scholarly journals Preparation and Evaluation of Antioxidant, Antimicrobial Activity of Seaweed (Kappaphycus alvarezii) based Herbal Hair Oil Formulation

2021 ◽  
Vol 23 (08) ◽  
pp. 314-325
Author(s):  
Pradeepa Duraisamy ◽  
◽  
Keerthika S ◽  
Aswani Ram Vinod ◽  
Dhana Rangesh Kumar V ◽  
...  
Keyword(s):  
Kappaphycus Alvarezii ◽  
Skin Irritation ◽  
Brown Seaweed ◽  
Biological Evaluation ◽  
The Other ◽  
Good Growth ◽  
Omega 3 ◽  
Aloe Barbadensis ◽  
Herbal Plants ◽  
Skin Irritation Test

The present uses of seaweed Kappaphycus alvarezii are as human foods, cosmetics, fertilizers, and for the extraction of industrial gums, chemicals and most importantly seaweeds are rich in source of Omega-3 fatty acid. The aim of present study involves preparation of poly herbal hair oil using methanol extract of brown seaweed and the other herbal plants. The prepared herbal oil was subjected to phytochemical screening, antioxidant activity, antibacterial activity, general characterization, physical and biological evaluation. The current studym involves preparation of poly herbal hair oil using Kappaphycus alvarezii, Aloe barbadensis miller, Murrays Koenigii and Ocimum tenuiflorum. The oil was prepared according to Ayurvedic pharmacopeia. The prepared formulations are assessed for primary skin irritation test on our forearm. The above said parameters were found to be good and within the standards. All the values in the evaluation of finished K. alvarezii based herbal oil showed that they are within the acceptable limits. It is a very good attempt to establish the herbal hair oil containing methanol extracts of red seaweed and the other herbal plants. Hence, it is concluded that the oil is beneficial in maintaining good growth of hairs, turning grey hairs to black, providing protection from dandruff, and results in lustrous looking hairs.

scholarly journals Formulation and Evaluation of Polyherbal Oil

2021 ◽  
pp. 690-697
Author(s):  
Neha N. Jagatap
Keyword(s):  
Radical Scavenging Activity ◽  
Skin Irritation ◽  
Radical Scavenging ◽  
Coconut Oil ◽  
Acid Value ◽  
Stability Study ◽  
Aloe Barbadensis ◽  
Plant Materials ◽  
Irritation Test ◽  
Skin Irritation Test

The aim of present study involves preparation of polyherbal hair oil using plant materials. The prepared polyherbal hair oil evaluated different parameters within the acceptable limits. Such as phytochemical screening, organoleptic characterization, specific gravity, pH, viscosity, acid value, saponification value, refractive index, and also stability study. Antimicrobial assay of the polyherbal hair oil was studied by the zone inhibition method. And these helps reduces dandruffs and scalp of hairs. And to provide nutrition’s of hairs. The antioxidant activity of the oil was studied by DPPH radical scavenging activity. The primary skin irritation test is carried out. Hence, these polyherbal hair oil increases hair growth, reduces hair loss, providing protection against dandruff. Now-a-days increasing demand of herbal formulation than synthetic formulation. They have better safety and also fewer side effects. Polyherbal hair oil using various fresh leaves of Hibiscus Rosa Sinesis, Aloe Barbadensis leaf, curry leaves, amla, shikekai. These formulations coconut oil as the base. Hair care products used both hair tonic as well as hair grooming aids.

scholarly journals Preparation and evaluation of poly herbal hair oil

2019 ◽  
Vol 9 (1) ◽  
pp. 68-73
Author(s):  
B. Ramya Kuber ◽  
Ch. Lavanya ◽  
Ch.Naga Haritha ◽  
S. Preethi ◽  
G. Rosa
Keyword(s):  
Skin Irritation ◽  
Radical Scavenging ◽  
Acid Value ◽  
The Body ◽  
Good Growth ◽  
Stability Studies ◽  
Irritation Test ◽  
Skin Irritation Test ◽  
Wrightia Tinctoria ◽  
Herbal Formulations

In Ayurvedic medicine, herbs are used as an integral part of health care system. Besides healthcare, herbs are also used for beautification of the body and for preparation of various cosmetics and colours. The aim of present study involves preparation of poly herbal hair oil using fresh leaves of various plants. The prepared herbal oils were subjected to phytochemical screening, General characterization, Physical and Biological evaluation.The aim of present study involves preparation of poly herbal hair oil using fresh leaves of Sphaeranthus indicus, Wrightia tinctoria, Eclipta alba, Hibiscus Rosa sinensis. The oil was prepared according to Ayurvedic pharmacopeia. The evaluation of prepared poly herbal hair oil was carried out by various parameters such as organoleptic, phytochemical, specific gravity, pH, viscosity, acid value, saponification value, refractive index and stability studies. Antimicrobial activity of the poly herbal hair oil was studied by the zone of inhibition method. The Antioxidant activity of the oil was studied by DPPH radical scavenging test. The prepared formulations are assessed for primary skin irritation test on our forearm. Above parameters were found to be good and within the standards and among three concentrations of prepared poly herbal hair oil, third concentration showed better results than other two concentrations. All the values in the evaluation of finished product showed that they are within the acceptable limits. Hence, it is concluded that the oil is beneficial in maintaining good growth of hairs, turning grey hairs to black, providing protection from dandruff, and results in lustrous looking hairs. Keywords: Hair, Herbal formulations, Hair oil, Stability studies.

A Composite Model for Multiple Assays of Skin Irritation

1986 ◽  
Vol 2 (3) ◽  
pp. 309-320 ◽  
Author(s):  
George Cruzan ◽  
Walden E. Dalbey ◽  
Christopher J. D'Aleo ◽  
Edward J. Singer
Keyword(s):  
Petroleum Refinery ◽  
Skin Irritation ◽  
Test Site ◽  
Composite Model ◽  
The Other ◽  
Test Material ◽  
Boiling Range ◽  
Irritation Test ◽  
Skin Irritation Test ◽  
Skin Irritants

A model for skin irritation was developed for simultaneous evalua tion of the influence on irritation of abrasion, occlusion, and dura tion of treatment and for fulfillment of requirements for labeling considerations under DOT, CPSC-FHSA, OSHA, and EEC. This model greatly reduces the number of animals required to address submissions under multiple agencies compared to performing each test separately. In this model, which we have called a Composite Skin Irritation test, a test material is placed on three pairs of intact and abraded sites on each rabbit; one pair of sites is occluded for 4 hours, one for 24 hours, and the other left unoccluded for 24 hours. Results are presented from 88 composite tests with 80 petroleum- related materials. For the materials tested, abrasion of the skin had no effect on the irritation response. Occlusion of the test site gener ally did not result in dramatic increases in response, except for petroleum refinery streams with a boiling range below 500° F. Exposure for 4 hours rather than 24 hours generally resulted in less irritation; however, for individual compounds, -the irritation from the 4-hour exposure could not be predicted from the response to the 24-hour exposure. Of the 80 materials tested, 12 would be labeled as skin irritants under CPSC guidelines, three under OSHA, and 20 under EEC. Of the 20 that would be labeled under EEC criteria, only seven would be labeled under CPSC criteria. At least for petroleum-related materials, results from skin irritation studies performed under one set of conditions cannot be used to predict the degree of irritation that would be produced under a dif ferent set of exposure conditions.

NEW GENERATION FEED ADDITIVE IN POULTRY BREEDING

1970 ◽  
pp. 67-69
Author(s):  
L. I. Naumova ◽  
М. Т. Klychnikov ◽  
N. F. Klychnikova
Keyword(s):  
Laying Hens ◽  
Far East ◽  
Brown Seaweed ◽  
Test Group ◽  
Live Weight ◽  
Production Quality ◽  
Feed Additive ◽  
Poultry Production ◽  
Omega 3 ◽  
Mineral Substances

The analysis of different doses of complex feed additive to poultry ration have been made. The influence of new feed additive with bioresources of the Far East use on productive poultry indexes, on production quality and digestibility of nutritious matters of mixed feed has been studied. Patrinia scabiosifolia, Acanthopanax sesseliflorum, cones of cedare nut husk, brown seaweed, macro- and microelements, vitamins were the object of research. As a result of these researches author presents more effective norms of complex feed additive use in poultry farming of Khabarovsk Kray. The recipe of feed additive from local vegetable resources and complex of vitamins and minerals for use in laying hens nutrition was worked out. The aim of this work was to rise zootechnic and economic indexes of poultry production. The introduction of complex feed additive in ration influenced positively on the digestibility, raised the content of Omega-3 fat acid in egg of laying hens. The increase of Omega-3 fat acid quantity promotes decrease of cholesterol in yolk of egg. In the experimental groups there was a more intensive use of nutrients in diet, mainly due to raw protein, fats, mineral substances – calcium and phosphorus. The use of a new feed additive had a positive effect on the hatchability of eggs, the development of internal organs (heart, liver) and the live weight of chicks obtained from the eggs of chickens in experimental groups. Additionally, the content of mineral substances (calcium, potassium, phosphorus) in the egg of test group was higher than in the control on average by 2.3-5.1%.

Brown Seaweed Lipids as Potential Source of Omega-3 PUFA in Biological Systems

2011 ◽  
pp. 329-339 ◽  
Author(s):  
Kazuo Miyashita ◽  
Bhaskar Narayan ◽  
Takayuki Tsukui ◽  
Hiroyuki Kamogawa ◽  
Masayuki Abe ◽  
...  
Keyword(s):  
Biological Systems ◽  
Brown Seaweed ◽  
Omega 3 ◽  
Potential Source

scholarly journals Biological Evaluation, Molecular Docking, and SAR Studies of Novel 2-(2,4-Dihydroxyphenyl)-1H- Benzimidazole Analogues

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 870
Author(s):  
Joanna Matysiak ◽  
Alicja Skrzypek ◽  
Monika Karpińska ◽  
Kamila Czarnecka ◽  
Paweł Szymański ◽  
...  
Keyword(s):  
Molecular Docking ◽  
High Selectivity ◽  
Antioxidant Properties ◽  
Binding Mode ◽  
Biological Evaluation ◽  
The Other ◽  
Docking Simulations ◽  
Sar Studies ◽  
Structure Activity

In the present study, new 4-(1H-benzimidazol-2-yl)-benzene-1,3-diols, modified in both rings, have been synthesized and their efficacies as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors have been determined. The modified Ellman’s spectrophotometric method was applied for the biological evaluation. The compounds showed strong (IC50 80–90 nM) AChE and moderate (IC50 5–0.2 µM) BuChE inhibition in vitro. Some compounds were effective toward AChE/BuChE, exhibiting high selectivity ratios versus BuChE, while the other compounds were active against both enzymes. The structure–activity relationships were discussed. The compounds inhibited also in vitro self-induced Aβ(1–42) aggregation and exhibited antioxidant properties. The docking simulations showed that the benzimidazoles under consideration interact mainly with the catalytic site of AChE and mimic the binding mode of tacrine.

Amended Final Report on the Safety Assessment of Cocamide DEA

1996 ◽  
Vol 15 (6) ◽  
pp. 527-542 ◽  
Keyword(s):  
Expert Panel ◽  
Present Report ◽  
Skin Irritation ◽  
Surfactant Solution ◽  
Nitroso Compounds ◽  
Final Report ◽  
Test Substance ◽  
Cosmetic Products ◽  
Patch Tests ◽  
Skin Irritation Test

Cocamide DEA is a mixture of ethanolamides of Coconut Acid that is used as a surfactant-foam booster and viscosity-increasing agent-aqueous in cosmetic products. Production formulation data submitted to the Food and Drug Administration in 1994 indicated that this ingredient was used in 745 products. The Cosmetic Ingredient Review (CIR) Expert Panel had previously evaluated the safety of Cocamide DEA, Lauramide DEA, Linoleamide DEA, and Oleamide DEA in cosmetics and concluded that they were safe as cosmetic ingredients at the concentrations that were currently being used (50%). CIR's decision to reevaluate the safety of Cocamide DEA in cosmetics is based on occupational studies indicating that this ingredient may have sensitization potential; however, the Expert Panel has determined that these studies are not relevant to cosmetic use. Furthermore, the Panel agreed that its original conclusion on Cocamide DEA should be clarified relative to use of this ingredient in rinse-off and leave-on products. Clarification of the original conclusion is based on the results of a skin irritation test in which 15 volunteers were tested with a surfactant solution containing 10% Cocamide DEA, the highest concentration tested in predictive patch tests. Additional comments that were made during the Panel's review of other data in the present report include that the severe ocular irritation reactions induced by a chemical (p H 9–10.5) containing >64% Cocamide DEA were likely a result of p H; that the renal effects noted in Fischer 344 rats in the National Toxicology Program (NTP) subchronic dermal toxicity study may be species-related and not test substance-related; and with reference to an ongoing NTP two-year chronic study that was initiated in 1993, that the results will be reviewed when the study is available. On the basis of the animal and clinical data presented in the present report, the Expert Panel concluded that Cocamide DEA is safe as used in rinse-off products and safe at concentrations 10% in leave-on cosmetic products. It was also concluded that Cocamide DEA should not be used as an ingredient in cosmetic products in which N-nitroso compounds are formed.

scholarly journals Pre-validation of an in vitro skin irritation test for medical devices using the reconstructed human tissue model EpiDerm™

2018 ◽  
Vol 50 ◽  
pp. 407-417 ◽  
Author(s):  
Helena Kandarova ◽  
Jamin A. Willoughby ◽  
Wim H. De Jong ◽  
Silvia Letasiova ◽  
Tatiana Milasova ◽  
...  
Keyword(s):  
Medical Devices ◽  
Human Tissue ◽  
Skin Irritation ◽  
Tissue Model ◽  
Irritation Test ◽  
Skin Irritation Test

scholarly journals Development of Lidocaine-Loaded Dissolving Microneedle for Rapid and Efficient Local Anesthesia

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1067
Author(s):  
Huisuk Yang ◽  
Geonwoo Kang ◽  
Mingyu Jang ◽  
Daniel Junmin Um ◽  
Jiwoo Shin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Local Anesthesia ◽  
Local Anesthetic ◽  
Clinical Performance ◽  
Skin Irritation ◽  
Onset Time ◽  
Fast Onset ◽  
Limit Test ◽  
Skin Irritation Test ◽  
Administration Methods

Lidocaine is a local anesthetic agent used in the form of injection and topical cream. However, these formulation types have limitations of being either painful or slow-acting, thereby hindering effective and complete clinical performance of lidocaine. Dissolving microneedles (DMNs) are used to overcome these limitations owing to their fast onset time and minimally invasive administration methods. Using hyaluronic acid and lidocaine to produce the drug solution, a lidocaine HCl encapsulated DMN (Li-DMN) was fabricated by centrifugal lithography. The drug delivery rate and local anesthetic quality of Li-DMNs were evaluated using the pig cadaver insertion test and Von Frey behavior test. Results showed that Li-DMNs could deliver sufficient lidocaine for anesthesia that is required to be utilized for clinical level. Results from the von Frey test showed that the anesthetic effect of Li-DMNs was observed within 10 min after administration, thus confirming fast onset time. A toxicity test for appropriate clinical application standard was conducted with a microbial limit test and an animal skin irritation test, showing absence of skin irritation and irritation-related microorganisms. Overall, Li-DMN is a possible alternative drug delivery method for local anesthesia, meeting the requirements for clinical conditions and overcoming the drawbacks of other conventional lidocaine administration methods.

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