(s):  
Chen Ajiang
Keyword(s):  
Drinking Water ◽  
Liver Cancer ◽  
Media Coverage ◽  
Analytical Framework ◽  
Huai River ◽  
High Incidence ◽  
Water Courses ◽  
Water Conservancy ◽  
The Huai River Basin

This chapter discusses a research site in the Huai River Basin, using the perspective of ‘ins and outs’ as an analytical framework. The pollution in Huangmengying Village mostly comes from upstream, but water conservancy projects, the nature of water courses and flows of pollution also have an impact. Media coverage of cancer in the area emphasized the role of external pollution from industry, but this study also found a relationship between smoking and cancer among men and between hepatitis B and liver cancer. There was also an association between drinking water and the high incidence of digestive tract diseases, which declined when the water supply was improved. The phenomenon of ‘cancer villages’ is therefore also shaped by the living conditions and lifestyle of the villagers.

Producing anti-regime protest news in a polarized and clientelistic media system: A frame building approach

Journalism ◽  
2021 ◽  
pp. 146488492110366
Author(s):  
Lindita Camaj
Keyword(s):  
Media Coverage ◽  
Analytical Framework ◽  
Structural Factors ◽  
Individual Level ◽  
Frame Building ◽  
System A ◽  
Media System ◽  
The Individual ◽  
Depth Interviews

This study examines media coverage of the 2019 anti-government protests in Montenegro. Based on 13 in-depth interviews and a quantitative content analysis, the data shed light on ways in which democratization struggles are manifested via protest framing in a polarized media system. This paper argues that media clientelism, as manifested through political parallelism and media instrumentalization, provides a better theoretical and analytical framework to understand not only the influence of structural factors that determine protest coverage, but also the role of ideology and journalism cultures embraced at the individual level. This framework is helpful to understand the role of media in democratic struggle not only in emerging and defective democracies, but also in increasingly polarizing societies in the West.

Role of p38gamma-delta in liver cancer

2012 ◽  
Vol 120 (10) ◽  
Author(s):  
A Tomas Loba ◽  
E Manieri ◽  
G Sabio
Keyword(s):  
Liver Cancer

Role of the IQGAP1/IQGAP2 imbalance in Liver Cancer

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
F Pinna ◽  
R Pellegrino ◽  
O Neumann ◽  
J Baues ◽  
A Eberhardt ◽  
...  
Keyword(s):  
Liver Cancer

Board of Director Characteristics, Institutional Ownership, and Fraud: Evidence from Australia

2004 ◽  
Vol 23 (2) ◽  
pp. 105-117 ◽  
Author(s):  
Vineeta D. Sharma
Keyword(s):  
Research Evidence ◽  
Institutional Ownership ◽  
Board Of Director ◽  
Composition And Structure ◽  
High Incidence ◽  
The Board Of Directors ◽  
Director Characteristics ◽  
The Relationship ◽  
The U.S

Due to the high incidence of fraud in Australia, regulatory reports suggest strengthening the monitoring role of the board of directors (BOD). These reports recommend greater independence and no duality (chairperson of the BOD should not be the CEO) on the BOD. While there is no Australian evidence, research evidence in the U.S. supports these suggested reforms. It is not clear whether the research evidence observed in the U.S. will generalize to the Australian setting because of contextual differences. This study extends the U.S. findings to the Australian context and investigates the relationship between two attributes of the BOD, independence and duality, and fraud. In addition, I examine whether institutional ownership plays a role in the context of fraud. The more highly concentrated institutional ownership in Australia suggests the presence of some relationship. Using a matched sample of fraud and no-fraud firms from 1988–2000, I find that as the percentage of independent directors and the percentage of independent institutional ownership increases, the likelihood of fraud decreases. As expected, the results show a positive relationship between duality and the likelihood of fraud. These results support the call for strengthening the composition and structure of the BOD in Australia.

ROLE OF SCIENCE IN POLICY, SYSTEMS STRENGTHENING AND SUSTAINABLE SERVICE DELIVERY OF ARSENIC SAFE DRINKING WATER

2019 ◽  
Author(s):  
Prosun Bhattacharya ◽  
◽  
Md. Tahmidul Islam ◽  
Dara Johnston ◽  
Nargis Akter ◽  
...  
Keyword(s):  
Drinking Water ◽  
Service Delivery ◽  
Safe Drinking Water ◽  
Policy Systems

scholarly journals Possible Role of IRS-4 in the Origin of Multifocal Hepatocellular Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2560
Author(s):  
Luis G. Guijarro ◽  
Patricia Sanmartin-Salinas ◽  
Eva Pérez-Cuevas ◽  
M. Val Toledo-Lobo ◽  
Jorge Monserrat ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Hepg2 Cells ◽  
Cellular Polarity ◽  
Ki 67 ◽  
Tissue Samples ◽  
Vitro Analysis ◽  
Tumoral Cells

New evidence suggests that insulin receptor substrate 4 (IRS-4) may play an important role in the promotion of tumoral growth. In this investigation, we have evaluated the role of IRS-4 in a pilot study performed on patients with liver cancer. We used immunohistochemistry to examine IRS-4 expression in biopsies of tumoral tissue from a cohort of 31 patient suffering of hepatocellular carcinoma (HCC). We simultaneously analyzed the expression of the cancer biomarkers PCNA, Ki-67, and pH3 in the same tissue samples. The in vitro analysis was conducted by studying the behavior of HepG2 cells following IRS-4 overexpression/silencing. IRS-4 was expressed mainly in the nuclei of tumoral cells from HCC patients. In contrast, in healthy cells involved in portal triads, canaliculi, and parenchymal tissue, IRS-4 was observed in the cytosol and the membrane. Nuclear IRS-4 in the tumoral region was found in 69.9 ± 3.2%, whereas in the surrounding healthy hepatocytes, nuclear IRS-4 was rarely observed. The percentage of tumoral cells that exhibited nuclear PCNA and Ki-67 were 52.1 ± 7%, 6.1 ± 1.1% and 1.3 ± 0.2%, respectively. Furthermore, we observed a significant positive linear correlation between nuclear IRS-4 and PCNA (r = 0.989; p < 0.001). However, when we correlated the nuclear expression of IRS-4 and Ki-67, we observed a significant positive curvilinear correlation (r = 0.758; p < 0.010). This allowed us to define two populations, (IRS-4 + Ki-67 ≤ 69%) and (IRS-4 + Ki-67 > 70%). The population with lower levels of IRS-4 and Ki-67 had a higher risk of suffering from multifocal liver cancer (OR = 16.66; CI = 1.68–164.8 (95%); p < 0.05). Immunoblot analyses showed that IRS-4 in normal human liver biopsies was lower than in HepG2, Huh7, and Chang cells. Treatment of HepG2 with IGF-1 and EGF induced IRS-4 translocation to the nucleus. Regulation of IRS-4 levels via HepG2 transfection experiments revealed the protein’s role in proliferation, cell migration, and cell-collagen adhesion. Nuclear IRS-4 is increased in the tumoral region of HCC. IRS-4 and Ki-67 levels are significantly correlated with the presence of multifocal HCC. Moreover, upregulation of IRS-4 in HepG2 cells induced proliferation by a β-catenin/Rb/cyclin D mechanism, whereas downregulation of IRS-4 caused a loss in cellular polarity and in its adherence to collagen as well as a gain in migratory and invasive capacities, probably via an integrin α2 and focal adhesion cascade (FAK) mechanism.

scholarly journals The Impact of Ultraviolet Radiation on the Aetiology and Development of Uveal Melanoma

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1700
Author(s):  
Melissa Chalada ◽  
Charmaine A. Ramlogan-Steel ◽  
Bijay P. Dhungel ◽  
Christopher J. Layton ◽  
Jason C. Steel
Keyword(s):  
Risk Factors ◽  
Ultraviolet Radiation ◽  
Uveal Melanoma ◽  
World Health Organisation ◽  
World Health ◽  
Genetic Mutations ◽  
High Incidence ◽  
The World ◽  
The Impact

Uveal melanoma (UM) is currently classified by the World Health Organisation as a melanoma caused by risk factors other than cumulative solar damage. However, factors relating to ultraviolet radiation (UVR) susceptibility such as light-coloured skin and eyes, propensity to burn, and proximity to the equator, frequently correlate with higher risk of UM. These risk factors echo those of the far more common cutaneous melanoma (CM), which is widely accepted to be caused by excessive UVR exposure, suggesting a role of UVR in the development and progression of a proportion of UM. Indeed, this could mean that countries, such as Australia, with high UVR exposure and the highest incidences of CM would represent a similarly high incidence of UM if UVR exposure is truly involved. Most cases of UM lack the typical genetic mutations that are related to UVR damage, although recent evidence in a small minority of cases has shown otherwise. This review therefore reassesses statistical, environmental, anatomical, and physiological evidence for and against the role of UVR in the aetiology of UM.

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